{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:53:22Z","timestamp":1790409202952,"version":"4.1.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2010,1,7]],"date-time":"2010-01-07T00:00:00Z","timestamp":1262822400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1007\/s00277-009-0887-3","type":"journal-article","created":{"date-parts":[[2010,1,6]],"date-time":"2010-01-06T03:45:21Z","timestamp":1262749521000},"page":"607-612","source":"Crossref","is-referenced-by-count":30,"title":["Acquired haemophilia caused by non-haemophilic factor VIII gene variants"],"prefix":"10.1007","volume":"89","author":[{"given":"Andreas","family":"Tiede","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roswith","family":"Eisert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Czwalinna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Miesbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Scharrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold","family":"Ganser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,1,7]]},"reference":[{"key":"887_CR1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1055\/s-0038-1650169","volume":"45","author":"D Green","year":"1981","unstructured":"Green D, Lechner K (1981) A survey of 215 non-hemophilic patients with inhibitors to factor VIII. Thromb Haemost 45:200\u2013203","journal-title":"Thromb Haemost"},{"key":"887_CR2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s002770050263","volume":"74","author":"D S\u00f6hngen","year":"1997","unstructured":"S\u00f6hngen D, Specker C, Bach D, Kuntz BM, Burk M, Aul C, Kobbe G, Heyll A, Hollmig KA, Schneider W (1997) Acquired factor VIII inhibitors in nonhemophilic patients. Ann Hematol 74:89\u201393","journal-title":"Ann Hematol"},{"key":"887_CR3","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1046\/j.1365-2141.2003.04731.x","volume":"124","author":"P Collins","year":"2004","unstructured":"Collins P, Macartney N, Davies R, Lees S, Giddings J, Majer R (2004) A population based, unselected, consecutive cohort of patients with acquired haemophilia A. Br J Haematol 124:86\u201390","journal-title":"Br J Haematol"},{"key":"887_CR4","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00277-008-0665-7","volume":"88","author":"A Tiede","year":"2009","unstructured":"Tiede A, Huth-Kuhne A, Oldenburg J, Grossmann R, Geisen U, Krause M, Brand B, Alberio L, Klamroth R, Spannagl M, Knobl P (2009) Immunosuppressive treatment for acquired haemophilia: current practice and future directions in Germany, Austria and Switzerland. Ann Hematol 88:365\u2013370","journal-title":"Ann Hematol"},{"key":"887_CR5","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1182\/blood.V93.7.2267","volume":"93","author":"K Peerlinck","year":"1999","unstructured":"Peerlinck K, Jacquemin MG, Arnout J, Hoylaerts MF, Gilles JG, Lavend\u2019homme R, Johnson KM, Freson K, Scandella D, Saint-Remy JM, Vermylen J (1999) Antifactor VIII antibody inhibiting allogeneic but not autologous factor VIII in patients with mild hemophilia A. Blood 93:2267\u20132273","journal-title":"Blood"},{"key":"887_CR6","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.1182\/blood.V89.12.4371","volume":"89","author":"K Fijnvandraat","year":"1997","unstructured":"Fijnvandraat K, Turenhout EA, van den Brink EN, ten Cate JW, van Mourik JA, Peters M, Voorberg J (1997) The missense mutation Arg593 \u2013>Cys is related to antibody formation in a patient with mild hemophilia A. Blood 89:4371\u20134377","journal-title":"Blood"},{"key":"887_CR7","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1182\/blood.V90.5.1902","volume":"90","author":"AR Thompson","year":"1997","unstructured":"Thompson AR, Murphy ME, Liu M, Saenko EL, Healey JF, Lollar P, Scandella D (1997) Loss of tolerance to exogenous and endogenous factor VIII in a mild hemophilia a patient with an Arg593 to Cys mutation. Blood 90:1902\u20131910","journal-title":"Blood"},{"key":"887_CR8","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1055\/s-0037-1615061","volume":"79","author":"CR Hay","year":"1998","unstructured":"Hay CR, Ludlam CA, Colvin BT, Hill FG, Preston FE, Wasseem N, Bagnall R, Peake IR, Berntorp E, Mauser Bunschoten EP, Fijnvandraat K, Kasper CK, White G, Santagostino E (1998) Factor VIII inhibitors in mild and moderate-severity haemophilia A. UK haemophilia centre directors organisation. Thromb Haemost 79:762\u2013766","journal-title":"Thromb Haemost"},{"key":"887_CR9","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1046\/j.1538-7836.2003.00230.x","volume":"1","author":"A Sharathkumar","year":"2003","unstructured":"Sharathkumar A, Lillicrap D, Blanchette VS, Kern M, Leggo J, Stain AM, Brooker L, Carcao MD (2003) Intensive exposure to factor VIII is a risk factor for inhibitor development in mild hemophilia A. J Thromb Haemost 1:1228\u20131236","journal-title":"J Thromb Haemost"},{"key":"887_CR10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1055\/s-0038-1653759","volume":"73","author":"B Verbruggen","year":"1995","unstructured":"Verbruggen B, Novakova I, Wessels H, Boezeman