{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:29:44Z","timestamp":1792225784302,"version":"4.4.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2010,6,26]],"date-time":"2010-06-26T00:00:00Z","timestamp":1277510400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1007\/s00277-010-1007-0","type":"journal-article","created":{"date-parts":[[2010,6,25]],"date-time":"2010-06-25T09:06:43Z","timestamp":1277456803000},"page":"1207-1213","source":"Crossref","is-referenced-by-count":37,"title":["Endocrine and bone disease in appropriately treated adult patients with beta-thalassemia major"],"prefix":"10.1007","volume":"89","author":[{"given":"Marina","family":"Baldini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Forti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Marcon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Massimo","family":"Ulivieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Orsatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Tampieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Airaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Zanaboni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Domenica","family":"Cappellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,6,26]]},"reference":[{"key":"1007_CR1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1196\/annals.1345.006","volume":"1054","author":"C Borgna-Pignatti","year":"2005","unstructured":"Borgna-Pignatti C, Cappellini MD, De Stefano P, Del Vecchio GC, Forni GL, Gamberini MR, Ghilardi R, Origa R, Piga A, Romeo MA, Zhao H, Cnaan A (2005) Survival and complications in thalassemia. Ann N Y Acad Sci 1054:40\u201347","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"1007_CR2","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.bone.2005.10.001","volume":"38","author":"MG Vogiatzi","year":"2006","unstructured":"Vogiatzi MG, Macklin EA, Fung EB, Vichinsky E, Olivieri N, Kwiatkowski J, Cohen A, Neufeld E, Giardina PJ (2006) Prevalence of fractures among the thalassemia syndromes in North America. Bone 38(4):571\u2013575","journal-title":"Bone"},{"issue":"3","key":"1007_CR3","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1359\/jbmr.080505","volume":"24","author":"MG Vogiatzi","year":"2009","unstructured":"Vogiatzi MG, Macklin EA, Fung EB, Cheung AM, Vichinsky E, Olivieri N, Kirby M, Kwiatkowski JL, Cunningham M, Holm IA, Lane J, Schneider R, Fleisher M, Grady RW, Peterson CC, Giardina PJ, Network Thalassemia Clinical Research (2009) Bone disease in thalassemia: a frequent and still unresolved problem. J Bone Miner Res 24(3):543\u2013557","journal-title":"J Bone Miner Res"},{"key":"1007_CR4","unstructured":"Cappellini M.D, Cohen A, Eleftheriou A, Piga A, Porter J, Taher A (2008) Guidelines for the clinical management of thalassemia; 2nd revised Edition. Thalassemia International Federation. http:\/\/thalassemia.org.cy"},{"issue":"4","key":"1007_CR5","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1182\/blood-2004-10-3982","volume":"106","author":"JC Wood","year":"2005","unstructured":"Wood JC, Enriquez C, Ghugre N, Tyzka JM, Carson S, Nelson MD, Coates TD (2005) MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood 106(4):1460\u20131465","journal-title":"Blood"},{"issue":"7","key":"1007_CR6","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s12098-008-0140-4","volume":"75","author":"AP Dubey","year":"2008","unstructured":"Dubey AP, Parakh A, Dublish S (2008) Current trends in the management of beta thalassemia. Indian J Pediatr 75(7):739\u2013743","journal-title":"Indian J Pediatr"},{"issue":"2","key":"1007_CR7","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1046\/j.1365-2141.2000.02382.x","volume":"111","author":"S Perrotta","year":"2000","unstructured":"Perrotta S, Cappellini MD, Bertoldo F, Servedio V, Iolascon G, D'Agruma L, Gasparini P, Siciliani MC, Iolascon A (2000) Osteoporosis in beta-thalassaemia major patients: analysis of the genetic background. Br J Haematol 111(2):461\u2013466","journal-title":"Br J Haematol"},{"key":"1007_CR8","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1196\/annals.1345.051","volume":"1054","author":"R Origa","year":"2005","unstructured":"Origa R, Fiumana E, Gamberini MR, Armari S, Mottes M, Sangalli A, Paglietti E, Galanello R, Borgna-Pignatti C (2005) Osteoporosis in beta-thalassemia: clinical and genetic aspects. Ann N Y Acad Sci 1054:451\u2013456","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"1007_CR9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1600-0609.2008.01168.x","volume":"82","author":"N Skordis","year":"2009","unstructured":"Skordis N (2009) The labyrinth of bone disease in thalassaemia: the search for Ariadne's thread continues. Eur J Haematol 82(1):13\u201314","journal-title":"Eur J Haematol"},{"issue":"4","key":"1007_CR10","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.mehy.2006.03.051","volume":"67","author":"O Gurevitch","year":"2006","unstructured":"Gurevitch O, Slavin S (2006) The hematological etiology of osteoporosis. Med Hypotheses 67(4):729\u2013735","journal-title":"Med Hypotheses"},{"issue":"Suppl 1","key":"1007_CR11","first-page":"86","volume":"6","author":"E Voskaridou","year":"2008","unstructured":"Voskaridou E, Terpos E (2008) Pathogenesis and management of osteoporosis in thalassemia. Pediatr Endocrinol Rev 6(Suppl 1):86\u201393","journal-title":"Pediatr Endocrinol Rev"},{"issue":"3","key":"1007_CR12","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/10245330600702851","volume":"11","author":"OS Salama","year":"2006","unstructured":"Salama