{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:59:38Z","timestamp":1771657178400,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T00:00:00Z","timestamp":1501113600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1007\/s00277-017-3063-1","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T10:14:59Z","timestamp":1501150499000},"page":"1715-1726","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical dissection of thrombotic microangiopathy"],"prefix":"10.1007","volume":"96","author":[{"given":"Eunjeong","family":"Kang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin Hye","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doyeun","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwon Wook","family":"Joo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yon Su","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Soo","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seonyang","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajeong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngil","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,7,27]]},"reference":[{"key":"3063_CR1","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1056\/NEJMra1312353","volume":"371","author":"JN George","year":"2014","unstructured":"George JN, Nester CM (2014) Syndromes of thrombotic microangiopathy. N Engl J Med 371:654\u2013666","journal-title":"N Engl J Med"},{"key":"3063_CR2","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1056\/NEJMra020528","volume":"347","author":"JL Moake","year":"2002","unstructured":"Moake JL (2002) Thrombotic microangiopathies. N Engl J Med 347:589\u2013600","journal-title":"N Engl J Med"},{"key":"3063_CR3","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1093\/ndt\/gfs279","volume":"27","author":"T Barbour","year":"2012","unstructured":"Barbour T, Johnson S, Cohney S, Hughes P (2012) Thrombotic microangiopathy and associated renal disorders. Nephrol Dial Transplant 27:2673\u20132685","journal-title":"Nephrol Dial Transplant"},{"key":"3063_CR4","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1182\/blood-2015-06-640995","volume":"126","author":"RA Brodsky","year":"2015","unstructured":"Brodsky RA (2015) Complement in hemolytic anemia. Blood 126:2459\u20132465","journal-title":"Blood"},{"key":"3063_CR5","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/jth.13571","volume":"15","author":"M Scully","year":"2017","unstructured":"Scully M, Cataland S, Coppo P et al (2017) Consensus on the standardization of terminology in thrombotic thrombocytopenic purpura and related thrombotic microangiopathies. J Thromb Haemost 15:312\u2013322","journal-title":"J Thromb Haemost"},{"key":"3063_CR6","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/bjh.12569","volume":"163","author":"N Shah","year":"2013","unstructured":"Shah N, Rutherford C, Matevosyan K et al (2013) Role of ADAMTS13 in the management of thrombotic microangiopathies including thrombotic thrombocytopenic purpura (TTP). Br J Haematol 163:514\u2013519","journal-title":"Br J Haematol"},{"key":"3063_CR7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s12185-011-0771-5","volume":"93","author":"MJ Jang","year":"2011","unstructured":"Jang MJ, Chong SY, Kim IH et al (2011) Clinical features of severe acquired ADAMTS13 deficiency in thrombotic thrombocytopenic purpura: the Korean TTP registry experience. Int J Hematol 93:163\u2013169","journal-title":"Int J Hematol"},{"key":"3063_CR8","unstructured":"Group KDIGOKAKIW (2012) KDIGO clinical practice guideline for acute kidney injury. Kidney Inter (Suppl.): 1\u2013138"},{"key":"3063_CR9","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1046\/j.1526-0968.2002.00390.x","volume":"6","author":"H Baeyer von","year":"2002","unstructured":"von Baeyer H (2002) Plasmapheresis in thrombotic microangiopathy-associated syndromes: review of outcome data derived from clinical trials and open studies. Ther Apher 6:320\u2013328","journal-title":"Ther Apher"},{"key":"3063_CR10","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1007\/s00277-015-2411-2","volume":"94","author":"JN Saultz","year":"2015","unstructured":"Saultz JN, Wu HM, Cataland S (2015) Headache prevalence following recovery from TTP and aHUS. Ann Hematol 94:1473\u20131476","journal-title":"Ann Hematol"},{"key":"3063_CR11","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/sj.bmt.1705160","volume":"36","author":"MT Martinez","year":"2005","unstructured":"Martinez MT, Bucher C, Stussi G et al (2005) Transplant-associated microangiopathy (TAM) in recipients of allogeneic hematopoietic stem cell transplants. Bone Marrow Transplant 36:993\u20131000","journal-title":"Bone Marrow Transplant"},{"key":"3063_CR12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.blre.2014.11.001","volume":"29","author":"S Jodele","year":"2015","unstructured":"Jodele S, Laskin BL, Dandoy CE et