{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:09:30Z","timestamp":1780394970877,"version":"3.54.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T00:00:00Z","timestamp":1508803200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Intervent Radiol"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1007\/s00270-017-1826-7","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T15:43:57Z","timestamp":1508859837000},"page":"459-465","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Safety and Efficacy of Transarterial Radioembolization Combined with Chemoembolization for Bilobar Hepatocellular Carcinoma: A Single-Center Retrospective Study"],"prefix":"10.1007","volume":"41","author":[{"given":"Joon Ho","family":"Kwon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6768-4396","authenticated-orcid":false,"given":"Gyoung Min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kichang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Yun","family":"Won","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man Deuk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Yun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhyung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woosun","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Seek","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Hyub","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,10,24]]},"reference":[{"issue":"2","key":"1826_CR1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","volume":"61","author":"A Jemal","year":"2011","unstructured":"Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69\u201390.","journal-title":"CA Cancer J Clin"},{"issue":"12","key":"1826_CR2","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1056\/NEJMra1001683","volume":"365","author":"HB El-Serag","year":"2011","unstructured":"El-Serag HB. Hepatocellular carcinoma. N Engl J Med. 2011;365(12):1118\u201327.","journal-title":"N Engl J Med"},{"issue":"9822","key":"1826_CR3","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0140-6736(11)61347-0","volume":"379","author":"A Forner","year":"2012","unstructured":"Forner A, Llovet JM, Bruix J. Hepatocellular carcinoma. Lancet. 2012;379(9822):1245\u201355.","journal-title":"Lancet"},{"issue":"5","key":"1826_CR4","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.bpg.2014.08.009","volume":"28","author":"B Sangro","year":"2014","unstructured":"Sangro B. Chemoembolization and radioembolization. Best Pract Res Clin Gastroenterol. 2014;28(5):909\u201319.","journal-title":"Best Pract Res Clin Gastroenterol"},{"issue":"Suppl 2","key":"1826_CR5","doi-asserted-by":"crossref","first-page":"ii30","DOI":"10.1093\/annonc\/mdt055","volume":"24","author":"V Marco Di","year":"2013","unstructured":"Di Marco V, De Vita F, Koskinas J, et al. Sorafenib: from literature to clinical practice. Ann Oncol. 2013;24(Suppl 2):ii30\u20137.","journal-title":"Ann Oncol"},{"issue":"5","key":"1826_CR6","doi-asserted-by":"crossref","first-page":"e0154986","DOI":"10.1371\/journal.pone.0154986","volume":"11","author":"YY Cho","year":"2016","unstructured":"Cho YY, Lee M, Kim HC, et al. Radioembolization is a safe and effective treatment for hepatocellular carcinoma with portal vein thrombosis: a propensity score analysis. PLoS ONE. 2016;11(5):e0154986.","journal-title":"PLoS ONE"},{"issue":"7","key":"1826_CR7","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.jvir.2014.04.014","volume":"25","author":"N Rostambeigi","year":"2014","unstructured":"Rostambeigi N, Dekarske AS, Austin EE, et al. Cost effectiveness of radioembolization compared with conventional transarterial chemoembolization for treatment of hepatocellular carcinoma. J Vasc Interv Radiol. 2014;25(7):1075\u201384.","journal-title":"J Vasc Interv Radiol"},{"issue":"11","key":"1826_CR8","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1007\/s00270-016-1426-y","volume":"39","author":"L Lobo","year":"2016","unstructured":"Lobo L, Yakoub D, Picado O, et al. Unresectable hepatocellular carcinoma: radioembolization versus chemoembolization: a systematic review and meta-analysis. Cardiovasc Intervent Radiol. 2016;39(11):1580\u20138.","journal-title":"Cardiovasc Intervent Radiol"},{"issue":"3","key":"1826_CR9","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1002\/hep.26191","volume":"57","author":"B Gil-Alzugaray","year":"2013","unstructured":"Gil-Alzugaray B, Chopitea A, Inarrairaegui M, et al. Prognostic factors and prevention of radioembolization-induced liver disease. Hepatology. 2013;57(3):1078\u201387.","journal-title":"Hepatology"},{"issue":"7","key":"1826_CR10","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1002\/cncr.23339","volume":"112","author":"B Sangro","year":"2008","unstructured":"Sangro B, Gil-Alzugaray B, Rodriguez J, et al. Liver disease induced by radioembolization of liver tumors: description and possible risk factors. Cancer. 