{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:52:28Z","timestamp":1790614348463,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T00:00:00Z","timestamp":1667606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T00:00:00Z","timestamp":1667606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T00:00:00Z","timestamp":1667606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Guangzhou Municipal Science and Technology Project, China","award":["202102010243"],"award-info":[{"award-number":["202102010243"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Laparoscopic pancreaticoduodenectomy (LPD) may induce intense inflammatory response which might be related to the patient's outcomes. Clinical dexmedetomidine (DEX) has been widely used for opioid\u2010sparing anesthesia and satisfactory sedation. The objective of this study was to investigate the influence of DEX on inflammatory response and postoperative complications in LPD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010nine patients undergoing LPD were randomly assigned to two groups: normal saline (NS) and DEX. The primary outcome was the neutrophil\u2010to\u2010lymphocyte ratio (NLR) differences postoperatively within 48 h. Secondary outcomes were postoperative complications, the length of postoperative hospital stay and the incidence of ICU admission. Other outcomes included anesthetics consumption and intraoperative vital signs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NLR at postoperative day 2 to baseline ratio decreased significantly in the DEX group (<jats:italic>P<\/jats:italic>\u2009=\u20090.032). Less major complications were observed in the DEX group such as pancreatic fistula, delayed gastric emptying and intra\u2010abdominal infection (NS vs. DEX, 21.7% vs. 13.6%, <jats:italic>P<\/jats:italic>\u2009=\u20090.315; 10.9% vs. 2.3%, <jats:italic>P<\/jats:italic>\u2009=\u20090.226; 17.4% vs. 11.4%, <jats:italic>P<\/jats:italic>\u2009=\u20090.416, respectively) though there were no statistical differences. Three patients were transferred to the ICU after surgery in the NS group, while there was none in the DEX group (<jats:italic>P<\/jats:italic>\u2009=\u20090.242). The median postoperative hospital stay between groups were similar (<jats:italic>P<\/jats:italic>\u2009=\u20090.313). Both intraoperative propofol and opioids were less in the DEX group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intraoperative DEX reduced the early postoperative inflammatory response in LPD. It also reduced the use of narcotics that may related to reduced major complications, which need additional research further.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-022-06802-8","type":"journal-article","created":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T17:12:58Z","timestamp":1667668378000},"page":"500-509","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Dexmedetomidine on Systemic Inflammation and Postoperative Complications in Laparoscopic Pancreaticoduodenectomy: A Double\u2010blind Randomized Controlled Trial"],"prefix":"10.1002","volume":"47","author":[{"given":"Yan\u2010Xin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology The Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou Guangdong PR 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