{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:42:43Z","timestamp":1790257363976,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2009,3,17]],"date-time":"2009-03-17T00:00:00Z","timestamp":1237248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1007\/s00277-009-0727-5","type":"journal-article","created":{"date-parts":[[2009,3,16]],"date-time":"2009-03-16T11:15:01Z","timestamp":1237202101000},"page":"1059-1067","source":"Crossref","is-referenced-by-count":16,"title":["Opposite expression pattern of Src kinase Lyn in acute and chronic haematological malignancies"],"prefix":"10.1007","volume":"88","author":[{"given":"Kais","family":"Hussein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"von Neuhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guntram","family":"B\u00fcsche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Buhr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Kreipe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Bock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,3,17]]},"reference":[{"issue":"2","key":"727_CR1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1080\/08977190600581327","volume":"24","author":"ML Hibbs","year":"2006","unstructured":"Hibbs ML, Harder KW (2006) The duplicitous nature of the Lyn tyrosine kinase in growth factor signalling. Growth Factors 24(2):137\u2013149. doi: 10.1080\/08977190600581327","journal-title":"Growth Factors"},{"issue":"12","key":"727_CR2","doi-asserted-by":"crossref","first-page":"6910","DOI":"10.4049\/jimmunol.169.12.6910","volume":"169","author":"Y Xu","year":"2002","unstructured":"Xu Y, Beavitt SJ, Harder KW, Hibbs ML, Tarlinton DM (2002) The activation and subsequent regulatory roles of Lyn and CD19 after B cell receptor ligation are independent. J Immunol 169(12):6910\u20136918","journal-title":"J Immunol"},{"issue":"1","key":"727_CR3","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4049\/jimmunol.173.1.100","volume":"173","author":"V Hernandez-Hansen","year":"2004","unstructured":"Hernandez-Hansen V, Smith AJ, Surviladze Z et al (2004) Dysregulated FcepsilonRI Signalling and altered Fyn and SHIP activities in Lyn-deficient mast cells. J Immunol 173(1):100\u2013112","journal-title":"J Immunol"},{"issue":"2","key":"727_CR4","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0092-8674(95)90171-X","volume":"83","author":"ML Hibbs","year":"1995","unstructured":"Hibbs ML, Tarlinton DM, Armes J et al (1995) Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell 83(2):301\u2013311. doi: 10.1016\/0092-8674(95) 90171-X","journal-title":"Cell"},{"issue":"4","key":"727_CR5","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S1074-7613(01)00208-4","volume":"15","author":"KW Harder","year":"2001","unstructured":"Harder KW, Parsons LM, Armes J et al (2001) Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage. Immunity 15(4):603\u2013615. doi: 10.1016\/S1074-7613(01) 00208-4","journal-title":"Immunity"},{"issue":"23","key":"727_CR6","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1038\/sj.onc.1209351","volume":"25","author":"BJ Lannutti","year":"2006","unstructured":"Lannutti BJ, Minear J, Blake N, Drachman JG (2006) Increased megakaryocytopoiesis in Lyn-deficient mice. Oncogene 25(23):3316\u20133324. doi: 10.1038\/sj.onc.1209351","journal-title":"Oncogene"},{"key":"727_CR7","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1182\/blood-2007-04-083501","volume":"110","author":"A Tefferi","year":"2007","unstructured":"Tefferi A, Thiele J, Orazi A et al (2007) Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panel. Blood 110:1092\u20131097. doi: 10.1182\/blood-2007-04-083501","journal-title":"Blood"},{"issue":"10","key":"727_CR8","doi-asserted-by":"crossref","first-page":"3736","DOI":"10.1182\/blood-2003-10-3566","volume":"103","author":"BJ Lannutti","year":"2004","unstructured":"Lannutti BJ, Drachman JG (2004) Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors. Blood 103(10):3736\u20133743. doi: 10.1182\/blood-2003-10-3566","journal-title":"Blood"},{"issue":"6","key":"727_CR9","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/sj.leu.2401429","volume":"13","author":"V Roginskaya","year":"1999","unstructured":"Roginskaya V, Zuo S, Caudell E, Nambudiri G, Kraker AJ, Corey SJ (1999) Therapeutic targeting of Src-kinase Lyn in myeloid leukemic cell growth. Leukemia 13(6):855\u2013861. doi: 10.1038\/sj\/leu\/2401429","journal-title":"Leukemia"},{"issue":"2","key":"727_CR10","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1172\/JCI200522094","volume":"115","author":"A Contri","year":"2005","unstructured":"Contri A, Brunati AM, Trentin L et al (2005) Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis. J Clin Invest 115(2):369\u2013378","journal-title":"J Clin Invest"},{"issue":"8","key":"727_CR11","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1182\/blood-2006-05-024307","volume":"108","author":"CH Mermel","year":"2006","unstructured":"Mermel CH, McLemore ML, Liu F, Pereira S, Woloszynek J, Lowell CA, Link DC (2006) Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis. Blood 108(8):2562\u20132568. doi: 10.1182\/blood-2006-05-024307","journal-title":"Blood"},{"issue":"4","key":"727_CR12","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1182\/blood-2007-04-082099","volume":"111","author":"C Dos Santos","year":"2008","unstructured":"Dos Santos C, Demur C, Bardet V, Prade-Houdellier N, Payrastre B, R\u00e9cher C (2008) A critical role for Lyn in acute myeloid signalling. Blood 111(4):2269\u20132279. doi: 10.1182\/blood-2007-04-082099","journal-title":"Blood"},{"issue":"8","key":"727_CR13","first-page":"1128","volume":"90","author":"J Thiele","year":"2005","unstructured":"Thiele