2008;112(7):1538\u201346.","journal-title":"Cancer"},{"issue":"4","key":"1826_CR11","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1007\/s00270-015-1071-x","volume":"38","author":"A Denys","year":"2015","unstructured":"Denys A, Pracht M, Duran R, et al. How to prepare a patient for transarterial radioembolization? A practical guide. Cardiovasc Intervent Radiol. 2015;38(4):794\u2013805.","journal-title":"Cardiovasc Intervent Radiol"},{"issue":"10","key":"1826_CR12","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.jvir.2011.06.006","volume":"22","author":"PM Piana","year":"2011","unstructured":"Piana PM, Gonsalves CF, Sato T, et al. Toxicities after radioembolization with yttrium-90 SIR-spheres: incidence and contributing risk factors at a single center. J Vasc Interv Radiol. 2011;22(10):1373\u20139.","journal-title":"J Vasc Interv Radiol"},{"issue":"7","key":"1826_CR13","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s12149-011-0499-6","volume":"25","author":"YH Kao","year":"2011","unstructured":"Kao YH, Tan EH, Ng CE, et al. Clinical implications of the body surface area method versus partition model dosimetry for yttrium-90 radioembolization using resin microspheres: a technical review. Ann Nucl Med. 2011;25(7):455\u201361.","journal-title":"Ann Nucl Med"},{"issue":"10","key":"1826_CR14","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1097\/01.RVI.0000236744.34720.73","volume":"17","author":"R Salem","year":"2006","unstructured":"Salem R, Thurston KG. Radioembolization with yttrium-90 microspheres: a state-of-the-art brachytherapy treatment for primary and secondary liver malignancies: part 3: comprehensive literature review and future direction. J Vasc Interv Radiol. 2006;17(10):1571\u201393.","journal-title":"J Vasc Interv Radiol"},{"issue":"3","key":"1826_CR15","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1055\/s-2007-1007122","volume":"19","author":"JM Llovet","year":"1999","unstructured":"Llovet JM, Bru C, Bruix J. Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis. 1999;19(3):329\u201338.","journal-title":"Semin Liver Dis"},{"issue":"11","key":"1826_CR16","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1111\/j.1365-2036.2012.05089.x","volume":"35","author":"DY Kim","year":"2012","unstructured":"Kim DY, Ryu HJ, Choi JY, et al. Radiological response predicts survival following transarterial chemoembolisation in patients with unresectable hepatocellular carcinoma. Aliment Pharmacol Ther. 2012;35(11):1343\u201350.","journal-title":"Aliment Pharmacol Ther"},{"issue":"2","key":"1826_CR17","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/liv.12637","volume":"35","author":"A Fouly El","year":"2015","unstructured":"El Fouly A, Ertle J, El Dorry A, et al. In intermediate stage hepatocellular carcinoma: radioembolization with yttrium 90 or chemoembolization? Liver Int. 2015;35(2):627\u201335.","journal-title":"Liver Int"},{"issue":"6","key":"1826_CR18","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.cgh.2012.12.039","volume":"11","author":"R Salem","year":"2013","unstructured":"Salem R, Lewandowski RJ. Chemoembolization and radioembolization for hepatocellular carcinoma. Clin Gastroenterol Hepatol. 2013;11(6):604\u201311 (quiz e43\u20134).","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"6","key":"1826_CR19","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/hep.21176","volume":"43","author":"A Sangiovanni","year":"2006","unstructured":"Sangiovanni A, Prati GM, Fasani P, et al. The natural history of compensated cirrhosis due to hepatitis C virus: a 17-year cohort study of 214 patients. Hepatology. 2006;43(6):1303\u201310.","journal-title":"Hepatology"},{"issue":"1","key":"1826_CR20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/hep.21980","volume":"47","author":"LM Kulik","year":"2008","unstructured":"Kulik LM, Carr BI, Mulcahy MF, et al. Safety and efficacy of 90Y radiotherapy for hepatocellular carcinoma with and without portal vein thrombosis. Hepatology. 2008;47(1):71\u201381.","journal-title":"Hepatology"},{"issue":"9","key":"1826_CR21","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.jvir.2009.05.030","volume":"20","author":"A Riaz","year":"2009","unstructured":"Riaz A, Lewandowski RJ, Kulik LM, et al. Complications following radioembolization with yttrium-90 microspheres: a comprehensive literature review. J Vasc Interv Radiol. 2009;20(9):1121\u201330 (quiz 1131).","journal-title":"J Vasc Interv Radiol"},{"issue":"5","key":"1826_CR22","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.ijrobp.2008.10.005","volume":"74","author":"AS Kennedy","year":"2009","unstructured":"Kennedy AS, McNeillie P, Dezarn WA, et al. Treatment parameters and outcome in 680 treatments of internal radiation with resin 90Y-microspheres for unresectable hepatic tumors. Int J Radiat Oncol Biol Phys. 2009;74(5):1494\u2013500.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"12","key":"1826_CR23","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.jvir.2015.08.027","volume":"26","author":"TJ Ward","year":"2015","unstructured":"Ward TJ, Tamrazi A, Lam MG, et al. Management of high hepatopulmonary shunting in patients undergoing hepatic radioembolization. J Vasc Interv Radiol. 