{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:52:00Z","timestamp":1788306720115,"version":"build-2803163510"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100010109","name":"Medical University of Graz","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010109","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s00277-018-3254-4","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:34:42Z","timestamp":1517877282000},"page":"989-998","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Malignancy and chemotherapy induced haemophagocytic lymphohistiocytosis in children and adolescents\u2014a single centre experience of 20\u00a0years"],"prefix":"10.1007","volume":"97","author":[{"given":"Volker","family":"Strenger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Merth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herwig","family":"Lackner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan W.","family":"Aberle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald H.","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus G.","family":"Seidel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Schwinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Sperl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Sovinz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Karastaneva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Benesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Urban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,6]]},"reference":[{"issue":"12","key":"3254_CR1","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1002\/pbc.25646","volume":"62","author":"B Tesi","year":"2015","unstructured":"Tesi B, Chiang SC, El-Ghoneimy D, Hussein AA, Langenskiold C, Wali R, Fadoo Z, Silva JP, Lecumberri R, Unal S, Nordenskjold M, Bryceson YT, Henter JI, Meeths M (2015) Spectrum of atypical clinical presentations in patients with biallelic PRF1 missense mutations. Pediatr Blood Cancer 62(12):2094\u20132100. \n                    https:\/\/doi.org\/10.1002\/pbc.25646","journal-title":"Pediatr Blood Cancer"},{"issue":"8","key":"3254_CR2","doi-asserted-by":"publisher","first-page":"997","DOI":"10.3324\/haematol.2015.123562","volume":"100","author":"K Lehmberg","year":"2015","unstructured":"Lehmberg K, Nichols KE, Henter JI, Girschikofsky M, Greenwood T, Jordan M, Kumar A, Minkov M, La Rosee P, Weitzman S, Study Group on Hemophagocytic Lymphohistiocytosis Subtypes of the Histiocyte S (2015) Consensus recommendations for the diagnosis and management of hemophagocytic lymphohistiocytosis associated with malignancies. Haematologica 100(8):997\u20131004. \n                    https:\/\/doi.org\/10.3324\/haematol.2015.123562","journal-title":"Haematologica"},{"issue":"4","key":"3254_CR3","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1007\/s12032-013-0740-3","volume":"30","author":"RS Mehta","year":"2013","unstructured":"Mehta RS, Smith RE (2013) Hemophagocytic lymphohistiocytosis (HLH): a review of literature. Med Oncol 30(4):740. \n                    https:\/\/doi.org\/10.1007\/s12032-013-0740-3","journal-title":"Med Oncol"},{"issue":"8","key":"3254_CR4","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1002\/pbc.26033","volume":"63","author":"MG Sinno","year":"2016","unstructured":"Sinno MG, Rosen D, Wittler R (2016) Concomitant presentation of hemophagocytic lymphohistiocytosis and posttransplant lymphoproliferative disease-like lymphoma in a mildly immunosuppressed leukemia patient: an unusual association. Pediatr Blood Cancer 63(8):1474\u20131476. \n                    https:\/\/doi.org\/10.1002\/pbc.26033","journal-title":"Pediatr Blood Cancer"},{"issue":"9","key":"3254_CR5","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1007\/s00277-016-2727-6","volume":"95","author":"Q Bin","year":"2016","unstructured":"Bin Q, Gao JH, Luo JM (2016) Prognostic factors of early outcome in pediatric hemophagocytic lymphohistiocytosis: an analysis of 116 cases. Ann Hematol 95(9):1411\u20131418. \n                    https:\/\/doi.org\/10.1007\/s00277-016-2727-6","journal-title":"Ann Hematol"},{"issue":"7","key":"3254_CR6","doi-asserted-by":"publisher","first-page":"e440","DOI":"10.1097\/MPH.0b013e31829f381b","volume":"36","author":"S Pastore","year":"2014","unstructured":"Pastore S, Barbieri F, Di