{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:41:49Z","timestamp":1792442509744,"version":"4.5.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Intervent Radiol"],"DOI":"10.1007\/s00270-026-04647-5","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:26:08Z","timestamp":1792441568000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cost Analysis of Percutaneous Segmentectomy Versus Chemoembolisation and Radioembolisation in Hepatocellular Carcinoma: A Retrospective Multicentre Cohort Study"],"prefix":"10.1007","author":[{"given":"Pierleone","family":"Lucatelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Crocetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Argir\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Iezzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Reale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Grillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetyana","family":"Shchipska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Maresca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Lippi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Bozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Cioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Madonna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Pignataro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Corona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Panebianco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Catalano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gallivanone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00f2","family":"Schiesaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnese","family":"Bonino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Pedicini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Laghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1889-8798","authenticated-orcid":false,"given":"Ezio","family":"Lanza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"4647_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209\u201349. https:\/\/doi.org\/10.3322\/caac.21660.","journal-title":"CA Cancer J Clin"},{"key":"4647_CR2","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229\u201363. https:\/\/doi.org\/10.3322\/caac.21834.","journal-title":"CA Cancer J Clin"},{"key":"4647_CR3","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1016\/j.jhep.2022.08.021","volume":"77","author":"H Rumgay","year":"2022","unstructured":"Rumgay H, Arnold M, Ferlay J, et al. Global burden of primary liver cancer in 2020 and predictions to 2040. J Hepatol. 2022;77:1598\u2013606. https:\/\/doi.org\/10.1016\/j.jhep.2022.08.021.","journal-title":"J Hepatol"},{"key":"4647_CR4","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1097\/HEP.0000000000000466","volume":"78","author":"AG Singal","year":"2023","unstructured":"Singal AG, Llovet JM, Yarchoan M, et al. AASLD practice guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma. Hepatology. 2023;78:1922\u201365. https:\/\/doi.org\/10.1097\/HEP.0000000000000466.","journal-title":"Hepatology"},{"key":"4647_CR5","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.jhep.2018.03.019","volume":"69","author":"European Association for the Study of the Liver","year":"2018","unstructured":"European Association for the Study of the Liver. EASL clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol. 2018;69:182\u2013236. https:\/\/doi.org\/10.1016\/j.jhep.2018.03.019.","journal-title":"J Hepatol"},{"key":"4647_CR6","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s00270-022-03117-y","volume":"45","author":"P Lucatelli","year":"2022","unstructured":"Lucatelli P, Argir\u00f2 R, Crocetti L, et al. Percutaneous thermal segmentectomy: proof of concept. Cardiovasc Intervent Radiol. 2022;45:665\u201376. https:\/\/doi.org\/10.1007\/s00270-022-03117-y.","journal-title":"Cardiovasc Intervent Radiol"},{"key":"4647_CR7","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1007\/s11547-024-01877-w","volume":"129","author":"P Lucatelli","year":"2024","unstructured":"Lucatelli P, Rocco B, Argir\u00f2 R, et al. Percutaneous thermal segmentectomy for liver malignancies over 3 cm: mid-term oncological performance and predictors of sustained complete response from a multicentric Italian retrospective study. Radiol Med. 2024;129:1543\u201354. https:\/\/doi.org\/10.1007\/s11547-024-01877-w.","journal-title":"Radiol Med"},{"key":"4647_CR8","doi-asserted-by":"publisher","first-page":"3543","DOI":"10.1007\/s00261-024-04784-w","volume":"50","author":"S Romano","year":"2025","unstructured":"Romano S, Lanza E, Ammirabile A, et al. Anatomic sub-segmentectomy with single-session combined transcatheter arterial embolization\/microwave ablation for the treatment of hepatocellular carcinoma: preliminary results. Abdom Radiol. 2025;50:3543\u201352. https:\/\/doi.org\/10.1007\/s00261-024-04784-w.","journal-title":"Abdom Radiol"},{"key":"4647_CR9","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1007\/s00270-020-02583-6","volume":"43","author":"R Iezzi","year":"2020","unstructured":"Iezzi R, Posa A, Tanzilli A, et al. Balloon-occluded MWA (b-MWA) followed by balloon-occluded TACE (b-TACE): technical note on a new combined single-step therapy for single large HCC. Cardiovasc Intervent Radiol. 2020;43:1702\u20137. https:\/\/doi.org\/10.1007\/s00270-020-02583-6.","journal-title":"Cardiovasc Intervent Radiol"},{"key":"4647_CR10","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1016\/j.jvir.2023.02.016","volume":"34","author":"X Wu","year":"2023","unstructured":"Wu X, Heller M, Kwong A, Fidelman N, Mehta N. Cost-effectiveness analysis of interventional liver-directed therapies for a single, small hepatocellular carcinoma in liver transplant candidates. J Vasc Interv Radiol. 