{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:45:22Z","timestamp":1761741922378},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"vor","delay-in-days":5035,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p>The tumor diameter of gastric carcinoma, measured by gross or histologic examination, is a rough indicator of actual tumor size. Therefore we investigated the utility of three\u2010dimensional reconstruction of tumors in gastric carcinoma. Altogether 105 primary gastric carcinoma lesions, consisting of 16 advanced and 89 early carcinomas, were analyzed. A total of 942 lesion tissue sections, comprising 2 to 37\u00a0sections per lesion (mean 9\u00a0sections), were examined histologically. Surface rendering using a computer graphics analysis program was then performed from serial sections to create a three\u2010dimensional reconstruction of tumor morphology from which to measure tumor volume. For the 105 lesions the tumor diameter ranged between 4 and 106\u00a0mm (average \u00b1 SE: 32.4 \u00b1 2.0\u00a0mm), and tumor volume ranged between 4 and 5853\u00a0mm<jats:sup>3<\/jats:sup> (average \u00b1 SE: 773.0 \u00b1 104.6\u00a0mm<jats:sup>3<\/jats:sup>). A significant correlation was found between tumor diameter and the log of the tumor volume (<jats:italic>r<\/jats:italic>= 0.733, <jats:italic>p<\/jats:italic> &lt; 0.0001). Although the logs of tumor volume for advanced carcinomas were all &gt; 2.5, in 11 of these 16 patients (66%) the tumor diameter was &lt; 4\u00a0cm, and in one patient &lt; 2\u00a0cm. In addition, tumor diameter did not differ significantly between the 16 advanced and the 89 early gastric carcinomas (<jats:italic>p<\/jats:italic>= 0.114), whereas the log of the tumor volume did (<jats:italic>p<\/jats:italic> &lt; 0.0001). In conclusion, conventional measurements of tumor diameter as a rough indicator of tumor size can predict the actual tumor size of a gastric carcinoma. Three\u2010dimensional reconstruction using computer graphics provides a better estimation of true tumor size and extent of progression than tumor diameter.<\/jats:p>","DOI":"10.1007\/s002689910096","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T05:57:49Z","timestamp":1030255069000},"page":"603-607","source":"Crossref","is-referenced-by-count":7,"title":["Measuring the Tumor Volume of Gastric Carcinoma by Computer Image Analysis: Clinical Significance"],"prefix":"10.1002","volume":"24","author":[{"given":"Shiro","family":"Kikuchi","sequence":"first","affiliation":[{"name":"Department of Surgery School of Medicine Kitasato University 1\u201015\u20101\u00a0Kitasato, Sagamihara\u2010shi, Kanagawa 228 Japan<!--<country1>JP<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Hiki","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Medicine Kitasato University 1\u201015\u20101\u00a0Kitasato, Sagamihara\u2010shi, Kanagawa 228 Japan<!--<country1>JP<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzuru","family":"Sakakibara","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Medicine Kitasato University 1\u201015\u20101\u00a0Kitasato, Sagamihara\u2010shi, Kanagawa 228 Japan<!--<country1>JP<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Kakita","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Medicine Kitasato University 1\u201015\u20101\u00a0Kitasato, Sagamihara\u2010shi, Kanagawa 228 Japan<!--<country1>JP<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadahito","family":"Kuwao","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kitasato University 1\u201015\u20101\u00a0Kitasato, Sagamihara\u2010shi, Kanagawa 228 Japan<!--<country1>JP<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,12]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002689910096.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002689910096\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s002689910096","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T19:18:32Z","timestamp":1705000712000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s002689910096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["10.1007\/s002689910096"],"URL":"https:\/\/doi.org\/10.1007\/s002689910096","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,5]]}}}