{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:35:42Z","timestamp":1784039742945,"version":"3.55.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T00:00:00Z","timestamp":1521158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s00277-018-3274-0","type":"journal-article","created":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T14:35:16Z","timestamp":1521210916000},"page":"1027-1039","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Donor-recipient killer immunoglobulin like receptor (KIR) genotype matching has a protective effect on chronic graft versus host disease and relapse incidence following HLA-identical sibling hematopoietic stem cell transplantation"],"prefix":"10.1007","volume":"97","author":[{"given":"Ugur","family":"Sahin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klara","family":"Dalva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Funda","family":"Gungor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celalettin","family":"Ustun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meral","family":"Beksac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,16]]},"reference":[{"key":"3274_CR1","doi-asserted-by":"publisher","first-page":"271695","DOI":"10.1155\/2012\/271695","volume":"2012","author":"M Beksac","year":"2012","unstructured":"Beksac M, Dalva K (2012) Role of killer immunoglobulin-like receptor and ligand matching in donor selection. Bone Marrow Res 2012:271695\u2013271696. https:\/\/doi.org\/10.1155\/2012\/271695","journal-title":"Bone Marrow Res"},{"issue":"10","key":"3274_CR2","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.it.2007.07.008","volume":"28","author":"JR Passweg","year":"2007","unstructured":"Passweg JR, Huard B, Tiercy JM, Roosnek E (2007) HLA and KIR polymorphisms affect NK-cell anti-tumor activity. Trends Immunol 28(10):437\u2013441. https:\/\/doi.org\/10.1016\/j.it.2007.07.008","journal-title":"Trends Immunol"},{"issue":"7","key":"3274_CR3","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0167-5699(90)90097-S","volume":"11","author":"HG Ljunggren","year":"1990","unstructured":"Ljunggren HG, Karre K (1990) In search of the 'missing self': MHC molecules and NK cell recognition. Immunol Today 11(7):237\u2013244","journal-title":"Immunol Today"},{"issue":"2","key":"3274_CR4","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1053\/j.seminhematol.2005.01.010","volume":"42","author":"KC Hsu","year":"2005","unstructured":"Hsu KC, Dupont B (2005) Natural killer cell receptors: regulating innate immune responses to hematologic malignancy. Semin Hematol 42(2):91\u2013103","journal-title":"Semin Hematol"},{"issue":"9","key":"3274_CR5","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1056\/NEJMoa1200503","volume":"367","author":"JM Venstrom","year":"2012","unstructured":"Venstrom JM, Pittari G, Gooley TA, Chewning JH, Spellman S, Haagenson M, Gallagher MM, Malkki M, Petersdorf E, Dupont B, Hsu KC (2012) HLA-C-dependent prevention of leukemia relapse by donor activating KIR2DS1. N Engl J Med 367(9):805\u2013816. https:\/\/doi.org\/10.1056\/NEJMoa1200503","journal-title":"N Engl J Med"},{"issue":"5562","key":"3274_CR6","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1126\/science.1068440","volume":"295","author":"L Ruggeri","year":"2002","unstructured":"Ruggeri L, Capanni M, Urbani E, Perruccio K, Shlomchik WD, Tosti A, Posati S, Rogaia D, Frassoni F, Aversa F, Martelli MF, Velardi A (2002) Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 295(5562):2097\u20132100. https:\/\/doi.org\/10.1126\/science.1068440","journal-title":"Science"},{"issue":"3","key":"3274_CR7","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/j.0001-2815.2004.00182.x","volume":"63","author":"A Bishara","year":"2004","unstructured":"Bishara A, De Santis D, Witt CC, Brautbar C, Christiansen FT, Or R, Nagler A, Slavin S (2004) The beneficial role of inhibitory KIR genes of HLA class I NK epitopes in haploidentically mismatched stem cell allografts may be masked by residual donor-alloreactive T cells causing GVHD. Tissue Antigens 63(3):204\u2013211. https:\/\/doi.org\/10.1111\/j.0001-2815.2004.00182.x","journal-title":"Tissue