{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T06:23:56Z","timestamp":1749623036208,"version":"3.37.3"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1007\/s00277-018-3251-7","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T01:47:50Z","timestamp":1518140870000},"page":"899-904","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Polyneuropathy and myopathy in beta-thalassemia major patients"],"prefix":"10.1007","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5204-8856","authenticated-orcid":false,"given":"P.","family":"Nemtsas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Arnaoutoglou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Perifanis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Koutsouraki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Spanos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Arnaoutoglou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Chalkia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Pantelidou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Orologas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"issue":"11","key":"3251_CR1","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1056\/NEJMra050436","volume":"353","author":"D Rund","year":"2005","unstructured":"Rund D, Rachmilewitz E (2005) Beta-thalassemia. N Engl J Med 353(11):1135\u20131146. \n                    https:\/\/doi.org\/10.1056\/NEJMra050436","journal-title":"N Engl J Med"},{"issue":"2","key":"3251_CR2","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1097\/GIM.0b013e3181cd68ed","volume":"12","author":"A Cao","year":"2010","unstructured":"Cao A, Galanello R (2010) Beta-thalassemia. Genet Med 12(2):61\u201376. \n                    https:\/\/doi.org\/10.1097\/GIM.0b013e3181cd68ed","journal-title":"Genet Med"},{"key":"3251_CR3","unstructured":"Cappellini MD, Cohen A, Eleftheriou A et al. In Guidelines for the clinical management of thalassaemia, 2nd Revised Edition. Nicosia (CY): 2008"},{"key":"3251_CR4","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1007\/s00277-015-2378-z","volume":"94","author":"P Nemtsas","year":"2015","unstructured":"Nemtsas P, Arnaoutoglou M, Perifanis V et al (2015) Neurological complications of beta-thalassemia. Ann Hematol 94:1261\u20131265","journal-title":"Ann Hematol"},{"issue":"5","key":"3251_CR5","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.thromres.2012.07.013","volume":"130","author":"KM Musallam","year":"2012","unstructured":"Musallam KM, Taher AT, Karimi M, Rachmilewitz EA (2012) Cerebral infarction in beta-thalassemia intermedia: breaking the silence. Thromb Res 130(5):695\u2013702. \n                    https:\/\/doi.org\/10.1016\/j.thromres.2012.07.013","journal-title":"Thromb Res"},{"issue":"8","key":"3251_CR6","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1007\/s00277-016-2713-z","volume":"95","author":"M Karimi","year":"2016","unstructured":"Karimi M, Haghpanah S, Pishdad P, Rachmilewitz EA (2016) Frequency of silent cerebral ischemia in patients with transfusion-dependent beta-thalassemia major compared to healthy individuals. Ann Hematol 95(8):1387. \n                    https:\/\/doi.org\/10.1007\/s00277-016-2713-z","journal-title":"Ann Hematol"},{"issue":"5","key":"3251_CR7","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/S0887-8994(98)00004-6","volume":"18","author":"DI Zafeiriou","year":"1998","unstructured":"Zafeiriou DI, Kousi AA, Tsantali CT et al (1998) Neurophysiologic evaluation of long-term desferrioxamine therapy in beta-thalassemia patients. Pediatr Neurol 18(5):420\u2013424. \n                    https:\/\/doi.org\/10.1016\/S0887-8994(98)00004-6","journal-title":"Pediatr Neurol"},{"key":"3251_CR8","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1136\/jnnp.2003.024794","volume":"75","author":"E Stamboulis","year":"2004","unstructured":"Stamboulis E, Vlachou N, Drossou-Servou M et al (2004) Axonal sensorimotor neuropathy in patients with beta-thalassaemia. J Neurol Neurosurg Psychiatry 75:1483\u20131486","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"5","key":"3251_CR9","doi-asserted-by":"publisher","first-page":"358","DOI":"10.5144\/0256-4947.2006.358","volume":"26","author":"RA Sawaya","year":"2006","unstructured":"Sawaya RA, Zahed L, Taher A (2006) Peripheral neuropathy in thalassaemia. Ann Saudi