{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T04:20:29Z","timestamp":1769746829931,"version":"3.49.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2017,7,9]],"date-time":"2017-07-09T00:00:00Z","timestamp":1499558400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1007\/s00277-017-3055-1","type":"journal-article","created":{"date-parts":[[2017,7,9]],"date-time":"2017-07-09T08:07:04Z","timestamp":1499587624000},"page":"1493-1500","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Telomere shortening, TP53 mutations and deletions in chronic lymphocytic leukemia result in increased chromosomal instability and breakpoint clustering in heterochromatic regions"],"prefix":"10.1007","volume":"96","author":[{"given":"Kathrin","family":"Thomay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Fedder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winfried","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Kreipe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Stadler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Titgemeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo","family":"Zander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Schlegelberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gudrun","family":"G\u00f6hring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,7,9]]},"reference":[{"key":"3055_CR1","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1056\/NEJM200012283432602","volume":"343","author":"H Dohner","year":"2000","unstructured":"Dohner H, Stilgenbauer S, Benner A et al (2000) Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 343:1910\u20131916","journal-title":"N Engl J Med"},{"key":"3055_CR2","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/ajh.23491","volume":"88","author":"M Hallek","year":"2013","unstructured":"Hallek M (2013) Chronic lymphocytic leukemia: 2013 update on diagnosis, risk stratification and treatment. Am J Hematol 88:803\u2013816","journal-title":"Am J Hematol"},{"key":"3055_CR3","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/gcc.22293","volume":"54","author":"GM Rigolin","year":"2015","unstructured":"Rigolin GM, Del Giudice I, Formigaro L et al (2015) Chromosome aberrations detected by conventional karyotyping using novel mitogens in chronic lymphocytic leukemia: clinical and biologic correlations. Genes Chromosomes Cancer 54:818\u2013826","journal-title":"Genes Chromosomes Cancer"},{"key":"3055_CR4","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1182\/blood.V89.7.2516","volume":"89","author":"H Dohner","year":"1997","unstructured":"Dohner H, Stilgenbauer S, James MR et al (1997) 11q deletions identify a new subset of B cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis. Blood 89:2516\u20132522","journal-title":"Blood"},{"key":"3055_CR5","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1182\/blood-2013-05-498287","volume":"122","author":"M Hallek","year":"2013","unstructured":"Hallek M (2013) Signaling the end of chronic lymphocytic leukemia: new frontline treatment strategies. Blood 122:3723\u20133734","journal-title":"Blood"},{"key":"3055_CR6","doi-asserted-by":"crossref","unstructured":"Dos Santos P, Panero J, Palau Nagore V, Stanganelli C, Bezares RF, Slavutsky I (2015) Telomere shortening associated with increased genomic complexity in chronic lymphocytic leukemia. Tumour Biol","DOI":"10.1007\/s13277-015-3556-2"},{"key":"3055_CR7","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/gcc.22171","volume":"53","author":"M Hoxha","year":"2014","unstructured":"Hoxha M, Fabris S, Agnelli L et al (2014) Relevance of telomere\/telomerase system impairment in early stage chronic lymphocytic leukemia. Genes Chromosomes Cancer 53:612\u2013621","journal-title":"Genes Chromosomes Cancer"},{"key":"3055_CR8","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/bjh.13023","volume":"167","author":"TT Lin","year":"2014","unstructured":"Lin TT, Norris K, Heppel NH et al (2014) Telomere dysfunction accurately predicts clinical outcome in chronic lymphocytic leukaemia, even in patients with early stage disease. Br J Haematol 167:214\u2013223","journal-title":"Br J Haematol"},{"key":"3055_CR9","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.blre.2011.02.002","volume":"25","author":"T Zenz","year":"2011","unstructured":"Zenz T, Mertens