{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:22:04Z","timestamp":1770823324048,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"vor","delay-in-days":5035,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2000,5]]},"abstract":"Abstract.<\/jats:title>Total or subtotal parathyroidectomy is considered the treatment of choice for multiple endocrine neoplasia type I (MEN\u2010I)\u2010associated primary hyperparathyroidism (HPT). However, persistent or recurrent HPT is frequently observed. The development of a rapid two\u2010site immunoradiometric assay (IRMA) method for measuring intact parathormone (PTH) has provided a valuable tool for recognizing possible surgical failures. Our experience includes 16\u00a0MEN\u2010I patients (10 females, 6\u00a0males) of mean age 35.5 years operated on between 1990 and 1996. Total parathyroidectomy (TPTX) with autotransplantation of parathyroid tissue was the standard treatment. Blood samples for PTH measurement were drawn at the induction of anesthesia (basal value), 10 and 20\u00a0minutes after the removal of each gland, and 60\u00a0minutes after TPTX. Rapid PTH measurement, which required only 15\u00a0minutes of incubation at 37\u00b0C, showed a highly significant correlation (p<\/jats:italic> < 0.0001) with the standard method. Circulating PTH levels exhibited a stepwise decrease during TPTX, reaching a mean value of 22.3% of the baseline 20\u00a0minutes after removal of the last gland. Two patients showed a prompt decrease of PTH after removal of the single enlarged gland, featuring the kinetics observed in the adenomas. One of these two patients was successfully treated with more conservative surgery. None of the patients showed persistence or recurrence of HPT. In our experience, intraoperative measurement of PTH seems to be a valuable adjunct in both the diagnosis of multiglandular involvement and the prediction of surgical treatment in patients with primary parathyroid hyperplasia.<\/jats:p>","DOI":"10.1007\/s002689910091","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T05:57:49Z","timestamp":1030255069000},"page":"556-563","source":"Crossref","is-referenced-by-count":59,"title":["Intraoperative Parathormone Measurement in Patients with Multiple Endocrine Neoplasia Type I Syndrome and Hyperparathyroidism"],"prefix":"10.1002","volume":"24","author":[{"given":"Francesco","family":"Tonelli","sequence":"first","affiliation":[{"name":"Surgery Unit Department of Clinical Physiopathology University of Florence Medical School V. le Morgagni 85 50134 Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Spini","sequence":"additional","affiliation":[{"name":"Surgery Unit Department of Clinical Physiopathology University of Florence Medical School V. le Morgagni 85 50134 Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariasilvia","family":"Tommasi","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit Department of Clinical Physiopathology University of Florence Medical School V. le Morgagni 85 50134 Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Gabbrielli","sequence":"additional","affiliation":[{"name":"Surgery Unit Department of Clinical Physiopathology University of Florence Medical School V. le Morgagni 85 50134 Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Amorosi","sequence":"additional","affiliation":[{"name":"Institute of Pathology University of Florence Medical School V. le Morgagni 85 50134 Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Brocchi","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit Department of Clinical Physiopathology University of Florence Medical School V. le Morgagni 85 50134 Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luisa","family":"Brandi","sequence":"additional","affiliation":[{"name":"Endocrine Unit Department of Clinical Physiopathology University of Florence Medical School V. le Pieraccini 6 50139 Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,12]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002689910091.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002689910091\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s002689910091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T19:18:47Z","timestamp":1705000727000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s002689910091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["10.1007\/s002689910091"],"URL":"https:\/\/doi.org\/10.1007\/s002689910091","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,5]]}}}