Leo G, Valencic E, Tommasini A, Ventura A (2014) Hemophagocytic lymphohistiocytosis in total parenteral nutrition dependent children: description of 5 cases and practical tips for management. J Pediatr Hematol Oncol 36(7):e440\u2013e442. \n                    https:\/\/doi.org\/10.1097\/MPH.0b013e31829f381b","journal-title":"J Pediatr Hematol Oncol"},{"issue":"7","key":"3254_CR7","doi-asserted-by":"publisher","first-page":"978","DOI":"10.3324\/haematol.2014.121608","volume":"100","author":"SF Bode","year":"2015","unstructured":"Bode SF, Ammann S, Al-Herz W, Bataneant M, Dvorak CC, Gehring S, Gennery A, Gilmour KC, Gonzalez-Granado LI, Gross-Wieltsch U, Ifversen M, Lingman-Framme J, Matthes-Martin S, Mesters R, Meyts I, van Montfrans JM, Pachlopnik Schmid J, Pai SY, Soler-Palacin P, Schuermann U, Schuster V, Seidel MG, Speckmann C, Stepensky P, Sykora KW, Tesi B, Vraetz T, Waruiru C, Bryceson YT, Moshous D, Lehmberg K, Jordan MB, Ehl S, Inborn Errors Working Party of the E (2015) The syndrome of hemophagocytic lymphohistiocytosis in primary immunodeficiencies: implications for differential diagnosis and pathogenesis. Haematologica 100(7):978\u2013988. \n                    https:\/\/doi.org\/10.3324\/haematol.2014.121608","journal-title":"Haematologica"},{"issue":"4","key":"3254_CR8","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1111\/bjh.13462","volume":"170","author":"K Lehmberg","year":"2015","unstructured":"Lehmberg K, Sprekels B, Nichols KE, Woessmann W, Muller I, Suttorp M, Bernig T, Beutel K, Bode SF, Kentouche K, Kolb R, Langler A, Minkov M, Schilling FH, Schmid I, Vieth S, Ehl S, Zur Stadt U, Janka GE (2015) Malignancy-associated haemophagocytic lymphohistiocytosis in children and adolescents. Br J Haematol 170(4):539\u2013549. \n                    https:\/\/doi.org\/10.1111\/bjh.13462","journal-title":"Br J Haematol"},{"issue":"7","key":"3254_CR9","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1002\/pbc.25967","volume":"63","author":"JM Foley","year":"2016","unstructured":"Foley JM, Borders H, Kurt BA (2016) A diagnostic dilemma: similarity of neuroradiological findings in central nervous system hemophagocytic lymphohistiocytosis and aspergillosis. Pediatr Blood Cancer 63(7):1296\u20131299. \n                    https:\/\/doi.org\/10.1002\/pbc.25967","journal-title":"Pediatr Blood Cancer"},{"issue":"12","key":"3254_CR10","doi-asserted-by":"publisher","first-page":"3519","DOI":"10.1007\/s00520-013-1937-x","volume":"21","author":"H Lackner","year":"2013","unstructured":"Lackner H, Seidel MG, Strenger V, Sovinz P, Schwinger W, Benesch M, Sperl D, Urban C (2013) Hemophagocytic syndrome in children with acute monoblastic leukemia\u2014another cause of fever of unknown origin. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 21(12):3519\u20133523. \n                    https:\/\/doi.org\/10.1007\/s00520-013-1937-x","journal-title":"Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer"},{"issue":"3","key":"3254_CR11","doi-asserted-by":"publisher","first-page":"474","DOI":"10.3324\/haematol.2013.097394","volume":"99","author":"K Delavigne","year":"2014","unstructured":"Delavigne K, Berard E, Bertoli S, Corre J, Duchayne E, Demur C, Mansat-De Mas V, Borel C, Picard M, Alvarez M, Sarry A, Huguet F, Recher C (2014) Hemophagocytic syndrome in patients with acute myeloid leukemia undergoing intensive chemotherapy. Haematologica 99(3):474\u2013480. \n                    https:\/\/doi.org\/10.3324\/haematol.2013.097394","journal-title":"Haematologica"},{"issue":"2","key":"3254_CR12","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1002\/pbc.21039","volume":"48","author":"JI Henter","year":"2007","unstructured":"Henter JI, Horne A, Arico M, Egeler RM, Filipovich AH, Imashuku S, Ladisch S, McClain K, Webb D, Winiarski J, Janka G (2007) HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 48(2):124\u2013131. \n                    https:\/\/doi.org\/10.1002\/pbc.21039","journal-title":"Pediatr Blood Cancer"},{"issue":"3","key":"3254_CR13","doi-asserted-by":"publisher","first-page":"233","DOI":"10.3109\/09273948.2012.665123","volume":"20","author":"H Yao","year":"2012","unstructured":"Yao H, Liu Y, Ding W, Xu Y, Cheng Y (2012) Ocular findings in a patient with virus-associated hemophagocytic syndrome. Ocul Immunol Inflamm 