{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:51:30Z","timestamp":1790419890074,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,1,13]],"date-time":"2018-01-13T00:00:00Z","timestamp":1515801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"the National Science Foundation of China","award":["81470301, 81670128"],"award-info":[{"award-number":["81470301, 81670128"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1007\/s00277-018-3228-6","type":"journal-article","created":{"date-parts":[[2018,1,13]],"date-time":"2018-01-13T04:42:19Z","timestamp":1515818539000},"page":"605-616","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Phosphatidylserine-exposing blood and endothelial cells contribute to the hypercoagulable state in essential thrombocythemia patients"],"prefix":"10.1007","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1932-6898","authenticated-orcid":false,"given":"Dongxia","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muxin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihe","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie A.","family":"Novakovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengxiang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Kou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayan","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,1,13]]},"reference":[{"issue":"5","key":"3228_CR1","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1038\/leu.2008.72","volume":"22","author":"F Cervantes","year":"2008","unstructured":"Cervantes F, Passamonti F, Barosi G (2008) Life expectancy and prognostic factors in the classic BCR\/ABL-negative myeloproliferative disorders. Leukemia 22(5):905\u2013914. https:\/\/doi.org\/10.1038\/leu.2008.72","journal-title":"Leukemia"},{"issue":"1","key":"3228_CR2","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1002\/ajh.24607","volume":"92","author":"A Tefferi","year":"2017","unstructured":"Tefferi A, Barbui T (2017) Polycythemia vera and essential thrombocythemia: 2017 update on diagnosis, risk-stratification, and management. Am J Hematol 92(1):94\u2013108. https:\/\/doi.org\/10.1002\/ajh.24607","journal-title":"Am J Hematol"},{"key":"3228_CR3","doi-asserted-by":"publisher","first-page":"5857","DOI":"10.1182\/blood-2011-02-339002","volume":"17","author":"A Carobbio","year":"2011","unstructured":"Carobbio A, Thiele J, Passamonti F et al (2011) Risk factors for arterial and venous thrombosis in WHO-defined essential thrombocythemia: an international study of 891 patients. Blood 17:5857\u20135859","journal-title":"Blood"},{"issue":"4","key":"3228_CR4","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/leu.2011.314","volume":"26","author":"H Reikvam","year":"2012","unstructured":"Reikvam H (2012) Venous thromboembolism in patients with essential thrombocythemia and polycythemia vera. Leukemia 26(4):563\u2013571. https:\/\/doi.org\/10.1038\/leu.2011.314","journal-title":"Leukemia"},{"issue":"1","key":"3228_CR5","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1056\/NEJMoa043800","volume":"353","author":"CN Harrison","year":"2005","unstructured":"Harrison CN, Campbell PJ, Buck G, Wheatley K, East CL, Bareford D, Wilkins BS, van der Walt JD, Reilly JT, Grigg AP, Revell P, Woodcock BE, Green AR, United Kingdom Medical Research Council Primary Thrombocythemia 1 Study (2005) Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia. N Engl J Med 353(1):33\u201345. https:\/\/doi.org\/10.1056\/NEJMoa043800","journal-title":"N Engl J Med"},{"issue":"10","key":"3228_CR6","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1182\/blood-2012-07-443770","volume":"121","author":"H