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Forty-five studies including 2205 patients were analyzed. Across predominantly uncontrolled studies, clinically relevant improvements were observed, with pooled Visual Analogue Scale reductions of\u2009\u2212\u200937.5 points at 1\u00a0month and\u2009\u2212\u200937.1 at 12\u00a0months. Western Ontario and McMaster Universities Osteoarthritis Index improved by\u2009\u2212\u200928.9 at 1\u00a0month, and Knee Injury and Osteoarthritis Outcome Score-Pain by\u2009+\u200923.6 at 6\u00a0months. Mean changes exceeded clinically important thresholds. No significant subgroup interaction between permanent and temporary embolic agents was observed. The most frequent adverse events were transient skin discoloration (11%) and hematoma (3%). Overall, the certainty of evidence ranged from very low to low.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical Abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s00270-026-04502-7","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:45:57Z","timestamp":1781646357000},"page":"1682-1697","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Outcome and Safety of Genicular Artery Embolization for Knee Osteoarthritis: A Systematic Review and Meta-Analysis"],"prefix":"10.1007","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3532-7383","authenticated-orcid":false,"given":"Arian Taheri","family":"Amin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac Eli Mart\u00ednez","family":"Safar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Baquero","family":"Trujillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Guillermo Trujillo","family":"Buritica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Jannusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Minko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"4502_CR1","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","volume":"393","author":"DJ Hunter","year":"2019","unstructured":"Hunter DJ, Bierma-Zeinstra S. 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