{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T03:43:56Z","timestamp":1768967036295,"version":"3.49.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T00:00:00Z","timestamp":1397606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1007\/s00277-014-2061-9","type":"journal-article","created":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T10:45:51Z","timestamp":1397558751000},"page":"977-982","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Lack of noncanonical RAS mutations in cytogenetically normal acute myeloid leukemia"],"prefix":"10.1007","volume":"93","author":[{"given":"Christoph W. M.","family":"Reuter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Krauter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredrick O.","family":"Onono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Bunke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederik","family":"Damm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicitas","family":"Thol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gudrun","family":"G\u00f6hring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Schlegelberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Heuser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold","family":"Ganser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,4,16]]},"reference":[{"key":"2061_CR1","first-page":"4682","volume":"49","author":"JL Bos","year":"1989","unstructured":"Bos JL (1989) Ras oncogenes in human cancer: a review. Cancer Res 49:4682\u20134689","journal-title":"Cancer Res"},{"key":"2061_CR2","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1182\/blood.V96.5.1655","volume":"96","author":"CW Reuter","year":"2000","unstructured":"Reuter CW, Morgan MA, Bergmann L (2000) Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies? Blood 96:1655\u20131669","journal-title":"Blood"},{"key":"2061_CR3","doi-asserted-by":"crossref","first-page":"5615","DOI":"10.1182\/blood-2012-04-423905","volume":"119","author":"C Thiede","year":"2012","unstructured":"Thiede C (2012) Mutant DNMT3A: teaming up to transform. Blood 119:5615\u20135617","journal-title":"Blood"},{"key":"2061_CR4","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1056\/NEJMoa1301689","volume":"368","author":"Cancer Genome Atlas Research Network","year":"2013","unstructured":"Cancer Genome Atlas Research Network (2013) Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med 368:2059\u20132074","journal-title":"N Engl J Med"},{"key":"2061_CR5","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nature13038","volume":"506","author":"LI Shlush","year":"2014","unstructured":"Shlush LI, Zandi S, Mitchell A, Chen WC, Brandwein JM, Gupta V et al (2014) Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature 506:328\u2013333","journal-title":"Nature"},{"key":"2061_CR6","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1056\/NEJMoa074306","volume":"358","author":"RF Schlenk","year":"2008","unstructured":"Schlenk RF, D\u00f6hner K, Krauter J, Fr\u00f6hling S, Corbacioglu A, Bullinger L et al (2008) Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med 358:1909\u20131918","journal-title":"N Engl J Med"},{"key":"2061_CR7","doi-asserted-by":"crossref","first-page":"4595","DOI":"10.1200\/JCO.2007.15.2058","volume":"26","author":"P Paschka","year":"2008","unstructured":"Paschka P, Marcucci G, Ruppert AS, Whitman SP, Mr\u00f3zek K, Maharry K et al (2008) Wilms\u2019 tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study. J Clin Oncol 26:4595\u20134602","journal-title":"J Clin Oncol"},{"key":"2061_CR8","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1200\/JCO.2009.23.0342","volume":"28","author":"F Damm","year":"2010","unstructured":"Damm F, Heuser M, Morgan M, Yun H, Grosshennig A, G\u00f6hring G et al (2010) Single nucleotide polymorphism in the mutational hotspot of WT1 predicts a favorable outcome in patients with cytogenetically normal acute myeloid leukemia. J Clin Oncol 28:578\u2013585","journal-title":"J Clin Oncol"},{"key":"2061_CR9","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1182\/blood-2005-03-0867","volume":"106","author":"DT Bowen","year":"2005","unstructured":"Bowen DT, Frew ME, Hills R, Gale RE, Wheatley K, Groves MJ et al (2005) RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60\u00a0years. Blood 106:2113\u20132119","journal-title":"Blood"},{"key":"2061_CR10","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1182\/blood-2005-08-3522","volume":"107","author":"U Bacher","year":"2006","unstructured":"Bacher U, Haferlach T, Schoch