{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T02:01:22Z","timestamp":1793671282250,"version":"4.5.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Sihtasutus Eesti Teadusagentuur","award":["PRG1255"],"award-info":[{"award-number":["PRG1255"]}],"id":[{"id":"https:\/\/ror.org\/00jjeja18","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is a lack of population\u2010based studies on acute mesenteric ischemia (AMI). We have therefore performed a nationwide epidemiological study in Estonia, addressing incidence, demographics, interventions and mortality of AMI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective population\u2010based review was conducted of all adult cases of AMI accrued from the digital Estonian Health Insurance Fund and Causes of Death Registry for 2016\u20132020 based on international classification of diseases (ICD\u201010) diagnostic codes and procedure codes (NOMESCO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 577 cases of AMI were identified\u2014an annual incidence of 8.7 per 100,000. The median age was 79 (range 32\u2013104) and 57% were female. Predominating comorbidities included hypertensive disease (81%), atherosclerosis (67%), and atrial fibrillation (52%). The majority of cases (60%) were caused by superior mesenteric artery occlusion (thrombosis 54%, embolism 12%, and unclear 34%). Inferior mesenteric artery occlusion occurred in 7%, non\u2010occlusive mesenteric ischemia in 7%, venous thrombosis in 4%, whereas the type remained unclear in 21% of cases. 40% of patients received intervention (revascularization and\/or intestinal resection) and 13% active non\u2010operative treatment. In 21% an exploratory laparotomy or laparoscopy revealed unsalvageable bowel prompting end\u2010of\u2010life care, which was the only management in a further 25% of cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The population\u2010based annual incidence of AMI in Estonia was 8.7 per 100,000 during the study period. The overall hospital mortality and 1 year mortality were 64% and 74%, respectively. In the 53% of patients who received active treatment hospital mortality was 32% and 1 year all\u2010cause mortality was 51%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov Identifier NCT04867499.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00268-022-06805-5","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T14:03:54Z","timestamp":1666188234000},"page":"173-181","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Epidemiology of Acute Mesenteric Ischemia: A Population\u2010Based Investigation"],"prefix":"10.1002","volume":"47","clinical-trial-number":[{"clinical-trial-number":"nct04867499","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Karri","family":"Kase","sequence":"first","affiliation":[{"name":"Department of Surgery Tartu University Hospital Tartu Estonia"},{"name":"Faculty of Medicine University of Tartu Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Reintam Blaser","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Tartu University Hospital Tartu Estonia"},{"name":"Department of Intensive Care Medicine Lucerne Cantonal Hospital Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadri","family":"Tamme","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Tartu Tartu Estonia"},{"name":"Department of Anaesthesiology and Intensive Care Tartu University Hospital Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merli","family":"M\u00e4ndul","sequence":"additional","affiliation":[{"name":"Estonian Genome Centre, Institute of Genomics University of Tartu Tartu Estonia"},{"name":"Institute of Mathematics and Statistics University of Tartu Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair","family":"Forbes","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Tartu Tartu Estonia"},{"name":"Department of Internal Medicine Tartu University Hospital Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peep","family":"Talving","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Tartu Tartu Estonia"},{"name":"Division of Acute Care Surgery, Department of Surgery North Estonia Medical Centre Tallinn Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Murruste","sequence":"additional","affiliation":[{"name":"Department of Surgery Tartu University Hospital Tartu Estonia"},{"name":"Faculty of Medicine University of Tartu Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,19]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semvascsurg.2009.12.001"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605\u2010015\u20102830\u20103"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2016.00022"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2017.01.010"},{"key":"e_1_2_13_6_1","unstructured":"https:\/\/www.stat.ee\/et. 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Study was retrospective and Ethics Committee gave approval to do study without consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Approval for the study was obtained from the Research Ethics Committee of the University of Tartu (number 345\u00a0M-5) and from the Estonian Committee on Bioethics and Human Research (number 1.1-12\/1238).","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}