{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T13:56:01Z","timestamp":1773150961389,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2013,6,22]],"date-time":"2013-06-22T00:00:00Z","timestamp":1371859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2013,6,22]],"date-time":"2013-06-22T00:00:00Z","timestamp":1371859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1007\/s00277-013-1820-3","type":"journal-article","created":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T06:59:19Z","timestamp":1371797959000},"page":"1665-1673","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Unrelated cord blood transplantation for central nervous system relapse in high-risk childhood acute lymphoblastic leukemia"],"prefix":"10.1007","volume":"92","author":[{"given":"Changcheng","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baolin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huilan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangquan","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingbing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zimin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,6,22]]},"reference":[{"key":"1820_CR1","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1182\/blood-2004-04-1616","volume":"104","author":"CH Pui","year":"2004","unstructured":"Pui CH, Sandlund JT, Pei D et al (2004) Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children\u2019s Research Hospital. Blood 104:2690\u20132696","journal-title":"Blood"},{"key":"1820_CR2","doi-asserted-by":"publisher","first-page":"2730","DOI":"10.1056\/NEJMoa0900386","volume":"360","author":"CH Pui","year":"2009","unstructured":"Pui CH, Campana D, Pei D et al (2009) Treating childhood acute lymphoblastic leukemia without cranial irradiation. N Engl J Med 360:2730\u20132741","journal-title":"N Engl J Med"},{"key":"1820_CR3","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1038\/leu.2009.253","volume":"24","author":"LB Silverman","year":"2010","unstructured":"Silverman LB, Stevenson KE, O'Brien JE et al (2010) Long-term results of Dana-Farber Cancer Institute ALL Consortium protocols for children with newly diagnosed acute lymphoblastic leukemia (1985\u20132000). Leukemia 24:320\u2013334","journal-title":"Leukemia"},{"key":"1820_CR4","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1200\/JCO.1995.13.2.333","volume":"13","author":"RC Ribeiro","year":"1995","unstructured":"Ribeiro RC, Rivera GK, Hudson M et al (1995) An intensive retreatment protocol for children with an isolated CNS relapse of acute lymphoblastic leukemia. J Clin Oncol 13:333\u2013338","journal-title":"J Clin Oncol"},{"key":"1820_CR5","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1200\/JCO.1999.17.12.3745","volume":"17","author":"AK Ritchey","year":"1999","unstructured":"Ritchey AK, Pollock BH, Lauer SJ, Andejeski Y, Barredo J, Buchanan GR (1999) Improved survival of children with isolated CNS relapse of acute lymphoblastic leukemia; a Pediatric Oncology Group Study. J Clin Oncol 17:3745\u20133752","journal-title":"J Clin Oncol"},{"key":"1820_CR6","doi-asserted-by":"publisher","first-page":"3142","DOI":"10.1200\/JCO.2005.03.3373","volume":"24","author":"JC Barredo","year":"2006","unstructured":"Barredo JC, Devidas M, Lauer SJ et al (2006) Isolated CNS relapse of acute lymphoblastic leukemia treated with intensive systemic chemotherapy and delayed CNS radiation: a Pediatric Oncology Group study. J Clin Oncol 24:3142\u20133149","journal-title":"J Clin Oncol"},{"key":"1820_CR7","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1046\/j.1365-2141.2003.04158.x","volume":"120","author":"EC Morris","year":"2003","unstructured":"Morris EC, Harrison G, Bailey CC et al (2003) Prognostic factors and outcome for children after second central nervous system relapse of acute lymphoblastic leukaemia. Br J Haematol 120:787\u2013789","journal-title":"Br J Haematol"},{"key":"1820_CR8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/sj.bmt.1705202","volume":"37","author":"T Yoshihara","year":"2006","unstructured":"Yoshihara T, Morimoto A, Kuroda H et al (2006) Allogeneic stem cell