{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:27:50Z","timestamp":1794324470801,"version":"4.9.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Baoshan District Health Commission Talents","award":["BSWSYX-20242"],"award-info":[{"award-number":["BSWSYX-20242"]}]},{"DOI":"10.13039\/501100010167","name":"Shanghai Shen Kang Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC2023CRD026"],"award-info":[{"award-number":["SHDC2023CRD026"]}],"id":[{"id":"10.13039\/501100010167","id-type":"DOI","asserted-by":"publisher"}]},{"name":"China Academy of Information and Communications Technology","award":["2023-325"],"award-info":[{"award-number":["2023-325"]}],"id":[{"id":"https:\/\/ror.org\/038dte259","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Intervent Radiol"],"DOI":"10.1007\/s00270-026-04526-z","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T21:26:57Z","timestamp":1787606817000},"page":"2452-2458","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Prospective, Randomized Controlled Trial of Intravascular Ultrasound-Guided versus Digital Subtraction Angiography-Guided Mechanical Thrombectomy in Acute Intermediate-Risk and High-Risk Pulmonary Embolism"],"prefix":"10.1007","volume":"49","author":[{"given":"Da","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honggang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"issue":"9","key":"4526_CR1","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1161\/CIRCRESAHA.115.306841","volume":"118","author":"AM Wendelboe","year":"2016","unstructured":"Wendelboe AM, Raskob GE. Global burden of thrombosis: epidemiologic aspects. Circ Res. 2016;118(9):1340\u20137. https:\/\/doi.org\/10.1161\/CIRCRESAHA.115.306841.","journal-title":"Circ Res"},{"issue":"4","key":"4526_CR2","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1093\/eurheartj\/ehz236","volume":"41","author":"K Keller","year":"2020","unstructured":"Keller K, Hobohm L, Ebner M, et al. Trends in thrombolytic treatment and outcomes of acute pulmonary embolism in Germany. Eur Heart J. 2020;41(4):522\u20139. https:\/\/doi.org\/10.1093\/eurheartj\/ehz236.","journal-title":"Eur Heart J"},{"issue":"4","key":"4526_CR3","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1093\/eurheartj\/ehz236","volume":"41","author":"K Zhen","year":"2020","unstructured":"Zhen K, et al. Trends in thrombolytic treatment and outcomes of acute pulmonary embolism in Germany. Eur Heart J. 2020;41(4):522\u20139. https:\/\/doi.org\/10.1093\/eurheartj\/ehz236.","journal-title":"Eur Heart J"},{"issue":"4","key":"4526_CR4","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1093\/eurheartj\/ehz405","volume":"41","author":"SV Konstantinides","year":"2019","unstructured":"Konstantinides SV, Meyer G, Becattini C, et al. 2019 ESC guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J. 2019;41(4):543\u2013603. https:\/\/doi.org\/10.1093\/eurheartj\/ehz405.","journal-title":"Eur Heart J"},{"issue":"3","key":"4526_CR5","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1183\/13993003.00024-2016","volume":"48","author":"C Becattini","year":"2016","unstructured":"Becattini C, et al. Acute pulmonary embolism: mortality prediction by the 2014 European Society of Cardiology risk stratification model. Eur Respir J. 2016;48(3):780\u20136. https:\/\/doi.org\/10.1183\/13993003.00024-2016.","journal-title":"Eur Respir J"},{"issue":"23","key":"4526_CR6","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1001\/jama.2014.5990","volume":"311","author":"S Chatterjee","year":"2014","unstructured":"Chatterjee S, Chakraborty A, Weinberg I, et al. Thrombolysis for pulmonary embolism and risk of all-cause mortality, major bleeding, and intracranial hemorrhage: a meta-analysis. JAMA. 2014;311(23):2414\u201321. https:\/\/doi.org\/10.1001\/jama.2014.5990.","journal-title":"JAMA"},{"issue":"20","key":"4526_CR7","doi-asserted-by":"publisher","first-page":"e774","DOI":"10.1161\/CIR.0000000000000707","volume":"140","author":"J Giri","year":"2019","unstructured":"Giri J, Sista AK, Weinberg I, et al. Interventional therapies for acute pulmonary embolism: current status and principles for the development of novel evidence: a scientific statement from the American Heart Association. Circulation. 2019;140(20):e774\u2013801. https:\/\/doi.org\/10.1161\/CIR.0000000000000707.","journal-title":"Circulation"},{"issue":"9","key":"4526_CR8","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.jcin.2018.12.022","volume":"12","author":"T Tu","year":"2019","unstructured":"Tu T, Toma C, Tapson VF, et al. A prospective, single-arm, multicenter trial of catheter-directed mechanical thrombectomy for intermediate-risk acute pulmonary embolism. JACC Cardiovasc Interv. 2019;12(9):859\u201369. https:\/\/doi.org\/10.1016\/j.jcin.2018.12.022.","journal-title":"JACC Cardiovasc Interv"},{"issue":"3","key":"4526_CR9","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.jcin.2020.09.053","volume":"14","author":"AK Sista","year":"2021","unstructured":"Sista AK, Horowitz JM, Tapson VF, et al. Indigo aspiration system for treatment of pulmonary embolism. JACC Cardiovasc Interv. 2021;14(3):319\u201329. https:\/\/doi.org\/10.1016\/j.jcin.2020.09.053.","journal-title":"JACC Cardiovasc Interv"},{"issue":"5","key":"4526_CR10","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1161\/CIRCULATIONAHA.124.072364","volume":"151","author":"WA Jaber","year":"2025","unstructured":"Jaber WA, et al. Large-bore mechanical thrombectomy versus catheter-directed thrombolysis in the management of intermediate-risk pulmonary embolism: primary results of the PEERLESS randomized controlled trial. Circulation. 