{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:44:11Z","timestamp":1761518651177},"reference-count":0,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[1998,7,1]],"date-time":"1998-07-01T00:00:00Z","timestamp":899251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1998,7]]},"abstract":"Abstract<\/jats:title>Calcitriol, via its receptor (VDR), inhibits parathyroid hormone (PTH) secretion and cell proliferation. Physically linked polymorphic VDR alleles denoted b<\/jats:italic>,a<\/jats:italic>, and T<\/jats:italic>, comprise a novel risk factor for postmenopausal primary hyperparathyroidism (pHPT) by their presumed coupling to reduced VDR expression. This study examines VDR gene polymorphisms, parathyroid calcium\u2010regulated cytoplasmic calcium concentrations ([Ca2+<\/jats:sup>]i<\/jats:sub>) and parathyroid expression of a calcium sensor protein (CAS\/gp330). Genomic DNA was obtained from 66 postmenopausal women with pHPT and 66 age\u2010matched female controls. Polymorphic VDR alleles were detected after polymerase chain reaction (PCR) and restriction digestion. Cryosections of pathologic parathyroid glands from 41 of the patients were immunostained with a monoclonal anti\u2010CAS\/gp330 antibody. Homozygosity for the VDR alleles b<\/jats:italic>, a<\/jats:italic>, and T<\/jats:italic> was overrepresented in pHPT (p<\/jats:italic> < 0.01\u20130.05) but did not couple to ED50<\/jats:sub> for calcium\u2010regulated [Ca2+<\/jats:sup>]i<\/jats:sub>. The enlarged parathyroid glands possessed heterogeneous down\u2010regulation of CAS\/gp330. This down\u2010regulation was the least conspicuous in the BB<\/jats:italic>genotype, and these few patients generally had larger parathyroid lesions (p<\/jats:italic> < 0.05). The VDR haplotype baT<\/jats:italic>is a risk factor for pHPT possibly by hampering the regulatory actions of calcitriol. In contrast the BAt<\/jats:italic> haplotype seems to be underrepresented in pHPT and to couple to larger parathyroid lesions as well as less deranged CAS\/gp330 expression and parathyroid cell function. HPT in these individuals may relate to genetic events principally altering the regulation of cell proliferation, rather than calcium sensing of the parathyroid cells.<\/jats:p>","DOI":"10.1007\/s002689900456","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T05:57:49Z","timestamp":1030255069000},"page":"700-707","source":"Crossref","is-referenced-by-count":8,"title":["Vitamin D Receptor Gene Polymorphism and Parathyroid Calcium Sensor Protein (CAS\/gp330) Expression in Primary Hyperparathyroidism"],"prefix":"10.1002","volume":"22","author":[{"given":"Tobias","family":"Carling","sequence":"first","affiliation":[{"name":"Department of Surgery University Hospital S\u2010751 85 Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Ridefelt","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry University Hospital S\u2010751 85 Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Hellman","sequence":"additional","affiliation":[{"name":"Department of Surgery University Hospital S\u2010751 85 Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claes","family":"Juhlin","sequence":"additional","affiliation":[{"name":"Department of Surgery University Hospital S\u2010751 85 Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Lundgren","sequence":"additional","affiliation":[{"name":"Department of Surgery University Hospital S\u2010751 85 Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"\u212bkerstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Surgery University Hospital S\u2010751 85 Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Rastad","sequence":"additional","affiliation":[{"name":"Department of Surgery University Hospital S\u2010751 85 Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1998,7]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002689900456.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002689900456\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s002689900456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T16:52:31Z","timestamp":1703695951000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s002689900456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,7]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1998,7]]}},"alternative-id":["10.1007\/s002689900456"],"URL":"https:\/\/doi.org\/10.1007\/s002689900456","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,7]]}}}