{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:22:33Z","timestamp":1770823353119,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1997,1,1]],"date-time":"1997-01-01T00:00:00Z","timestamp":852076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The nonadenomatous parathyroid glands associated with parathyroid adenoma in patients with primary hyperparathyroidism (pHPT) are assumed to exhibit suppressed secretion of parathyroid hormone (PTH). Because the function of these glands is of clinical importance for calcium homeostasis after surgery for pHPT, we studied the decrease of serum levels associated with intact PTH (i\u2010PTH) and amino\u2010terminal PTH (N\u2010PTH) after excision of a parathyroid adenoma. Blood samples were obtained from the cubital vein and the inferior thyroid vein in six patients with pHPT. The results show that the levels of both i\u2010PTH and N\u2010PTH decreased after removal of the parathyroid adenoma (<jats:italic>p<\/jats:italic>&lt; 0.05 for both). Because the reduction was more pronounced for i\u2010PTH than for N\u2010PTH, the N\/i ratio increased from 0.54 \u00b1 0.33 to 3.76 \u00b1 1.62 (<jats:italic>p<\/jats:italic>&lt; 0.05). Furthermore, the levels of i\u2010PTH and N\u2010PTH were higher centrally than peripherally both before and after adenoma excision (<jats:italic>p<\/jats:italic>&lt; 0.05). The results therefore suggest that the secretion of i\u2010PTH and N\u2010PTH in the remaining normal\u2010size parathyroid glands is not completely suppressed. Furthermore, in these parathyroid glands the secretion of amino\u2010terminal PTH fragments is relatively predominant when compared to the release of the intact PTH. The findings underscore the importance of the N\u2010terminal PTH fragment for maintaining calcium homeostasis during the early postoperative period after surgery for pHPT and may explain the rarity of prolonged hypocalcemia after parathyroidectomy.<\/jats:p>","DOI":"10.1007\/s002689900189","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T05:57:49Z","timestamp":1030255069000},"page":"30-35","source":"Crossref","is-referenced-by-count":3,"title":["Intraoperative Secretion of Intact Parathyroid Hormone and Amino\u2010Terminal Parathyroid Hormone Fragments from Normal Parathyroid Glands Associated with Solitary Parathyroid Adenoma"],"prefix":"10.1002","volume":"21","author":[{"given":"Anders","family":"Bergenfelz","sequence":"first","affiliation":[{"name":"Department of Surgery Lund University Hospital Lund University S\u2010221 85 Lund Sweden<!--<country1>SE<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Ahr\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Medicine Malm\u00f6 University Hospital Lund University S\u2010221 85 Lund Sweden<!--<country1>SE<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1997,1]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002689900189.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002689900189\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s002689900189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T16:06:52Z","timestamp":1703693212000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s002689900189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,1]]}},"alternative-id":["10.1007\/s002689900189"],"URL":"https:\/\/doi.org\/10.1007\/s002689900189","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,1]]}}}