OS, Al-Tonbary YA, Shahin RA, Eldeen OA (2006) Unbalanced bone turnover in children with beta-thalassemia. Hematology 11(3):197\u2013202","journal-title":"Hematology"},{"issue":"3","key":"1007_CR13","first-page":"902","volume":"111","author":"R Dresner Pollack","year":"2000","unstructured":"Dresner Pollack R, Rachmilewitz E, Blumenfeld A, Idelson M, Goldfarb AW (2000) Bone mineral metabolism in adults with beta-thalassaemia major and intermedia. Br J Haematol 111(3):902\u2013907","journal-title":"Br J Haematol"},{"issue":"1","key":"1007_CR14","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1046\/j.1365-2141.2001.02549.x","volume":"112","author":"E Voskaridou","year":"2001","unstructured":"Voskaridou E, Kyrtsonis MC, Terpos E, Skordili M, Theodoropoulos I, Bergele A, Diamanti E, Kalovidouris A, Loutradi A, Loukopoulos D (2001) Bone resorption is increased in young adults with thalassaemia major. Br J Haematol 112(1):36\u201341","journal-title":"Br J Haematol"},{"issue":"5","key":"1007_CR15","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1359\/jbmr.040113","volume":"19","author":"N Morabito","year":"2004","unstructured":"Morabito N, Gaudio A, Lasco A, Atteritano M, Pizzoleo MA, Cincotta M, La Rosa M, Guarino R, Meo A, Frisina N (2004) Osteoprotegerin and RANKL in the pathogenesis of thalassemia-induced osteoporosis: new pieces of the puzzle. J Bone Miner Res 19(5):722\u2013727","journal-title":"J Bone Miner Res"},{"key":"1007_CR16","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1006\/taap.1996.8101","volume":"143","author":"H Hiratsuka","year":"1997","unstructured":"Hiratsuka H, Katsuta O, Toyota N, Tsuchitani M, Akiba T, Marumo F, Umemura T (1997) Iron deposition at mineralization fronts and osteoid formation following chronic cadmium exposure in ovariectomized rats. Toxicol Appl Pharmacol 143:348\u2013356","journal-title":"Toxicol Appl Pharmacol"},{"issue":"8","key":"1007_CR17","doi-asserted-by":"crossref","first-page":"3966","DOI":"10.1210\/jc.2002-021548","volume":"88","author":"P Mahachoklertwattana","year":"2003","unstructured":"Mahachoklertwattana P, Sirikulchayanonta V, Chuansumrit A, Karnsombat P, Choubtum L, Sriphrapradang A, Domrongkitchaiporn S, Sirisriro R, Rajatanavin R (2003) Bone histomorphometry in children and adolescents with beta-thalassemia disease: iron-associated focal osteomalacia. J Clin Endocrinol Metab 88(8):3966\u20133972","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"1007_CR18","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s00223-002-1044-3","volume":"74","author":"E Carmina","year":"2004","unstructured":"Carmina E, Di Fede G, Napoli N, Renda G, Vitale G, Lo Pinto C, Bruno D, Malizia R, Rini GB (2004) Hypogonadism and hormone replacement therapy on bone mass of adult women with thalassemia major. Calcif Tissue Int 74(1):68\u201371","journal-title":"Calcif Tissue Int"},{"issue":"2","key":"1007_CR19","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00198-008-0650-y","volume":"20","author":"S Adami","year":"2009","unstructured":"Adami S, Giannini S, Bianchi G, Sinigaglia L, Di Munno O, Fiore CE, Minisola S, Rossini M (2009) Vitamin D status and response to treatment in post-menopausal osteoporosis. Osteoporos Int 20(2):239\u2013244","journal-title":"Osteoporos Int"},{"issue":"6","key":"1007_CR20","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.bone.2005.11.018","volume":"38","author":"N Napoli","year":"2006","unstructured":"Napoli N, Carmina E, Bucchieri S, Sferrazza C, Rini GB, Di Fede G (2006) Low serum levels of 25-hydroxy vitamin D in adults affected by thalassemia major or intermedia. Bone 38(6):888\u2013892","journal-title":"Bone"},{"issue":"2","key":"1007_CR21","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s00774-005-0660-1","volume":"24","author":"NG Angelopoulos","year":"2006","unstructured":"Angelopoulos NG, Goula A, Rombopoulos G, Kaltzidou V, Katounda E, Kaltsas D, Tolis G (2006) Hypoparathyroidism in transfusion-dependent patients with beta-thalassemia. J Bone Miner Metab 24(2):138\u2013145","journal-title":"J Bone Miner Metab"},{"issue":"4","key":"1007_CR22","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1365-2265.2006.02479.x","volume":"64","author":"BA Laway","year":"2006","unstructured":"Laway BA, Goswami R, Singh N, Gupta N, Seith A (2006) Pattern of bone mineral density in patients with sporadic idiopathic hypoparathyroidism. Clin Endocrinol (Oxf) 64(4):405\u2013409","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"1007_CR23","doi-asserted-by":"crossref","first-page":"334","DOI":"10.14310\/horm.2002.1111030","volume":"6","author":"A Christoforidis","year":"2007","unstructured":"Christoforidis A, Kazantzidou E, Tsatra I, Tsantali H, Koliakos G, Hatzipantelis E, Katzos G, Athanassiou-Metaxa M (2007) Normal lumbar bone mineral density in optimally treated children and young adolescents with beta-thalassaemia major. Hormones (Athens) 6(4):334\u2013340","journal-title":"Hormones (Athens)"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-010-1007-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00277-010-1007-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-010-1007-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T06:56:44Z","timestamp":1740207404000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00277-010-1007-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,26]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["1007"],"URL":"https:\/\/doi.org\/10.1007\/s00277-010-1007-0","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,26]]}}}