20(3):233\u2013234. \n                    https:\/\/doi.org\/10.3109\/09273948.2012.665123","journal-title":"Ocul Immunol Inflamm"},{"issue":"8","key":"3254_CR14","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1007\/s00277-017-2993-y","volume":"96","author":"M Lin","year":"2017","unstructured":"Lin M, Park S, Hayden A, Giustini D, Trinkaus M, Pudek M, Mattman A, Schneider M, Chen LYC (2017) Clinical utility of soluble interleukin-2 receptor in hemophagocytic syndromes: a systematic scoping review. Ann Hematol 96(8):1241\u20131251. \n                    https:\/\/doi.org\/10.1007\/s00277-017-2993-y","journal-title":"Ann Hematol"},{"issue":"9","key":"3254_CR15","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/sj.bmt.1704265","volume":"32","author":"HJ Dornbusch","year":"2003","unstructured":"Dornbusch HJ, Strenger V, Kerbl R, Lackner H, Schwinger W, Sovinz P, Urban C (2003) Procalcitonin and C-reactive protein do not discriminate between febrile reaction to anti-T-lymphocyte antibodies and Gram-negative sepsis. Bone Marrow Transplant 32(9):941\u2013945. \n                    https:\/\/doi.org\/10.1038\/sj.bmt.1704265","journal-title":"Bone Marrow Transplant"},{"issue":"5","key":"3254_CR16","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s00520-004-0721-3","volume":"13","author":"HJ Dornbusch","year":"2005","unstructured":"Dornbusch HJ, Strenger V, Kerbl R, Lackner H, Schwinger W, Sovinz P, Urban C (2005) Procalcitonin\u2014a marker of invasive fungal infection? Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 13(5):343\u2013346. \n                    https:\/\/doi.org\/10.1007\/s00520-004-0721-3","journal-title":"Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer"},{"issue":"9","key":"3254_CR17","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1007\/s00520-007-0381-1","volume":"16","author":"HJ Dornbusch","year":"2008","unstructured":"Dornbusch HJ, Strenger V, Sovinz P, Lackner H, Schwinger W, Kerbl R, Urban C (2008) Non-infectious causes of elevated procalcitonin and C-reactive protein serum levels in pediatric patients with hematologic and oncologic disorders. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 16(9):1035\u20131040. \n                    https:\/\/doi.org\/10.1007\/s00520-007-0381-1","journal-title":"Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer"},{"issue":"3","key":"3254_CR18","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.jpeds.2010.02.064","volume":"157","author":"A Marabelle","year":"2010","unstructured":"Marabelle A, Bergeron C, Billaud G, Mekki Y, Girard S (2010) Hemophagocytic syndrome revealing primary HHV-6 infection. J Pediatr 157(3):511. \n                    https:\/\/doi.org\/10.1016\/j.jpeds.2010.02.064","journal-title":"J Pediatr"},{"issue":"3","key":"3254_CR19","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.bbmt.2011.07.025","volume":"18","author":"Y Mori","year":"2012","unstructured":"Mori Y, Miyamoto T, Kato K, Kamezaki K, Kuriyama T, Oku S, Takenaka K, Iwasaki H, Harada N, Shiratsuchi M, Abe Y, Nagafuji K, Teshima T, Akashi K (2012) Different risk factors related to adenovirus- or BK virus-associated hemorrhagic cystitis following allogeneic stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 18(3):458\u2013465. \n                    https:\/\/doi.org\/10.1016\/j.bbmt.2011.07.025","journal-title":"Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00277-018-3254-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-018-3254-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-018-3254-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T20:22:28Z","timestamp":1549398148000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00277-018-3254-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,6]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["3254"],"URL":"https:\/\/doi.org\/10.1007\/s00277-018-3254-4","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,6]]},"assertion":[{"value":"30 July 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"After approval by the local ethic committee, we evaluated patients who were diagnosed as having HLH during their treatment at the Division of Paediatric Haematology\/Oncology, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, between 1995 and 2014.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}