transplantation in children with acute lymphoblastic leukemia after isolated central nervous system relapse: our experiences and review of the literature. Bone Marrow Transplant 37:25\u201331","journal-title":"Bone Marrow Transplant"},{"key":"1820_CR9","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.bbmt.2008.03.011","volume":"14","author":"PD Harker-Murray","year":"2008","unstructured":"Harker-Murray PD, Thomas AJ, Wagner JE et al (2008) Allogeneic hematopoietic cell transplantation in children with relapsed acute lymphoblastic leukemia isolated to the central nervous system. Biol Blood Marrow Transplant 14:685\u2013692","journal-title":"Biol Blood Marrow Transplant"},{"key":"1820_CR10","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/sj.leu.2405037","volume":"22","author":"M Eapen","year":"2008","unstructured":"Eapen M, Zhang MJ, Devidas M et al (2008) Outcomes after HLA-matched sibling transplantation or chemotherapy in children with acute lymphoblastic leukemia in a second remission after an isolated central nervous system relapse: a collaborative study of the Children\u2019s Oncology Group and the Center for International Blood and Marrow Transplant Research. Leukemia 22:281\u2013286","journal-title":"Leukemia"},{"key":"1820_CR11","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1111\/j.1365-2141.2004.04975.x","volume":"125","author":"Y Nagatoshi","year":"2004","unstructured":"Nagatoshi Y, Kawano Y, Nagayama J, Okamura J (2004) Treatment of isolated central nervous system relapse in high-risk lymphoid malignancy with allogeneic bone marrow transplantation and extended intrathecal therapy. Br J Haematol 125:766\u2013768","journal-title":"Br J Haematol"},{"key":"1820_CR12","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1046\/j.1365-2141.1998.00825.x","volume":"102","author":"P Bordigoni","year":"1998","unstructured":"Bordigoni P, Esperou H, Souillet G et al (1998) Total body irradiation-high-dose cytosine arabinoside and melphalan followed by allogeneic bone marrow transplantation from HLA-identical siblings in the treatment of children with acute lymphoblastic leukaemia after relapse while receiving chemotherapy: a Societe Franc\u00b8aise de Greffe de Moelle study. Br J Haematol 102:656\u2013665","journal-title":"Br J Haematol"},{"key":"1820_CR13","first-page":"515","volume":"15","author":"A Borgmann","year":"1995","unstructured":"Borgmann A, Hartmann R, Schmid H et al (1995) Isolated extramedullary relapse in children with acute lymphoblastic leukemia: a comparison between treatment results of chemotherapy and bone marrow transplantation. Bone Marrow Transplant 15:515\u2013521","journal-title":"Bone Marrow Transplant"},{"key":"1820_CR14","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1053\/bbmt.2002.v8.pm12064362","volume":"8","author":"JN Barker","year":"2002","unstructured":"Barker JN, Krepski TP, DeFor TE, Davies SM, Wagner JE, Weisdorf DJ (2002) Searching for unrelated donor hematopoietic stem cells: availability and speed of umbilical cord blood versus bone marrow. Biol Blood Marrow Transplant 8:257\u2013260","journal-title":"Biol Blood Marrow Transplant"},{"key":"1820_CR15","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1182\/blood.V92.10.3515","volume":"92","author":"EW Petersdorf","year":"1998","unstructured":"Petersdorf EW, Gooley TA, Anasetti C et al (1998) Optimizing outcome after unrelated marrow transplantation by comprehensive matching of HLA class I and II alleles in the donor and recipient. Blood 92:3515\u20133520","journal-title":"Blood"},{"key":"1820_CR16","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1182\/blood.V91.1.340","volume":"91","author":"L Garderet","year":"1998","unstructured":"Garderet L, Dulphy N, Douay C et al (1998) The umbilical cord blood alphabeta T-cell repertoire: characteristics of a polyclonal and naive but completely formed repertoire. Blood 91:340\u2013346","journal-title":"Blood"},{"key":"1820_CR17","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.ejca.2010.10.019","volume":"47","author":"N Sirvent","year":"2011","unstructured":"Sirvent N, Suciu S, Rialland X et al (2011) Prognostic significance of the initial cerebro-spinal fluid (CSF) involvement of children with acute lymphoblastic leukaemia (ALL) treated without cranial irradiation: results of European Organization for Research and Treatment of Cancer (EORTC) Children Leukemia Group study 58881. Eur J Cancer 47:239\u2013247","journal-title":"Eur J Cancer"},{"key":"1820_CR18","first-page":"825","volume":"15","author":"D Przepiorka","year":"1995","unstructured":"Przepiorka D, Weisdorf D, Martin P et al (1995) 1994 Consensus conference on acute GvHD grading. Bone Marrow Transplant 15:825\u2013828","journal-title":"Bone Marrow Transplant"},{"key":"1820_CR19","first-page":"250","volume":"28","author":"KM Sullivan","year":"1991","unstructured":"Sullivan KM, Agura E, Anasetti C et al (1991) Chronic graft-versus-host disease and other late complications of bone marrow transplantation. Semin Hematol 28:250\u2013259","journal-title":"Semin Hematol"},{"key":"1820_CR20","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1200\/JCO.2000.18.2.340","volume":"18","author":"SM Davies","year":"2000","unstructured":"Davies SM, Ramsay NK, Klein JP et al (2000) Comparison of preparative regimens in transplants for children with acute lymphoblastic leukemia. J Clin Oncol 18:340\u2013347","journal-title":"J Clin Oncol"},{"key":"1820_CR21","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1056\/NEJMoa035091","volume":"349","author":"CH Pui","year":"2003","unstructured":"Pui CH, Cheng C, Leung W et al (2003) Extended follow-up of long-term survivors of childhood acute lymphoblastic leukemia. N Engl J Med 349:640\u2013649","journal-title":"N Engl J Med"},{"key":"1820_CR22","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1016\/j.bbmt.2012.02.016","volume":"18","author":"P Christopoulos","year":"2012","unstructured":"Christopoulos P, Bertz H, Ihorst G, Marks R, W\u00e4sch R, Finke J (2012) Radiation-free allogeneic conditioning with fludarabine, carmustine, and thiotepa for acute lymphoblastic leukemia and other hematologic malignancies necessitating enhanced central nervous system activity. Biol Blood Marrow Transplant 18:1430\u20131437","journal-title":"Biol Blood Marrow Transplant"},{"key":"1820_CR23","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1080\/10428190701784417","volume":"49","author":"F Ostronoff","year":"2008","unstructured":"Ostronoff F, Ostronoff M, Fernandes HS et al (2008) Evidence for a graft-versus-leukemia effect in the central nervous system. Leuk Lymphoma 49:365\u2013369","journal-title":"Leuk Lymphoma"},{"key":"1820_CR24","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1002\/pbc.21200","volume":"50","author":"R Tanoshima","year":"2008","unstructured":"Tanoshima R, Goto H, Yanagimachi M, Kajiwara R, Kuroki F, Yokota S (2008) Graft versus leukemia effect against juvenile myelomonocytic leukemia after unrelated cord blood transplantation. Pediatr Blood Cancer 50:665\u2013667","journal-title":"Pediatr Blood Cancer"},{"key":"1820_CR25","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1002\/ajh.20616","volume":"81","author":"M Ostronoff","year":"2006","unstructured":"Ostronoff M, Domingues MC, Ostronoff F et al (2006) Reduced intensity conditioning allogeneic bone marrow transplantation following central nervous system (CNS) relapse of acute promyelocytic leukemia: evidence for a graft-versus-leukemia effect in the CNS. Am J Hematol 81:387\u2013388","journal-title":"Am J Hematol"},{"key":"1820_CR26","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1038\/sj.bmt.1704290","volume":"32","author":"CM Mandigers","year":"2003","unstructured":"Mandigers CM, Verdonck LF, Meijerink JP, Dekker AW, Schattenberg AV, Raemaekers JM (2003) Graft-versus-lymphoma effect of donor lymphocyte infusion in indolent lymphomas relapsed after allogeneic stem cell transplantation. Bone Marrow Transplant 32:1159\u20131163","journal-title":"Bone Marrow Transplant"},{"key":"1820_CR27","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3109\/10428199909083396","volume":"34","author":"G Varadi","year":"1999","unstructured":"Varadi G, Or R, Kapelushnik J et al (1999) Graft-versus-lymphoma