Gisslinger","year":"2013","unstructured":"Gisslinger H, Gotic M, Holowiecki J, Penka M, Thiele J, Kvasnicka HM, Kralovics R, Petrides PE, for all members of the ANAHYDRET Study Group (2013) Anagrelide compared with hydroxyurea in WHO-classified essential thrombocythemia: the ANAHYDRET Study, a randomized controlled trial. Blood 121(10):1720\u20131728. https:\/\/doi.org\/10.1182\/blood-2012-07-443770","journal-title":"Blood"},{"issue":"10","key":"3228_CR7","doi-asserted-by":"publisher","first-page":"4061","DOI":"10.1182\/blood-2008-06-164087","volume":"112","author":"M Marchetti","year":"2008","unstructured":"Marchetti M, Castoldi E, Spronk HM et al (2008) Thrombin generation and activated protein C resistance in patients with essential thrombocythemia and polycythemia vera. Blood 112(10):4061\u20134068. https:\/\/doi.org\/10.1182\/blood-2008-06-164087","journal-title":"Blood"},{"issue":"3","key":"3228_CR8","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/j.1365-2141.2004.05277.x","volume":"128","author":"MA Elliott","year":"2005","unstructured":"Elliott MA, Tefferi A (2005) Thrombosis and haemorrhage in polycythaemia vera and essential thrombocythaemia. Br J Haematol 128(3):275\u2013290. https:\/\/doi.org\/10.1111\/j.1365-2141.2004.05277.x","journal-title":"Br J Haematol"},{"issue":"5","key":"3228_CR9","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1002\/ajh.24338","volume":"91","author":"YC Elala","year":"2016","unstructured":"Elala YC, Lasho TL, Gangat N, Finke C, Barraco D, Haider M, Abou Hussein AK, Hanson CA, Ketterling RP, Pardanani A, Tefferi A (2016) Calreticulin variant stratified driver mutational status and prognosis in essential thrombocythemia. Am J Hematol 91(5):503\u2013506. https:\/\/doi.org\/10.1002\/ajh.24338","journal-title":"Am J Hematol"},{"issue":"7","key":"3228_CR10","doi-asserted-by":"publisher","first-page":"893","DOI":"10.3324\/haematol.2014.118299","volume":"100","author":"C Assaf Al","year":"2015","unstructured":"Al Assaf C, Van Obbergh F, Billiet J, Lierman E, Devos T, Graux C, Hervent AS, Emmerechts J, Tousseyn T, de Paepe P, Papadopoulos P, Michaux L, Vandenberghe P (2015) Analysis of phenotype and outcome in essential thrombocythemia with CALR or JAK2 mutations. Haematologica 100(7):893\u2013897. https:\/\/doi.org\/10.3324\/haematol.2014.118299","journal-title":"Haematologica"},{"issue":"1","key":"3228_CR11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/ejh.12389","volume":"94","author":"N Gangat","year":"2015","unstructured":"Gangat N, Wassie EA, Lasho TL, Finke C, Ketterling RP, Hanson CA, Pardanani A, Wolanskyj AP, Maffioli M, Casalone R, Passamonti F, Tefferi A (2015) Mutations and thrombosis in essential thrombocythemia: prognostic interaction with age and thrombosis history. Eur J Haematol 94(1):31\u201336. https:\/\/doi.org\/10.1111\/ejh.12389","journal-title":"Eur J Haematol"},{"issue":"2","key":"3228_CR12","first-page":"169","volume":"91","author":"E Arellano-Rodrigo","year":"2006","unstructured":"Arellano-Rodrigo E, Alvarez-Larran A, Reverter JC et al (2006) Increased platelet and leukocyte activation as contributing mechanisms for thrombosis in essential thrombocythemia and correlation with the JAK2 mutational status. Haematologica 91(2):169\u2013175","journal-title":"Haematologica"},{"issue":"10","key":"3228_CR13","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1182\/blood-2012-10-429134","volume":"121","author":"C Patrono","year":"2013","unstructured":"Patrono C, Rocca B (2013) Platelet activation and inhibition