D, Dohner H, Stilgenbauer S (2011) Importance of genetics in chronic lymphocytic leukemia. Blood Rev 25:131\u2013137","journal-title":"Blood Rev"},{"key":"3055_CR10","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/leu.2012.194","volume":"27","author":"L Veronese","year":"2013","unstructured":"Veronese L, Tournilhac O, Callanan M et al (2013) Telomeres and chromosomal instability in chronic lymphocytic leukemia. Leukemia 27:490\u2013493","journal-title":"Leukemia"},{"key":"3055_CR11","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1093\/carcin\/bgh296","volume":"26","author":"JW Shay","year":"2005","unstructured":"Shay JW, Wright WE (2005) Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis 26:867\u2013874","journal-title":"Carcinogenesis"},{"key":"3055_CR12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3324\/haematol.2011.057109","volume":"97","author":"D Rossi","year":"2012","unstructured":"Rossi D, Gaidano G (2012) ATM and chronic lymphocytic leukemia: mutations, and not only deletions, matter. Haematologica 97:5\u20138","journal-title":"Haematologica"},{"key":"3055_CR13","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.leukres.2009.10.027","volume":"34","author":"K Lange","year":"2010","unstructured":"Lange K, Gadzicki D, Schlegelberger B, Gohring G (2010) Recurrent involvement of heterochromatic regions in multiple myeloma\u2014a multicolor FISH study. Leuk Res 34:1002\u20131006","journal-title":"Leuk Res"},{"key":"3055_CR14","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1093\/bioinformatics\/bti146","volume":"21","author":"B Hiller","year":"2005","unstructured":"Hiller B, Bradtke J, Balz H, Rieder H (2005) CyDAS: a cytogenetic data analysis system. Bioinformatics 21:1282\u20131283","journal-title":"Bioinformatics"},{"key":"3055_CR15","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00277-007-0337-z","volume":"86","author":"G Gohring","year":"2007","unstructured":"Gohring G, Karow A, Steinemann D et al (2007) Chromosomal aberrations in congenital bone marrow failure disorders\u2014an early indicator for leukemogenesis? Ann Hematol 86:733\u2013739","journal-title":"Ann Hematol"},{"key":"3055_CR16","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.cancergencyto.2010.07.128","volume":"203","author":"NA Heerema","year":"2010","unstructured":"Heerema NA, Byrd JC, Dal Cin PS et al (2010) Stimulation of chronic lymphocytic leukemia cells with CpG oligodeoxynucleotide gives consistent karyotypic results among laboratories: a CLL research consortium (CRC) study. Cancer Genet Cytogenet 203:134\u2013140","journal-title":"Cancer Genet Cytogenet"},{"key":"3055_CR17","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/S0002-9440(10)63534-1","volume":"163","author":"S Perner","year":"2003","unstructured":"Perner S, Bruderlein S, Hasel C et al (2003) Quantifying telomere lengths of human individual chromosome arms by centromere-calibrated fluorescence in situ hybridization and digital imaging. Am J Pathol 163:1751\u20131756","journal-title":"Am J Pathol"},{"key":"3055_CR18","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1186\/1471-2164-15-784","volume":"15","author":"S Feurstein","year":"2014","unstructured":"Feurstein S, Rucker FG, Bullinger L et al (2014) Haploinsufficiency of ETV6 and CDKN1B in patients with acute myeloid leukemia and complex karyotype. BMC Genomics 15:784","journal-title":"BMC Genomics"},{"key":"3055_CR19","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1038\/sj.leu.2404935","volume":"21","author":"C Haferlach","year":"2007","unstructured":"Haferlach C, Dicker F, Schnittger S, Kern W, Haferlach T (2007) Comprehensive genetic characterization of CLL: a study on 506 cases analysed with chromosome banding analysis, interphase FISH, IgV (H) status and immunophenotyping. Leukemia 21:2442\u20132451","journal-title":"Leukemia"},{"key":"3055_CR20","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.1002\/cncr.29566","volume":"121","author":"PA Thompson","year":"2015","unstructured":"Thompson PA, O'Brien SM, Wierda WG et al (2015) Complex karyotype is a stronger predictor than del (17p) for an inferior outcome in relapsed or refractory chronic lymphocytic leukemia patients treated with ibrutinib-based regimens. Cancer 