{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:48:08Z","timestamp":1773773288036,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pylorus\u2010preserving gastrectomy (PPG) has been considered reasonable reduction surgery. However, even patients in whom more than 1 year passed after surgery frequently have a feeling of gastric fullness after meals and long\u2010term retention of foods in the residual stomach. To treat this syndrome, cisapride has been administered. We studied the emptying time of a semisolid diet (radioisotope method using <jats:sup>99m<\/jats:sup>Tc\u2010tin colloid\u2010labeled rice gruel) and the emptying time of a fluid diet (acetaminophen method with orange juice) before and after oral administration of cisapride (15\u00a0mg\/day for 1\u00a0month) in 14 patients (10\u00a0men, 4 women; 32\u201370 years old, average 60.6 years) who underwent PPG (Billroth I procedure, D<jats:sub>2<\/jats:sub> lymph node dissection, curability A) for treatment of early gastric cancer. Ten healthy volunteers without gastrointestinal symptoms and digestive diseases (7\u00a0men, 3 women; 28\u201361 years old, average 49.8 years) were enrolled as controls. The results showed obviously delayed emptying time of the semisolid diet before administration of cisapride in patients with PPG compared with that of the control group, whereas the emptying curves for the fluid diet showed an almost normal pattern. One month after the start of cisapride administration the emptying time of the semisolid diet was improved, and the emptying curves were close to the patterns in the control group. Emptying of the fluid diet was slightly accelerated compared with that before administration of cisapride, and the emptying curves showed almost the same pattern as in the control group. A postgastrectomy symptom, \u201cgastric fullness,\u201d after PPG was alleviated by cisapride. These results showed that cisapride improved delayed emptying of a semisolid diet after PPG and prevented the feeling of gastric fullness after meals due to retention in the residual stomach.<\/jats:p>","DOI":"10.1007\/s002689900346","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T05:57:49Z","timestamp":1030255069000},"page":"35-41","source":"Crossref","is-referenced-by-count":28,"title":["Physiologic Effects of Cisapride on Gastric Emptying after Pylorus\u2010Preserving Gastrectomy for Early Gastric Cancer"],"prefix":"10.1002","volume":"22","author":[{"given":"Ryouichi","family":"Tomita","sequence":"first","affiliation":[{"name":"Department of First Surgery Nihon University School of Medicine 30\u20101 Oyaguchi Kamimachi Itabashi\u2010ku Tokyo 173 Japan<!--<country1>JP<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiro","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Department of First Surgery Nihon University School of Medicine 30\u20101 Oyaguchi Kamimachi Itabashi\u2010ku Tokyo 173 Japan<!--<country1>JP<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhisa","family":"Tanjoh","sequence":"additional","affiliation":[{"name":"Department of First Surgery Nihon University School of Medicine 30\u20101 Oyaguchi Kamimachi Itabashi\u2010ku Tokyo 173 Japan<!--<country1>JP<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1998,1]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002689900346.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002689900346\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s002689900346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T16:36:47Z","timestamp":1703695007000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s002689900346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,1]]}},"alternative-id":["10.1007\/s002689900346"],"URL":"https:\/\/doi.org\/10.1007\/s002689900346","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,1]]}}}