{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:03:17Z","timestamp":1774566197098,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1998,1]]},"abstract":"Abstract<\/jats:title>This study evaluates the hemodynamic effects of the administration of 10% pentastarch solution (PS) during the initial treatment of hypovolemia in trauma patients. This prospective randomized phase II study included trauma patients admitted to the emergency room with hemorrhagic hypovolemia: systolic blood pressure (SBP) < 90\u00a0mmHg. Upon admission, the patients were randomized to receive 10% PS (n<\/jats:italic>= 12) or isotonic 0.9% NaCl solution (IS) (n<\/jats:italic>= 11), infused intravenously in 250\u2010ml boluses, repeated until SBP > 100\u00a0mmHg. Blood pressure, infused volumes necessary to maintain SBP, and overall survival rates were determined and compared between groups. SBP increased significantly following either IS (from 64.4 \u00b1 9.2\u00a0mmHg to 111.1 \u00b1 6.3\u00a0mmHg), or PS (from 63.7 \u00b1 10.6\u00a0mmHg to 108.1 \u00b1 9.8\u00a0mmHg) when compared to admission values (p<\/jats:italic> < 0.05). Endovenous volumes infused were greater (p<\/jats:italic>= 0.001) in IS patients (1420 \u00b1 298\u00a0ml) than in PS patients (356 \u00b1 64\u00a0ml). No blood was transfused into PS patients, compared to 370 \u00b1 140\u00a0ml of red blood cells transfused into IS patients (p<\/jats:italic>= 0.015). Mortality rates were similar in the two groups (p<\/jats:italic>= 0.725). We concluded that PS is a safe, efficient method for inducing hemodynamic recovery of hypovolemic trauma patients, with a clear reduction in the intravenous volumes required for acute resuscitation.<\/jats:p>","DOI":"10.1007\/s002689900340","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T05:57:49Z","timestamp":1030255069000},"page":"2-5","source":"Crossref","is-referenced-by-count":32,"title":["Use of Pentastarch Solution in the Treatment of Patients with Hemorrhagic Hypovolemia: Randomized Phase II Study in the Emergency Room"],"prefix":"10.1002","volume":"22","author":[{"given":"Riad N.","family":"Younes","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Hospital AC Camargo R. Prof Antonio Prudente 211 S\u00e3o Paulo SP 01509\u2010010 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ko C.","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Surgery University of S\u00e3o Paulo School of Medicine Laborat\u00f3rio de Fisiopatologia Cir\u00fargica (LIM\u201062) Divis\u00e3o de Experimenta\u00e7\u00e3o Instituto do Cora\u00e7\u00e3o S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio J.","family":"Amino","sequence":"additional","affiliation":[{"name":"Department of Surgery University of S\u00e3o Paulo School of Medicine Laborat\u00f3rio de Fisiopatologia Cir\u00fargica (LIM\u201062) Divis\u00e3o de Experimenta\u00e7\u00e3o Instituto do Cora\u00e7\u00e3o S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Itinoshe","sequence":"additional","affiliation":[{"name":"Department of Surgery University of S\u00e3o Paulo School of Medicine Laborat\u00f3rio de Fisiopatologia Cir\u00fargica (LIM\u201062) Divis\u00e3o de Experimenta\u00e7\u00e3o Instituto do Cora\u00e7\u00e3o S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Rocha e Silva","sequence":"additional","affiliation":[{"name":"Department of Surgery University of S\u00e3o Paulo School of Medicine Laborat\u00f3rio de Fisiopatologia Cir\u00fargica (LIM\u201062) Divis\u00e3o de Experimenta\u00e7\u00e3o Instituto do Cora\u00e7\u00e3o S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Birolini","sequence":"additional","affiliation":[{"name":"Department of Surgery University of S\u00e3o Paulo School of Medicine Laborat\u00f3rio de Fisiopatologia Cir\u00fargica (LIM\u201062) Divis\u00e3o de Experimenta\u00e7\u00e3o Instituto do Cora\u00e7\u00e3o S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1998,1]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002689900340.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002689900340\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s002689900340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T16:36:31Z","timestamp":1703694991000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s002689900340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,1]]}},"alternative-id":["10.1007\/s002689900340"],"URL":"https:\/\/doi.org\/10.1007\/s002689900340","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,1]]}}}