{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T21:10:01Z","timestamp":1771708201676,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T00:00:00Z","timestamp":1397952000000},"content-version":"vor","delay-in-days":4767,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2001,4]]},"abstract":"Abstract<\/jats:title>Temporary obliteration of the pancreatic duct has been suggested to be beneficial in chronic pancreatitis, segmental pancreatic transplantation, and following Roux\u2010Y pancreaticojejunostomy. Little is known, however, as to whether obliteration of the duct alters exocrine pancreatic physiology. Therefore we studied in male inbred Lewis rats the immediate effects of Ethibloc\u2010induced duct obliteration (Ethibloc: Ethicon, Norderstedt, Germany) on pancreatic microcirculation, inflammation, and tissue injury (n<\/jats:italic>= 8), and compared these effects with those caused by experimental pancreatitis (4% sodium taurocholate; n<\/jats:italic>= 8). Animals receiving an intraductal infusion of saline served as controls (n<\/jats:italic>= 8). Duct occlusion with Ethibloc resulted in a marked decrease (p<\/jats:italic> < 0.05) in capillary red blood cell (RBC) velocity and functional capillary density (FCD) to 88 \u00b1 39 \u03bcm\/s (baseline 716 \u00b1 40 \u03bcm\/s) and 72 \u00b1 33\u00a0cm\u22121<\/jats:sup> (baseline 493 \u00b1 21\u00a0cm\u22121<\/jats:sup>), respectively, which was even more pronounced when compared with that observed in experimental pancreatitis (333 \u00b1 62 \u03bcm\/s and 195 \u00b1 44\u00a0cm\u22121<\/jats:sup>, respectively). In parallel, the manifestation of tissue damage was found to be more severe after Ethibloc; and chloracetate esterase staining showed a larger number of infiltrating leukocytes [555 \u00b1 86\/high power field (HPF) versus pancreatitis: 160 \u00b1 12\/HPF; p<\/jats:italic> < 0.05). We conclude that intraductal application of Ethibloc induces significant microcirculatory failure and a marked inflammatory response, which are even more pronounced when compared with the changes observed with experimental pancreatitis. Based on these results and the fact that there is no direct proof for a benefit of temporary duct occlusion by Ethibloc, it is proposed that the procedure be reevaluated for its use in pancreatic surgery.<\/jats:p>","DOI":"10.1007\/s002680020041","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T05:57:49Z","timestamp":1030255069000},"page":"432-437","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Temporary Pancreatic Duct Occlusion by Ethibloc: Cause of Microcirculatory Shutdown, Acute Inflammation, and Pancreas Necrosis"],"prefix":"10.1002","volume":"25","author":[{"given":"Thorsten","family":"Plusczyk","sequence":"first","affiliation":[{"name":"Department of General Surgery University of Saarland Kirrbergerstrasse 66421 Homburg\/Saar Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Westermann","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Experimental Surgery University of Saarland Kirrbergerstrasse, 66421 Homburg\/Saar Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Bersal","sequence":"additional","affiliation":[{"name":"Department of General Surgery University of Saarland Kirrbergerstrasse 66421 Homburg\/Saar Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Menger","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Experimental Surgery University of Saarland Kirrbergerstrasse, 66421 Homburg\/Saar Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gernot","family":"Feifel","sequence":"additional","affiliation":[{"name":"Department of General Surgery University of Saarland Kirrbergerstrasse 66421 Homburg\/Saar Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,20]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002680020041.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002680020041\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s002680020041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T19:42:20Z","timestamp":1703706140000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s002680020041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["10.1007\/s002680020041"],"URL":"https:\/\/doi.org\/10.1007\/s002680020041","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4]]}}}