{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:01:41Z","timestamp":1703721701009},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1997,1,1]],"date-time":"1997-01-01T00:00:00Z","timestamp":852076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In a randomized study, prevention of goiter recurrence with <jats:sc>l<\/jats:sc>\u2010thyroxine was compared with pure iodide substitution after thyroid surgery for nodular goiter in an iodine\u2010deficient area. Altogether 107 patients were followed up for 52 weeks after thyroid resection. The thyroid volume was determined sonographically. Free thyroxine, total thyroxine, thyrotropin, thyroglobulin, and antibodies to thyroglobulin and thyroid peroxidase were measured. The thyroid volume decreased slightly over the course of a year in the two therapy groups. There was no significant difference between the two groups. Recurrences were seen with both <jats:sc>l<\/jats:sc>\u2010thyroxine medication and iodide substitution. The thyroglobulin levels fell significantly over the 52\u2010week follow\u2010up period in the iodide group. Antibody formation was not observed under iodine substitution. In an area of iodine deficiency, substitution with iodide is just as effective as medicating the patients with <jats:sc>l<\/jats:sc>\u2010thyroxine for preventing recurrences.<\/jats:p>","DOI":"10.1007\/s002689900186","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T05:57:49Z","timestamp":1030255069000},"page":"10-14","source":"Crossref","is-referenced-by-count":23,"title":["Iodide or <scp>l<\/scp>\u2010Thyroxine to Prevent Recurrent Goiter in an Iodine\u2010Deficient Area: Prospective Sonographic Study"],"prefix":"10.1002","volume":"21","author":[{"given":"J.","family":"Feldkamp","sequence":"first","affiliation":[{"name":"Department of Endocrinology Heinrich\u2010Heine\u2010University Moorenstrasse 5 D\u201040225 D\u00fcsseldorf Germany<!--<country1>DE<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Seppel","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Heinrich\u2010Heine\u2010University Moorenstrasse 5 D\u201040225 D\u00fcsseldorf Germany<!--<country1>DE<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Heinrich\u2010Heine\u2010University Moorenstrasse 5 D\u201040225 D\u00fcsseldorf Germany<!--<country1>DE<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Klisch","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Heinrich\u2010Heine\u2010University Moorenstrasse 5 D\u201040225 D\u00fcsseldorf Germany<!--<country1>DE<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Schlaghecke","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Heinrich\u2010Heine\u2010University Moorenstrasse 5 D\u201040225 D\u00fcsseldorf Germany<!--<country1>DE<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.E.","family":"Goretzki","sequence":"additional","affiliation":[{"name":"Department of Surgery Heinrich\u2010Heine\u2010University Moorenstrasse 5 D\u201040225 D\u00fcsseldorf Germany<!--<country1>DE<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.D.","family":"R\u00f6her","sequence":"additional","affiliation":[{"name":"Department of Surgery Heinrich\u2010Heine\u2010University Moorenstrasse 5 D\u201040225 D\u00fcsseldorf Germany<!--<country1>DE<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1997,1]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002689900186.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002689900186\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s002689900186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T16:06:44Z","timestamp":1703693204000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s002689900186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,1]]}},"alternative-id":["10.1007\/s002689900186"],"URL":"https:\/\/doi.org\/10.1007\/s002689900186","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,1]]}}}