{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:36:06Z","timestamp":1792438566396,"version":"4.5.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Intervent Radiol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>This systematic review and meta-analysis summarises the current literature on invasive treatment options of cystic hepatic echinococcosis (CE), comparing percutaneous radiological interventions to surgery, still the cornerstone of treatment in many countries.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A literature search was conducted in Medline and EMBASE databases (PROSPERO registration number: CRD42019126150). The primary outcome was recurrence of cysts after treatment. Secondary outcomes were complications, duration of hospitalisation, mortality and treatment conversion.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The number of eligible prospective studies, in particular RCTs, was limited. In the four included studies, only conventional surgery is compared directly to percutaneous techniques. From the available data, in terms of recurrence, percutaneous treatment of hydatid cysts is non-inferior to open surgery. With regard to complications and length of hospital stay, outcomes favour percutaneous therapy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Although evidence from prospective research is small, percutaneous treatment in CE is an effective, safe and less invasive alternative to surgery.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00270-021-02911-4","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T17:04:10Z","timestamp":1626455050000},"page":"1689-1696","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Percutaneous Versus Surgical Interventions for Hepatic Cystic Echinococcosis: A Systematic Review and Meta-Analysis"],"prefix":"10.1007","volume":"44","author":[{"given":"G. L. E.","family":"M\u00f6nnink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8955-6288","authenticated-orcid":false,"given":"C.","family":"Stijnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. M.","family":"van Delden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Spijker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. P.","family":"Grobusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"key":"2911_CR1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s40249-020-0630-9","volume":"9","author":"D Engels","year":"2020","unstructured":"Engels D, Zhou X-N. Neglected tropical diseases: an effective global response to local poverty-related disease priorities. Infect Dis Poverty. 2020;9:10.","journal-title":"Infect Dis Poverty"},{"key":"2911_CR2","doi-asserted-by":"publisher","first-page":"296","DOI":"10.3201\/eid1202.050499","volume":"12","author":"CM Budke","year":"2006","unstructured":"Budke CM, Deplazes P, Torgerson PR. Global socioeconomic impact of cystic echinococcosis. Emerg Infect Dis. 2006;12:296\u2013303.","journal-title":"Emerg Infect Dis"},{"key":"2911_CR3","unstructured":"WHO. Echinococcosis: WHO; 2020 [updated 23 March 2020. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/echinococcosis."},{"key":"2911_CR4","doi-asserted-by":"publisher","unstructured":"Deplazes P, Gottstein B, Junghanss T. Alveolar and cystic echinococcosis in Europe: Old burdens and new challenges. Vet Parasitol. 2015;213:73\u20135. https:\/\/doi.org\/10.1016\/j.vetpar.2015.08.001.","DOI":"10.1016\/j.vetpar.2015.08.001"},{"key":"2911_CR5","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1128\/CMR.00050-07","volume":"21","author":"A Dalessandro","year":"2008","unstructured":"Dalessandro A, Rausch RL. New aspects of neotropical polycystic (Echinococcus vogeli) and unicystic (Echinococcus oligarthrus) echinococcosis. Clin Microbiol Rev. 2008;21:380\u2013401.","journal-title":"Clin Microbiol Rev"},{"key":"2911_CR6","doi-asserted-by":"publisher","first-page":"528","DOI":"10.3201\/eid2103.141205","volume":"21","author":"K Stijnis","year":"2015","unstructured":"Stijnis K, Dijkmans AC, Bart A, Brosens LAA, Muntau B, Schoen C, et al. Echinococcus vogeli in immigrant from Suriname to the Netherlands. Emerg Infect Dis. 