al (2015) A new paradigm: diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury. Blood Rev 29:191\u2013204","journal-title":"Blood Rev"},{"key":"3063_CR13","doi-asserted-by":"crossref","first-page":"834","DOI":"10.5858\/2003-127-834-TTPAHU","volume":"127","author":"GA Hosler","year":"2003","unstructured":"Hosler GA, Cusumano AM, Hutchins GM (2003) Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome are distinct pathologic entities. A review of 56 autopsy cases. Arch Pathol Lab Med 127:834\u2013839","journal-title":"Arch Pathol Lab Med"},{"key":"3063_CR14","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1681\/ASN.2005080810","volume":"17","author":"V Eremina","year":"2006","unstructured":"Eremina V, Cui S, Gerber H et al (2006) Vascular endothelial growth factor a signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival. J Am Soc Nephrol 17:724\u2013735","journal-title":"J Am Soc Nephrol"},{"key":"3063_CR15","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.2215\/CJN.00860115","volume":"10","author":"GS Markowitz","year":"2015","unstructured":"Markowitz GS, Bomback AS, Perazella MA (2015) Drug-induced glomerular disease: direct cellular injury. Clin J Am Soc Nephrol 10:1291\u20131299","journal-title":"Clin J Am Soc Nephrol"},{"key":"3063_CR16","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1111\/j.1600-6143.2010.03156.x","volume":"10","author":"M Noris","year":"2010","unstructured":"Noris M, Remuzzi G (2010) Thrombotic microangiopathy after kidney transplantation. Am J Transplant 10:1517\u20131523","journal-title":"Am J Transplant"},{"key":"3063_CR17","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.semnephrol.2013.08.003","volume":"33","author":"D Kavanagh","year":"2013","unstructured":"Kavanagh D, Goodship TH, Richards A (2013) Atypical hemolytic uremic syndrome. Semin Nephrol 33:508\u2013530","journal-title":"Semin Nephrol"},{"key":"3063_CR18","doi-asserted-by":"crossref","first-page":"e151","DOI":"10.1097\/MJT.0b013e31829b59dc","volume":"23","author":"A Nayer","year":"2016","unstructured":"Nayer A, Asif A (2016) Atypical hemolytic-uremic syndrome: a clinical review. Am J Ther 23:e151\u2013e158","journal-title":"Am J Ther"},{"key":"3063_CR19","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1159\/000437001","volume":"41","author":"R Dahlan","year":"2015","unstructured":"Dahlan R, Sontrop JM, Li L et al (2015) Primary and secondary thrombotic microangiopathy referred to a single plasma exchange center for suspected thrombotic thrombocytopenic purpura: 2000-2011. Am J Nephrol 41:429\u2013437","journal-title":"Am J Nephrol"},{"key":"3063_CR20","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1097\/01.tp.0000230373.82376.46","volume":"82","author":"C Uderzo","year":"2006","unstructured":"Uderzo C, Bonanomi S, Busca A et al (2006) Risk factors and severe outcome in thrombotic microangiopathy after allogeneic hematopoietic stem cell transplantation. Transplantation 82:638\u2013644","journal-title":"Transplantation"},{"key":"3063_CR21","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1182\/blood-2011-02-321315","volume":"118","author":"BL Laskin","year":"2011","unstructured":"Laskin BL, Goebel J, Davies SM, Jodele S (2011) Small vessels, big trouble in the kidneys and beyond: hematopoietic stem cell transplantation-associated thrombotic microangiopathy. Blood 118:1452\u20131462","journal-title":"Blood"},{"key":"3063_CR22","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1046\/j.1600-6143.2003.00222.x","volume":"3","author":"V Karthikeyan","year":"2003","unstructured":"Karthikeyan V, Parasuraman R, Shah V et al (2003) Outcome of plasma exchange therapy in thrombotic microangiopathy after renal transplantation. Am J Transplant 3:1289\u20131294","journal-title":"Am J Transplant"},{"key":"3063_CR23","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1097\/TP.0000000000000601","volume":"99","author":"FS Fontbrune de","year":"2015","unstructured":"de Fontbrune FS, Galambrun C, Sirvent A et al (2015) Use of eculizumab in patients with allogeneic stem cell transplant-associated thrombotic microangiopathy: a study from the SFGM-TC. Transplantation 99:1953\u20131959","journal-title":"Transplantation"},{"key":"3063_CR24","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/oxfordjournals.ndt.a027822","volume":"13","author":"F Bridoux","year":"1998","unstructured":"Bridoux F, Vrtovsnik F, Noel C et al (1998) Renal thrombotic microangiopathy in systemic lupus erythematosus: clinical correlations and long-term renal survival. Nephrol Dial Transplant 13:298\u2013304","journal-title":"Nephrol Dial Transplant"},{"key":"3063_CR25","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/jth.12826","volume":"13","author":"L Zafrani","year":"2015","unstructured":"Zafrani L, Mariotte E, Darmon M et al (2015) Acute renal failure is prevalent in patients with thrombotic