{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T02:10:32Z","timestamp":1781835032319,"version":"3.54.5"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2012,11,25]],"date-time":"2012-11-25T00:00:00Z","timestamp":1353801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1007\/s00277-012-1634-8","type":"journal-article","created":{"date-parts":[[2012,11,24]],"date-time":"2012-11-24T09:19:16Z","timestamp":1353748756000},"page":"527-531","source":"Crossref","is-referenced-by-count":15,"title":["Combined cobalamin and iron deficiency anemia: a diagnostic approach using a model based on age and homocysteine assessment"],"prefix":"10.1007","volume":"92","author":[{"given":"Angel F.","family":"Remacha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. P.","family":"Sard\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Canals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Queralt\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Zapico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Remacha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Carrascosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,11,25]]},"reference":[{"key":"1634_CR1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/00365510050184994","volume":"60","author":"WP Oosterhuis","year":"2000","unstructured":"Oosterhuis WP, Niessen RW, Bossuyt PM, Sanders GT, Sturk A (2000) Diagnostic value of the mean corpuscular volume in the detection of vitamin B12 deficiency. Scand J Clin Lab Invest 60:9\u201318","journal-title":"Scand J Clin Lab Invest"},{"key":"1634_CR2","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0899-9007(01)00666-9","volume":"17","author":"CH Chui","year":"2001","unstructured":"Chui CH, Lau FY, Wong R, Soo OY, Lam CK, Lee PW, Leung HK, So CK, Tsoi WC, Tang N, Lam WK, Cheng G (2001) Vitamin B12 deficiency\u2014need for a new guideline. Nutrition 17:917\u2013920","journal-title":"Nutrition"},{"key":"1634_CR3","doi-asserted-by":"crossref","first-page":"348S","DOI":"10.3945\/ajcn.111.013441","volume":"94","author":"R Carmel","year":"2011","unstructured":"Carmel R (2011) Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II. Am J Clin Nutr 94:348S\u2013358S","journal-title":"Am J Clin Nutr"},{"key":"1634_CR4","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1182\/blood-2008-03-040253","volume":"112","author":"R Carmel","year":"2008","unstructured":"Carmel R (2008) How I treat cobalamin (vitamin B12) deficiency. Blood 112:2214\u20132221","journal-title":"Blood"},{"key":"1634_CR5","volume-title":"The megaloblastic anaemias","author":"I Chanarin","year":"1990","unstructured":"Chanarin I (1990) The megaloblastic anaemias, 3rd edn. Blackwell, Oxford","edition":"3"},{"key":"1634_CR6","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1079\/BJN19850148","volume":"54","author":"GM Craig","year":"1985","unstructured":"Craig GM, Elliot C, Hughes KR (1985) Masked vitamin B12 and folate deficiency in the elderly. Br J Nutr 54:613\u2013619","journal-title":"Br J Nutr"},{"key":"1634_CR7","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1002\/ajh.20996","volume":"82","author":"JW Harper","year":"2007","unstructured":"Harper JW, Holleran SF, Ramakrishnan R, Bhagat G, Green PH (2007) Anemia in celiac disease is multifactorial in etiology. Am J Hematol 82:996\u20131000","journal-title":"Am J Hematol"},{"issue":"2 Suppl","key":"1634_CR8","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1177\/15648265080292S111","volume":"29","author":"J Metz","year":"2008","unstructured":"Metz J (2008) A high prevalence of biochemical evidence of vitamin B12 or folate deficiency does not translate into a comparable prevalence of anemia. Food Nutr Bull 29(2 Suppl):S74\u2013S85","journal-title":"Food Nutr Bull"},{"issue":"Suppl 1","key":"1634_CR9","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1111\/j.1753-4887.2009.00163.x","volume":"67","author":"G Varela-Moreiras","year":"2009","unstructured":"Varela-Moreiras G, Murphy MM, Scott JM (2009) Cobalamin, folic acid, and homocysteine. Nutr Rev 67(Suppl 1):S69\u2013S72","journal-title":"Nutr Rev"},{"issue":"2 Suppl","key":"1634_CR10","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1177\/15648265080292S108","volume":"29","author":"R Green","year":"2008","unstructured":"Green R (2008) Indicators for assessing folate and vitamin B12 status and for monitoring the efficacy of intervention strategies. Food Nutr Bull 29(2 Suppl):S52\u2013S63","journal-title":"Food Nutr Bull"},{"key":"1634_CR11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/qjmed\/hcn138","volume":"102","author":"N Dali-Youcef","year":"2009","unstructured":"Dali-Youcef N, Andr\u00e8s E (2009) An update on cobalamin deficiency in adults. QJM 102:17\u201328","journal-title":"QJM"},{"key":"1634_CR12","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1365-2796.2011.02485.x","volume":"271","author":"A David Smith","year":"2012","unstructured":"David Smith A, Refsum H (2012) Do we need to reconsider the desirable blood level of vitamin B12? J Intern Med 271:179\u2013182","journal-title":"J Intern Med"},{"key":"1634_CR13","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1093\/ajcn\/77.2.420","volume":"77","author":"AF Remacha","year":"2003","unstructured":"Remacha AF, Cadafalch J, Sard\u00e0 P, Barcel\u00f3 M, Fuster M (2003) Vitamin B-12 metabolism in HIV-infected patients in the age of highly active