{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T16:56:13Z","timestamp":1767372973138},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T00:00:00Z","timestamp":1683331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T00:00:00Z","timestamp":1683331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T00:00:00Z","timestamp":1683331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"he China Youth Innovation Fund of the Second Affiliated Hospital of Harbin Medical University","award":["CX2016\u201014"],"award-info":[{"award-number":["CX2016\u201014"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the value of mixed reality (MR) in sentinel lymph node biopsy (SLNB) in patients with breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 300 patients with breast cancer who underwent SLNB enrolled and were randomly divided into two groups. In group A, only dye (an injection of methylene blue) was used to detect sentinel lymph nodes, while in group B MR was used for positioning in addition to dye. (MR localization method: Before the surgery, we built a 1:1 3D reconstruction model based on the patient's CT or MRI original data, and after the patient was injected with dye, we completed MR localization by overlapping the pre\u2010marked image with the model.)<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During surgery, the detection time in group B was significantly shorter than in group A (3.62\u2009\u00b1\u20091.20 vs.7.87\u2009\u00b1\u20091.86; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). At 1\u2010month post\u2010surgery follow\u2010up, the incidence of pain in group B was lower than that in group A (2.70 vs. 8.28%, <jats:italic>p<\/jats:italic>\u2009=\u20090.036). The incidence of upper limb dysfunction was lower in group B than in group A (2.03 vs. 8.97%, <jats:italic>p<\/jats:italic>\u2009=\u20090.009). In terms of the incidence of pain, group B was better than group A (0.68 vs. 3.45%, <jats:italic>p<\/jats:italic>\u2009=\u20090.094). The satisfaction of the two groups was scored, and the results showed that group B was better than group A (4.04\u2009\u00b1\u20090.91 vs.3.32\u2009\u00b1\u20090.94, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The application of MR to SLNB in breast cancer can significantly reduce the detection time and the occurrence of complications and improve patient satisfaction.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-023-07028-y","type":"journal-article","created":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T20:01:13Z","timestamp":1683403273000},"page":"1961-1970","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Application of Mixed Reality to Sentinel Lymph Node Biopsy in Breast Cancer"],"prefix":"10.1002","volume":"47","author":[{"given":"Lin","family":"Tao","sequence":"first","affiliation":[{"name":"Inpatient Department of Ultrasound The Second Affiliated Hospital of Harbin Medical University 150081 Harbin Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenchu","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Mammary Surgery The Second Affiliated Hospital of Harbin Medical University NO. 246 Xuefu Road, Nangang District 150081 Harbin Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Surgery The Fourth Affiliated Hospital of Harbin Medical University 150081 Harbin Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Mammary Surgery The Second Affiliated Hospital of Harbin Medical University NO. 246 Xuefu Road, Nangang District 150081 Harbin Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Mammary Surgery The Second Affiliated Hospital of Harbin Medical University NO. 246 Xuefu Road, Nangang District 150081 Harbin Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Mammary Surgery The Second Affiliated Hospital of Harbin Medical University NO. 246 Xuefu Road, Nangang District 150081 Harbin Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Mammary Surgery The Second Affiliated Hospital of Harbin Medical University NO. 246 Xuefu Road, Nangang District 150081 Harbin Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaowen","family":"Qiu","sequence":"additional","affiliation":[{"name":"College of Information and Computer Engineering Northeast Forestry University No. 26 Hexing Road, Xiangfang District 150040 Harbin Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenlong","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Mammary Surgery The Second Affiliated Hospital of Harbin Medical University NO. 246 Xuefu Road, Nangang District 150081 Harbin Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Mammary Surgery The Second Affiliated Hospital of Harbin Medical University NO. 246 Xuefu Road, Nangang District 150081 Harbin Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,6]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"ZhengY WuC ZhangM(2013) The epidemic and characteristics of female breast cancer in China.China Oncol 561\u2013569."},{"issue":"6","key":"e_1_2_12_3_1","first-page":"29","article-title":"Application and clinical analysis of methylene blue combined with the nuclide tracing method in the sentinel lymph node biopsy of early breast cancer","volume":"4","author":"Zhang C","year":"2017","journal-title":"E\u2010J Trans Med"},{"issue":"7","key":"e_1_2_12_4_1","first-page":"505","article-title":"Sentinel lymph node biopsy in breast cancer: consensus and future","volume":"16","author":"Wang Y","year":"2009","journal-title":"Chin J Bases Clin General Surg"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(10)70207\u20102"},{"issue":"6","key":"e_1_2_12_6_1","first-page":"483","article-title":"Canadian Association of General Surgeons and American College of Surgeons Evidence Based Reviews in Surgery.27. Quality\u2010of\u2010life outcomes with sentinel node biopsy versus standard axillary treatment in patients with operable breast cancer. Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial","volume":"51","author":"Latosinsky S","year":"2008","journal-title":"Can J Surg"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012782"},{"issue":"3","key":"e_1_2_12_8_1","first-page":"375","article-title":"Application and research progress of three\u2010dimensional printing based on medical imaging in the diagnosis and treatment of cardiovascular diseases","volume":"33","author":"Song H","year":"2017","journal-title":"Chin J Med Imag Technol"},{"issue":"1","key":"e_1_2_12_9_1","first-page":"15","article-title":"Application of 3D printing technology in foot and ankle surgery","volume":"52","author":"Jiang Y","year":"2015","journal-title":"Int J Orthopaed"},{"issue":"8","key":"e_1_2_12_10_1","first-page":"654","article-title":"Application of three\u2010dimensional printing to surgical treatment of congenital heart disease","volume":"28","author":"Gao Q","year":"2018","journal-title":"Chin J Clin Thoracic Cardiovascular Surg"},{"issue":"1","key":"e_1_2_12_11_1","first-page":"66","article-title":"Application of 3D printing technology in medicine and hepatobiliary surgery","volume":"24","author":"Yang H","year":"2016","journal-title":"J Hepatobiliary Surg"},{"issue":"2","key":"e_1_2_12_12_1","first-page":"52","article-title":"Application and progress of 3D printing technology in foot and ankle surgery","volume":"3","author":"Huang R","year":"2016","journal-title":"Chin J Foot Ankle Surg"},{"issue":"08","key":"e_1_2_12_13_1","first-page":"855","article-title":"Expert consensus and technical guidelines for sentinel lymph node biopsy using the dye method in early\u2010stage breast cancer (2018 edition)","volume":"38","author":"Guo B","year":"2018","journal-title":"Chin J Pract Surg"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010016\u20105669\u20102"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012782"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2006.05.013"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2013.10.020"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12282\u2010011\u20100280\u20107"},{"key":"e_1_2_12_19_1","doi-asserted-by":"crossref","volume-title":"Fuzzy geometrical approach based on unit hyper\u2010cubes for image contrast enhancement","author":"Versaci M","DOI":"10.1109\/ICSIPA.2015.7412240"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-023-07028-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00268-023-07028-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-023-07028-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-023-07028-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T17:55:31Z","timestamp":1704650131000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-023-07028-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,6]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1007\/s00268-023-07028-y"],"URL":"https:\/\/doi.org\/10.1007\/s00268-023-07028-y","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,6]]},"assertion":[{"value":"15 April 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"I confirm that I have read the Editorial Policy pages. This study was conducted with approval from the Ethics Committee of The Second Affiliated Hospital of Harbin Medical University (KY2018-155). This study was conducted in accordance with the declaration of Helsinki. Written informed consent was obtained from all participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}