{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:48:18Z","timestamp":1789602498446,"version":"build-2803163510"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Intervent Radiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the utility of pre-procedural knee MRI prior to genicular artery embolization (GAE) for the prognostication of early outcomes for symptomatic knee osteoarthritis (KOA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A single-center study including 39 patients received GAE from 9\/2021\u20134\/2025 with pre-procedural MRIs. MRIs were evaluated for structural abnormalities including menisci, ligaments, cartilage, marrow signal, and loose bodies. For 24 patients, synovitis was assessed using a semiquantitative method. Clinical outcomes were measured with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scoring system at pre-GAE and three-month postintervention. Categorical response was assessed as a 50% reduction in the WOMAC Pain. Student t-tests were used to evaluate WOMAC pain reduction, and subset analysis was performed between MRI structural abnormalities and categorical response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty-two knees received GAE with pre-procedural MRIs (33 with contrast). There was a 34.6% clinical response rate (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20098\/52). Lateral meniscus and cartilage abnormality were predictive of poor categorical response at three months (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.039\u20130.040).\u2009\u2265\u20094 structural abnormalities were associated with poor treatment response (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004). Pre-GAE synovitis was not predictive of categorical response at three months (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.809). Kellgren\u2013Lawrence\u2009\u2265\u20093 was predictive of poor response (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Lower adverse event rate was observed with temporary embolic compared to permanent embolic (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.032).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pre-GAE knee MRI may offer short-term prognostic utility. Pre-procedural abnormalities in the lateral menisci and cartilage can predict poor response to GAE at three months. A greater degree of structural abnormality (\u2265\u20094 structural abnormalities) was associated with poor response. Temporary embolic agent may be safer than permanent embolic agent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphic Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s00270-025-04159-8","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T17:16:04Z","timestamp":1755882964000},"page":"1818-1827","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prognostication of Three-Month Genicular Artery Embolization Outcomes Using Pre-Procedural MRIs"],"prefix":"10.1007","volume":"48","author":[{"given":"Wali","family":"Badar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layth","family":"Alkhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Al-Qawasmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Varadhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Husnain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mudassir","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Anitescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendon","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narayan","family":"Sundaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikin","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"4159_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1323091","volume":"11","author":"E Li","year":"2024","unstructured":"Li E, Tan J, Xu K, Pan Y, Xu P. 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