{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:18:46Z","timestamp":1786979926981,"version":"build-2736575974"},"reference-count":0,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[1998,7,1]],"date-time":"1998-07-01T00:00:00Z","timestamp":899251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1998,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    When mutations of the\n                    <jats:italic>RET<\/jats:italic>\n                    proto\u2010oncogene were found in 1993 to account for hereditary medullary thyroid carcinoma (MTC), surgeons obtained the opportunity to operate on patients prophylactically (i.e., at a clinically asymptomatic stage). Whether this approach is justified, and, if so, when and to which extent surgery should be performed remained to be clarified. A questionnaire was sent to all surgical departments in Germany and Austria. All of the patients who fulfilled the following criteria were enrolled: (1) preoperatively proved\n                    <jats:italic>RET<\/jats:italic>\n                    mutation; (2) age \u2264 20 years, (3) clinically asymptomatic thyroid C cell disease; and (4) TNM classification pT0\u20131\/pNX\/pN0\u20131\/M0. Seventy\u2010five patients were identified, and fifteen mutations were detected in six codons. Two adolescents had unilateral pheochromocytomas as part of the multiple endocrine neoplasia II (MEN\u2010II) syndrome. No hyperparathyroidism was noted. All patients underwent total thyroidectomy, and 57 patients went on to have lymph node dissection. Parathyroid glands were removed in 34 patients and autografted in 11. Histopathology revealed MTC in 46 patients (61%, youngest 4 years); C cell hyperplasia (CCH) only was detected in the other 29 patients. Three patients had lymph node metastases (LNMs) the youngest being age 14 years. Calcitonin levels were not useful for differentiating between CCH and MTC, but in all patients with LNMs at least the stimulated calcitonin levels were assayed. After surgery, five patients (6.7%) sustained permanent hypoparathyroidism, and one patient (1.3%) had a permanent unilateral recurrent nerve palsy. All but three patients (96%) were biochemically cured. In conclusion, prophylactic total thyroidectomy can be performed safely in experienced centers. We recommend prophylactic total thyroidectomy at age 6. Cervicocentral lymph node dissection should be included when calcitonin levels are elevated or if patients are older than 10 years. Bilateral lymph node dissection should be performed if LNMs are suspected or when patients with elevated calcitonin are older than 15 years.\n                  <\/jats:p>","DOI":"10.1007\/s002689900463","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T01:57:49Z","timestamp":1030240669000},"page":"744-751","source":"Crossref","is-referenced-by-count":156,"title":["Prophylactic Thyroidectomy in 75 Children and Adolescents with Hereditary Medullary Thyroid Carcinoma: German and Austrian Experience"],"prefix":"10.1002","volume":"22","author":[{"given":"Henning","family":"Dralle","sequence":"first","affiliation":[{"name":"Martin\u2010Luther\u2010Universit\u00e4t Halle\u2010Wittenberg Klinik f\u00fcr Allgemeinchirurgie Ernst\u2010Grube\u2010Strasse 40 06097 Halle\/Saale Germany<!--<country1>DE<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Gimm","sequence":"additional","affiliation":[{"name":"Martin\u2010Luther\u2010Universit\u00e4t Halle\u2010Wittenberg Klinik f\u00fcr Allgemeinchirurgie Ernst\u2010Grube\u2010Strasse 40 06097 Halle\/Saale Germany<!--<country1>DE<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Simon","sequence":"additional","affiliation":[{"name":"Heinrich\u2010Heine\u2010Universit\u00e4t Klinik f\u00fcr Allgemeine und Unfallchirurgie Moorenstrasse 5 40225 D\u00fcsseldorf Germany<!--<country1>DE<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Frank\u2010Raue","sequence":"additional","affiliation":[{"name":"Gemeinschaftspraxis Innere Medizin\u2010Endokrinologie Br\u00fcckenstrasse 21 69120 Heidelberg Germany<!--<country1>DE<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter","family":"G\u00f6rtz","sequence":"additional","affiliation":[{"name":"St. Marien\u2010Hospital Allgemein\u2010 und Gef\u00e4sschirurgie Altstadtstrasse 23 44534 L\u00fcnen Germany<!--<country1>DE<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Niederle","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik Klinische Abteilung f\u00fcr Allgemeinchirurgie W\u00e4hringer G\u00fcrtel 18\u201020 1090 Vienna Austria<!--<country1>AT<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Wahl","sequence":"additional","affiliation":[{"name":"B\u00fcrgerhospital Frankfurt am Main Chirurgische Klinik Nibelungenallee 37\u201041 60318 Frankfurt am Main Germany<!--<country1>DE<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Koch","sequence":"additional","affiliation":[{"name":"Westpfalz\u2010Klinikum GmbH Chirurgische Klinik I Hellmut\u2010Hartert\u2010Strasse 1 67655 Kaiserslautern Germany<!--<country1>DE<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"Walgenbach","sequence":"additional","affiliation":[{"name":"Universit\u00e4t Rostock Klinik und Poliklinik f\u00fcr Innere Medizin E.\u2010Heydemann\u2010Strasse 6 18055 Rostock Germany<!--<country1>DE<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Hampel","sequence":"additional","affiliation":[{"name":"Johannes\u2010Gutenberg\u2010Universit\u00e4t Mainz Klinik\u2010 und Poliklinik f\u00fcr Allgemein\u2010 und Abdominalchirurgie Langenbeck\u2010Strasse 1 55101 Mainz Germany<!--<country1>DE<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Ritter","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Grosshadern Medizinische Klinik und Poliklinik II Marchioninistrasse 15 81377 Munich Germany<!--<country1>DE<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fritz","family":"Spelsberg","sequence":"additional","affiliation":[{"name":"Krankenhaus Martha\u2010Maria Chirurgische Abteilung Wolfsrather Strasse 109 81479 Munich Germany<!--<country1>DE<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Heiss","sequence":"additional","affiliation":[{"name":"Zentralklinikum Augsburg Klinik f\u00fcr Allgemein\u2010 und Visceralchirurgie, Postfach 101920 86009 Augsburg Germany<!--<country1>DE<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul","family":"Hinze","sequence":"additional","affiliation":[{"name":"Martin\u2010Luther\u2010Universit\u00e4t Halle\u2010Wittenberg Institut f\u00fcr Pathologie Magdeburger Strasse 14 06097 Halle\/Saale Germany<!--<country1>DE<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"H\u00f6ppner","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Hormon\u2010 und Fortpflanzungsforschung Grandweg 64 22529 Hamburg Germany<!--<country1>DE<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1998,7]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002689900463.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002689900463\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s002689900463","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T11:52:24Z","timestamp":1703677944000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s002689900463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,7]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1998,7]]}},"alternative-id":["10.1007\/s002689900463"],"URL":"https:\/\/doi.org\/10.1007\/s002689900463","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,7]]}}}