2015;21:528\u201330.","journal-title":"Emerg Infect Dis"},{"key":"2911_CR7","doi-asserted-by":"publisher","first-page":"292","DOI":"10.3201\/eid1402.070742","volume":"14","author":"D Tappe","year":"2008","unstructured":"Tappe D, Stich A, Frosch M. Emergence of polycystic neotropical echinococcosis. Emerg Infect Dis. 2008;14:292\u20137.","journal-title":"Emerg Infect Dis"},{"key":"2911_CR8","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.3748\/wjg.v18.i13.1425","volume":"18","author":"G Grosso","year":"2012","unstructured":"Grosso G, Gruttadauria S, Biondi A, Marventano S, Mistretta A. Worldwide epidemiology of liver hydatidosis including the Mediterranean area. World J Gastroenterol. 2012;18:1425\u201337.","journal-title":"World J Gastroenterol"},{"key":"2911_CR9","doi-asserted-by":"publisher","first-page":"39","DOI":"10.14218\/JCTH.2015.00036","volume":"4","author":"T Pakala","year":"2016","unstructured":"Pakala T, Molina M, Wu GY. Hepatic echinococcal cysts: a review. J Clin Transl Hepatol. 2016;4:39\u201346.","journal-title":"J Clin Transl Hepatol"},{"key":"2911_CR10","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/S1473-3099(12)70155-X","volume":"12","author":"K Wahlers","year":"2012","unstructured":"Wahlers K, Menezes CN, Wong ML, Zeyhle E, Ahmed ME, Ocaido M, et al. Cystic echinococcosis in sub-Saharan Africa. Lancet Infect Dis. 2012;12:871\u201380.","journal-title":"Lancet Infect Dis"},{"key":"2911_CR11","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/S1473-3099(07)70134-2","volume":"7","author":"PS Craig","year":"2007","unstructured":"Craig PS, McManus DP, Lightowlers MW, Chabalgoity JA, Garcia HH, Gavidia CM, et al. Prevention and control of cystic echinococcosis. Lancet Infect Dis. 2007;7:385\u201394.","journal-title":"Lancet Infect Dis"},{"key":"2911_CR12","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.tmaid.2018.09.012","volume":"28","author":"A Khan","year":"2019","unstructured":"Khan A, Ahmed H, Simsek S. War, migration and cystic Echinococcosis. Travel Med Infect Dis. 2019;28:111\u20132.","journal-title":"Travel Med Infect Dis"},{"key":"2911_CR13","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1097\/SLE.0b013e31828a0b78","volume":"23","author":"Q-W Tai","year":"2013","unstructured":"Tai Q-W, Tuxun T, Zhang J-H, Zhao J-M, Cao J, Muhetajiang M, et al. The role of laparoscopy in the management of liver hydatid cyst: a single-center experience and world review of the literature. Surg laparosc Endosc Percutaneous Techn. 2013;23:171\u20135.","journal-title":"Surg laparosc Endosc Percutaneous Techn"},{"key":"2911_CR14","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1007\/s00268-005-0058-1","volume":"29","author":"G Yagci","year":"2005","unstructured":"Yagci G, Ustunsoz B, Kaymakcioglu N, Bozlar U, Gorgulu S, Simsek A, et al. Results of surgical, laparoscopic, and percutaneous treatment for hydatid disease of the liver: 10 Years experience with 355 patients. World J Surg. 2005;29:1670\u20139.","journal-title":"World J Surg"},{"key":"2911_CR15","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S1995-7645(12)60035-2","volume":"5","author":"S Mandal","year":"2012","unstructured":"Mandal S, Mandal MD. Human cystic echinococcosis: epidemiologic, zoonotic, clinical, diagnostic and therapeutic aspects. Asian Pac J Trop Med. 2012;5:253\u201360.","journal-title":"Asian Pac J Trop Med"},{"issue":"3","key":"2911_CR16","first-page":"189","volume":"32","author":"S Mohan","year":"2011","unstructured":"Mohan S, Garg SK, Kathuria M, Baijal SS. Mechanical suction through wide bore catheters for nonsurgical management of Gharbi type III hepatic hydatid cysts. Trop Gastroenterol. 