in polycythemia vera and essential thrombocythemia. Blood 121(10):1701\u20131711. https:\/\/doi.org\/10.1182\/blood-2012-10-429134","journal-title":"Blood"},{"issue":"11","key":"3228_CR14","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.3324\/haematol.2009.013375","volume":"94","author":"F Cervantes","year":"2009","unstructured":"Cervantes F, Arellano-Rodrigo E, Alvarez-Larr\u00e1n A (2009) Blood cell activation in the myeloproliferative neoplasms. Haematologica 94(11):1484\u20131488. https:\/\/doi.org\/10.3324\/haematol.2009.013375","journal-title":"Haematologica"},{"issue":"4","key":"3228_CR15","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1002\/ajh.21974","volume":"86","author":"M Panova-Noeva","year":"2011","unstructured":"Panova-Noeva M, Marchetti M, Spronk HM, Russo L, Diani E, Finazzi G, Salmoiraghi S, Rambaldi A, Barbui T, ten Cate H, Falanga A (2011) Platelet-induced thrombin generation by the calibrated automated thrombogram assay is increased in patients with essential thrombocythemia and polycythemia vera. Am J Hematol 86(4):337\u2013342. https:\/\/doi.org\/10.1002\/ajh.21974","journal-title":"Am J Hematol"},{"issue":"Suppl 1","key":"3228_CR16","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/jth.12228","volume":"1","author":"VM Chen","year":"2013","unstructured":"Chen VM, Hogg PJ (2013) Encryption and decryption of tissue factor. J Thromb Haemost 1(Suppl 1):277\u2013284","journal-title":"J Thromb Haemost"},{"issue":"5860","key":"3228_CR17","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1126\/science.1152066","volume":"319","author":"T Yeung","year":"2008","unstructured":"Yeung T, Gilbert GE, Shi J, Silvius J, Kapus A, Grinstein S (2008) Membrane phosphatidylserine regulates surface charge and protein localisation. Science 319(5860):210\u2013213. https:\/\/doi.org\/10.1126\/science.1152066","journal-title":"Science"},{"issue":"4","key":"3228_CR18","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1160\/TH15-09-0710","volume":"115","author":"Z He","year":"2016","unstructured":"He Z, Si Y, Jiang T, Ma R, Zhang Y, Cao M, Li T, Yao Z, Zhao L, Fang S, Yu B, Dong Z, Thatte HS, Bi Y, Kou J, Yang S, Piao D, Hao L, Zhou J, Shi J (2016) Phosphotidylserine exposure and neutrophil extracellular traps enhance procoagulant activity in patients with inflammatory bowel disease. Thromb Haemost 115(4):738\u2013751. https:\/\/doi.org\/10.1160\/TH15-09-0710","journal-title":"Thromb Haemost"},{"issue":"8","key":"3228_CR19","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1111\/j.1538-7836.2004.00837.x","volume":"2","author":"M Bonomini","year":"2004","unstructured":"Bonomini M, Dottori S, Amoroso L, Arduini A, Sirolli V (2004) Increased platelet phosphatidylserine exposure and caspase activation in chronic uremia. J Thromb Haemost 2(8):1275\u20131281. https:\/\/doi.org\/10.1111\/j.1538-7836.2004.00837.x","journal-title":"J Thromb Haemost"},{"issue":"6","key":"3228_CR20","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1160\/TH12-11-0811","volume":"109","author":"X Tan","year":"2013","unstructured":"Tan X, Shi J, Fu Y, Gao C, Yang X, Li J, Wang W, Hou J, Li H, Zhou J (2013) Role of erythrocytes and platelets in the hypercoagulable status in polycythemia vera through phosphatidylserine exposure and microparticle generation. Thromb Haemost 109(6):1025\u20131032. https:\/\/doi.org\/10.1160\/TH12-11-0811","journal-title":"Thromb Haemost"},{"issue":"2","key":"3228_CR21","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1002\/ajh.21338","volume":"84","author":"E Arellano-Rodrigo","year":"2009","unstructured":"Arellano-Rodrigo