2023;34:1237\u201346. https:\/\/doi.org\/10.1016\/j.jvir.2023.02.016.","journal-title":"J Vasc Interv Radiol"},{"key":"4647_CR11","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-022-02396-6","volume":"22","author":"JC Alonso","year":"2022","unstructured":"Alonso JC, Casans I, Gonz\u00e1lez FM, et al. Economic evaluations of radioembolization with Itrium-90 microspheres in hepatocellular carcinoma: a systematic review. BMC Gastroenterol. 2022;22:326. https:\/\/doi.org\/10.1186\/s12876-022-02396-6.","journal-title":"BMC Gastroenterol"},{"key":"4647_CR12","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1007\/s00270-025-04214-4","volume":"48","author":"C Rognoni","year":"2025","unstructured":"Rognoni C, Bhoori S, Crocetti L, et al. Cost-benefit analysis of trans-arterial radio-embolization with Y-90 glass microspheres versus drug-eluting bead trans-arterial chemo-embolization in patients with hepatocellular carcinoma in Italy. Cardiovasc Intervent Radiol. 2025;48:1614\u201324. https:\/\/doi.org\/10.1007\/s00270-025-04214-4.","journal-title":"Cardiovasc Intervent Radiol"},{"key":"4647_CR13","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1007\/s00270-023-03362-9","volume":"46","author":"F Veloso Gomes","year":"2023","unstructured":"Veloso Gomes F, de Ba\u00e8re T, Verset G, et al. Transarterial chemoembolization with anthracyclines-loaded polyethylene glycol drug eluting microspheres for the treatment of hepatocellular carcinoma: a pooled multicentric analysis of survival in 580 patients. Cardiovasc Intervent Radiol. 2023;46:436\u201346. https:\/\/doi.org\/10.1007\/s00270-023-03362-9.","journal-title":"Cardiovasc Intervent Radiol"},{"key":"4647_CR14","doi-asserted-by":"publisher","first-page":"2342","DOI":"10.1002\/hep.31819","volume":"74","author":"R Salem","year":"2021","unstructured":"Salem R, Johnson GE, Kim E, et al. Yttrium-90 radioembolization for the treatment of solitary, unresectable HCC: the LEGACY study. Hepatology. 2021;74:2342\u201352. https:\/\/doi.org\/10.1002\/hep.31819.","journal-title":"Hepatology"},{"key":"4647_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-12-9","volume":"12","author":"P Guyot","year":"2012","unstructured":"Guyot P, Ades AE, Ouwens MJ, Welton NJ. Enhanced secondary analysis of survival data: reconstructing the data from published Kaplan-Meier survival curves. BMC Med Res Methodol. 2012;12:9. https:\/\/doi.org\/10.1186\/1471-2288-12-9.","journal-title":"BMC Med Res Methodol"},{"key":"4647_CR16","unstructured":"Istituto Nazionale di Statistica. Indice dei prezzi al consumo per le rivalutazioni monetarie. https:\/\/www.istat.it\/it\/archivio\/30440."},{"key":"4647_CR17","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1148\/radiol.211806","volume":"303","author":"E Dhondt","year":"2022","unstructured":"Dhondt E, Lambert B, Hermie L, et al. 90Y radioembolization versus drug-eluting bead chemoembolization for unresectable hepatocellular carcinoma: results from the TRACE phase II randomized controlled trial. Radiology. 2022;303:699\u2013710. https:\/\/doi.org\/10.1148\/radiol.211806.","journal-title":"Radiology"},{"key":"4647_CR18","unstructured":"Ministero della Salute. Nomenclatore delle prestazioni di assistenza specialistica ambulatoriale. DM 23 giugno 2023. https:\/\/www.salute.gov.it."},{"key":"4647_CR19","unstructured":"Ministero della Salute. Tariffe DRG nazionali. DM 18 ottobre 2012. https:\/\/www.salute.gov.it."},{"key":"4647_CR20","doi-asserted-by":"publisher","first-page":"333","DOI":"10.6061\/clinics\/2017(06)02","volume":"72","author":"LB de Paiva Haddad","year":"2017","unstructured":"de Paiva Haddad LB, Ducatti L, Mendes LRBC, Andraus W, D\u2019Albuquerque LAC. Predictors of micro-costing components in liver transplantation. Clinics (Sao Paulo). 2017;72:333\u201342. https:\/\/doi.org\/10.6061\/clinics\/2017(06)02.","journal-title":"Clinics (Sao Paulo)"},{"key":"4647_CR21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0280442","volume":"18","author":"L Gaugain","year":"2023","unstructured":"Gaugain L, Cawston H, Dubois de Gennes C, et al. Cost-utility analysis of atezolizumab with bevacizumab in untreated unresectable or advanced hepatocellular carcinoma in France. PLoS ONE. 2023;18:e0280442. https:\/\/doi.org\/10.1371\/journal.pone.0280442.","journal-title":"PLoS ONE"}],"container-title":["CardioVascular and Interventional Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00270-026-04647-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00270-026-04647-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00270-026-04647-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:26:09Z","timestamp":1792441569000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00270-026-04647-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,19]]},"references-count":21,"alternative-id":["4647"],"URL":"https:\/\/doi.org\/10.1007\/s00270-026-04647-5","relation":{},"ISSN":["1432-086X"],"issn-type":[{"value":"1432-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,19]]},"assertion":[{"value":"6 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This retrospective observational study was conducted in accordance with the ethical standards of the institutional committees of all five participating centres. Under the applicable institutional policies, retrospective studies not modifying patient management are considered implicitly approved and do not require a dedicated approval number. All procedures performed in this study were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.","order":2,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"For this type of study, consent for publication is not required.","order":3,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Formal Institutional Review Board approval with a dedicated approval number was not sought for this retrospective study, consistent with the institutional policies. Documentation of institutional policy is available from the corresponding author upon request.","order":4,"name":"Ethics","label":"Institutional Review Board approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}