{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:13:50Z","timestamp":1793826830216,"version":"4.6.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Intervent Radiol"],"DOI":"10.1007\/s00270-025-04172-x","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T17:24:20Z","timestamp":1756488260000},"page":"220-228","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Thermal Ablation for Giant Hepatic Hemangiomas: A Meta-Analysis with Subgroup Analysis of Microwave and Radiofrequency Ablation Techniques"],"prefix":"10.1007","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5414-6548","authenticated-orcid":false,"given":"Alperen","family":"Elek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6236-5633","authenticated-orcid":false,"given":"Ahmet","family":"G\u00fcnkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8742-1818","authenticated-orcid":false,"given":"Victor Arthur","family":"Ohannesian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norhane","family":"Chadli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3546-7773","authenticated-orcid":false,"given":"Ismail","family":"Oran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"4172_CR1","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2023.2285705","volume":"41","author":"Q Cai","year":"2024","unstructured":"Cai Q, Qian TG, Zhao QY, Feng SY, Yang Q, Luo YC, Dai YQ, Liang P, Yu XL, Liu FY, Han ZY, Du QW, Li X, Yu J. Percutaneous microwave ablation versus sclerotherapy for large hepatic hemangioma: a multi-center cohort study. Int J Hyperthermia. 2024;41: 2285705.","journal-title":"Int J Hyperthermia"},{"key":"4172_CR2","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1007\/s00270-024-03876-w","volume":"47","author":"M Kusbeci","year":"2024","unstructured":"Kusbeci M, Elek A, Ozturk E, Bozkaya H, Cinar C, Parildar M, Oran I. Long-term outcomes of transarterial chemoembolization of giant liver hemangiomas with lipiodol-bleomycin emulsion. Cardiovasc Intervent Radiol. 2024;47:1506\u201314.","journal-title":"Cardiovasc Intervent Radiol"},{"key":"4172_CR3","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1097\/MEG.0000000000002724","volume":"36","author":"J Li","year":"2024","unstructured":"Li J, Zhang S, Ning C, Li G, Guo S. Efficacy of radiofrequency ablation vs. transcatheter arterial embolization for hepatic hemangiomas. Eur J Gastroenterol Hepatol. 2024;36:750\u20137.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"4172_CR4","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1080\/02656736.2018.1493541","volume":"35","author":"Z Wang","year":"2018","unstructured":"Wang Z, Tang X, Qi X, Shi Y, Chi J, Li P, Zhai B. Feasibility, safety, and efficacy of ultrasound-guided percutaneous microwave ablation for giant hepatic hemangioma. Int J Hyperthermia. 2018;35:246\u201352.","journal-title":"Int J Hyperthermia"},{"key":"4172_CR5","volume":"69","author":"W Farhat","year":"2021","unstructured":"Farhat W, Ammar H, Said MA, Mizouni A, Ghabry L, Hammami E, Gupta R, Habiba Ben H, Mabrouk MB, Ali AB. Surgical management of giant hepatic hemangioma: A 10-year single center experience. Ann Med Surg (Lond). 2021;69: 102542.","journal-title":"Ann Med Surg (Lond)"},{"key":"4172_CR6","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1111\/hpb.12391","volume":"17","author":"J Qiu","year":"2015","unstructured":"Qiu J, Chen S, Wu H. Quality of life can be improved by surgical management of giant hepatic haemangioma with enucleation as the preferred option. HPB (Oxford). 2015;17:490\u20134.","journal-title":"HPB (Oxford)"},{"key":"4172_CR7","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.amsu.2019.02.001","volume":"39","author":"L Chen","year":"2019","unstructured":"Chen L, Zhang L, Tian M, Hu Q, Zhao L, Xiong J. Safety and effective of laparoscopic microwave ablation for giant hepatic hemangioma: a retrospective cohort study. Ann Med Surg (Lond). 