effect after allogeneic peripheral blood stem cell transplantation for primary central nervous system lymphoma. Leuk Lymphoma 34:185\u2013190","journal-title":"Leuk Lymphoma"},{"key":"1820_CR28","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/sj.bmt.1705540","volume":"39","author":"RT Kamble","year":"2007","unstructured":"Kamble RT, Chang CC, Sanchez S, Carrum G (2007) Central nervous system graft-versus-host disease: report of two cases and literature review. Bone Marrow Transplant 39:49\u201352","journal-title":"Bone Marrow Transplant"},{"key":"1820_CR29","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.1182\/blood-2007-11-118893","volume":"112","author":"H Narimatsu","year":"2008","unstructured":"Narimatsu H, Miyakoshi S, Yamaguchi T et al (2008) Chronic graft-versus-host disease following umbilical cord blood transplantation: retrospective survey involving 1072 patients in Japan. Blood 112:2579\u20132582","journal-title":"Blood"},{"key":"1820_CR30","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.bbmt.2007.06.004","volume":"13","author":"M Arora","year":"2007","unstructured":"Arora M, Nagaraj S, Wagner JE et al (2007) Chronic graft-versus-host disease (cGVHD) following unrelated donor hematopoietic stem cell transplantation (HSCT): higher response rate in recipients of unrelated donor (URD) umbilical cord blood (UCB). Biol Blood Marrow Transplant 13:1145\u20131152","journal-title":"Biol Blood Marrow Transplant"},{"key":"1820_CR31","doi-asserted-by":"publisher","first-page":"4293","DOI":"10.1182\/blood-2009-05-220525","volume":"114","author":"MR Verneris","year":"2009","unstructured":"Verneris MR, Brunstein CG, Barker J et al (2009) Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 units. Blood 114:4293\u20134299","journal-title":"Blood"},{"key":"1820_CR32","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3346\/jkms.2008.23.1.98","volume":"23","author":"YH Lee","year":"2008","unstructured":"Lee YH, Lim YJ, Kim JY, Kim YD, Lee SW (2008) Pre-engraftment syndrome in hematopoietic stem cell transplantation. J Korean Med Sci 23:98\u2013103","journal-title":"J Korean Med Sci"},{"key":"1820_CR33","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1016\/j.bbmt.2009.07.001","volume":"15","author":"H Frangoul","year":"2009","unstructured":"Frangoul H, Wang L, Harrell FE Jr, Ho R, Domm J (2009) Pre-engraftment syndrome after unrelated cord blood transplant is a strong predictor of acute and chronic graft versus-host disease. Biol Blood Marrow Transplant 15:1485\u20131488","journal-title":"Biol Blood Marrow Transplant"},{"key":"1820_CR34","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.bbmt.2009.10.022","volume":"16","author":"KJ Patel","year":"2010","unstructured":"Patel KJ, Rice RD, Hawke R et al (2010) Pre-engraftment syndrome after double-unit cord blood transplantation: a distinct syndrome not associated with acute graft-versus host disease. Biol Blood Marrow Transplant 16:435\u2013440","journal-title":"Biol Blood Marrow Transplant"},{"key":"1820_CR35","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/j.1600-0609.2011.01709.x","volume":"88","author":"X Wang","year":"2012","unstructured":"Wang X, Liu H, Li L et al (2012) Pre-engraftment syndrome after unrelated donor umbilical cord blood transplantation in patients with hematologic malignancies. Eur J Haematol 88:39\u201345","journal-title":"Eur J Haematol"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-013-1820-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-013-1820-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-013-1820-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-013-1820-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T01:32:15Z","timestamp":1659058335000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-013-1820-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,22]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["1820"],"URL":"https:\/\/doi.org\/10.1007\/s00277-013-1820-3","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,22]]},"assertion":[{"value":"7 February 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}