Med 26(5):358\u2013363. \n                    https:\/\/doi.org\/10.5144\/0256-4947.2006.358","journal-title":"Ann Saudi Med"},{"key":"3251_CR10","doi-asserted-by":"publisher","first-page":"S219","DOI":"10.1016\/S1388-2457(14)50720-1","volume":"125","author":"PPV Nemtsas","year":"2014","unstructured":"Nemtsas PPV, Koutsouraki E, Orologas A, Arnaoutoglou M (2014) Is precautionary neurophysiological monitoring useful for beta-thalassemia patients? Clin Neurophysiol 125:S219. \n                    https:\/\/doi.org\/10.1016\/S1388-2457(14)50720-1","journal-title":"Clin Neurophysiol"},{"key":"3251_CR11","unstructured":"Barbara E. Shapiro DCP (2005) Electromyography and neuromuscular disorders. Elsevier"},{"key":"3251_CR12","unstructured":"J. K (2013) Electrodiagnosis in diseases of nerve and muscle principles and practice. Oxford University Press"},{"issue":"2","key":"3251_CR13","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1212\/01.WNL.0000149522.32823.EA","volume":"64","author":"JD England","year":"2005","unstructured":"England JD, Gronseth GS, Franklin G, Miller RG, Asbury AK, Carter GT, Cohen JA, Fisher MA, Howard JF, Kinsella LJ, Latov N, Lewis RA, Low PA, Sumner AJ, American Academy of Neurology, American Association of Electrodiagnostic Medicine, American Academy of Physical Medicine and Rehabilitation (2005) Distal symmetric polyneuropathy: a definition for clinical research: report of the American Academy of Neurology, the American Association of Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. Neurology 64(2):199\u2013207. \n                    https:\/\/doi.org\/10.1212\/01.WNL.0000149522.32823.EA","journal-title":"Neurology"},{"key":"3251_CR14","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1053\/euhj.2001.2822","volume":"22","author":"LJ Anderson","year":"2001","unstructured":"Anderson LJ, Holden S, Davis B et al (2001) Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J 22:2171\u20132179","journal-title":"Eur Heart J"},{"key":"3251_CR15","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/S0140-6736(04)15436-6","volume":"363","author":"Y Gandon","year":"2004","unstructured":"Gandon Y, Olivie D, Guyader D et al (2004) Non-invasive assessment of hepatic iron stores by MRI. Lancet 363:357\u2013362","journal-title":"Lancet"},{"key":"3251_CR16","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1111\/j.1600-0609.2009.01223.x","volume":"82","author":"A Christoforidis","year":"2009","unstructured":"Christoforidis A, Perifanis V, Spanos G et al (2009) MRI assessment of liver iron content in thalassamic patients with three different protocols: comparisons and correlations. Eur J Haematol 82:388\u2013392","journal-title":"Eur J Haematol"},{"key":"3251_CR17","doi-asserted-by":"publisher","first-page":"299","DOI":"10.3109\/03630269.2015.1064003","volume":"39","author":"E Vlachaki","year":"2015","unstructured":"Vlachaki E, Agapidou A, Spanos G et al (2015) Five years of deferasirox therapy for cardiac iron in beta-thalassemia major. Hemoglobin 39:299\u2013304","journal-title":"Hemoglobin"},{"issue":"1","key":"3251_CR18","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.braindev.2005.03.006","volume":"28","author":"M Economou","year":"2006","unstructured":"Economou M, Zafeiriou DI, Kontopoulos E, Gompakis N, Koussi A, Perifanis V, Athanassiou-Metaxa M (2006) Neurophysiologic and intellectual evaluation of beta-thalassemia patients. Brain and Development 28(1):14\u201318. \n                    https:\/\/doi.org\/10.1016\/j.braindev.2005.03.006","journal-title":"Brain and Development"},{"key":"3251_CR19","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s00277-016-2841-5","volume":"96","author":"M Ouederni","year":"2017","unstructured":"Ouederni M, Ben Khaled M, Mellouli F et al (2017) Myocardial and liver iron overload, assessed using T2* magnetic resonance imaging with an excel spreadsheet for post processing in Tunisian thalassemia major patients. Ann Hematol 96:133\u2013139","journal-title":"Ann Hematol"},{"key":"3251_CR20","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1196\/annals.1345.014","volume":"1054","author":"EA Rachmilewitz","year":"2005","unstructured":"Rachmilewitz EA, Weizer-Stern O, Adamsky K et al (2005) Role of iron in inducing oxidative stress in thalassemia: can it be prevented by inhibition of absorption