{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T11:47:26Z","timestamp":1707911246526},"reference-count":0,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T00:00:00Z","timestamp":1392854400000},"content-version":"vor","delay-in-days":4890,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p>A total of 30 patients (18\u00a0men, 12 women; 43\u201379 years, mean 58.9 years) 1.0 to 1.5 years (mean 1.25 years) after distal gastrectomy for early gastric cancer (Billorth I, D<jats:sub>2<\/jats:sub> lymph node dissection, curability A) were divided into two groups based on the occurrence of interdigestive migrating motor complex (IMMC) phase III (pIII) from the duodenum and their postoperative gastrointestinal symptoms. They were compared before and after cisapride therapy (at an oral dose of 7.5\u00a0mg\/day for 3\u00a0months). Results were as follows. Before cisapride therapy: (1) Patients in the IMMC\u2010pIII\u2010positive group (<jats:italic>n<\/jats:italic>= 20) had more appetite and ate more food with less decrease in body weight than those in the IMMC\u2010pIII\u2010negative group (<jats:italic>n<\/jats:italic>= 10); (2) patients in the IMMC\u2010pIII\u2010positive group clearly had fewer symptoms, such as early dumping (systemic) symptoms, symptoms of reflux esophagitis (e.g., heartburn, feeling of regurgitation, difficult swallowing), nausea, abdominal pain, diarrhea, abdominal distension, and borborygmus, than the IMMC\u2010pIII\u2010negative group. After cisapride therapy: eight patients (80%) in the IMMC\u2010pIII\u2010negative group became IMMC\u2010pIII\u2010positive, and their appetite and food consumption were obviously improved; body weight increased in six patients (60%), with alleviation of other abdominal symptoms and disappearance of the early dumping syndrome. These results showed a more satisfactory condition in regard to gastrointestinal symptoms in the IMMC\u2010pIII\u2010positive group than in the IMMC\u2010pIII\u2010negative group. It is concluded that cisapride therapy results in the occurrence of IMMC\u2010pIII and subsequently alleviates various abdominal symptoms, contributing to the improved postoperative gastrointestinal condition of patients after gastrectomy.<\/jats:p>","DOI":"10.1007\/s002680010248","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T05:57:49Z","timestamp":1030255069000},"page":"1250-1257","source":"Crossref","is-referenced-by-count":12,"title":["Relation between Gastroduodenal Interdigestive Migrating Motor Complex and Postoperative Gastrointestinal Symptoms before and after Cisapride Therapy following Distal Gastrectomy for Early Gastric Cancer"],"prefix":"10.1002","volume":"24","author":[{"given":"Ryouichi","family":"Tomita","sequence":"first","affiliation":[{"name":"First Department of Surgery Nihon University School of Medicine 30\u20101 Ooyaguchi Kamimachi, Itabashi\u2010ku Tokyo 173 0032 Japan<!--<country1>JP<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhisa","family":"Tanjoh","sequence":"additional","affiliation":[{"name":"First Department of Surgery Nihon University School of Medicine 30\u20101 Ooyaguchi Kamimachi, Itabashi\u2010ku Tokyo 173 0032 Japan<!--<country1>JP<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Fujisaki","sequence":"additional","affiliation":[{"name":"First Department of Surgery Nihon University School of Medicine 30\u20101 Ooyaguchi Kamimachi, Itabashi\u2010ku Tokyo 173 0032 Japan<!--<country1>JP<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Fukuzawa","sequence":"additional","affiliation":[{"name":"First Department of Surgery Nihon University School of Medicine 30\u20101 Ooyaguchi Kamimachi, Itabashi\u2010ku Tokyo 173 0032 Japan<!--<country1>JP<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,20]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002680010248.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002680010248\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s002680010248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T19:28:06Z","timestamp":1705001286000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s002680010248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["10.1007\/s002680010248"],"URL":"https:\/\/doi.org\/10.1007\/s002680010248","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,10]]}}}