{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:50:11Z","timestamp":1776081011299,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients undergoing bariatric surgery have a high incidence of non\u2010alcoholic fatty liver disease (NAFLD). However, the effect of NAFLD or non\u2010alcoholic steatohepatitis (NASH) on the weight loss and resolution of obesity\u2010related disorders is a matter of debate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we compare the long\u2010term outcomes after bariatric with the presence of NAFLD in the liver biopsy at the time of surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The follow\u2010up was available for 226 out of 288 patients. The mean follow\u2010up time was 24.9 (\u00b1\u200913.6) months. The baseline histology showed that 112 patients (38.9%) had no NASH, 70 (24.3%) were borderline, and 106 (36.8%) had NASH. At follow\u2010up, the mean BMI dropped from (52\u2009\u00b1\u200910.2) to (36.6\u2009\u00b1\u20098) kg\/m <jats:sup>2<\/jats:sup>. Excess weight loss (EWL) was similar in all NAFLD groups. Type 2 diabetes mellitus dropped from 35.7 to 11.4%, hypertension from 65.6 to 36.7%, hyperlipidemia from 62.3 to 33%, and obstructive sleep apnea from 37.5 to 14.9%. Only hyperlipidemia was significantly associated with NASH compared to the groups with no NASH or borderline NASH (<jats:italic>p<\/jats:italic> value\u2009=\u20090.002 and <jats:italic>p<\/jats:italic> value\u2009=\u20090.04, respectively) during the first two years of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The beneficial effects of bariatric surgery are evident across all patients with NAFLD. Patients with NASH have comparable outcomes regarding weight loss and resolution of obesity\u2010related comorbidities.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-023-07153-8","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T14:02:30Z","timestamp":1695650550000},"page":"3281-3288","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Effect of Non\u2010Alcoholic Fatty Liver Disease on Weight Loss and Resolution of Obesity\u2010Related Disorders After Bariatric Surgery"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0448-2225","authenticated-orcid":false,"given":"Thaer S. A.","family":"Abdalla","sequence":"first","affiliation":[{"name":"Department of General, Visceral and Thoracic Surgery At the University Hospital Hamburg\u2010Eppendorf Martinistrasse 52 20251 Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasios D.","family":"Giannou","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Thoracic Surgery At the University Hospital Hamburg\u2010Eppendorf Martinistrasse 52 20251 Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed S. A.","family":"Abdalla","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Thoracic Surgery At the University Hospital Hamburg\u2010Eppendorf Martinistrasse 52 20251 Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob R.","family":"Izbicki","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Thoracic Surgery At the University Hospital Hamburg\u2010Eppendorf Martinistrasse 52 20251 Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Dupre\u00e9","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Thoracic Surgery At the University Hospital Hamburg\u2010Eppendorf Martinistrasse 52 20251 Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Mann","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Thoracic Surgery At the University Hospital Hamburg\u2010Eppendorf Martinistrasse 52 20251 Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Wolter","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Thoracic Surgery At the University Hospital Hamburg\u2010Eppendorf Martinistrasse 52 20251 Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.22.2845"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(14)60460\u20108"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(11)60105\u20100"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.159228"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016\u20105085(99)70506\u20108"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.04.001"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.171"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.11.039"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14937"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i2.475"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010013\u20101044\u20106"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.066"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1381\/096089204772787293"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9113430"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010022\u201006175\u2010w"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2022.03.011"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384\u2010011\u20101136\u20105"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010018\u20103450\u20102"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010007\u20109351\u20104"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010017\u20105505\u20101"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010017\u20102829\u20109"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100032\u20101306423"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13035"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100032\u20101306428"},{"key":"e_1_2_10_27_1","first-page":"CD007340","article-title":"Bariatric surgery for non\u2010alcoholic steatohepatitis in obese patients","volume":"2010","author":"Chavez\u2010Tapia NC","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.19569"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu5062019"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i24.3009"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101092"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010021\u201000501\u20109"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-023-07153-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00268-023-07153-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-023-07153-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-023-07153-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T04:20:22Z","timestamp":1709526022000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-023-07153-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,25]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1007\/s00268-023-07153-8"],"URL":"https:\/\/doi.org\/10.1007\/s00268-023-07153-8","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,25]]},"assertion":[{"value":"7 August 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Institutional Review Board. Our study includes male and female sex.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}