{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T09:03:56Z","timestamp":1764493436323},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"vor","delay-in-days":5035,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p>Clinical outcome after surgery for primary hyperparathyroidism was evaluated in a prospective long\u2010term, follow\u2010up study. From August 1, 1987 to August 31, 1998 a total of 360 patients were prospectively investigated and included in a follow\u2010up study. All patients underwent follow\u2010up examinations at regular surveillance intervals. The postoperative course is known for 94.5% of all patients. Follow\u2010up was 1\u00a0month to 10 years (median 24\u00a0months; mean 34.5 \u00b1 29.8\u00a0months). Asymptomatic primary hyperparathyroidism was rare (6%), and its true frequency could be confirmed only postoperatively because some of the patients were unaware of mild symptoms of hypercalcemic syndrome prior to surgery. Surgical cure was obtained in 97.7% of patients after initial cervical exploration; and successful parathyroidectomy provided long\u2010term relief of symptoms. Within 2 years postoperatively, 84% of the patients recovered fully from hypercalcemic syndrome; in 58% of these patients recovery occurred within the first month after surgery. Skeletal symptoms persisted in 24% of patients 2 years postoperatively. To date no patient has developed recurrence of primary hyperparathyroidism. During follow\u2010up in our study population mortality was significantly higher than the expected mortality risk for the German population as a whole (<jats:italic>p<\/jats:italic>= 0.00024). The present prospective follow\u2010up study yielded conclusive outcome research data after operative therapy for primary hyperparathyroidism. The high cure rate and low morbidity, as well as the increased mortality, in our study population during follow\u2010up after successful operative therapy for the disease emphasize the importance of early diagnosis and early surgical treatment for primary hyperparathyroidism, even in the absence of manifest symptoms.<\/jats:p>","DOI":"10.1007\/s002689910092","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T05:57:49Z","timestamp":1030255069000},"page":"564-570","source":"Crossref","is-referenced-by-count":47,"title":["Outcome after Surgery for Primary Hyperparathyroidism: Ten\u2010year Prospective Follow\u2010up Study"],"prefix":"10.1002","volume":"24","author":[{"given":"Siegfried","family":"Walgenbach","sequence":"first","affiliation":[{"name":"Department of General and Abdominal Surgery Johannes Gutenberg\u2010Universit\u00e4t Mainz Langenbeckstrasse 1, D 55101 Mainz Germany<!--<country1>DE<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Hommel","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics and Information Johannes Gutenberg\u2010Universit\u00e4t Mainz Obere Zahlbechenstrasse 69, D 55101 Mainz Germany<!--<country1>DE<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo","family":"Junginger","sequence":"additional","affiliation":[{"name":"Department of General and Abdominal Surgery Johannes Gutenberg\u2010Universit\u00e4t Mainz Langenbeckstrasse 1, D 55101 Mainz Germany<!--<country1>DE<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,12]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002689910092.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002689910092\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s002689910092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T19:18:50Z","timestamp":1705000730000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s002689910092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["10.1007\/s002689910092"],"URL":"https:\/\/doi.org\/10.1007\/s002689910092","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,5]]}}}