2011;32(3):189\u201395.","journal-title":"Trop Gastroenterol"},{"key":"2911_CR17","doi-asserted-by":"publisher","unstructured":"McManus DP, Gray DJ, Zhang W, Yang Y. Diagnosis, treatment, and management of echinococcosis. BMJ. 2012;344:e3866. https:\/\/doi.org\/10.1136\/bmj.e3866.","DOI":"10.1136\/bmj.e3866"},{"key":"2911_CR18","doi-asserted-by":"publisher","first-page":"e0005243","DOI":"10.1371\/journal.pntd.0005243","volume":"10","author":"M Stojkovic","year":"2016","unstructured":"Stojkovic M, Rosenberger KD, Steudle F, Junghanss T. Watch and wait management of inactive cystic echinococcosis \u2013 does the path to inactivity matter \u2013 analysis of a prospective patient cohort. PLOS Negl Trop Dis. 2016;10:e0005243.","journal-title":"PLOS Negl Trop Dis"},{"issue":"6","key":"2911_CR19","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1007\/s00270-014-0840-2","volume":"37","author":"O Akhan","year":"2014","unstructured":"Akhan O, Yildiz AE, Akinci D, Yildiz BD, Ciftci T. Is the adjuvant albendazole treatment really needed with PAIR in the management of liver hydatid cysts? A prospective, randomized trial with short-term follow-up results. Cardiovasc Intervent Radiol. 2014;37(6):1568\u201374.","journal-title":"Cardiovasc Intervent Radiol"},{"key":"2911_CR20","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.ijsu.2008.08.003","volume":"6","author":"SH Arif","year":"2008","unstructured":"Arif SH, Bari SUI, Wani NA, Zargar SA, Wani MA, Tabassum R, et al. Albendazole as an adjuvant to the standard surgical management of hydatid cyst liver. Int J Surg Lond Engl. 2008;6:448\u201351.","journal-title":"Int J Surg Lond Engl"},{"issue":"2","key":"2911_CR21","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.ijid.2004.08.001","volume":"9","author":"RA Smego Jr","year":"2005","unstructured":"Smego RA Jr, Sebanego P. Treatment options for hepatic cystic echinococcosis. Int J Infect Dis. 2005;9(2):69\u201376.","journal-title":"Int J Infect Dis"},{"key":"2911_CR22","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0001-706X(96)00642-0","volume":"64","author":"C Filice","year":"1997","unstructured":"Filice C, Brunetti E. Use of PAIR in human cystic echinococcosis. Acta Trop. 1997;64:95\u2013107.","journal-title":"Acta Trop"},{"issue":"4","key":"2911_CR23","doi-asserted-by":"publisher","first-page":"878","DOI":"10.2214\/AJR.16.16131","volume":"208","author":"O Akhan","year":"2017","unstructured":"Akhan O, Salik AE, Ciftci T, Akinci D, Islim F, Akpinar B. Comparison of long-term results of percutaneous treatment techniques for hepatic cystic echinococcosis types 2 and 3b. Am J Roentgenol. 2017;208(4):878\u201384.","journal-title":"Am J Roentgenol"},{"key":"2911_CR24","doi-asserted-by":"publisher","unstructured":"Giorgio A, Calisti G, de Stefano G, Farella N, Scognamiglio U, Giorgio V. Percutaneous treatment of hydatid liver cysts: an update. Recent Pat Antiinfect Drug Discov. 2012;7(3):231\u20136. https:\/\/doi.org\/10.2174\/157489112803521913.","DOI":"10.2174\/157489112803521913"},{"key":"2911_CR25","doi-asserted-by":"publisher","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","volume":"6","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG, Group TP. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLOS Med. 2009;6:e1000097.","journal-title":"PLOS Med"},{"issue":"1","key":"2911_CR26","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1002\/jrsm.1411","volume":"12","author":"L McGuinness","year":"2020","unstructured":"McGuinness L, Higgins J. Risk-Of-Bias VISualization (robvis): an R package and Shiny web app for visualizing risk-of-bias assessments. Res Synth Methods. 2020;12(1):55\u201361.","journal-title":"Res Synth Methods"},{"key":"2911_CR27","doi-asserted-by":"publisher","first-page":"20160640","DOI":"10.1259\/bjr.20160640","volume":"90","author":"TA Shera","year":"2017","unstructured":"Shera TA, Choh NA, Gojwari TA, Shera FA, Shaheen FA, Wani GM, et al. A comparison of imaging guided double percutaneous aspiration injection and surgery in the treatment of cystic echinococcosis of liver. Br J Radiol. 