E, Alvarez-Larran A, Reverter JC et al (2009) Platelet turnover, coagulation factors, and soluble markers of platelet and endothelial activation in essential thrombocythemia: relationship with thrombosis occurrence and JAK2 V617F allele burden. Am J Hematol 84(2):102\u2013108. https:\/\/doi.org\/10.1002\/ajh.21338","journal-title":"Am J Hematol"},{"issue":"23","key":"3228_CR22","doi-asserted-by":"publisher","first-page":"3787","DOI":"10.1182\/blood-2013-06-501452","volume":"122","author":"CM Hobbs","year":"2013","unstructured":"Hobbs CM, Manning H, Bennett C, Vasquez L, Severin S, Brain L, Mazharian A, Guerrero JA, Li J, Soranzo N, Green AR, Watson SP, Ghevaert C (2013) JAK2V617F leads to intrinsic changes in platelet formation and reactivity in a knock-in mouse model of essential thrombocythemia. Blood 122(23):3787\u20133797. https:\/\/doi.org\/10.1182\/blood-2013-06-501452","journal-title":"Blood"},{"issue":"2","key":"3228_CR23","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/j.1423-0410.2010.01375.x","volume":"100","author":"J Hou","year":"2011","unstructured":"Hou J, Fu Y, Zhou J, Li W, Xie R, Cao F, Gilbert GE, Shi J (2011) Lactadherin functions as a probe for phosphatidylserine exposure and as an anticoagulant in the study of stored platelets. Vox Sang 100(2):187\u2013195. https:\/\/doi.org\/10.1111\/j.1423-0410.2010.01375.x","journal-title":"Vox Sang"},{"issue":"7","key":"3228_CR24","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.1182\/blood-2002-07-1951","volume":"101","author":"J Shi","year":"2003","unstructured":"Shi J, Gilbert GE (2003) Lactadherin inhibits enzyme complexes of blood coagulation by competing for phospholipid-binding sites. Blood 101(7):2628\u20132636. https:\/\/doi.org\/10.1182\/blood-2002-07-1951","journal-title":"Blood"},{"issue":"5","key":"3228_CR25","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1007\/s12185-010-0596-7","volume":"91","author":"J Treli\u0144ski","year":"2010","unstructured":"Treli\u0144ski J, Wierzbowska A, Krawczy\u0144ska A, Sakowicz A, Pietrucha T, Smolewski P, Robak T, Chojnowski K (2010) Circulating endothelial cells in essential thrombocythemia and polycythemia vera: correlation with JAK2-V617F mutational status, angiogenic factors and coagulation activation markers. Int J Hematol 91(5):792\u2013798. https:\/\/doi.org\/10.1007\/s12185-010-0596-7","journal-title":"Int J Hematol"},{"issue":"13","key":"3228_CR26","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1182\/blood.V96.13.4261","volume":"96","author":"A Falanga","year":"2000","unstructured":"Falanga A, Marchetti M, Evangelista V, Vignoli A, Licini M, Balicco M, Manarini S, Finazzi G, Cerletti C, Barbui T (2000) Polymorphonuclear leukocyte activation and hemostasis in patients with essential thrombocythemia and polycythemia vera. Blood 96(13):4261\u20134266","journal-title":"Blood"},{"issue":"9464","key":"3228_CR27","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/S0140-6736(05)74230-6","volume":"365","author":"EJ Baxter","year":"2005","unstructured":"Baxter EJ, Scott LM, Campbell PJ et al (2005) Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 365(9464):1054\u20131061. https:\/\/doi.org\/10.1016\/S0140-6736(05)74230-6","journal-title":"Lancet"},{"issue":"25","key":"3228_CR28","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1056\/NEJMoa1312542","volume":"369","author":"J Nangalia","year":"2013","unstructured":"Nangalia J, Massie CE, Baxter EJ, Nice FL, Gundem G, Wedge DC, Avezov E, Li J, Kollmann K, Kent DG, Aziz A, Godfrey AL, Hinton J, Martincorena I, van Loo P, Jones