J, Kvasnicka HM, Facchetti F, Franco V, van der Walt J, Orazi A (2005) European consensus on grading bone marrow fibrosis and assessment of cellularity. Haematologica 90(8):1128\u20131132","journal-title":"Haematologica"},{"issue":"2","key":"727_CR14","doi-asserted-by":"crossref","first-page":"471","DOI":"10.2353\/ajpath.2006.060110","volume":"169","author":"O Bock","year":"2006","unstructured":"Bock O, Neuse J, Hussein K et al (2006) Aberrant collagenase expression in chronic idiopathic myelofibrosis is related to the stage of disease but not to the JAK2 mutation status. Am J Pathol 169(2):471\u2013481. doi: 10.2353\/ajpath.2006.060110","journal-title":"Am J Pathol"},{"issue":"2","key":"727_CR15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/PDM.0b013e318163f26e","volume":"17","author":"K Theophile","year":"2008","unstructured":"Theophile K, Jonigk D, Kreipe H, Bock O (2008) Amplification of mRNA from laser-microdissected single or clustered cells in formalin-fixed and paraffin-embedded tissues for application in quantitative real-time PCR. Diagn Mol Pathol 17(2):101\u2013106. doi: 10.1097\/PDM.0b013e318163f26e","journal-title":"Diagn Mol Pathol"},{"issue":"2","key":"727_CR16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1365-2141.2005.05594.x","volume":"130","author":"E Sakhinia","year":"2005","unstructured":"Sakhinia E, Faranghpour M, Liu Yin JA, Brady G, Hoyland JA, Byers RJ (2005) Routine expression profiling of microarray gene signatures in acute leukaemia by real-time PCR of human bone marrow. Br J Haematol 130(2):233\u2013248. doi: 10.1111\/j.1365-2141.2005.05594.x","journal-title":"Br J Haematol"},{"issue":"1","key":"727_CR17","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1365-2141.2005.05573.x","volume":"160","author":"O Bock","year":"2005","unstructured":"Bock O, Loch G, Schade U et al (2005) Osteosclerosis in advanced chronic Idiopathic myelofibrosis is associated with endothelial overexpression of Osteoprotegerin (OPG). Br J Haematol 160(1):76\u201382. doi: 10.1111\/j.1365-2141.2005.05573.x","journal-title":"Br J Haematol"},{"key":"727_CR18","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT Method. Methods 25:402\u2013408. doi: 10.1006\/meth.2001.1262","journal-title":"Methods"},{"issue":"4","key":"727_CR19","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00277-007-0252-3","volume":"86","author":"K Hussein","year":"2007","unstructured":"Hussein K, Brakensiek K, Buesche G, Buhr T, Wiese B, Kreipe H, Bock O (2007) Different involvement of the megakaryocytic lineage by the JAK2 (V617F) mutation in polycythemia vera, essential thrombocythemia and chronic idiopathic myelofibrosis. Ann Hematol 86(4):245\u2013253. doi: 10.1007\/s00277-007-0252-3","journal-title":"Ann Hematol"},{"issue":"9","key":"727_CR20","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1038\/sj.leu.2400756","volume":"11","author":"H Kiyoi","year":"1997","unstructured":"Kiyoi H, Naoe T, Yokota S et al (1997) Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia. Leukemia Study Group of the Ministry of Health and Welfare (Kohseisho). Leukemia 11(9):1447\u20131452. doi: 10.1038\/sj.leu.2400756","journal-title":"Leukemia"},{"issue":"2","key":"727_CR21","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1182\/blood.V101.2.690","volume":"101","author":"NJ Donato","year":"2003","unstructured":"Donato NJ, Wu JY, Stapley J, Gallick G, Lin H, Arlinghaus R, Talpaz M (2003) BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571. Blood 101(2):690\u2013698. doi: 10.1182\/blood.V101.2.690","journal-title":"Blood"},{"issue":"13","key":"727_CR22","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1093\/jnci\/djn188","volume":"100","author":"J Wu","year":"2008","unstructured":"Wu J, Meng F, Kong LY, Peng Z, Ying Y, Bornmann WG, Darnay BG, Lamothe B, Sun H, Talpaz M, Donato NJ (2008) Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase. J Natl Cancer Inst 100(13):926\u2013939. doi: 10.1093\/jnci\/djn188","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"727_CR23","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","volume":"136","author":"DP Bartel","year":"2009","unstructured":"Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136(2):215\u2013233. doi: 10.1016\/j.cell.2009.01.002","journal-title":"Cell"},{"issue":"5","key":"727_CR24","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/sj.leu.2404615","volume":"21","author":"K Hoshino","year":"2007","unstructured":"Hoshino K, Quint\u00e1s-Cardama A, Yang H, Sanchez-Gonzalez B, Garcia-Manero G (2007) Aberrant DNA methylation of the Src kinase Hck, but not of Lyn, in Philadelphia chromosome negative acute lymphocytic leukemia. Leukemia 21(5):906\u2013911","journal-title":"Leukemia"},{"issue":"5","key":"727_CR25","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/ng1343","volume":"36","author":"Y Hu","year":"2004","unstructured":"Hu Y, Liu Y, Pelletier S et al (2004) Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B- lymphoblastic leukemia but not chronic myeloid leukemia. Nat Genet 36(5):453\u2013461. doi: 10.1038\/ng1343","journal-title":"Nat Genet"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-009-0727-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00277-009-0727-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-009-0727-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T05:50:06Z","timestamp":1559022606000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00277-009-0727-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,17]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["727"],"URL":"https:\/\/doi.org\/10.1007\/s00277-009-0727-5","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,17]]}}}