{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:50:56Z","timestamp":1764996656044},"reference-count":0,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T00:00:00Z","timestamp":1392854400000},"content-version":"vor","delay-in-days":4890,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p>Gastric stasis is a frequent complication of pylorus\u2010preserving pancreatoduodenectomy (PPPD). We demonstrated that it might be attributable to delayed recovery of phase III activity of the gastric migrating motor complex due to low concentrations of plasma motilin caused by resection of the duodenum. Leucine 13\u2010motilin is effective for treating gastric stasis, but it is not yet available for clinical use. Whether erythromycin would improve early gastric stasis after PPPD was tested clinically and by manometry. A manometric tube assembly and a gastrostomy tube were inserted in the stomach of 10 patients at PPPD for pressure recording from the gastric antrum and jejunum and for gastric juice drainage, respectively. After baseline recording, erythromycin 5\u00a0mg\/kg was given intravenously on day 14 and saline as a placebo on day 17 every 4 hours four times a day. The daily volume of gastric juice output and the gastric motility index were measured. The mean period until the return of gastric phase III was 31 \u00b1 1\u00a0days. Erythromycin significantly increased the gastric motility index from 7.9 \u00b1 1.3\u00a0mmHg to 15.7 \u00b1 1.8\u00a0mmHg (<jats:italic>p<\/jats:italic>= 0.0005), whereas saline did not (7.2 \u00b1 1.6\u00a0mmHg to 6.5 \u00b1 1.2\u00a0mmHg; <jats:italic>p<\/jats:italic>= 0.21). Erythromycin significantly decreased the gastric juice output from 1080 \u00b1 190\u00a0ml to 738 \u00b1 199\u00a0ml (<jats:italic>p<\/jats:italic> &lt; 0.0001), but the saline injections did not (1064 \u00b1 174\u00a0ml to 1115 \u00b1 189\u00a0ml; <jats:italic>p<\/jats:italic>= 0.35). Erythromycin, a universally available motilin agonist, is a safe, effective, potent drug for the treatment of early gastric stasis after PPPD.<\/jats:p>","DOI":"10.1007\/s002680010244","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T05:57:49Z","timestamp":1030255069000},"page":"1236-1242","source":"Crossref","is-referenced-by-count":23,"title":["Manometric Evidence of Improved Early Gastric Stasis by Erythromycin after Pylorus\u2010preserving Pancreatoduodenectomy"],"prefix":"10.1002","volume":"24","author":[{"given":"Hiroaki","family":"Matsunaga","sequence":"first","affiliation":[{"name":"Department of Surgery and Oncology Kyushu University Graduate School of Medical Sciences Fukuoka 812\u20108582 Japan<!--<country1>JP<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Surgery and Oncology Kyushu University Graduate School of Medical Sciences Fukuoka 812\u20108582 Japan<!--<country1>JP<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunichi","family":"Takahata","sequence":"additional","affiliation":[{"name":"Department of Surgery and Oncology Kyushu University Graduate School of Medical Sciences Fukuoka 812\u20108582 Japan<!--<country1>JP<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Surgery and Oncology Kyushu University Graduate School of Medical Sciences Fukuoka 812\u20108582 Japan<!--<country1>JP<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Naritomi","sequence":"additional","affiliation":[{"name":"Department of Surgery and Oncology Kyushu University Graduate School of Medical Sciences Fukuoka 812\u20108582 Japan<!--<country1>JP<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Yokohata","sequence":"additional","affiliation":[{"name":"Department of Surgery and Oncology Kyushu University Graduate School of Medical Sciences Fukuoka 812\u20108582 Japan<!--<country1>JP<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Surgery and Oncology Kyushu University Graduate School of Medical Sciences Fukuoka 812\u20108582 Japan<!--<country1>JP<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Chijiiwa","sequence":"additional","affiliation":[{"name":"Department of Surgery and Oncology Kyushu University Graduate School of Medical Sciences Fukuoka 812\u20108582 Japan<!--<country1>JP<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,20]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002680010244.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002680010244\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s002680010244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T19:27:59Z","timestamp":1705001279000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s002680010244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["10.1007\/s002680010244"],"URL":"https:\/\/doi.org\/10.1007\/s002680010244","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,10]]}}}