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This study aims to systematically evaluate perioperative adverse events (AEs) in patients undergoing ILND and its reporting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review was conducted according to PRISMA. PubMed, MEDLINE, Scopus, and Embase were queried to identify studies discussing perioperative AEs in patients with melanoma, penile, and vulvar cancer following ILND.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our search generated 3.469 publications, with 296 studies meeting the inclusion criteria. Details of 14.421 patients were analyzed. Of these studies, 58 (19.5%) described intraoperative AEs (iAEs) as an outcome of interest. Overall, 68 (2.9%) patients reported at least one iAE. Postoperative AEs were reported in 278 studies, combining data on 10.898 patients. Overall, 5.748 (52.7%) patients documented\u2009\u22651 postoperative AEs. The most reported ILND\u2010related AEs were lymphatic AEs, with a total of 4.055 (38.8%) events. The pooled meta\u2010analysis confirmed that high BMI (RR 1.09; <jats:italic>p<\/jats:italic>\u2009=\u20090.006),\u2009\u22651 comorbidities (RR 1.79; <jats:italic>p<\/jats:italic>\u2009=\u20090.01), and diabetes (RR 1.81; <jats:italic>p<\/jats:italic>\u2009=\u2009\u2009&lt;\u20090.00001) are independent predictors for any AEs after ILND. When assessing the quality of the AEs reporting, we found 25% of studies reported at least 50% of the required criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ILND performed in melanoma, penile, and vulvar cancer patients is a morbid procedure. The quality of the AEs reporting is suboptimal. A more standardized AEs reporting system is needed to produce comparable data across studies for furthering the development of strategies to decrease AEs.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-022-06882-6","type":"journal-article","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T22:02:37Z","timestamp":1674943357000},"page":"962-974","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Assessment and Reporting of Perioperative Adverse Events and Complications in Patients Undergoing Inguinal Lymphadenectomy for Melanoma, Vulvar Cancer, and Penile Cancer: A Systematic Review and Meta\u2010analysis"],"prefix":"10.1002","volume":"47","author":[{"given":"Giovanni E.","family":"Cacciamani","sequence":"first","affiliation":[{"name":"Catherine and Joseph Aresty Department of Urology, USC Institute of Urology, Keck School of Medicine, University of Southern California Los Angeles CA 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