C, Kern W, Schnittger S (2006) Implications of NRAS mutations in AML: a study of 2502 patients. Blood 107:3847\u20133853","journal-title":"Blood"},{"key":"2061_CR11","doi-asserted-by":"crossref","first-page":"4603","DOI":"10.1200\/JCO.2007.14.0418","volume":"26","author":"A Neubauer","year":"2008","unstructured":"Neubauer A, Maharry K, Mr\u00f3zek K, Thiede C, Marcucci G, Paschka P et al (2008) Patients with acute myeloid leukemia and RAS mutations benefit most from postremission high-dose cytarabine: a Cancer and Leukemia Group B study. J Clin Oncol 26:4603\u20134609","journal-title":"J Clin Oncol"},{"key":"2061_CR12","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1182\/blood-2008-04-152157","volume":"113","author":"JW Tyner","year":"2009","unstructured":"Tyner JW, Erickson H, Deininger MW, Willis SG, Eide CA, Levine RL et al (2009) High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients. Blood 113:1749\u20131755","journal-title":"Blood"},{"key":"2061_CR13","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1182\/blood-2010-08-303479","volume":"117","author":"F Damm","year":"2011","unstructured":"Damm F, Heuser M, Morgan M, Wagner K, G\u00f6rlich K, Grosshennig A et al (2011) Integrative prognostic risk score in acute myeloid leukemia with normal karyotype. Blood 117:4561\u20134568","journal-title":"Blood"},{"key":"2061_CR14","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1111\/j.1365-2141.2005.05696.x","volume":"130","author":"MA Morgan","year":"2005","unstructured":"Morgan MA, Sebil T, Aydilek E, Peest D, Ganser A, Reuter CW (2005) Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells. Br J Haematol 130:912\u2013925","journal-title":"Br J Haematol"},{"key":"2061_CR15","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1200\/JCO.2004.06.060","volume":"22","author":"S Frohling","year":"2004","unstructured":"Frohling S, Schlenk RF, Stolze I, Bihlmayr J, Benner A, Kreitmeier S et al (2004) CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations. J Clin Oncol 22:624\u2013633","journal-title":"J Clin Oncol"},{"key":"2061_CR16","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1182\/blood-2005-05-2164","volume":"106","author":"K D\u00f6hner","year":"2005","unstructured":"D\u00f6hner K, Schlenk RF, Habdank M, Scholl C, R\u00fccker FG, Corbacioglu A et al (2005) Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations. Blood 106:3740\u20133746","journal-title":"Blood"},{"key":"2061_CR17","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1200\/JCO.2002.09.088","volume":"20","author":"K D\u00f6hner","year":"2002","unstructured":"D\u00f6hner K, Tobis K, Ulrich R, Fr\u00f6hling S, Benner A, Schlenk RF et al (2002) Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60\u00a0years old with acute myeloid leukemia and normal cytogenetics: a study of the Acute Myeloid Leukemia Study Group Ulm. J Clin Oncol 20:3254\u20133261","journal-title":"J Clin Oncol"},{"key":"2061_CR18","doi-asserted-by":"crossref","first-page":"4326","DOI":"10.1182\/blood.V99.12.4326","volume":"99","author":"C Thiede","year":"2002","unstructured":"Thiede C, Steudel C, Mohr B, Schaich M, Sch\u00e4kel U, Platzbecker U et al (2002) Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood 99:4326\u20134335","journal-title":"Blood"},{"issue":"14","key":"2061_CR19","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1200\/JCO.2009.27.6899","volume":"28","author":"K Wagner","year":"2010","unstructured":"Wagner K, Damm F, G\u00f6hring G, G\u00f6rlich K, Heuser M, Sch\u00e4fer I et al (2010) Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor. J Clin Oncol 28(14):2356\u20132364","journal-title":"J Clin Oncol"},{"key":"2061_CR20","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1182\/blood-2010-03-272146","volume":"116","author":"F Thol","year":"2010","unstructured":"Thol F, Damm F, Wagner K, Gohring G, Schlegelberger B, Hoelzer D et al (2010) Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia. Blood 116:614\u2013616","journal-title":"Blood"},{"key":"2061_CR21","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.1200\/JCO.2003.04.036","volume":"21","author":"BD Cheson","year":"2003","unstructured":"Cheson BD, Bennett JM, Kopecky KJ, B\u00fcchner T, Willman CL, Estey EH et al (2003) Revised recommendations of the international working group for diagnosis, standardization of response criteria, treatment outcomes, and reporting standards for therapeutic trials in acute myeloid leukemia. J Clin Oncol 21:4642\u20134649","journal-title":"J Clin