J, van den Berg M, Mauser-Bunschoten E (1995) The Nijmegen modification of the Bethesda assay for factor VIII:C inhibitors: improved specificity and reliability. Thromb Haemost 73:247\u2013251","journal-title":"Thromb Haemost"},{"key":"887_CR11","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s002510050595","volume":"50","author":"H Rammensee","year":"1999","unstructured":"Rammensee H, Bachmann J, Emmerich NP, Bachor OA, Stevanovic S (1999) SYFPEITHI: database for MHC ligands and peptide motifs. Immunogenetics 50:213\u2013219","journal-title":"Immunogenetics"},{"key":"887_CR12","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1093\/nar\/26.1.216","volume":"26","author":"G Kemball-Cook","year":"1998","unstructured":"Kemball-Cook G, Tuddenham EGD, Wacey AI (1998) The factor VIII structure and mutation resource site: HAMSTeRS version 4. Nucleic Acids Res 26:216\u2013219","journal-title":"Nucleic Acids Res"},{"key":"887_CR13","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1182\/blood-2002-05-1369","volume":"101","author":"M Jacquemin","year":"2003","unstructured":"Jacquemin M, Vantomme V, Buhot C, Lavend\u2019homme R, Burny W, Demotte N, Chaux P, Peerlinck K, Vermylen J, Maillere B, Van Der Bruggen P, Saint-Remy JM (2003) CD4+ T-cell clones specific for wild-type factor VIII: a molecular mechanism responsible for a higher incidence of inhibitor formation in mild\/moderate hemophilia A. Blood 101:1351\u20131358","journal-title":"Blood"},{"key":"887_CR14","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1172\/JCI117489","volume":"94","author":"JG Gilles","year":"1994","unstructured":"Gilles JG, Saint-Remy JM (1994) Healthy subjects produce both anti-factor VIII and specific anti-idiotypic antibodies. J Clin Invest 94:1496\u20131505","journal-title":"J Clin Invest"},{"key":"887_CR15","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1600-065X.1998.tb01221.x","volume":"164","author":"RR Singh","year":"1998","unstructured":"Singh RR, Hahn BH (1998) Reciprocal T-B determinant spreading develops spontaneously in murine lupus: implications for pathogenesis. Immunol Rev 164:201\u2013208","journal-title":"Immunol Rev"},{"key":"887_CR16","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1046\/j.1365-3148.1997.d01-39.x","volume":"7","author":"GF Lucas","year":"1997","unstructured":"Lucas GF, Pittman SJ, Davies S, Solanki T, Bruggemann K (1997) Post-transfusion purpura (PTP) associated with anti-HPA-1a, anti-HPA-2b and anti-HPA-3a antibodies. Transfus Med 7:295\u2013299","journal-title":"Transfus Med"},{"key":"887_CR17","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1046\/j.1537-2995.1995.35996029166.x","volume":"35","author":"BM Alving","year":"1995","unstructured":"Alving BM, Weinstein MJ, Finlayson JS, Menitove JE, Fratantoni JC (1995) Fibrin sealant: summary of a conference on characteristics and clinical uses. Transfusion 35:783\u2013790","journal-title":"Transfusion"},{"key":"887_CR18","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1365-2141.1993.tb03343.x","volume":"85","author":"H Banninger","year":"1993","unstructured":"Banninger H, Hardegger T, Tobler A, Barth A, Schupbach P, Reinhart W, L\u00e4mmle B, Furlan M (1993) Fibrin glue in surgery: frequent development of inhibitors of bovine thrombin and human factor V. Br J Haematol 85:528\u2013532","journal-title":"Br J Haematol"},{"key":"887_CR19","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1055\/s-2003-39678","volume":"35","author":"J Caers","year":"2003","unstructured":"Caers J, Reekmans A, Jochmans K, Naegels S, Mana F, Urbain D, Reynaert H (2003) Factor V inhibitor after injection of human thrombin (tissucol) into a bleeding peptic ulcer. Endoscopy 35:542\u2013544","journal-title":"Endoscopy"},{"key":"887_CR20","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1056\/NEJMoa011931","volume":"346","author":"N Casadevall","year":"2002","unstructured":"Casadevall N, Nataf J, Viron B, Kolta A, Kiladjian JJ, Martin-Dupont P, Michaud P, Papo T, Ugo V, Teyssandier I, Varet B, Mayeux P (2002) Pure red-cell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin. N Engl J Med 346:469\u2013475","journal-title":"N Engl J Med"},{"key":"887_CR21","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1056\/NEJM200312253492623","volume":"349","author":"SS Guest","year":"2003","unstructured":"Guest SS, Levitt L (2003) Pure red-cell aplasia secondary to antierythropoietin antibodies. N Engl J Med 349:2572\u20132573","journal-title":"N Engl J Med"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-009-0887-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00277-009-0887-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-009-0887-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T12:27:32Z","timestamp":1590496052000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00277-009-0887-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,7]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["887"],"URL":"https:\/\/doi.org\/10.1007\/s00277-009-0887-3","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,7]]}}}