2019;39:29\u201335.","journal-title":"Ann Med Surg (Lond)"},{"key":"4172_CR8","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1080\/02656736.2020.1766122","volume":"37","author":"Y Shi","year":"2020","unstructured":"Shi Y, Song J, Ding M, Tang X, Wang Z, Chi J, Wang T, Ji J, Zhai B. Microwave ablation versus transcatheter arterial embolization for large hepatic hemangiomas: clinical outcomes. Int J Hyperthermia. 2020;37:938\u201343.","journal-title":"Int J Hyperthermia"},{"key":"4172_CR9","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1097\/MCG.0b013e31829ef037","volume":"48","author":"J Gao","year":"2014","unstructured":"Gao J, Ding X, Ke S, Xin Z, Ning C, Sha Q, Sun W. Radiofrequency ablation in the treatment of large hepatic hemangiomas: a comparison of multitined and internally cooled electrodes. J Clin Gastroenterol. 2014;48:540\u20137.","journal-title":"J Clin Gastroenterol"},{"key":"4172_CR10","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1080\/02656736.2017.1392045","volume":"34","author":"F Liu","year":"2018","unstructured":"Liu F, Yu X, Liang P, Cheng Z, Han Z, Yu J. Ultrasonography-guided percutaneous microwave ablation for large hepatic cavernous haemangiomas. Int J Hyperthermia. 2018;34:1061\u20136.","journal-title":"Int J Hyperthermia"},{"key":"4172_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.706619","volume":"11","author":"S Wu","year":"2021","unstructured":"Wu S, Gao R, Yin T, Zhu R, Guo S, Xin Z, Li A, Kong X, Gao J, Sun W. Complications of radiofrequency ablation for hepatic hemangioma: a multicenter retrospective analysis on 291 cases. Front Oncol. 2021;11: 706619.","journal-title":"Front Oncol"},{"key":"4172_CR12","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hrobjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372: n71.","journal-title":"BMJ"},{"key":"4172_CR13","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.jamcollsurg.2010.08.006","volume":"211","author":"T Schnelldorfer","year":"2010","unstructured":"Schnelldorfer T, Ware AL, Smoot R, Schleck CD, Harmsen WS, Nagorney DM. Management of giant hemangioma of the liver: resection versus observation. J Am Coll Surg. 2010;211:724\u201330.","journal-title":"J Am Coll Surg"},{"key":"4172_CR14","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1007\/s00270-017-1703-4","volume":"40","author":"DK Filippiadis","year":"2017","unstructured":"Filippiadis DK, Binkert C, Pellerin O, Hoffmann RT, Krajina A, Pereira PL. Cirse quality assurance document and standards for classification of complications: the Cirse classification system. Cardiovasc Intervent Radiol. 2017;40:1141\u20136.","journal-title":"Cardiovasc Intervent Radiol"},{"key":"4172_CR15","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s00270-020-02611-5","volume":"44","author":"P Torkian","year":"2021","unstructured":"Torkian P, Li J, Kaufman JA, Jahangiri Y. Effectiveness of transarterial embolization in treatment of symptomatic hepatic hemangiomas: systematic review and meta-analysis. Cardiovasc Intervent Radiol. 2021;44:80\u201391.","journal-title":"Cardiovasc Intervent Radiol"},{"key":"4172_CR16","doi-asserted-by":"publisher","first-page":"268","DOI":"10.5604\/01.3001.0010.8653","volume":"17","author":"SQ Wen","year":"2018","unstructured":"Wen SQ, Wan M, Len KM, Hu QH, Xie XY, Wu Q, Liao GQ. Safety and efficacy of laparoscopic radiofrequency ablation for hepatic hemangiomas: a multicenter retrospective study. Ann Hepatol. 2018;17:268\u201373.","journal-title":"Ann Hepatol"},{"key":"4172_CR17","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s12885-019-5682-5","volume":"19","author":"X Li","year":"2019","unstructured":"Li X, An C, Liu F, Cheng Z, Han Z, Yu X, Dong L, Yu J, Liang P. The value of 3D visualization operative planning system in ultrasound-guided percutaneous microwave ablation for large hepatic hemangiomas: a clinical comparative study. BMC Cancer. 