{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T03:44:31Z","timestamp":1766720671817},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2012,5,24]],"date-time":"2012-05-24T00:00:00Z","timestamp":1337817600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1007\/s00277-012-1492-4","type":"journal-article","created":{"date-parts":[[2012,7,22]],"date-time":"2012-07-22T02:53:25Z","timestamp":1342925605000},"page":"1597-1602","source":"Crossref","is-referenced-by-count":6,"title":["Cell surface expression of CD25 antigen (surface IL-2 receptor alpha-chain) is not a prognostic marker in chronic lymphocytic leukemia: results of a retrospective study of 281 patients"],"prefix":"10.1007","volume":"91","author":[{"name":"on behalf of the Israeli CLL Study Group","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lev","family":"Shvidel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Braester","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osnat","family":"Bairey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Rahimi-Levene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yair","family":"Herishanu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamar","family":"Tadmor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Klepfish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Ruchlemer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mordechai","family":"Shtalrid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Berrebi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Polliack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,5,24]]},"reference":[{"key":"1492_CR1","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1182\/blood-2007-06-093906","volume":"111","author":"M Hallek","year":"2008","unstructured":"Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, D\u00f6hner H, Hillmen P, Keating MJ, Montserrat E, Rai KR, Kipps TJ, International Workshop on Chronic Lymphocytic Leukemia (2008) Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute\u2013Working Group 1996 guidelines. Blood 111:5446\u20135456","journal-title":"Blood"},{"key":"1492_CR2","unstructured":"Huang PY, Best OG, Belov L, Mulligan SP, Christopherson RI (2011) Surface profiles for sub-classification of chronic lymphocytic leukemia. Leuk Lymphoma Apr 3, Epub ahead of print"},{"key":"1492_CR3","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.blre.2008.03.003","volume":"22","author":"C Moreno","year":"2008","unstructured":"Moreno C, Montserrat E (2008) New prognostic markers in chronic lymphocytic leukemia. Blood Rev 22:211\u2013219","journal-title":"Blood Rev"},{"key":"1492_CR4","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1182\/blood.V70.2.418.418","volume":"70","author":"AS Freedman","year":"1987","unstructured":"Freedman AS, Boyd AW, Bieber FR, Daley J, Rosen K, Horowitz JC, Levy DN, Nadler LM (1987) Normal cellular counterparts of B cell chronic lymphocytic leukemia. Blood 70:418\u2013427","journal-title":"Blood"},{"key":"1492_CR5","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1034\/j.1600-0609.2002.01515.x","volume":"68","author":"V Hjalmar","year":"2002","unstructured":"Hjalmar V, Hast R, Kimby E (2002) Cell surface expression of CD25, CD54, and CD95 on B- and T-cells in chronic lymphocytic leukaemia in relation to trisomy 12, atypical morphology and clinical course. Eur J Haematol 68:127\u2013134","journal-title":"Eur J Haematol"},{"key":"1492_CR6","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/ajh.2830460304","volume":"46","author":"K Nakase","year":"1994","unstructured":"Nakase K, Kita K, Nasu K, Ueda T, Tanaka I, Shirakawa S, Tsudo M (1994) Differential expression of interleukin-2 receptors (alpha and beta chain) in mature lymphoid neoplasms. Am J Hematol 46:179\u2013183","journal-title":"Am J Hematol"},{"key":"1492_CR7","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0165-4608(96)00249-X","volume":"95","author":"A Tefferi","year":"1997","unstructured":"Tefferi A, Bartholmai BJ, Witzig TE, Jenkins RB, Li CY, Hanson CA, Mesa RA, Phyliky RL (1997) Clinical correlations of immunophenotypic variations and the presence of trisomy 12 in B-cell chronic lymphocytic leukemia. Cancer Genet Cytogenet 95:173\u2013177","journal-title":"Cancer Genet Cytogenet"},{"key":"1492_CR8","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1084\/jem.160.2.612","volume":"160","author":"M Tsudo","year":"1984","unstructured":"Tsudo M, Uchiyama T, Uchino H (1984) Expression of Tac antigen on activated normal human B cells. J Exp Med 160:612\u2013617","journal-title":"J Exp Med"},{"key":"1492_CR9","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.4049\/jimmunol.134.4.2387","volume":"134","author":"AW Boyd","year":"1985","unstructured":"Boyd AW, Fisher DC, Fox DA, Schlossman SF, Nadler LM (1985) Structural and functional characterization of IL 2 receptors on activated human B cells. J Immunol 134:2387\u20132392","journal-title":"J