2015;26(12):1751\u201360.","journal-title":"J Vasc Interv Radiol"},{"issue":"4","key":"1826_CR24","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0360-3016(95)00039-3","volume":"33","author":"TW Leung","year":"1995","unstructured":"Leung TW, Lau WY, Ho SK, et al. Radiation pneumonitis after selective internal radiation treatment with intraarterial 90yttrium-microspheres for inoperable hepatic tumors. Int J Radiat Oncol Biol Phys. 1995;33(4):919\u201324.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"1826_CR25","first-page":"293","volume":"24","author":"S Ho","year":"1997","unstructured":"Ho S, Lau WY, Leung TW, et al. Clinical evaluation of the partition model for estimating radiation doses from yttrium-90 microspheres in the treatment of hepatic cancer. Eur J Nucl Med. 1997;24(3):293\u20138.","journal-title":"Eur J Nucl Med"},{"issue":"10","key":"1826_CR26","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.jvir.2007.07.003","volume":"18","author":"L Bester","year":"2007","unstructured":"Bester L, Salem R. Reduction of arteriohepatovenous shunting by temporary balloon occlusion in patients undergoing radioembolization. J Vasc Interv Radiol. 2007;18(10):1310\u20134.","journal-title":"J Vasc Interv Radiol"},{"issue":"3","key":"1826_CR27","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1007\/s00270-012-0481-2","volume":"36","author":"LE Moreno-Luna","year":"2013","unstructured":"Moreno-Luna LE, Yang JD, Sanchez W, et al. Efficacy and safety of transarterial radioembolization versus chemoembolization in patients with hepatocellular carcinoma. Cardiovasc Intervent Radiol. 2013;36(3):714\u201323.","journal-title":"Cardiovasc Intervent Radiol"},{"issue":"6","key":"1826_CR28","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1111\/liv.12750","volume":"35","author":"FT Kolligs","year":"2015","unstructured":"Kolligs FT, Bilbao JI, Jakobs T, et al. Pilot randomized trial of selective internal radiation therapy vs. chemoembolization in unresectable hepatocellular carcinoma. Liver Int. 2015;35(6):1715\u201321.","journal-title":"Liver Int"},{"issue":"2","key":"1826_CR29","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.jvir.2009.10.013","volume":"21","author":"DA Kooby","year":"2010","unstructured":"Kooby DA, Egnatashvili V, Srinivasan S, et al. Comparison of yttrium-90 radioembolization and transcatheter arterial chemoembolization for the treatment of unresectable hepatocellular carcinoma. J Vasc Interv Radiol. 2010;21(2):224\u201330.","journal-title":"J Vasc Interv Radiol"},{"issue":"5","key":"1826_CR30","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1002\/cncr.24884","volume":"116","author":"BI Carr","year":"2010","unstructured":"Carr BI, Kondragunta V, Buch SC, et al. Therapeutic equivalence in survival for hepatic arterial chemoembolization and yttrium 90 microsphere treatments in unresectable hepatocellular carcinoma: a two-cohort study. Cancer. 2010;116(5):1305\u201314.","journal-title":"Cancer"},{"issue":"2","key":"1826_CR31","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1053\/j.gastro.2010.10.049","volume":"140","author":"R Salem","year":"2011","unstructured":"Salem R, Lewandowski RJ, Kulik L, et al. Radioembolization results in longer time-to-progression and reduced toxicity compared with chemoembolization in patients with hepatocellular carcinoma. Gastroenterology. 2011;140(2):497\u2013507 (e2).","journal-title":"Gastroenterology"},{"issue":"5","key":"1826_CR32","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1002\/hep.23944","volume":"52","author":"P Hilgard","year":"2010","unstructured":"Hilgard P, Hamami M, Fouly AE, et al. Radioembolization with yttrium-90 glass microspheres in hepatocellular carcinoma: European experience on safety and long-term survival. Hepatology. 2010;52(5):1741\u20139.","journal-title":"Hepatology"},{"issue":"5","key":"1826_CR33","first-page":"469","volume":"6","author":"MS Bhangoo","year":"2015","unstructured":"Bhangoo MS, Karnani DR, Hein PN, et al. Radioembolization with yttrium-90 microspheres for patients with unresectable hepatocellular carcinoma. J Gastrointest Oncol. 2015;6(5):469\u201378.","journal-title":"J Gastrointest Oncol"}],"container-title":["CardioVascular and Interventional Radiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00270-017-1826-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00270-017-1826-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00270-017-1826-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T16:23:37Z","timestamp":1517934217000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00270-017-1826-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,24]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["1826"],"URL":"https:\/\/doi.org\/10.1007\/s00270-017-1826-7","relation":{},"ISSN":["0174-1551","1432-086X"],"issn-type":[{"value":"0174-1551","type":"print"},{"value":"1432-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,24]]}}}