AV, Guglielmelli P, Tarpey P, Harding HP, Fitzpatrick JD, Goudie CT, Ortmann CA, Loughran SJ, Raine K, Jones DR, Butler AP, Teague JW, O'Meara S, McLaren S, Bianchi M, Silber Y, Dimitropoulou D, Bloxham D, Mudie L, Maddison M, Robinson B, Keohane C, Maclean C, Hill K, Orchard K, Tauro S, Du MQ, Greaves M, Bowen D, Huntly BJP, Harrison CN, Cross NCP, Ron D, Vannucchi AM, Papaemmanuil E, Campbell PJ, Green AR (2013) Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med 369(25):2391\u20132405. https:\/\/doi.org\/10.1056\/NEJMoa1312542","journal-title":"N Engl J Med"},{"issue":"1","key":"3228_CR29","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.thromres.2013.05.003","volume":"132","author":"M Panova-Noeva","year":"2013","unstructured":"Panova-Noeva M, Marchetti M, Russo L, Tartari CJ, Leuzzi A, Finazzi G, Rambaldi A, ten Cate H, Falanga A (2013) ADP-induced platelet aggregation and thrombin generation are increased in essential thrombocythemia and polycythemia vera. Thromb Res 132(1):88\u201393. https:\/\/doi.org\/10.1016\/j.thromres.2013.05.003","journal-title":"Thromb Res"},{"issue":"1","key":"3228_CR30","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1177\/107602960200800104","volume":"8","author":"K Presseizen","year":"2002","unstructured":"Presseizen K, Friedman Z, Shapiro H, Radnay J, Ellis MH (2002) Phosphatidylserine expression on the platelet membrane of patients with myeloproliferative disorders and its effect on platelet-dependent thrombin formation. Clin Appl Thromb Hemost 8(1):33\u201339. https:\/\/doi.org\/10.1177\/107602960200800104","journal-title":"Clin Appl Thromb Hemost"},{"issue":"3","key":"3228_CR31","first-page":"273","volume":"89","author":"DT Covas","year":"2004","unstructured":"Covas DT, de Lucena AI, Vianna Bonini Palma P (2004) Effects of hydroxyurea on the membrane of erythrocytes and platelets in sickle cell anemia. Haematologica 89(3):273\u2013280","journal-title":"Haematologica"},{"issue":"2","key":"3228_CR32","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.beha.2014.07.005","volume":"27","author":"F Passamonti","year":"2014","unstructured":"Passamonti F, Caramazza D, Mora B, Casalone R, Maffioli M (2014) It is time to change thrombosis risk assessment for PV and ET? Best Pract Res Clin Haematol 27(2):121\u2013127. https:\/\/doi.org\/10.1016\/j.beha.2014.07.005","journal-title":"Best Pract Res Clin Haematol"},{"key":"3228_CR33","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1111\/bjh.14202","volume":"179","author":"V Buxhofer-Ausch","year":"2016","unstructured":"Buxhofer-Ausch V, Gisslinger B, Schalling M et al (2016) Impact of white blood cell counts at diagnosis and during follow-up in patients with essential thrombocythaemia and prefibrotic primary myelofibrosis. Br J Haematol 179:166\u2013169","journal-title":"Br J Haematol"},{"issue":"2","key":"3228_CR34","doi-asserted-by":"publisher","first-page":"315","DOI":"10.3324\/haematol.2010.031070","volume":"96","author":"T Barbui","year":"2011","unstructured":"Barbui T, Carobbio A, Finazzi G, Vannucchi AM, Barosi G, Antonioli E, Guglielmelli P, Pancrazzi A, Salmoiraghi S, Zilio P, Ottomano C, Marchioli R, Cuccovillo I, Bottazzi B, Mantovani A, Rambaldi A, on behalf of the AGIMM and IIC Investigators (2011) Inflammation and thrombosis in essential thrombocythemia and polycythemia vera: different role of C-reactive protein and pentraxin 3. Haematologica 96(2):315\u2013318. https:\/\/doi.org\/10.3324\/haematol.2010.031070","journal-title":"Haematologica"},{"issue":"5","key":"3228_CR35","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1038\/leu.2016.12","volume":"30","author":"S