Immunol"},{"key":"1492_CR10","first-page":"9","volume":"1","author":"AS Freedman","year":"1987","unstructured":"Freedman AS, Boyd AW, Berrebi A, Horowitz JC, Levy DN, Rosen KJ, Daley J, Slaughenhoupt B, Levine H, Nadler LM (1987) Expression of B cell activation antigens on normal and malignant B cells. Leukemia 1:9\u201315","journal-title":"Leukemia"},{"key":"1492_CR11","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/ajh.2830340305","volume":"34","author":"A Berrebi","year":"1990","unstructured":"Berrebi A, Bassous-Guedj L, Vorst E, Dagan S, Shtalrid M, Freedman A (1990) Further characterization of prolymphocytic leukemia cells as a tumor of activated B cells. Am J Hematol 34:181\u2013185","journal-title":"Am J Hematol"},{"issue":"Suppl 2","key":"1492_CR12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3109\/10428194.2011.568651","volume":"52","author":"JE Janik","year":"2011","unstructured":"Janik JE (2011) Tumor markers in hairy cell leukemia. Leuk Lymphoma 52(Suppl 2):69\u201371","journal-title":"Leuk Lymphoma"},{"key":"1492_CR13","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/sj.leu.2404497","volume":"21","author":"K Nakase","year":"2007","unstructured":"Nakase K, Kita K, Miwa H, Nishii K, Shikami M, Tanaka I, Tsutani H, Ueda T, Nasu K, Kyo T, Dohy H, Shiku H, Katayama N (2007) Clinical and prognostic significance of cytokine receptor expression in adult acute lymphoblastic leukemia: interleukin-2 receptor alpha-chain predicts a poor prognosis. Leukemia 21:326\u2013332","journal-title":"Leukemia"},{"key":"1492_CR14","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1080\/10428190802108888","volume":"49","author":"Y Oki","year":"2008","unstructured":"Oki Y, Kato H, Matsuo K, Kuwatsuka Y, Taji H, Yamamoto K, Kagami Y, Morishima Y (2008) Prognostic value of serum soluble interleukin-2 receptor level in patients with diffuse large B cell lymphoma, treated with CHOP or RCHOP-based therapy. Leuk Lymphoma 49:1345\u20131351","journal-title":"Leuk Lymphoma"},{"key":"1492_CR15","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.leukres.2005.11.019","volume":"30","author":"D Capello","year":"2006","unstructured":"Capello D, Zucchetto A, Degan M, Bomben R, Dal Bo M, Efremov DG, Laurenti L, Del Poeta G, Gaidano G, Gattei V (2006) Immunophenotypic characterization of IgVH3-72 B-cell chronic lymphocytic leukaemia (B-CLL). Leuk Res 30:1197\u20131199","journal-title":"Leuk Res"},{"key":"1492_CR16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/jcp.20269","volume":"204","author":"A Zucchetto","year":"2005","unstructured":"Zucchetto A, Sonego P, Degan M, Bomben R, Dal Bo M, Russo S, Attadia V, Rupolo M, Buccisano F, Del Principe MI, Del Poeta G, Pucillo C, Colombatti A, Campanini R, Gattei V (2005) Signature of B-CLL with different prognosis by shrunken centroids of surface antigen expression profiling. J Cell Physiol 204:113\u2013123","journal-title":"J Cell Physiol"},{"key":"1492_CR17","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO;2-V","volume":"48","author":"JL Binet","year":"1981","unstructured":"Binet JL, Auquier A, Dighiero G, Chastang C, Piguet H, Goasguen J, Vaugier G, Potron G, Colona P, Oberling F, Thomas M, Tchernia G, Jacquillat C, Boivin P, Lesty C, Duault MT, Monconduit M, Belabbes S, Gremy F (1981) A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer 48:198\u2013206","journal-title":"Cancer"},{"key":"1492_CR18","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/ajh.22160","volume":"86","author":"L Shvidel","year":"2011","unstructured":"Shvidel L, Braester A, Bairey O, Rahimi-Levene N, Klepfish A, Herishanu Y, Shtalrid M, Polliack A, Berrebi A, Israeli CLL Study Group (2011) Survival trends among 1,325 patients with chronic lymphocytic leukemia seen over the past 40 years in Israel. Am J Hematol 86:985\u2013992","journal-title":"Am J Hematol"},{"key":"1492_CR19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1034\/j.1600-0609.2003.02838.x","volume":"70","author":"J Vilpo","year":"2003","unstructured":"Vilpo J, Tobin G, Hulkkonen J, Hurme M, Thunberg U, Sundstr\u00f6m C, Vilpo L, Rosenquist R (2003) Surface antigen expression and correlation with variable heavy-chain gene mutation status in chronic lymphocytic leukemia. Eur J Haematol 70:53\u201359","journal-title":"Eur J Haematol"},{"key":"1492_CR20","doi-asserted-by":"crossref","unstructured":"Sulda ML, Kuss BJ, Hall RK, Bailey S, Macardle PJ (2012) Clinical utility of molecular and flow cytometric markers in chronic lymphocytic leukaemia. Intern Med J 42:137\u2013146","DOI":"10.1111\/j.1445-5994.2010.02294.x"},{"issue":"21","key":"1492_CR21","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1182\/blood-2009-03-208256","volume":"114","author":"M Herling","year":"2009","unstructured":"Herling M, Patel KA, Weit N, Lilienthal N, Hallek M, Keating MJ, Jones D (2009) High TCL1 levels are a marker of B-cell receptor pathway responsiveness and adverse outcome in chronic lymphocytic leukemia. Blood 