{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:47:01Z","timestamp":1792000021302,"version":"4.4.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,6,2]],"date-time":"2009-06-02T00:00:00Z","timestamp":1243900800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1007\/s00277-009-0755-1","type":"journal-article","created":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T07:57:27Z","timestamp":1243843047000},"page":"35-43","source":"Crossref","is-referenced-by-count":19,"title":["Prevalence and analysis of t(14;18) and t(11;14) chromosomal translocations in healthy Indian population"],"prefix":"10.1007","volume":"89","author":[{"given":"Mridula","family":"Nambiar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathees C.","family":"Raghavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,6,2]]},"reference":[{"key":"755_CR1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1146\/annurev.iy.10.040192.004033","volume":"10","author":"SJ Korsmeyer","year":"1992","unstructured":"Korsmeyer SJ (1992) Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes. Annu Rev Immunol 10:785\u2013807. doi: 10.1146\/annurev.iy.10.040192.004033","journal-title":"Annu Rev Immunol"},{"issue":"21","key":"755_CR2","doi-asserted-by":"crossref","first-page":"7439","DOI":"10.1073\/pnas.82.21.7439","volume":"82","author":"ML Cleary","year":"1985","unstructured":"Cleary ML, Sklar J (1985) Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18. Proc Natl Acad Sci U S A 82(21):7439\u20137443. doi: 10.1073\/pnas.82.21.7439","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"755_CR3","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1080\/10428190601043351","volume":"48","author":"CS Sahni","year":"2007","unstructured":"Sahni CS, Desai SB (2007) Distribution and clinicopathologic characteristics of non-Hodgkin's lymphoma in India: a study of 935 cases using WHO classification of lymphoid neoplasms (2000). Leuk Lymphoma 48(1):122\u2013133. doi: 10.1080\/10428190601043351","journal-title":"Leuk Lymphoma"},{"issue":"1","key":"755_CR4","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1023\/A:1008325827059","volume":"11","author":"KN Naresh","year":"2000","unstructured":"Naresh KN, Srinivas V, Soman CS (2000) Distribution of various subtypes of non-Hodgkin's lymphoma in India: a study of 2773 lymphomas using R.E.A.L. and WHO Classifications. Ann Oncol 11(1):63\u201367. doi: 10.1023\/A:1008325827059","journal-title":"Ann Oncol"},{"issue":"12","key":"755_CR5","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.1182\/blood.V99.12.4265","volume":"99","author":"JJ Biagi","year":"2002","unstructured":"Biagi JJ, Seymour JF (2002) Insights into the molecular pathogenesis of follicular lymphoma arising from analysis of geographic variation. Blood 99(12):4265\u20134275. doi: 10.1182\/blood.V99.12.4265","journal-title":"Blood"},{"key":"755_CR6","first-page":"139","volume":"1786","author":"M Nambiar","year":"2008","unstructured":"Nambiar M, Kari V, Raghavan SC (2008) Chromosomal translocations in cancer. Biochim Biophys Acta 1786:139\u2013152","journal-title":"Biochim Biophys Acta"},{"issue":"8","key":"755_CR7","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1073\/pnas.84.8.2396","volume":"84","author":"A Bakhshi","year":"1987","unstructured":"Bakhshi A et al (1987) Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners. Proc Natl Acad Sci U S A 84(8):2396\u20132400. doi: 10.1073\/pnas.84.8.2396","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"755_CR8","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0092-8674(85)80070-2","volume":"41","author":"A Bakhshi","year":"1985","unstructured":"Bakhshi A et al (1985) Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell 41(3):899\u2013906. doi: 10.1016\/S0092-8674(85)80070-2","journal-title":"Cell"},{"issue":"11","key":"755_CR9","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1182\/blood.V95.11.3520","volume":"95","author":"U Jager","year":"2000","unstructured":"Jager U et al (2000) Follicular lymphomas' BCL-2\/IgH junctions contain templated