and by antioxidants? Ann N Y Acad Sci 1054:118\u2013123","journal-title":"Ann N Y Acad Sci"},{"key":"3251_CR21","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12868-017-0369-9","volume":"18","author":"Z Yarjanli","year":"2017","unstructured":"Yarjanli Z, Ghaedi K, Esmaeili A et al (2017) Iron oxide nanoparticles may damage to the neural tissue through iron accumulation, oxidative stress, and protein aggregation. BMC Neurosci 18:51","journal-title":"BMC Neurosci"},{"issue":"4","key":"3251_CR22","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1089\/ars.2013.5813","volume":"21","author":"S Levi","year":"2014","unstructured":"Levi S, Taveggia C (2014) Iron homeostasis in peripheral nervous system, still a black box? Antioxid Redox Signal 21(4):634\u2013648. \n                    https:\/\/doi.org\/10.1089\/ars.2013.5813","journal-title":"Antioxid Redox Signal"},{"issue":"6-7","key":"3251_CR23","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1016\/j.neuint.2010.03.015","volume":"56","author":"D Johnstone","year":"2010","unstructured":"Johnstone D, Milward EA (2010) Genome-wide microarray analysis of brain gene expression in mice on a short-term high iron diet. Neurochem Int 56(6-7):856\u2013863. \n                    https:\/\/doi.org\/10.1016\/j.neuint.2010.03.015","journal-title":"Neurochem Int"},{"issue":"1","key":"3251_CR24","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1212\/WNL.60.1.22","volume":"60","author":"VA Street","year":"2003","unstructured":"Street VA, Bennett CL, Goldy JD, Shirk AJ, Kleopa KA, Tempel BL, Lipe HP, Scherer SS, Bird TD, Chance PF (2003) Mutation of a putative protein degradation gene LITAF\/SIMPLE in Charcot-Marie-Tooth disease 1C. Neurology 60(1):22\u201326. \n                    https:\/\/doi.org\/10.1212\/WNL.60.1.22","journal-title":"Neurology"},{"issue":"1","key":"3251_CR25","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/ng798","volume":"30","author":"A Cuesta","year":"2002","unstructured":"Cuesta A, Pedrola L, Sevilla T, Garc\u00eda-Planells J, Chumillas MJ, Mayordomo F, LeGuern E, Mar\u00edn I, V\u00edlchez JJ, Palau F (2002) The gene encoding ganglioside-induced differentiation-associated protein 1 is mutated in axonal Charcot-Marie-Tooth type 4A disease. Nat Genet 30(1):22\u201325. \n                    https:\/\/doi.org\/10.1038\/ng798","journal-title":"Nat Genet"},{"issue":"6","key":"3251_CR26","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s12185-011-0961-1","volume":"94","author":"J Munoz","year":"2011","unstructured":"Munoz J, Ferrari N, Kuriakose P (2011) Iron-overload myopathy. Int J Hematol 94(6):503\u2013504. \n                    https:\/\/doi.org\/10.1007\/s12185-011-0961-1","journal-title":"Int J Hematol"},{"issue":"6","key":"3251_CR27","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1586\/ehm.09.56","volume":"2","author":"S Rivella","year":"2009","unstructured":"Rivella S, Rachmilewitz E (2009) Future alternative therapies for beta-thalassemia. Expert Rev Hematol 2(6):685\u2013697. \n                    https:\/\/doi.org\/10.1586\/ehm.09.56","journal-title":"Expert Rev Hematol"},{"issue":"11","key":"3251_CR28","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1002\/ajh.24530","volume":"91","author":"A Makis","year":"2016","unstructured":"Makis A, Hatzimichael E, Papassotiriou I, Voskaridou E (2016) 2017 clinical trials update in new treatments of beta-thalassemia. Am J Hematol 91(11):1135\u20131145. \n                    https:\/\/doi.org\/10.1002\/ajh.24530","journal-title":"Am J Hematol"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00277-018-3251-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-018-3251-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-018-3251-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T21:59:47Z","timestamp":1549663187000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00277-018-3251-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,9]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["3251"],"URL":"https:\/\/doi.org\/10.1007\/s00277-018-3251-7","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"type":"print","value":"0939-5555"},{"type":"electronic","value":"1432-0584"}],"subject":[],"published":{"date-parts":[[2018,2,9]]},"assertion":[{"value":"23 May 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}