114(21):4675\u20134686","journal-title":"Blood"},{"key":"1492_CR22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/cyto.b.20390","volume":"74","author":"S Quijano","year":"2008","unstructured":"Quijano S, L\u00f3pez A, Rasillo A, Sayagu\u00e9s JM, Barrena S, S\u00e1nchez ML, Teodosio C, Giraldo P, Giralt M, P\u00e9rez MC, Romero M, Perdiguer L, Orfao A (2008) Impact of trisomy 12, del(13q), del(17p), and del(11q) on the immunophenotype, DNA ploidy status, and proliferative rate of leukemic B-cells in chronic lymphocytic leukemia. Cytometry B Clin Cytom 74:139\u2013149","journal-title":"Cytometry B Clin Cytom"},{"key":"1492_CR23","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1038\/sj.leu.2402282","volume":"15","author":"Y Aalto","year":"2001","unstructured":"Aalto Y, El-Rifa W, Vilpo L, Ollila J, Nagy B, Vihinen M, Vilpo J, Knuutila S (2001) Distinct gene expression profiling in chronic lymphocytic leukemia with 11q23 deletion. Leukemia 15:1721\u20131728","journal-title":"Leukemia"},{"issue":"5","key":"1492_CR24","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1309\/AJCPQS4OXJJSZ5KN","volume":"133","author":"NM Hassanein","year":"2010","unstructured":"Hassanein NM, Perkinson KR, Alcancia F, Goodman BK, Weinberg JB, Lagoo AS (2010) A single tube, four-color flow cytometry assay for evaluation of ZAP-70 and CD38 expression in chronic lymphocytic leukemia. Am J Clin Pathol 133(5):708\u2013717","journal-title":"Am J Clin Pathol"},{"key":"1492_CR25","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3109\/10428199209049799","volume":"7","author":"V Barak","year":"1992","unstructured":"Barak V, Ginzburg M, Kalickman I, Polliack A (1992) Serum soluble interleukin-2 receptor levels are associated with clinical disease status and histopathological grade in non-Hodgkin's lymphoma and chronic lymphocytic leukemia. Leuk Lymphoma 7:431\u2013438","journal-title":"Leuk Lymphoma"},{"key":"1492_CR26","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3109\/10428199509107900","volume":"19","author":"WU Knauf","year":"1995","unstructured":"Knauf WU, Knuutila S, Zeigmeister B, Thiel E (1995) Trisomy 12 in B-cell chronic lymphocytic leukemia: correlation with advanced disease, atypical morphology, high levels of sCD25, and with refractoriness to treatment. Leuk Lymphoma 19:289\u2013294","journal-title":"Leuk Lymphoma"},{"issue":"3","key":"1492_CR27","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1182\/blood.V86.3.1115.1115","volume":"86","author":"T Decker","year":"1995","unstructured":"Decker T, Flohr T, Trautmann P, Aman MJ, Holter W, Majdic O, Huber C, Peschel C (1995) Role of accessory cells in cytokine production by T cells in chronic B-cell lymphocytic leukemia. Blood 86(3):1115\u20131123","journal-title":"Blood"},{"key":"1492_CR28","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1007\/s00277-010-0994-1","volume":"89","author":"T Decker","year":"2010","unstructured":"Decker T, Bogner C, Oelsner M, Peschel C, Ringshausen I (2010) Antiapoptotic effect of interleukin-2 (IL-2) in B-CLL cells with low and high affinity IL-2 receptors. Ann Hematol 89:1125\u20131132","journal-title":"Ann Hematol"},{"key":"1492_CR29","first-page":"92","volume":"8","author":"J Burton","year":"1994","unstructured":"Burton J, Kay NE (1994) Does IL-2 receptor expression and secretion in chronic B-cell leukemia have a role in down-regulation of the immune system? Leukemia 8:92\u201396","journal-title":"Leukemia"},{"key":"1492_CR30","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1182\/blood-2003-03-0989","volume":"102","author":"S Deaglio","year":"2003","unstructured":"Deaglio S, Capobianco A, Bergui L, D\u00fcrig J, Morabito F, D\u00fchrsen U, Malavasi F (2003) CD38 is a signaling molecule in B-cell chronic lymphocytic leukemia cells. Blood 102:2146\u20132155","journal-title":"Blood"},{"key":"1492_CR31","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1136\/jcp.41.9.951","volume":"41","author":"JV Melo","year":"1988","unstructured":"Melo JV, Robinson DS, De Oliveira MP, Thompson IW, Lampert IA, Ng JP, Galton DA, Catovsky D (1988) Morphology and immunology of circulating cells in leukaemic phase of follicular lymphoma. J Clin Pathol 41:951\u2013959","journal-title":"J Clin Pathol"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-012-1492-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00277-012-1492-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-012-1492-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T15:51:47Z","timestamp":1687621907000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00277-012-1492-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,24]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["1492"],"URL":"https:\/\/doi.org\/10.1007\/s00277-012-1492-4","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"type":"print","value":"0939-5555"},{"type":"electronic","value":"1432-0584"}],"subject":[],"published":{"date-parts":[[2012,5,24]]}}}