{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:32:27Z","timestamp":1791639147494,"version":"4.3.4"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T00:00:00Z","timestamp":1394064000000},"content-version":"vor","delay-in-days":5543,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1999,1]]},"abstract":"Abstract<\/jats:title>Assessment of the malignant potential of parathyroid tumors in the absence of metastases can be difficult using morphologic criteria alone. In this study we have examined a total of\n58 parathyroid tumors (31 benign, 15\u00a0malignant, and 12 equivocal) from\n54 patients using immunohistochemistry with monoclonal antibodies directed against the retinoblastoma (RB) protein and the cell cycle\u2010associated antigen Ki\u201067 to evaluate their role as diagnostic markers. RB protein immunoreactivity was not useful for distinguishing between benign and malignant parathyroid tumors. Analysis of the proliferation marker Ki\u201067 showed that there was a trend toward more intense staining in the malignant cases. The Ki\u201067 labeling index was highest in the parathyroid cancers (median 33) and lowest in the sporadic primary adenomas (median 2). An observation that might have clinical implications is that tumors from patients with familial hyperparathyroidism linked to chromosome 1q showed a high Ki\u201067\u00a0index, indicating strong proliferative activity (median 25). This correlates well with the clinical observation of tumors with malignant potential in this syndrome. Because of the considerable overlap between groups of tumors, Ki\u201067 is not suitable for definitive differentiation between benign and malignant tumors. However, Ki\u201067\u00a0may give valuable information about which patients should be followed more closely.<\/jats:p>","DOI":"10.1007\/s002689900567","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T05:57:49Z","timestamp":1030255069000},"page":"68-74","source":"Crossref","is-referenced-by-count":72,"title":["Evaluation of Retinoblastoma and Ki\u201067 Immunostaining as Diagnostic Markers of Benign and Malignant Parathyroid Disease"],"prefix":"10.1002","volume":"23","author":[{"given":"Filip","family":"Farnebo","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine Endocrine Tumor Unit, CMM L8:01 Karolinska Hospital SE\u2010171 76 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"Auer","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Karolinska Hospital SE\u2010171 76 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars\u2010Ove","family":"Farnebo","sequence":"additional","affiliation":[{"name":"Department of Surgery Karolinska Hospital SE\u2010171 76 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin Tean","family":"Teh","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Endocrine Tumor Unit, CMM L8:01 Karolinska Hospital SE\u2010171 76 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Twigg","sequence":"additional","affiliation":[{"name":"Kolling Institute of Medical Research Royal North Shore Hospital Sydney New South Wales 2065 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla","family":"Aspenblad","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Karolinska Hospital SE\u2010171 76 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman W.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Michigan Hospital 1500\u00a0Medical Center Drive TC 2920\u2010D Ann Arbor Michigan 48109 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Grimelius","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Karolinska Hospital SE\u2010171 76 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Endocrine Tumor Unit, CMM L8:01 Karolinska Hospital SE\u2010171 76 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Sandelin","sequence":"additional","affiliation":[{"name":"Department of Surgery Karolinska Hospital SE\u2010171 76 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,6]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002689900567.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002689900567\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s002689900567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T16:53:06Z","timestamp":1704991986000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s002689900567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,1]]}},"alternative-id":["10.1007\/s002689900567"],"URL":"https:\/\/doi.org\/10.1007\/s002689900567","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,1]]}}}