nucleotide insertions: novel insights into the mechanism of t(14;18) translocation. Blood 95(11):3520\u20133529","journal-title":"Blood"},{"issue":"5","key":"755_CR10","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/bies.20353","volume":"28","author":"SC Raghavan","year":"2006","unstructured":"Raghavan SC, Lieber MR (2006) DNA structures at chromosomal translocation sites. Bioessays 28(5):480\u2013494. doi: 10.1002\/bies.20353","journal-title":"Bioessays"},{"issue":"15","key":"755_CR11","doi-asserted-by":"crossref","first-page":"6475","DOI":"10.1128\/MCB.25.15.6475-6484.2005","volume":"25","author":"SC Raghavan","year":"2005","unstructured":"Raghavan SC, Hsieh CL, Lieber MR (2005) Both V(D) J coding ends but neither signal end can recombine at the bcl-2 major breakpoint region, and the rejoining is ligase IV dependent. Mol Cell Biol 25(15):6475\u20136484. doi: 10.1128\/MCB.25.15.6475-6484.2005","journal-title":"Mol Cell Biol"},{"issue":"14","key":"755_CR12","doi-asserted-by":"crossref","first-page":"5904","DOI":"10.1128\/MCB.25.14.5904-5919.2005","volume":"25","author":"SC Raghavan","year":"2005","unstructured":"Raghavan SC et al (2005) Double-strand break formation by the RAG complex at the bcl-2 major breakpoint region and at other non-B DNA structures in vitro. Mol Cell Biol 25(14):5904\u20135919. doi: 10.1128\/MCB.25.14.5904-5919.2005","journal-title":"Mol Cell Biol"},{"issue":"6978","key":"755_CR13","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature02355","volume":"428","author":"SC Raghavan","year":"2004","unstructured":"Raghavan SC et al (2004) A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex. Nature 428(6978):88\u201393. doi: 10.1038\/nature02355","journal-title":"Nature"},{"key":"755_CR14","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.2741\/2397","volume":"12","author":"SC Raghavan","year":"2007","unstructured":"Raghavan SC, Lieber MR (2007) DNA structure and human diseases. Front Biosci 12:4402\u20134408. doi: 10.2741\/2397","journal-title":"Front Biosci"},{"issue":"Suppl 1","key":"755_CR15","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/annonc\/5.suppl_1.S71","volume":"5","author":"ME Williams","year":"1994","unstructured":"Williams ME, Swerdlow SH (1994) Cyclin D1 overexpression in non-Hodgkin's lymphoma with chromosome 11 bcl-1 rearrangement. Ann Oncol 5(Suppl 1):71\u201373","journal-title":"Ann Oncol"},{"issue":"6017","key":"755_CR16","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/315340a0","volume":"315","author":"Y Tsujimoto","year":"1985","unstructured":"Tsujimoto Y et al (1985) Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11;14) chromosome translocation. Nature 315(6017):340\u2013343. doi: 10.1038\/315340a0","journal-title":"Nature"},{"issue":"9","key":"755_CR17","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1182\/blood.V85.9.2528.bloodjournal8592528","volume":"85","author":"J Limpens","year":"1995","unstructured":"Limpens J et al (1995) Lymphoma-associated translocation t(14;18) in blood B cells of normal individuals. Blood 85(9):2528\u20132536","journal-title":"Blood"},{"issue":"3","key":"755_CR18","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S1044-579X(03)00016-6","volume":"13","author":"F Schuler","year":"2003","unstructured":"Schuler F, Hirt C, Dolken G (2003) Chromosomal translocation t(14;18) in healthy individuals. Semin Cancer Biol 13(3):203\u2013209. doi: 10.1016\/S1044-579X(03)00016-6","journal-title":"Semin Cancer Biol"},{"issue":"3","key":"755_CR19","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/gcc.10178","volume":"36","author":"S Janz","year":"2003","unstructured":"Janz S, Potter M, Rabkin CS (2003) Lymphoma- and leukemia-associated chromosomal translocations in healthy individuals. Genes Chromosomes Cancer 36(3):211\u2013223. doi: 10.1002\/gcc.10178","journal-title":"Genes Chromosomes Cancer"},{"key":"755_CR20","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/sj.leu.2404035","volume":"20","author":"S Roulland","year":"2006","unstructured":"Roulland S et al (2006) Long-term clonal persistence