{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:17:19Z","timestamp":1705018639780},"reference-count":0,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[1998,8,1]],"date-time":"1998-08-01T00:00:00Z","timestamp":901929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1998,8]]},"abstract":"Abstract<\/jats:title>Vascularized knee joint transplantations have been performed in various animal systems. Up to now no allogeneic vascularized transplantation of a fresh and perfused human knee joint has been realized. This paper reports on the first four grafted human knee joints, performed between April 1996 and July 1997 at the Trauma Center Murnau. The indication for transplantation of a human knee joint is total loss of the joint, including the extensor apparatus, following severe trauma. Management of this defect is first to effect closure of the soft tissue defect combined with external transfixation and bone cement spacers. For the second phase the external stabilization is switched to internal stabilization using femoral and tibial nails and a temporary knee joint prosthesis manufactured of polyethylene. The transplantations are performed with respect to ABO compatibility, ignoring the HLA system after a negative crossmatch. Osteosyntheses are employed by femoral and tibial nails. The vascular anastomoses are established in an end\u2010to\u2010side technique between the recipient's superficial femoral vessels and the graft vascular pedicles. Immunosuppression starts as quadruple induction therapy for 3\u00a0days. Subsequently it is reduced to a two\u2010drug maintenance protocol with cyclosporin A and azathioprine. We utilize radiography, digital subtraction angiography, duplex sonography, scintigraphy, and arthroscopy for graft monitoring. Six months after transplantation the osteotomies were bridged with callus, and the patients were completely mobilized. The motion in the transplanted knee joint ranges from complete extension to 110\u00b0 flexion.<\/jats:p>","DOI":"10.1007\/s002689900476","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T05:57:49Z","timestamp":1030255069000},"page":"818-823","source":"Crossref","is-referenced-by-count":20,"title":["Allogeneic Vascularized Grafting of Human Knee Joints under Postoperative Immunosuppression of the Recipient"],"prefix":"10.1002","volume":"22","author":[{"given":"Gunther O.","family":"Hofmann","sequence":"first","affiliation":[{"name":"Trauma Center Murnau Professor K\u00fcntscher\u2010Str. 8 D\u201082418 Murnau Germany"},{"name":"Institute for Surgical Research University of Munich Klinikum Grosshadern, Marchioninistr. 15 D\u201081377 Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin H.","family":"Kirschner","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Munich Klinikum Grosshadern, Marchioninistr. 15 D\u201081377 Munich Germany"},{"name":"Institute for Surgical Research University of Munich Klinikum Grosshadern, Marchioninistr. 15 D\u201081377 Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frithjof D.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Trauma Center Murnau Professor K\u00fcntscher\u2010Str. 8 D\u201082418 Murnau Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Brauns","sequence":"additional","affiliation":[{"name":"Trauma Center Murnau Professor K\u00fcntscher\u2010Str. 8 D\u201082418 Murnau Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Gonschorek","sequence":"additional","affiliation":[{"name":"Trauma Center Murnau Professor K\u00fcntscher\u2010Str. 8 D\u201082418 Murnau Germany"},{"name":"Institute for Surgical Research University of Munich Klinikum Grosshadern, Marchioninistr. 15 D\u201081377 Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"B\u00fchren","sequence":"additional","affiliation":[{"name":"Trauma Center Murnau Professor K\u00fcntscher\u2010Str. 8 D\u201082418 Murnau Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1998,8]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002689900476.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002689900476\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s002689900476","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T20:24:14Z","timestamp":1705004654000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s002689900476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,8]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1998,8]]}},"alternative-id":["10.1007\/s002689900476"],"URL":"https:\/\/doi.org\/10.1007\/s002689900476","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,8]]}}}