2019;19:550.","journal-title":"BMC Cancer"},{"key":"4172_CR18","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.jhep.2010.07.024","volume":"54","author":"SY Park","year":"2011","unstructured":"Park SY, Tak WY, Jung MK, Jeon SW, Cho CM, Kweon YO, Kim KC. Symptomatic-enlarging hepatic hemangiomas are effectively treated by percutaneous ultrasonography-guided radiofrequency ablation. J Hepatol. 2011;54:559\u201365.","journal-title":"J Hepatol"},{"key":"4172_CR19","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1080\/02656736.2020.1732484","volume":"37","author":"C Qu","year":"2020","unstructured":"Qu C, Liu H, Li XQ, Feng K, Ma K. Percutaneous ultrasound-guided \u2018three-step\u2019 radiofrequency ablation for giant hepatic hemangioma (5\u201315 cm): a safe and effective new technique. Int J Hyperthermia. 2020;37:212\u20139.","journal-title":"Int J Hyperthermia"},{"key":"4172_CR20","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1007\/s00464-015-4274-y","volume":"30","author":"X Zhang","year":"2016","unstructured":"Zhang X, Yan L, Li B, Wen T, Wang W, Xu M, Wei Y, Yang J. Comparison of laparoscopic radiofrequency ablation versus open resection in the treatment of symptomatic-enlarging hepatic hemangiomas: a prospective study. Surg Endosc. 2016;30:756\u201363.","journal-title":"Surg Endosc"},{"key":"4172_CR21","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1007\/s00270-014-0934-x","volume":"37","author":"TJ Ziemlewicz","year":"2014","unstructured":"Ziemlewicz TJ, Wells SA, Lubner MA, Musat AI, Hinshaw JL, Cohn AR, Lee FT Jr. Microwave ablation of giant hepatic cavernous hemangiomas. Cardiovasc Intervent Radiol. 2014;37:1299\u2013305.","journal-title":"Cardiovasc Intervent Radiol"},{"key":"4172_CR22","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1148\/radiol.2021204444","volume":"301","author":"N Ayoobi Yazdi","year":"2021","unstructured":"Ayoobi Yazdi N, Mehrabinejad MM, Dashti H, Pourghorban R, Nassiri Toosi M, Rokni Yazdi H. Percutaneous sclerotherapy with bleomycin and ethiodized oil: a promising treatment in symptomatic giant liver hemangioma. Radiology. 2021;301:464\u201371.","journal-title":"Radiology"},{"key":"4172_CR23","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.3465","volume":"37","author":"M Zhang","year":"2021","unstructured":"Zhang M, Li Y, Sugiyama SI, Verrelli DI, Matsumoto Y, Tominaga T, Qian Y, Tupin S, Anzai H, Ohta M. Incomplete stent expansion in flow-diversion treatment affects aneurysmal haemodynamics: a quantitative comparison of treatments affected by different severities of malapposition occurring in different segments of the parent artery. Int J Numer Method Biomed Eng. 2021;37: e3465.","journal-title":"Int J Numer Method Biomed Eng"},{"key":"4172_CR24","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1136\/neurintsurg-2020-016724","volume":"13","author":"M Zhang","year":"2021","unstructured":"Zhang M, Tupin S, Anzai H, Kohata Y, Shojima M, Suzuki K, Okamoto Y, Tanaka K, Yagi T, Fujimura S, Ohta M. Implementation of computer simulation to assess flow diversion treatment outcomes: systematic review and meta-analysis. J Neurointerv Surg. 2021;13:164\u201370.","journal-title":"J Neurointerv Surg"}],"container-title":["CardioVascular and Interventional Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00270-025-04172-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00270-025-04172-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00270-025-04172-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T15:04:00Z","timestamp":1770131040000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00270-025-04172-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,29]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["4172"],"URL":"https:\/\/doi.org\/10.1007\/s00270-025-04172-x","relation":{},"ISSN":["1432-086X"],"issn-type":[{"value":"1432-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,29]]},"assertion":[{"value":"25 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}