{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:38:54Z","timestamp":1773157134167,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1997,3,1]],"date-time":"1997-03-01T00:00:00Z","timestamp":857174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1997,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Twelve patients with von Hippel\u2010Lindau disease were collected in our institute from 1981 to 1995. All had a family history of the disease. Eleven patients underwent abdominal computed tomography, sonography, or angiographic studies. Ten had pancreatic involvement that included cystic lesions in nine and a solid lesion in one. Seven patients were asymptomatic. Another three presented with obstructive jaundice or upper gastrointestinal (UGI) bleeding. Except for case 8, who died of a central nervous system complication soon after diagnosis of the pancreatic lesion, the other patients had been found to have pancreatic involvement for a variable period of time, ranging from 1 to 13 years (median 5 years). Serous cystadenoma was proved pathologically in two with cystic lesions, and pancreatic endocrine tumor was diagnosed in one with a solid mass. One patient (case 1) underwent biliary bypass due to obstructive jaundice and died of cholangitis and pneumonia 6 years later. One patient (case 3) had total pancreatectomy and lived well with good diabetic control for more than 5 years. The patient with a solid lesion was explored because of repeated UGI bleeding. Surgical resection was impossible owing to advanced tumor with vascular involvement, and a pancreatic endocrine tumor was diagnosed pathologically. He was followed for 1 year. The other seven patients remained asymptomatic during the successive follow\u2010up period. From a literature review and our own experience, we suggest that conservative measures are adequate for the cystic lesions; however, aggressive resection is mandatory for a solid pancreatic lesion in von Hippel\u2010Lindau disease.<\/jats:p>","DOI":"10.1007\/s002689900234","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T05:57:49Z","timestamp":1030255069000},"page":"307-312","source":"Crossref","is-referenced-by-count":33,"title":["Management of Pancreatic Lesions in von Hippel\u2010Lindau Disease"],"prefix":"10.1002","volume":"21","author":[{"given":"Tsung\u2010Yen","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Surgery Division of General Surgery Veterans General Hospital\u2010Taipei, National Yang Ming University, Shipai Taipei Taiwan Republic of China<!--<country1>TW<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2010Hsi","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of General Surgery Veterans General Hospital\u2010Taipei, National Yang Ming University, Shipai Taipei Taiwan Republic of China<!--<country1>TW<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Ming","family":"Shyr","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of General Surgery Veterans General Hospital\u2010Taipei, National Yang Ming University, Shipai Taipei Taiwan Republic of China<!--<country1>TW<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wing\u2010Yiu","family":"Lui","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of General Surgery Veterans General Hospital\u2010Taipei, National Yang Ming University, Shipai Taipei Taiwan Republic of China<!--<country1>TW<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1997,3]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002689900234.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002689900234\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s002689900234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T16:01:01Z","timestamp":1704988861000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s002689900234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1997,3]]}},"alternative-id":["10.1007\/s002689900234"],"URL":"https:\/\/doi.org\/10.1007\/s002689900234","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,3]]}}}