{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:11:46Z","timestamp":1787609506973,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100006275","name":"Friede Springer Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006275","name":"Friede Springer Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The dual technique using blue dye in combination with a radioisotope is considered the gold standard for identifying sentinel lymph nodes (SLNs) in patients with breast cancer. Unfortunately, not all cancer centres have access to radioactive material, which jeopardizes the SLN identification rate and patient safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to assess the safety and efficacy of mitoxantrone hydrochloride injection (MHI) for identifying axillary SLNs in patients with primary breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>We have conducted a prospective non\u2010randomized analysis of patients diagnosed with invasive breast cancer who agreed to participate in the study between December 2019 and December 2022. We have used the patient's medical records to collect the data. We have used the SLN intraoperative identification rate as a marker for the efficacy of the technique and both the immediate and delayed complication rates and routine blood tests as markers for the safety of the technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of the 296 patients, 289 (97.6%) had their SLNs identified using MHI, while seven patients (2.3%) had four\u2010node sampling carried out because the SLNs were not identified. Liver functions were not significantly affected by MHI, and there was no technique\u2010related readmission or reported morbidity or mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We have found that the MHI technique is still inferior to the combined radioactive directed technique and patent blue V dye in SLN identification. Yet, it may serve as a safe and reliable alternative in cases where the radioactive technique is unavailable.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-023-07011-7","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T22:01:47Z","timestamp":1682114507000},"page":"1956-1960","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Safety and Efficacy of Mitoxantrone Hydrochloride Injection for Identification of Axillary Sentinel Lymph Nodes in Patients with Primary Breast Cancer"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6018-3783","authenticated-orcid":false,"given":"Ibrahim","family":"Elzayat","sequence":"first","affiliation":[{"name":"General Surgery Department Aswan University Hospital Aswan Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Abdelaal","sequence":"additional","affiliation":[{"name":"Surgery Department Sohag Oncology Centre Sohag Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif","family":"Monib","sequence":"additional","affiliation":[{"name":"Breast Unit West Hertfordshire Teaching Hospitals NHS Trust Hertfordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202502"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29644"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012782"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21568"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.90"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10606"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2014.11.006"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.914057"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.12290\/xhyxzz.2021\u20100281"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.4174\/astr.2020.98.6.283"},{"key":"e_1_2_15_13_1","unstructured":"GarcezT HarperN(2012)Association of Breast Surgery. Use of blue dye for SLNB. Accessed November 13 2020:https:\/\/associationofbreastsurgery.org.uk\/media\/64183\/final\u2010use\u2010of\u2010blue\u2010dye\u2010for\u2010slnb.pdf"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2020\u20100001"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijc.IJC_139_18"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13193\u2010017\u20100646\u20101"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249\u2010019\u20101447\u20103"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.3332\/ecancer.2016.674"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957\u2010017\u20101113\u20108"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.21037\/tcr\u201021\u20101239"},{"key":"e_1_2_15_21_1","article-title":"Identification rate of sentinel lymph node biopsy using single technique (isosulfan blue dye) in early breast cancer in Lopburi Cancer Hospital","volume":"46","author":"Areerattanavet K","year":"2021","journal-title":"J Dept Med Ser"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10143149"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2020.02.003"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.21037\/gs\u201020\u2010694"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-023-07011-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00268-023-07011-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-023-07011-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-023-07011-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T17:55:53Z","timestamp":1704650153000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-023-07011-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,21]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1007\/s00268-023-07011-7"],"URL":"https:\/\/doi.org\/10.1007\/s00268-023-07011-7","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,21]]},"assertion":[{"value":"26 March 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}