{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T01:57:22Z","timestamp":1774058242131,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[1996,10,1]],"date-time":"1996-10-01T00:00:00Z","timestamp":844128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1996,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:sc>l<\/jats:sc>\u2010Arginine inhibits the development of spontaneous, transplantable solid tumors and chemically induced mammary tumors. The aim of the present study was to investigate the effect of <jats:sc>l<\/jats:sc>\u2010arginine on chemically induced colorectal cancer in male Wistar rats. Colorectal cancer was induced in all animals by weekly subcutaneous injections of the colonic procarcinogen 1,2\u2010dimethyhydrazine (DMH) at a dosage of 20\u00a0mg\/kg body weight. Arginine was given in a 1% solution of drinking water. Group I was the DMH control; group II, arginine for 22 weeks; group III, arginine for the first 10 weeks only. Lymphocyte function was evaluated by measuring the thymic lymphocyte proliferative response to the T cell mitogen phytohemagglutinin. The results show that tumor incidence and tumor burden (tumors\/rat and tumors\/tumor\u2010bearing rat) were significantly reduced in both groups of animals receiving arginine compared to DMH controls (<jats:italic>p<\/jats:italic>&lt; 0.05). The tumor areas and volumes were also reduced in both arginine groups (<jats:italic>p<\/jats:italic>&lt; 0.05). Thymic lymphocyte stimulation indices were significantly increased by arginine supplementation (<jats:italic>p<\/jats:italic>&lt; 0.05). These results would be in keeping with the reduction in colorectal tumor production due to a \u201cnonspecific\u201d stimulation of the host immune system by l\u2010arginine.<\/jats:p>","DOI":"10.1007\/s002689900165","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T05:57:49Z","timestamp":1030255069000},"page":"1087-1091","source":"Crossref","is-referenced-by-count":45,"title":["Effect of Supplemental <scp>l<\/scp>\u2010Arginine in a Chemical\u2010Induced Model of Colorectal Cancer"],"prefix":"10.1002","volume":"20","author":[{"given":"Qingyong","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Surgery Institute of Clinical Science The Queen\u2019s University of Belfast Grosvenor Road Belfast BT12 6BJ Northern Ireland U.K.<!--<country1>GB<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Hoper","sequence":"additional","affiliation":[{"name":"Department of Surgery Institute of Clinical Science The Queen\u2019s University of Belfast Grosvenor Road Belfast BT12 6BJ Northern Ireland U.K.<!--<country1>GB<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Pathology Institute of Clinical Science The Queen\u2019s University of Belfast Grosvenor Road Belfast BT12 6BJ Northern Ireland U.K.<!--<country1>GB<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J.","family":"Rowlands","sequence":"additional","affiliation":[{"name":"Department of Surgery Institute of Clinical Science The Queen\u2019s University of Belfast Grosvenor Road Belfast BT12 6BJ Northern Ireland U.K.<!--<country1>GB<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1996,10]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002689900165.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002689900165\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s002689900165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T16:11:52Z","timestamp":1703693512000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s002689900165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,10]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1996,10]]}},"alternative-id":["10.1007\/s002689900165"],"URL":"https:\/\/doi.org\/10.1007\/s002689900165","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,10]]}}}