{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:40:17Z","timestamp":1777693217919,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[1998,8,1]],"date-time":"1998-08-01T00:00:00Z","timestamp":901929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1998,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fatty change in donor livers is a risk factor for poor function after orthotopic liver transplantation. Various prevalences of steatosis have been reported in time 0 biopsies. The aim of this research was to determine, in a longitudinal study, the degree (percent of hepatocytes involved) and type (size of vacuoles) of fatty change shown by various histologic techniques. Four staining methods were used on sections from three liver wedge biopsies\u2014at liver procurement, at the back\u2010table, and after reperfusion\u2014from 83 consecutive donor livers. Results in Sudan III\u2010stained (SS) sections showed the greatest sensitivity (87.1%), negative predictive value (91.8%), and agreement rate (\u03ba= 0.77) when compared with results in thin (1 \u03bcm) plastic\u2010embedded toluidine blue\u2010stained (TBS) sections. High\u2010grade steatosis (&gt;30% steatotic hepatocytes) was identified in 49.4% of SS sections, 46.9% of TBS sections, 38.5% of frozen hematoxylin\u2010eosin (H&amp;E)\u2010stained sections, and 20.7% of deparaffinated H&amp;E\u2010stained sections. Microscopic observations disclosed two types of steatotic pattern: (1) A predominantly small\u2010droplet lipid vacuolzation (high\u2010grade microsteatosis), similar to the steatosis associated with Reye syndrome, was seen in 29% of SS sections and 25% of TBS sections\u2014approximately one\u2010fourth of grafts; and (2) a combined pattern of large and small fat drops (high\u2010grade macromicrosteatosis) was seen in 20% of SS sections and 22% of TBS sections. We concluded that moderate to severe steatosis is a frequent finding in donor livers. The difficulty in detecting lipidic microvacuoles in H&amp;E\u2010stained sections may be the reason for underestimating the grade of fatty change or even for diagnosing as normal some biopsies with high\u2010grade microsteatosis.<\/jats:p>","DOI":"10.1007\/s002689900479","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T05:57:49Z","timestamp":1030255069000},"page":"837-844","source":"Crossref","is-referenced-by-count":88,"title":["Hepatic Steatosis in Liver Transplant Donors: Common Feature of Donor Population?"],"prefix":"10.1002","volume":"22","author":[{"given":"Miguel Angel","family":"Garc\u00eda Ure\u00f1a","sequence":"first","affiliation":[{"name":"Department of Surgery and Abdominal Organs Transplantation University Hospital \u201c12 de Octubre \u201d Cra. de Andaluc\u00eda Km 5, 4 28041 Madrid Spain<!--<country1>ES<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Colina","family":"Ruiz\u2010Delgado","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital \u201c12 de Octubre \u201d Cra. de Andaluc\u00eda Km 5, 4 28041 Madrid Spain<!--<country1>ES<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique Moreno","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Surgery and Abdominal Organs Transplantation University Hospital \u201c12 de Octubre \u201d Cra. de Andaluc\u00eda Km 5, 4 28041 Madrid Spain<!--<country1>ES<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Jim\u00e9nez","family":"Romero","sequence":"additional","affiliation":[{"name":"Department of Surgery and Abdominal Organs Transplantation University Hospital \u201c12 de Octubre \u201d Cra. de Andaluc\u00eda Km 5, 4 28041 Madrid Spain<!--<country1>ES<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio Garc\u00eda","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Surgery and Abdominal Organs Transplantation University Hospital \u201c12 de Octubre \u201d Cra. de Andaluc\u00eda Km 5, 4 28041 Madrid Spain<!--<country1>ES<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmelo Loinzaz","family":"Segurola","sequence":"additional","affiliation":[{"name":"Department of Surgery and Abdominal Organs Transplantation University Hospital \u201c12 de Octubre \u201d Cra. de Andaluc\u00eda Km 5, 4 28041 Madrid Spain<!--<country1>ES<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Gonz\u00e1lez\u2010Pinto","sequence":"additional","affiliation":[{"name":"Department of Surgery and Abdominal Organs Transplantation University Hospital \u201c12 de Octubre \u201d Cra. de Andaluc\u00eda Km 5, 4 28041 Madrid Spain<!--<country1>ES<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram\u00f3n G\u00f3mez","family":"Sanz","sequence":"additional","affiliation":[{"name":"Department of Surgery and Abdominal Organs Transplantation University Hospital \u201c12 de Octubre \u201d Cra. de Andaluc\u00eda Km 5, 4 28041 Madrid Spain<!--<country1>ES<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1998,8]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002689900479.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002689900479\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s002689900479","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T20:24:19Z","timestamp":1705004659000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s002689900479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,8]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1998,8]]}},"alternative-id":["10.1007\/s002689900479"],"URL":"https:\/\/doi.org\/10.1007\/s002689900479","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,8]]}}}