thrombocytopenic purpura associated with low plasma ADAMTS13 activity. J Thromb Haemost 13:380\u2013389","journal-title":"J Thromb Haemost"},{"key":"3063_CR26","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1182\/blood-2005-10-007252","volume":"108","author":"J Caprioli","year":"2006","unstructured":"Caprioli J, Noris M, Brioschi S et al (2006) Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome. Blood 108:1267\u20131279","journal-title":"Blood"},{"key":"3063_CR27","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1056\/NEJM199910073411506","volume":"341","author":"E Ritz","year":"1999","unstructured":"Ritz E, Orth SR (1999) Nephropathy in patients with type 2 diabetes mellitus. N Engl J Med 341:1127\u20131133","journal-title":"N Engl J Med"},{"key":"3063_CR28","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1038\/ki.1996.527","volume":"50","author":"M Krolewski","year":"1996","unstructured":"Krolewski M, Eggers PW, Warram JH (1996) Magnitude of end-stage renal disease in IDDM: a 35 year follow-up study. Kidney Int 50:2041\u20132046","journal-title":"Kidney Int"},{"key":"3063_CR29","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.2215\/CJN.04500511","volume":"7","author":"YH Chou","year":"2012","unstructured":"Chou YH, Lien YC, Hu FC et al (2012) Clinical outcomes and predictors for ESRD and mortality in primary GN. Clin J Am Soc Nephrol 7:1401\u20131408","journal-title":"Clin J Am Soc Nephrol"},{"key":"3063_CR30","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1093\/ndt\/12.12.2569","volume":"12","author":"L Frimat","year":"1997","unstructured":"Frimat L, Briancon S, Hestin D et al (1997) IgA nephropathy: prognostic classification of end-stage renal failure. L\u2019Association des Nephrologues de l'Est. Nephrol Dial Transplant 12:2569\u20132575","journal-title":"Nephrol Dial Transplant"},{"key":"3063_CR31","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1471-2369-15-94","volume":"15","author":"H Lee","year":"2014","unstructured":"Lee H, Hwang JH, Paik JH et al (2014) Long-term prognosis of clinically early IgA nephropathy is not always favorable. BMC Nephrol 15:94","journal-title":"BMC Nephrol"},{"key":"3063_CR32","volume":"7","author":"J Xie","year":"2012","unstructured":"Xie J, Kiryluk K, Wang W et al (2012) Predicting progression of IgA nephropathy: new clinical progression risk score. PLoS One 7:e38904","journal-title":"PLoS One"},{"key":"3063_CR33","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.krcp.2015.08.004","volume":"34","author":"DC Jin","year":"2015","unstructured":"Jin DC, Yun SR, Lee SW et al (2015) Lessons from 30 years\u2019 data of Korean end-stage renal disease registry, 1985-2015. Kidney Res Clin Pract 34:132\u2013139","journal-title":"Kidney Res Clin Pract"},{"key":"3063_CR34","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1007\/s00467-012-2276-8","volume":"27","author":"R Vilalta","year":"2012","unstructured":"Vilalta R, Lara E, Madrid A et al (2012) Long-term eculizumab improves clinical outcomes in atypical hemolytic uremic syndrome. Pediatr Nephrol 27:2323\u20132326","journal-title":"Pediatr Nephrol"},{"key":"3063_CR35","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.transci.2016.09.017","volume":"55","author":"F Gediz","year":"2016","unstructured":"Gediz F, Payzin BK, Ecemis S et al (2016) Efficacy and safety of eculizumab in adult patients with atypical hemolytic uremic syndrome: a single center experience from Turkey. Transfus Apher Sci 55:357\u2013362","journal-title":"Transfus Apher Sci"},{"key":"3063_CR36","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1182\/asheducation.V2012.1.604.3798564","volume":"2012","author":"JN George","year":"2012","unstructured":"George JN, Al-Nouri ZL (2012) Diagnostic and therapeutic challenges in the thrombotic thrombocytopenic purpura and hemolytic uremic syndromes. Hematol Am Soc Hematol Educ Program 2012:604\u2013609","journal-title":"Hematol Am Soc Hematol Educ Program"},{"key":"3063_CR37","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3349\/ymj.2006.47.3.437","volume":"47","author":"WK Bae","year":"2006","unstructured":"Bae WK, Lee YK, Cho MS et al (2006) A case of hemolytic uremic syndrome caused by Escherichia coli O104:H4. Yonsei Med J 47:437\u2013439","journal-title":"Yonsei Med J"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00277-017-3063-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-017-3063-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-017-3063-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T14:41:30Z","timestamp":1659278490000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00277-017-3063-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,27]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["3063"],"URL":"https:\/\/doi.org\/10.1007\/s00277-017-3063-1","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,27]]}}}