2025;151(5):260\u201373. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.124.072364.","journal-title":"Circulation"},{"issue":"11","key":"4526_CR11","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1016\/j.jvir.2009.08.002","volume":"20","author":"WT Kuo","year":"2009","unstructured":"Kuo WT, Gould MK, Louie JD, Rosenberg JK, Sze DY, Hofmann LV. Catheter-directed therapy for the treatment of massive pulmonary embolism: systematic review and meta-analysis of modern techniques. J Vasc Interv Radiol. 2009;20(11):1431\u201340. https:\/\/doi.org\/10.1016\/j.jvir.2009.08.002.","journal-title":"J Vasc Interv Radiol"},{"issue":"5","key":"4526_CR12","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1016\/s0735-1097(01)01175-5","volume":"37","author":"GS Mintz","year":"2001","unstructured":"Mintz GS, Nissen SE, Anderson WD, et al. American College of Cardiology clinical expert consensus document on standards for acquisition, measurement and reporting of intravascular ultrasound studies (ivus)31When citing this document, the American College of Cardiology would appreciate the following citation format: Mintz GS, Nissen SE, Anderson WD, Bailey SR, Erbel R, Fitzgerald PJ, Pinto FJ, Rosenfield K, Siegel RJ, Tuzcu EM, Yock PG. ACC Clinical Expert Consensus Document on Standards for the acquisition, measurement and reporting of intravascular ultrasound studies: a report of the American College of Cardiology Task Force on Clinical Expert Consensus Documents (Committee to Develop a Clinical Expert Consensus Document on Standards for Acquisition, Measurement and Reporting of Intravascular Ultrasound Studies [IVUS]). J Am Coll Cardiol2001;37:1478\u201392.33Address for reprints: This document is available on the ACC Website at www.acc.org. Reprints of this document are available for $5.00 each by calling 800-253-4636 (U.S. only) or writing to the Resource Center, American College of Cardiology, Educational Services, 9111 Old Georgetown Road, Bethesda, MD 20814-1699. J Am Coll Cardiol. 2001;37(5):1478\u201392. https:\/\/doi.org\/10.1016\/s0735-1097(01)01175-5.","journal-title":"J Am Coll Cardiol"},{"issue":"31","key":"4526_CR13","doi-asserted-by":"publisher","first-page":"2839","DOI":"10.1093\/eurheartj\/ehae372","volume":"45","author":"YG Ko","year":"2024","unstructured":"Ko YG, Lee SJ, Ahn CM, et al. Intravascular ultrasound-guided drug-coated balloon angioplasty for femoropopliteal artery disease: a clinical trial. Eur Heart J. 2024;45(31):2839\u201347. https:\/\/doi.org\/10.1093\/eurheartj\/ehae372.","journal-title":"Eur Heart J"},{"issue":"4","key":"4526_CR14","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.3390\/tomography9040111","volume":"9","author":"R Desai","year":"2023","unstructured":"Desai R, Raval M, Adompreh-Fia KS, et al. Role of Intravascular Ultrasound in Pulmonary Embolism Patients Undergoing Mechanical Thrombectomy: A Systematic Review. Tomography. 2023;9(4):1393\u2013407. https:\/\/doi.org\/10.3390\/tomography9040111.","journal-title":"Tomography"},{"issue":"3","key":"4526_CR15","doi-asserted-by":"publisher","first-page":"E385","DOI":"10.1002\/ccd.28985","volume":"97","author":"VS Effoe","year":"2021","unstructured":"Effoe VS, Kumar G, Sachdeva R. Intravascular ultrasound-guided pulmonary artery embolectomy for saddle pulmonary embolism. Catheter Cardiovasc Interv. 2021;97(3):E385\u20139. https:\/\/doi.org\/10.1002\/ccd.28985.","journal-title":"Catheter Cardiovasc Interv"},{"issue":"14","key":"4526_CR16","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.4244\/EIJ-D-22-00732","volume":"18","author":"C Toma","year":"2023","unstructured":"Toma C, Jaber WA, Weinberg MD, et al. Acute outcomes for the full US cohort of the FLASH mechanical thrombectomy registry in pulmonary embolism&nbsp. EuroIntervention. 2023;18(14):1201\u201312. https:\/\/doi.org\/10.4244\/EIJ-D-22-00732.","journal-title":"EuroIntervention"}],"container-title":["CardioVascular and Interventional Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00270-026-04526-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00270-026-04526-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00270-026-04526-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:11:34Z","timestamp":1794323494000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00270-026-04526-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,24]]},"references-count":16,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,11]]}},"alternative-id":["4526"],"URL":"https:\/\/doi.org\/10.1007\/s00270-026-04526-z","relation":{},"ISSN":["1432-086X"],"issn-type":[{"value":"1432-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,24]]},"assertion":[{"value":"3 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study is awaiting ethical approval.","order":2,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"For this type of study, informed consent is not required.","order":3,"name":"Ethics","label":"Informed Consent","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"For this type of study, consent for publication is not required.","order":4,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This trial provides high-level evidence regarding the potential superiority of an IVUS-guided strategy over conventional DSA guidance for mechanical thrombectomy in acute pulmonary embolism patients, potentially establishing a new standard for image-guided pulmonary interventions.","order":5,"name":"Ethics","label":"Expected Gain of Knowledge","group":{"name":"EthicsHeading","label":"Declarations"}}]}}