{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:29:46Z","timestamp":1759336186849},"reference-count":0,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[1997,11,1]],"date-time":"1997-11-01T00:00:00Z","timestamp":878342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The overall shortage of appropriate donor organs has prompted transplant physicians and surgeons to consider using organs from other nonhuman species. The shortage of appropriate human donor hearts for newborn recipients is especially severe. Presently, the pig appears to be the most appropriate source for organs. Humans and baboons uniformly develop high titers of complement\u2010fixing (IgM) anti\u2010pig xenoantibodies, resulting in complement\u2010mediated hyperacute rejection (HAR) of pig organs transplanted into mature baboons within minutes to hours. In contrast, newborn humans and baboons do not have high titers of anti\u2010pig IgM xenoantibody, and consequently pig cardiac xenografts transplanted into newborn baboons do not undergo HAR. Rather, these organs are rejected at days 3 to 4 by a distinctive immunologic process that involves natural killer cells and macrophages. With the addition of cyclosporine\u2010based triple immunosuppression, this process is reduced and graft life is prolonged to 6 to 7\u00a0days. This therapy, however, is not sufficient to prevent the induced humoral response to the graft, and the organs are rejected by antibody\u2010 and complement\u2010dependent mechanisms. Future treatment strategies to reduce this humoral response must incorporate immunodepletion columns, soluble complement\u2010inhibiting agents, and additional anti\u2010B lymphocyte agents. These strategies, in conjunction with the use of transgenic pig organs that express human membrane\u2010bound complement regulatory proteins or reduced xenoantigenic epitopes could further prolong graft life. Clinical trials are being formulated that would utilize pig organs as a \u201cbridge,\u201d sustaining a newborn human in need of a heart transplant until an appropriate donor is located.<\/jats:p>","DOI":"10.1007\/s002689900328","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T05:57:49Z","timestamp":1030255069000},"page":"924-931","source":"Crossref","is-referenced-by-count":3,"title":["Immature Host for Xenotransplantation"],"prefix":"10.1002","volume":"21","author":[{"given":"Robert E.","family":"Michler","sequence":"first","affiliation":[{"name":"Cardiac Transplantation Research Laboratory Division of Cardiothoracic Surgery College of Physicians and Surgeons Columbia University Milstein Hospital Building 7\u2010435GN, 177 Fort Washington Avenue New York New York 10032 USA<!--<country1>US<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oktavijan P.","family":"Minanov","sequence":"additional","affiliation":[{"name":"Cardiac Transplantation Research Laboratory Division of Cardiothoracic Surgery College of Physicians and Surgeons Columbia University Milstein Hospital Building 7\u2010435GN, 177 Fort Washington Avenue New York New York 10032 USA<!--<country1>US<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Artrip","sequence":"additional","affiliation":[{"name":"Cardiac Transplantation Research Laboratory Division of Cardiothoracic Surgery College of Physicians and Surgeons Columbia University Milstein Hospital Building 7\u2010435GN, 177 Fort Washington Avenue New York New York 10032 USA<!--<country1>US<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silviu","family":"Itescu","sequence":"additional","affiliation":[{"name":"Cardiac Transplantation Research Laboratory Division of Cardiothoracic Surgery College of Physicians and Surgeons Columbia University Milstein Hospital Building 7\u2010435GN, 177 Fort Washington Avenue New York New York 10032 USA<!--<country1>US<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1997,11]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002689900328.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002689900328\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s002689900328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T16:11:32Z","timestamp":1703693492000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s002689900328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,11]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1997,11]]}},"alternative-id":["10.1007\/s002689900328"],"URL":"https:\/\/doi.org\/10.1007\/s002689900328","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,11]]}}}