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The primary endpoint is a composite of the safety of PVE\/HVE, 90-day mortality, and one year accrual monitoring of each participating center. Secondary endpoints include: feasibility of resection, the used PVE and HVE techniques, FLR-hypertrophy, liver function (subset of centers), overall survival, and disease-free survival. All complications after the PVE\/HVE procedure are documented. Liver volumes will be measured at week 1 and if applicable at week 3 and 6 after PVE\/HVE and follow-up visits will be held at 1, 3, 6, and 12\u00a0months after the resection.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Not applicable.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>DRAGON 1 is a prospective trial to assess the safety and feasibility of PVE\/HVE. Participating study centers will be trained, and procedures standardized using Work Instructions (WI) to prepare for the DRAGON 2 randomized controlled trial. Outcomes should reveal the accrual potential of centers, safety profile of combined PVE\/HVE and the effect of FLR-hypertrophy induction by PVE\/HVE in patients with CRLM and a small FLR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial Registration<\/jats:title>\n                <jats:p>Clinicaltrials.gov: NCT04272931 (February 17, 2020). Toestingonline.nl: NL71535.068.19 (September 20, 2019).<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00270-022-03176-1","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T18:27:38Z","timestamp":1659032858000},"page":"1391-1398","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Dragon 1 Protocol Manuscript: Training, Accreditation, Implementation and Safety Evaluation of Portal and Hepatic Vein Embolization (PVE\/HVE) to Accelerate Future Liver Remnant (FLR) Hypertrophy"],"prefix":"10.1007","volume":"45","clinical-trial-number":[{"clinical-trial-number":"nct04272931","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"ntr-7153506819","registry":"10.18810\/dutch-trial-register"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6356-3076","authenticated-orcid":false,"given":"R.","family":"Korenblik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Olij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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