2017;90:20160640.","journal-title":"Br J Radiol"},{"key":"2911_CR28","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1056\/NEJM199709253371303","volume":"337","author":"MS Khuroo","year":"1997","unstructured":"Khuroo MS, Wani NA, Javid G, Khan BA, Yattoo GN, Shah AH, et al. Percutaneous drainage compared with surgery for hepatic hydatid cysts. N Engl J Med. 1997;337:881\u20137.","journal-title":"N Engl J Med"},{"key":"2911_CR29","first-page":"314","volume":"83","author":"A Tan","year":"1998","unstructured":"Tan A, Yakut M, Kaymak\u00e7io\u01e7lu N, \u00d6zerhan IH, \u00c7etiner S, Akdeniz A. The results of surgical treatment and percutaneous drainage of hepatic hydatid disease. Int Surg. 1998;83:314\u20136.","journal-title":"Int Surg"},{"key":"2911_CR30","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1590\/0037-8682-0223-2015","volume":"48","author":"A Abdelraouf","year":"2015","unstructured":"Abdelraouf A, Abd El-Aal AA, Shoeib EY, Attia SS, Hanafy NA, Hassani M, et al. Clinical and serological outcomes with diff erent surgical approaches for human hepatic hydatidosis. Rev Soc Bras Med Trop. 2015;48:587\u201393.","journal-title":"Rev Soc Bras Med Trop"},{"key":"2911_CR31","first-page":"15","volume":"2017","author":"WH Organization","year":"2016","unstructured":"Organization WH. Meeting of the WHO informal working group on echinococcosis (WHO-IWGE), Geneva, Switzerland. Geneva, Switz World Health Org. 2016;2017:15\u20136.","journal-title":"Geneva, Switz World Health Org"},{"key":"2911_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actatropica.2009.11.001","volume":"114","author":"E Brunetti","year":"2010","unstructured":"Brunetti E, Kern P, Vuitton DA. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Trop. 2010;114:1\u201316.","journal-title":"Acta Trop"},{"key":"2911_CR33","doi-asserted-by":"publisher","first-page":"284","DOI":"10.5114\/aoms.2018.73344","volume":"15","author":"M Sokouti","year":"2019","unstructured":"Sokouti M, Sadeghi R, Pashazadeh S, Abadi SEH, Sokouti M, Ghojazadeh M, et al. A systematic review and meta-analysis on the treatment of liver hydatid cyst using meta-MUMS tool: comparing PAIR and laparoscopic procedures. Arch Med Sci AMS. 2019;15:284\u2013308.","journal-title":"Arch Med Sci AMS"},{"key":"2911_CR34","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1086\/378275","volume":"37","author":"RA Smego Jr","year":"2003","unstructured":"Smego RA Jr, Bhatti S, Khaliq AA, Beg MA. Percutaneous aspiration-injection-reaspiration drainage plus albendazole or mebendazole for hepatic cystic echinococcosis: a meta-analysis. Clin Infect Dis. 2003;37:1073\u201383.","journal-title":"Clin Infect Dis"},{"key":"2911_CR35","first-page":"33","volume":"19","author":"U Aydin","year":"2008","unstructured":"Aydin U, Yazici P, Onen Z, Ozsoy M, Zeytunlu M, Kili\u00e7 M, et al. The optimal treatment of hydatid cyst of the liver: radical surgery with a significant reduced risk of recurrence. Turk J Gastroenterol Off J Turk Soc Gastroenterol. 2008;19:33\u20139.","journal-title":"Turk J Gastroenterol Off J Turk Soc Gastroenterol"},{"key":"2911_CR36","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1503\/cjs.013010","volume":"55","author":"J Prousalidis","year":"2012","unstructured":"Prousalidis J, Kosmidis C, Anthimidis G, Kapoutzis K, Karamanlis E, Fachantidis E. Postoperative recurrence of cystic hydatidosis. Can J Surg J Can de Chir. 2012;55:15\u201320.","journal-title":"Can J Surg J Can de Chir"}],"container-title":["CardioVascular and Interventional Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00270-021-02911-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00270-021-02911-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00270-021-02911-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T20:03:36Z","timestamp":1635278616000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00270-021-02911-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,16]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["2911"],"URL":"https:\/\/doi.org\/10.1007\/s00270-021-02911-4","relation":{},"ISSN":["0174-1551","1432-086X"],"issn-type":[{"value":"0174-1551","type":"print"},{"value":"1432-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,16]]},"assertion":[{"value":"4 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare they have no conflict of interest.Consent for publication.For this type of study consent for publication is not required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This article does not contain any studies with human participants performed by any of the authors.Informed consent.For this type of study informed consent is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}