{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T20:31:50Z","timestamp":1772915510660,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[1996,7,1]],"date-time":"1996-07-01T00:00:00Z","timestamp":836179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1996,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transsphenoidal pituitary surgery has radically modified the management of pituitary\u2010dependent hypercortisolism (Cushing's disease). Bilateral adrenalectomy may, however, represent the ultimate treatment in some cases of hypercortisolism. In the present study we report our experience of bilateral adrenalectomy in 82 patients operated on during the last 15 years. The causes of hypercortisolism were Cushing's disease (<jats:italic>n<\/jats:italic>= 78), ectopic ACTH syndrome (<jats:italic>n<\/jats:italic>= 3), and primary adrenocortical nodular dysplasia (Carney\u2010Meador syndrome) (<jats:italic>n<\/jats:italic>= 1). Before operation 37% of the patients had severe symptoms of hypercortisolism. A bilateral posterior approach was undertaken in 58 patients, whereas 18 patients had an anterior transabdominal approach and 6 patients a laparoscopic approach. There were two operative deaths (2.4%). Postoperative complications occurred mostly in cases of advanced disease and were observed in 14 patients (17%), among whom 4 had severe complications. At long\u2010term follow\u2010up, one recurrence of hypercortisolism and 12\u00a0Nelson syndromes (15%) were observed. In conclusion, bilateral adrenalectomy carries an acceptable operative risk, and we recommend bilateral adrenalectomy rather than long\u2010term suppressive therapy in patients requiring prompt and definitive control of their hypercortisolism or after pituitary surgery failure.<\/jats:p>","DOI":"10.1007\/s002689900118","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T05:57:49Z","timestamp":1030255069000},"page":"775-780","source":"Crossref","is-referenced-by-count":37,"title":["Role and Operative Risk of Bilateral Adrenalectomy in Hypercortisolism"],"prefix":"10.1002","volume":"20","author":[{"given":"Yves","family":"Chapuis","sequence":"first","affiliation":[{"name":"Department of General and Digestive Surgery Cochin Hospital 27 Rue du Faubourg Saint\u2010Jacques 75014 Paris France<!--<country1>FR<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jol","family":"Pitre","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery Cochin Hospital 27 Rue du Faubourg Saint\u2010Jacques 75014 Paris France<!--<country1>FR<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filomena","family":"Conti","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery Cochin Hospital 27 Rue du Faubourg Saint\u2010Jacques 75014 Paris France<!--<country1>FR<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bassam","family":"Abboud","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery Cochin Hospital 27 Rue du Faubourg Saint\u2010Jacques 75014 Paris France<!--<country1>FR<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Pras\u2010Jude","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery Cochin Hospital 27 Rue du Faubourg Saint\u2010Jacques 75014 Paris France<!--<country1>FR<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Pierre","family":"Luton","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases Cochin Hospital 27 Rue du Faubourg Saint\u2010Jacques 75014 Paris France<!--<country1>FR<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1996,7]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002689900118.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002689900118\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s002689900118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T16:13:02Z","timestamp":1704989582000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s002689900118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,7]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1996,7]]}},"alternative-id":["10.1007\/s002689900118"],"URL":"https:\/\/doi.org\/10.1007\/s002689900118","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,7]]}}}