Koschmieder","year":"2016","unstructured":"Koschmieder S, Mughal TI, Hasselbalch HC, Barosi G, Valent P, Kiladjian JJ, Jeryczynski G, Gisslinger H, Jutzi JS, Pahl HL, Hehlmann R, Maria Vannucchi A, Cervantes F, Silver RT, Barbui T (2016) Myeloproliferative neoplasms and inflammation: whether to target the malignant clone or the inflammatory process or both. Leukemia 30(5):1018\u20131024. https:\/\/doi.org\/10.1038\/leu.2016.12","journal-title":"Leukemia"},{"key":"3228_CR36","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1182\/asheducation-2012.1.571","volume":"2012","author":"A Falanga","year":"2012","unstructured":"Falanga A, Marchetti M (2012) Thrombotic disease in the myeloproliferative neoplasms. Hematol Am Soc Hematol Educ Program 2012:571\u2013581. https:\/\/doi.org\/10.1182\/asheducation-2012.1.571","journal-title":"Hematol Am Soc Hematol Educ Program"},{"issue":"1","key":"3228_CR37","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1097\/01.moh.0000190107.54790.de","volume":"13","author":"V Afshar-Kharghan","year":"2006","unstructured":"Afshar-Kharghan V, Thiagarajan P (2006) Leukocyte adhesion and thrombosis. Curr Opin Hematol 13(1):34\u201339. https:\/\/doi.org\/10.1097\/01.moh.0000190107.54790.de","journal-title":"Curr Opin Hematol"},{"issue":"4430","key":"3228_CR38","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1126\/science.7352265","volume":"207","author":"VT Turitto","year":"1980","unstructured":"Turitto VT, Weiss HJ (1980) Red blood cells: their dual role in thrombus formation. Science 207(4430):541\u2013543. https:\/\/doi.org\/10.1126\/science.7352265","journal-title":"Science"},{"issue":"6","key":"3228_CR39","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1159\/000369665","volume":"34","author":"Z Zidova","year":"2014","unstructured":"Zidova Z, Kapralova K, Koralkova P, Mojzikova R, Dolezal D, Divoky V, Horvathova M (2014) DMT1-mutant erythrocytes have shortened life span, accelerated glycolysis and increased oxidative stress. Cell Physiol Biochem 34(6):2221\u20132231. https:\/\/doi.org\/10.1159\/000369665","journal-title":"Cell Physiol Biochem"},{"issue":"9","key":"3228_CR40","doi-asserted-by":"publisher","first-page":"3868","DOI":"10.1096\/fj.201700012R","volume":"31","author":"I Grechowa","year":"2017","unstructured":"Grechowa I, Horke S, Wallrath A, Vahl CF, Dorweiler B (2017) Human neutrophil elastase induces endothelial cell apoptosis by activating the PERK-CHOP branch of the unfolded protein response. FASEB J 31(9):3868\u20133881. https:\/\/doi.org\/10.1096\/fj.201700012R","journal-title":"FASEB J"},{"issue":"13","key":"3228_CR41","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1182\/blood-2016-09-739334","volume":"129","author":"M Cao","year":"2017","unstructured":"Cao M, Li T, He Z, Wang L, Yang X, Kou Y, Zou L, Dong X, Novakovic VA, Bi Y, Kou J, Yu B, Fang S, Wang J, Zhou J, Shi J (2017) Promyelocytic extracellular chromatin exacerbates coagulation and fibrinolysis in acute promyelocytic leukemia. Blood 129(13):1855\u20131864. https:\/\/doi.org\/10.1182\/blood-2016-09-739334","journal-title":"Blood"},{"issue":"5","key":"3228_CR42","doi-asserted-by":"publisher","first-page":"718","DOI":"10.3324\/haematol.2012.079129","volume":"98","author":"AL Godfrey","year":"2013","unstructured":"Godfrey AL, Chen E, Pagano F, Silber Y, Campbell PJ, Green AR (2013) Clonal analyses reveal associations of JAK2V617F homozygosity with hematologic features, age and gender in polycythemia vera and essential thrombocythemia. Haematologica 