121:3612\u20133621","journal-title":"Cancer"},{"key":"3055_CR21","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3324\/haematol.2011.048827","volume":"97","author":"A Skowronska","year":"2012","unstructured":"Skowronska A, Austen B, Powell JE et al (2012) ATM germline heterozygosity does not play a role in chronic lymphocytic leukemia initiation but influences rapid disease progression through loss of the remaining ATM allele. Haematologica 97:142\u2013146","journal-title":"Haematologica"},{"key":"3055_CR22","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0165-4608(98)00284-2","volume":"113","author":"MJ Bargetzi","year":"1999","unstructured":"Bargetzi MJ, Muhlematter D, Tichelli A, Jotterand M, Wernli M (1999) Dicentric translocation (9;12) presenting as refractory Philadelphia chromosome-positive acute B cell lymphoblastic leukemia. Cancer Genet Cytogenet 113:90\u201392","journal-title":"Cancer Genet Cytogenet"},{"key":"3055_CR23","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0092-8674(01)00542-6","volume":"107","author":"AH Peters","year":"2001","unstructured":"Peters AH, O'Carroll D, Scherthan H et al (2001) Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell 107:323\u2013337","journal-title":"Cell"},{"key":"3055_CR24","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1101\/gad.300704","volume":"18","author":"G Schotta","year":"2004","unstructured":"Schotta G, Lachner M, Sarma K et al (2004) A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev 18:1251\u20131262","journal-title":"Genes Dev"},{"key":"3055_CR25","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev.cellbio.22.010305.104518","volume":"22","author":"SA Stewart","year":"2006","unstructured":"Stewart SA, Weinberg RA (2006) Telomeres: cancer to human aging. Annu Rev Cell Dev Biol 22:531\u2013557","journal-title":"Annu Rev Cell Dev Biol"},{"key":"3055_CR26","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0092-8674(01)00492-5","volume":"106","author":"EH Blackburn","year":"2001","unstructured":"Blackburn EH (2001) Switching and signaling at the telomere. Cell 106:661\u2013673","journal-title":"Cell"},{"key":"3055_CR27","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/nchembio.2007.38","volume":"3","author":"MA Blasco","year":"2007","unstructured":"Blasco MA (2007) Telomere length, stem cells and aging. Nat Chem Biol 3:640\u2013649","journal-title":"Nat Chem Biol"},{"key":"3055_CR28","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.3892\/ol.2016.4388","volume":"11","author":"E Alhourani","year":"2016","unstructured":"Alhourani E, Othman MA, Melo JB et al (2016) BIRC3 alterations in chronic and B-cell acute lymphocytic leukemia patients. Oncol Lett 11:3240\u20133246","journal-title":"Oncol Lett"},{"key":"3055_CR29","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/leu.2013.333","volume":"28","author":"D Cortese","year":"2014","unstructured":"Cortese D, Sutton LA, Cahill N et al (2014) On the way towards a \u201cCLL prognostic index\u201d: focus on TP53, BIRC3, SF3B1, NOTCH1 and MYD88 in a population-based cohort. Leukemia 28:710\u2013713","journal-title":"Leukemia"},{"key":"3055_CR30","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1182\/blood-2015-07-659144","volume":"127","author":"F Nadeu","year":"2016","unstructured":"Nadeu F, Delgado J, Royo C et al (2016) Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia. Blood 127:2122\u20132130","journal-title":"Blood"},{"key":"3055_CR31","doi-asserted-by":"crossref","first-page":"675","DOI":"10.3324\/haematol.2012.069369","volume":"98","author":"R Foa","year":"2013","unstructured":"Foa R, Del Giudice I, Guarini A, Rossi D, Gaidano G (2013) Clinical implications of the molecular genetics of chronic lymphocytic leukemia. Haematologica 98:675\u2013685","journal-title":"Haematologica"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00277-017-3055-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-017-3055-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-017-3055-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T21:30:31Z","timestamp":1602451831000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00277-017-3055-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,9]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["3055"],"URL":"https:\/\/doi.org\/10.1007\/s00277-017-3055-1","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,9]]}}}