and evolution of t(14;18)-bearing B cells in healthy individuals. Leukemia 20:158\u2013162. doi: 10.1038\/sj.leu.2404035","journal-title":"Leukemia"},{"key":"755_CR21","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/jncimonographs\/lgn005","volume":"39","author":"G Dolken","year":"2008","unstructured":"Dolken G et al (2008) Age-dependent prevalence and frequency of circulating t(14;18)-positive cells in the peripheral blood of healthy individuals. J Natl Cancer Inst Monogr 39:44\u201347. doi: 10.1093\/jncimonographs\/lgn005","journal-title":"J Natl Cancer Inst Monogr"},{"key":"755_CR22","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/jncimonographs\/lgn002","volume":"39","author":"CS Rabkin","year":"2008","unstructured":"Rabkin CS et al (2008) t(14;18) Translocations and risk of follicular lymphoma. J Natl Cancer Inst Monogr 39:48\u201351. doi: 10.1093\/jncimonographs\/lgn002","journal-title":"J Natl Cancer Inst Monogr"},{"key":"755_CR23","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00320315","volume":"43","author":"F Berthold","year":"1981","unstructured":"Berthold F (1981) Isolation of human monocytes by Ficoll density gradient centrifugation. Blut 43:367\u2013371. doi: 10.1007\/BF00320315","journal-title":"Blut"},{"issue":"19","key":"755_CR24","doi-asserted-by":"crossref","first-page":"8910","DOI":"10.1073\/pnas.91.19.8910","volume":"91","author":"Y Liu","year":"1994","unstructured":"Liu Y et al (1994) BCL2 translocation frequency rises with age in humans. Proc Natl Acad Sci U S A 91(19):8910\u20138914. doi: 10.1073\/pnas.91.19.8910","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"755_CR25","doi-asserted-by":"crossref","first-page":"034103","DOI":"10.1088\/1748-6041\/3\/3\/034103","volume":"3","author":"M Nambiar","year":"2008","unstructured":"Nambiar M et al (2008) Amplification of chromosomal translocation junctions from paraffin-embedded tissues of follicular lymphoma patients. Biomed Mater 3(3):034103. doi: 10.1088\/1748-6041\/3\/3\/034103","journal-title":"Biomed Mater"},{"key":"755_CR26","first-page":"2876","volume":"55","author":"W Ji","year":"1995","unstructured":"Ji W et al (1995) Frequent detection of Bcl-2\/JH translocations in human blood and organ samples by a quantitative polymerase chain reaction assay. Cancer Res 55:2876\u20132882","journal-title":"Cancer Res"},{"issue":"5","key":"755_CR27","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/carcin\/17.5.1013","volume":"17","author":"JC Fuscoe","year":"1996","unstructured":"Fuscoe JC et al (1996) Quantification of t(14;18) in the lymphocytes of healthy adult humans as a possible biomarker for environmental exposures to carcinogens. Carcinogenesis 17(5):1013\u20131020. doi: 10.1093\/carcin\/17.5.1013","journal-title":"Carcinogenesis"},{"issue":"2","key":"755_CR28","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1182\/blood.V98.2.486","volume":"98","author":"M Yasukawa","year":"2001","unstructured":"Yasukawa M et al (2001) Low frequency of BCL-2\/J(H) translocation in peripheral blood lymphocytes of healthy Japanese individuals. Blood 98(2):486\u2013488. doi: 10.1182\/blood.V98.2.486","journal-title":"Blood"},{"issue":"2","key":"755_CR29","first-page":"291","volume":"141","author":"JC Aster","year":"1992","unstructured":"Aster JC et al (1992) Detection of the t(14;18) at similar frequencies in hyperplastic lymphoid tissues from American and Japanese patients. Am J Pathol 141(2):291\u2013299","journal-title":"Am J Pathol"},{"issue":"11","key":"755_CR30","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1084\/jem.20061292","volume":"203","author":"S Roulland","year":"2006","unstructured":"Roulland S et al (2006) Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis. J Exp Med 203(11):2425\u20132431. doi: 10.1084\/jem.20061292","journal-title":"J Exp Med"},{"issue":"3","key":"755_CR31","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1365-2141.2007.06671.x","volume":"138","author":"C Hirt","year":"2007","unstructured":"Hirt C et al (2007) Distribution of t(14;18)-positive, putative lymphoma