98(5):718\u2013721. https:\/\/doi.org\/10.3324\/haematol.2012.079129","journal-title":"Haematologica"},{"issue":"5","key":"3228_CR43","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1111\/bjh.13539","volume":"172","author":"JM Torregrosa","year":"2016","unstructured":"Torregrosa JM, Ferrer-Mar\u00edn F, Lozano ML, Moreno MJ, Martinez C, Anton AI, Rivera J, Vicente V (2016) Impaired leucocyte activation is underlining the lower thrombotic risk of essential thrombocythaemia patients with CALR mutations as compared with those with the JAK2 mutation. Br J Haematol 172(5):813\u2013815. https:\/\/doi.org\/10.1111\/bjh.13539","journal-title":"Br J Haematol"},{"issue":"8","key":"3228_CR44","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1038\/sj.leu.2403402","volume":"18","author":"Y Kubota","year":"2004","unstructured":"Kubota Y, Ohnishi H, Kitanaka A, Ishida T, Tanaka T (2004) Constitutive activation of PI3K is involved in the spontaneous proliferation of primary acute myeloid leukemia cells: direct evidence of PI3K activation. Leukemia 18(8):1438\u20131440. https:\/\/doi.org\/10.1038\/sj.leu.2403402","journal-title":"Leukemia"},{"issue":"3","key":"3228_CR45","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.thromres.2007.12.018","volume":"122","author":"S Rafail","year":"2008","unstructured":"Rafail S, Ritis K, Schaefer K, Kourtzelis I, Speletas M, Doumas M, Giaglis S, Kambas K, Konstantinides S, Kartalis G (2008) Leptin induces the expression of functional tissue factor in human neutrophils and peripheral blood mononuclear cells through JAK2-dependent mechanisms and TNF alpha involvement. Thromb Res 122(3):366\u2013375. https:\/\/doi.org\/10.1016\/j.thromres.2007.12.018","journal-title":"Thromb Res"},{"issue":"4","key":"3228_CR46","doi-asserted-by":"publisher","first-page":"e129","DOI":"10.3324\/haematol.2015.138958","volume":"101","author":"J Asp","year":"2016","unstructured":"Asp J, Andr\u00e9asson B, Hansson U, Wasslavik C, Abelsson J, Johansson P, Palmqvist L (2016) Mutation status of essential thrombocythemia and primary myelofibrosis defines clinical outcome. Haematologica 101(4):e129\u2013e132. https:\/\/doi.org\/10.3324\/haematol.2015.138958","journal-title":"Haematologica"},{"issue":"11","key":"3228_CR47","doi-asserted-by":"publisher","first-page":"2750","DOI":"10.1097\/01.ASN.0000093253.42641.C1","volume":"14","author":"S Myssina","year":"2003","unstructured":"Myssina S, Huber SM, Birka C, Lang PA, Lang KS, Friedrich B, Risler T, Wieder T, Lang F (2003) Inhibition of erythrocyte cation channels by erythropoietin. J Am Soc Nephrol 14(11):2750\u20132757. https:\/\/doi.org\/10.1097\/01.ASN.0000093253.42641.C1","journal-title":"J Am Soc Nephrol"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00277-018-3228-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-018-3228-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-018-3228-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T11:53:56Z","timestamp":1603626836000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00277-018-3228-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,13]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["3228"],"URL":"https:\/\/doi.org\/10.1007\/s00277-018-3228-6","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,13]]},"assertion":[{"value":"22 September 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Ethics Committee of Harbin Medical University according to the Helsinki Declaration and informed consent was obtained from all individual participants included in the study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}