{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:25:48Z","timestamp":1792146348341,"version":"4.4.0"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T00:00:00Z","timestamp":1393200000000},"content-version":"vor","delay-in-days":4771,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2001,2]]},"abstract":"Abstract.<\/jats:title>Hepatoblastoma is a rare pediatric malignancy that frequently appears in an advanced unresectable stage. Improved resectability and survival rate have been reported with the help of neoadjuvant chemotherapy. Between January 1987 and June 1995 a series of 20 patients were managed with a diagnosis of hepatoblastoma. The median age at diagnosis was 13\u00a0months (2\u00a0months to 7 years 10\u00a0months) with a male\/female ratio of 13:7. Chemotherapy effectively reduced the tumor volume (with statistical significance: p<\/jats:italic>= 0.008) and was able to convert seven of nine initially unresectable tumors (78%) to resectable ones. Altogether, 14 operations were done, 12\u00a0radical and 2 palliative, with or without adjuvant chemotherapy. The whole population was followed for a median duration of 33\u00a0months; and the median survival for the whole group was 26\u00a0months. The curative resection group displayed a 5\u2010year survival rate of 61.1%, but none in the noncurative group survived more than 13\u00a0months (p<\/jats:italic>= 0.0001). In the univariate analysis for prognostic factors, large tumor size at diagnosis and the absence of thrombocytopenia were associated with poor survival, but these differences were not statistically significant. Pure fetal histology was not associated with better prognosis. In this new era of neoadjuvant chemotherapy, the optimal management strategy for hepatoblastoma is still debated, with radical surgical resection at the earliest possible time being the final goal. For now an individualized approach appears to be the protocol of choice.<\/jats:p>","DOI":"10.1007\/s002680020052","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T05:57:49Z","timestamp":1030255069000},"page":"126-130","source":"Crossref","is-referenced-by-count":20,"title":["Clinical Characteristics and Prognosis of Patients with Hepatoblastoma"],"prefix":"10.1002","volume":"25","author":[{"given":"Sung\u2010Eun","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Seoul National University College of Medicine 28 Yongon\u2010dong, Chongno\u2010ku Seoul 110\u2010744 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki\u2010Hong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Seoul National University College of Medicine 28 Yongon\u2010dong, Chongno\u2010ku Seoul 110\u2010744 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Seoul National University College of Medicine 28 Yongon\u2010dong, Chongno\u2010ku Seoul 110\u2010744 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae\u2010Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Seoul National University College of Medicine 28 Yongon\u2010dong, Chongno\u2010ku Seoul 110\u2010744 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong\u2010Cheol","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Seoul National University College of Medicine 28 Yongon\u2010dong, Chongno\u2010ku Seoul 110\u2010744 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwi\u2010Won","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Seoul National University College of Medicine 28 Yongon\u2010dong, Chongno\u2010ku Seoul 110\u2010744 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo\u2010Ki","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Seoul National University College of Medicine 28 Yongon\u2010dong, Chongno\u2010ku Seoul 110\u2010744 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,24]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002680020052.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002680020052\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s002680020052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T19:38:02Z","timestamp":1703705882000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s002680020052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["10.1007\/s002680020052"],"URL":"https:\/\/doi.org\/10.1007\/s002680020052","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,2]]}}}