Oncol"},{"key":"2061_CR22","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/sim.4780050306","volume":"5","author":"EL Korn","year":"1986","unstructured":"Korn EL (1986) Censoring distributions as a measure of follow-up in survival analysis. Stat Med 5:255\u2013260","journal-title":"Stat Med"},{"key":"2061_CR23","first-page":"3074","volume":"93","author":"H Kiyoi","year":"1999","unstructured":"Kiyoi H, Naoe T, Nakano Y, Yokota S, Minami S, Miyawaki S et al (1999) Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Blood 93:3074\u20133080","journal-title":"Blood"},{"key":"2061_CR24","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1182\/blood.V83.6.1603.bloodjournal8361603","volume":"83","author":"A Neubauer","year":"1994","unstructured":"Neubauer A, Dodge RK, George SL, Davey FR, Silver RT, Schiffer CA et al (1994) Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia. Blood 83:1603\u20131611","journal-title":"Blood"},{"key":"2061_CR25","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1186\/1471-2407-8-299","volume":"8","author":"V Gelsi-Boyer","year":"2008","unstructured":"Gelsi-Boyer V, Trouplin V, Ad\u00e9la\u00efde J, Aceto N, Remy V, Pinson S et al (2008) Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes. BMC Cancer 8:299","journal-title":"BMC Cancer"},{"key":"2061_CR26","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1182\/blood-2005-06-2248","volume":"106","author":"S Schnittger","year":"2005","unstructured":"Schnittger S, Schoch C, Kern W, Mecucci C, Tschulik C, Martelli MF et al (2005) Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype. Blood 106:3733\u20133739","journal-title":"Blood"},{"key":"2061_CR27","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1182\/blood-2008-01-134262","volume":"113","author":"J Zhang","year":"2009","unstructured":"Zhang J, Wang J, Liu Y, Sidik H, Young KH, Lodish HF et al (2009) Oncogenic Kras-induced leukemogenesis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation. Blood 113:1304\u20131314","journal-title":"Blood"},{"key":"2061_CR28","first-page":"5211","volume":"56","author":"HM Koo","year":"1996","unstructured":"Koo HM, Monks A, Mikheev A, Rubinstein LV, Gray-Goodrich M, McWilliams MJ et al (1996) Enhanced sensitivity to 1-beta-d-arabinofuranosylcytosine and topoisomerase II inhibitors in tumor cell lines harboring activated ras oncogenes. Cancer Res 56:5211\u20135216","journal-title":"Cancer Res"},{"key":"2061_CR29","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1158\/1078-0432.CCR-04-2232","volume":"11","author":"T Illmer","year":"2005","unstructured":"Illmer T, Thiede C, Fredersdorf A, Stadler S, Neubauer A, Ehninger G et al (2005) Activation of the RAS pathway is predictive for a chemosensitive phenotype of acute myelogenous leukemia blasts. Clin Cancer Res 11:3217\u20133224","journal-title":"Clin Cancer Res"},{"issue":"1","key":"2061_CR30","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000356651","volume":"33","author":"S Zhao","year":"2014","unstructured":"Zhao S, Zhang Y, Sha K, Tang Q, Yang X, Yu C et al (2014) KRAS (G12D) Cooperates with AML1\/ETO to initiate a mouse model mimicking human acute myeloid leukemia. Cell Physiol Biochem 33(1):78\u201387","journal-title":"Cell Physiol Biochem"},{"issue":"25","key":"2061_CR31","doi-asserted-by":"crossref","first-page":"18219","DOI":"10.1074\/jbc.M113.475376","volume":"288","author":"G Kong","year":"2013","unstructured":"Kong G, Du J, Liu Y, Meline B, Chang YI, Ranheim EA, Wang J, Zhang J (2013) Notch1 gene mutations target KRAS G12D-expressing CD8+ cells and contribute to their leukemogenic transformation. J Biol Chem 288(25):18219\u201318227","journal-title":"J Biol Chem"},{"key":"2061_CR32","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/nature07485","volume":"456","author":"TJ Ley","year":"2008","unstructured":"Ley TJ, Mardis ER, Ding L, Fulton B, McLellan MD, Chen K et al (2008) DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature 456:66\u201372","journal-title":"Nature"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-014-2061-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00277-014-2061-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-014-2061-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T20:59:15Z","timestamp":1597697955000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00277-014-2061-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,16]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["2061"],"URL":"https:\/\/doi.org\/10.1007\/s00277-014-2061-9","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,16]]}}}