antiretroviral therapy: role of homocysteine in assessing vitamin B-12 status. Am J Clin Nutr 77:420\u2013424","journal-title":"Am J Clin Nutr"},{"key":"1634_CR14","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0002-9343(01)00883-X","volume":"111","author":"B Annibale","year":"2001","unstructured":"Annibale B, Capurso G, Chistolini A, D'Ambra G, DiGiulio E, Monarca B, DelleFave G (2001) Gastrointestinal causes of refractory iron deficiency anemia in patients without gastrointestinal symptoms. Am J Med 111:439\u2013445","journal-title":"Am J Med"},{"key":"1634_CR15","first-page":"585","volume":"90","author":"C Hershko","year":"2005","unstructured":"Hershko C, Hoffbrand AV, Keret D, Souroujon M, Maschler I, Monselise Y, Lahad A (2005) Role of autoimmune gastritis, Helicobacter pylori and celiac disease in refractory or unexplained iron deficiency anemia. Haematologica 90:585\u2013595","journal-title":"Haematologica"},{"key":"1634_CR16","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000243793","volume":"122","author":"C Hershko","year":"2009","unstructured":"Hershko C, Ronson A (2009) Iron deficiency, Helicobacter infection and gastritis. Acta Haematol 122:97\u2013102","journal-title":"Acta Haematol"},{"key":"1634_CR17","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1182\/blood-2005-09-3534","volume":"107","author":"C Hershko","year":"2006","unstructured":"Hershko C, Ronson A, Souroujon M, Maschler I, Heyd J, Patz J (2006) Variable hematologic presentation of autoimmune gastritis: age-related progression from iron deficiency to cobalamin depletion. Blood 107:1673\u20131679","journal-title":"Blood"},{"key":"1634_CR18","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.3748\/wjg.15.5121","volume":"15","author":"E Lahner","year":"2009","unstructured":"Lahner E, Annibale B (2009) Pernicious anemia: new insights from a gastroenterological point of view. World J Gastroenterol 15:5121\u20135128","journal-title":"World J Gastroenterol"},{"key":"1634_CR19","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1053\/j.seminhematol.2009.06.002","volume":"46","author":"C Hershko","year":"2009","unstructured":"Hershko C, Skikne B (2009) Pathogenesis and management of iron deficiency anemia: emerging role of celiac disease, Helicobacter pylori, and autoimmune gastritis. Semin Hematol 46:339\u2013350","journal-title":"Semin Hematol"},{"key":"1634_CR20","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000073341","volume":"21","author":"J Dierkes","year":"2003","unstructured":"Dierkes J, Ebert M, Malfertheiner P, Luley C (2003) Helicobacter pylori infection, vitamin B12 and homocysteine. A review. Dig Dis 21:237\u2013244","journal-title":"Dig Dis"},{"key":"1634_CR21","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s12185-011-0825-8","volume":"93","author":"AF Remacha","year":"2011","unstructured":"Remacha AF, Souto JC, Pi\u00f1ana JL, Sard\u00e0 MP, Queralt\u00f3 JM, Mart\u00ed-Fabregas J, Garc\u00eda-Moll X, F\u00e9rnandez C, Rodriguez A, Cuesta J (2011) Vitamin B12 deficiency, hyperhomocysteinemia and thrombosis: a case and control study. Int J Hematol 93:458\u2013464","journal-title":"Int J Hematol"},{"key":"1634_CR22","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1056\/NEJMra020542","volume":"347","author":"S Suerbaum","year":"2002","unstructured":"Suerbaum S, Michetti P (2002) Helicobacter pylori infection. N Engl J Med 347:1175\u20131186","journal-title":"N Engl J Med"},{"key":"1634_CR23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/10245330600938554","volume":"12","author":"C Beyan","year":"2007","unstructured":"Beyan C, Beyan E, Kaptan K, Ifran A, Uzar AI (2007) Post-gastrectomy anemia: evaluation of 72 cases with post-gastrectomy anemia. Hematology 12:81\u201384","journal-title":"Hematology"},{"key":"1634_CR24","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1751-553X.2007.00911.x","volume":"29","author":"CWJ Chan","year":"2007","unstructured":"Chan CWJ, Liu SYH, Kho CSB, Lau KHT, Liang YD, Chu WR, Ma SKE (2007) Diagnostic clues to megaloblastic anaemia without macrocytosis. Int Jnl Lab Hem 29:163\u2013171","journal-title":"Int Jnl Lab Hem"},{"key":"1634_CR25","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1532\/IJH97.E0311","volume":"81","author":"C Beyan","year":"2005","unstructured":"Beyan C, Kaptan K, Beyan E, Turan M (2005) The platelet count\/mean corpuscular hemoglobin ratio distinguishes combined iron and vitamin B12 deficiency from uncomplicated iron deficiency. Int J Hematol 81:301\u2013303","journal-title":"Int J Hematol"},{"key":"1634_CR26","first-page":"75","volume":"36","author":"AF Remacha","year":"1999","unstructured":"Remacha AF, Cadafalch J (1999) Cobalamin deficiency in patients infected with the human immunodeficiency virus. Semin Hematol 36:75\u201387","journal-title":"Semin Hematol"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-012-1634-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00277-012-1634-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-012-1634-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T01:43:57Z","timestamp":1562377437000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00277-012-1634-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,25]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["1634"],"URL":"https:\/\/doi.org\/10.1007\/s00277-012-1634-8","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,25]]}}}