precursor cells among B-cell subsets in healthy individuals. Br J Haematol 138(3):349\u2013353. doi: 10.1111\/j.1365-2141.2007.06671.x","journal-title":"Br J Haematol"},{"issue":"4","key":"755_CR32","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1200\/JCO.1996.14.4.1333","volume":"14","author":"G Dolken","year":"1996","unstructured":"Dolken G et al (1996) BCL-2\/JH rearrangements in circulating B cells of healthy blood donors and patients with nonmalignant diseases. J Clin Oncol 14(4):1333\u20131344","journal-title":"J Clin Oncol"},{"issue":"12","key":"755_CR33","first-page":"2271","volume":"6","author":"J Limpens","year":"1991","unstructured":"Limpens J et al (1991) Bcl-2\/JH rearrangements in benign lymphoid tissues with follicular hyperplasia. Oncogene 6(12):2271\u20132276","journal-title":"Oncogene"},{"issue":"6","key":"755_CR34","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.leukres.2005.10.001","volume":"30","author":"C Schmitt","year":"2006","unstructured":"Schmitt C et al (2006) The bcl-2\/IgH rearrangement in a population of 204 healthy individuals: occurrence, age and gender distribution, breakpoints, and detection method validity. Leuk Res 30(6):745\u2013750. doi: 10.1016\/j.leukres.2005.10.001","journal-title":"Leuk Res"},{"issue":"2","key":"755_CR35","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1200\/JCO.2001.19.2.420","volume":"19","author":"KE Summers","year":"2001","unstructured":"Summers KE et al (2001) Frequency of the Bcl-2\/IgH rearrangement in normal individuals: implications for the monitoring of disease in patients with follicular lymphoma. J Clin Oncol 19(2):420\u2013424","journal-title":"J Clin Oncol"},{"issue":"31","key":"755_CR36","doi-asserted-by":"crossref","first-page":"29126","DOI":"10.1074\/jbc.M103797200","volume":"276","author":"SC Raghavan","year":"2001","unstructured":"Raghavan SC, Kirsch IR, Lieber MR (2001) Analysis of the V(D) J recombination efficiency at lymphoid chromosomal translocation breakpoints. J Biol Chem 276(31):29126\u201329133. doi: 10.1074\/jbc.M103797200","journal-title":"J Biol Chem"},{"issue":"6","key":"755_CR37","doi-asserted-by":"crossref","first-page":"762","DOI":"10.4161\/cc.3.6.944","volume":"3","author":"SC Raghavan","year":"2004","unstructured":"Raghavan SC, Lieber MR (2004) Chromosomal translocations and non-B DNA structures in the human genome. Cell Cycle 3(6):762\u2013768","journal-title":"Cell Cycle"},{"issue":"3","key":"755_CR38","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1182\/blood-2004-02-0738","volume":"104","author":"C Hirt","year":"2004","unstructured":"Hirt C et al (2004) Low prevalence of circulating t(11;14)(q13;q32)-positive cells in the peripheral blood of healthy individuals as detected by real-time quantitative PCR. Blood 104(3):904\u2013905. doi: 10.1182\/blood-2004-02-0738","journal-title":"Blood"},{"key":"755_CR39","first-page":"3262","volume":"94","author":"S Stilgenbauer","year":"1999","unstructured":"Stilgenbauer S, Winkler D, Ott G (1999) Molecular characterization of 11q deletions points to a pathogenic role of the ATM gene in mantle cell lymphoma. Cancer Res 94:3262\u20133264","journal-title":"Cancer Res"},{"issue":"4","key":"755_CR40","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrc1589","volume":"5","author":"R Kuppers","year":"2005","unstructured":"Kuppers R (2005) Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer 5(4):251\u2013262. doi: 10.1038\/nrc1589","journal-title":"Nat Rev Cancer"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-009-0755-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00277-009-0755-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-009-0755-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T01:10:54Z","timestamp":1589850654000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00277-009-0755-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,2]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["755"],"URL":"https:\/\/doi.org\/10.1007\/s00277-009-0755-1","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,2]]}}}