Antigens"},{"issue":"4","key":"3274_CR8","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.bbmt.2009.11.022","volume":"16","author":"HJ Symons","year":"2010","unstructured":"Symons HJ, Leffell MS, Rossiter ND, Zahurak M, Jones RJ, Fuchs EJ (2010) Improved survival with inhibitory killer immunoglobulin receptor (KIR) gene mismatches and KIR haplotype B donors after nonmyeloablative, HLA-haploidentical bone marrow transplantation. Biol Blood Marrow Transplant 16(4):533\u2013542. https:\/\/doi.org\/10.1016\/j.bbmt.2009.11.022","journal-title":"Biol Blood Marrow Transplant"},{"issue":"6","key":"3274_CR9","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/j.bbmt.2011.11.024","volume":"18","author":"D Weisdorf","year":"2012","unstructured":"Weisdorf D, Cooley S, Devine S, Fehniger TA, DiPersio J, Anasetti C, Waller EK, Porter D, Farag S, Drobyski W, Defor T, Haagenson M, Curtsinger J, Miller J (2012) T cell-depleted partial matched unrelated donor transplant for advanced myeloid malignancy: KIR ligand mismatch and outcome. Biol Blood Marrow Transplant 18(6):937\u2013943. https:\/\/doi.org\/10.1016\/j.bbmt.2011.11.024","journal-title":"Biol Blood Marrow Transplant"},{"issue":"1","key":"3274_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169512","volume":"12","author":"C Neuchel","year":"2017","unstructured":"Neuchel C, Furst D, Niederwieser D, Bunjes D, Tsamadou C, Wulf G, Pfreundschuh M, Wagner E, Stuhler G, Einsele H, Schrezenmeier H, Mytilineos J (2017) Impact of donor activating KIR genes on HSCT outcome in C1-ligand negative myeloid disease patients transplanted with unrelated donors-a retrospective study. PLoS One 12(1):e0169512. https:\/\/doi.org\/10.1371\/journal.pone.0169512","journal-title":"PLoS One"},{"issue":"7","key":"3274_CR11","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/sj.bmt.1705609","volume":"39","author":"RM Sobecks","year":"2007","unstructured":"Sobecks RM, Ball EJ, Maciejewski JP, Rybicki LA, Brown S, Kalaycio M, Pohlman B, Andresen S, Theil KS, Dean R, Bolwell BJ (2007) Survival of AML patients receiving HLA-matched sibling donor allogeneic bone marrow transplantation correlates with HLA-Cw ligand groups for killer immunoglobulin-like receptors. Bone Marrow Transplant 39(7):417\u2013424. https:\/\/doi.org\/10.1038\/sj.bmt.1705609","journal-title":"Bone Marrow Transplant"},{"issue":"3","key":"3274_CR12","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1182\/blood-2003-01-0091","volume":"102","author":"S Giebel","year":"2003","unstructured":"Giebel S, Locatelli F, Lamparelli T, Velardi A, Davies S, Frumento G, Maccario R, Bonetti F, Wojnar J, Martinetti M, Frassoni F, Giorgiani G, Bacigalupo A, Holowiecki J (2003) Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors. Blood 102(3):814\u2013819. https:\/\/doi.org\/10.1182\/blood-2003-01-0091","journal-title":"Blood"},{"issue":"10","key":"3274_CR13","doi-asserted-by":"publisher","first-page":"3825","DOI":"10.1182\/blood-2002-04-1197","volume":"100","author":"SM Davies","year":"2002","unstructured":"Davies SM, Ruggieri L, DeFor T, Wagner JE, Weisdorf DJ, Miller JS, Velardi A, Blazar BR (2002) Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants. Killer immunoglobulin-like receptor. Blood 100(10):3825\u20133827. https:\/\/doi.org\/10.1182\/blood-2002-04-1197","journal-title":"Blood"},{"issue":"6","key":"3274_CR14","doi-asserted-by":"publisher","first-page":"2594","DOI":"10.1182\/blood-2004-04-1441","volume":"105","author":"DW Beelen","year":"2005","unstructured":"Beelen DW, Ottinger HD, Ferencik S, Elmaagacli AH, Peceny R, Trenschel R, Grosse-Wilde H (2005) Genotypic inhibitory killer immunoglobulin-like receptor ligand incompatibility enhances the long-term antileukemic effect of unmodified allogeneic hematopoietic stem cell transplantation in patients with myeloid leukemias. Blood 105(6):2594\u20132600. https:\/\/doi.org\/10.1182\/blood-2004-04-1441","journal-title":"Blood"},{"issue":"6","key":"3274_CR15","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1111\/j.1399-0039.2005.00396.x","volume":"65","author":"D Santis De","year":"2005","unstructured":"De Santis D, Bishara A, Witt CS, Nagler A, Brautbar C, Slavin S, Christiansen FT (2005) Natural killer cell HLA-C epitopes and killer cell immunoglobulin-like receptors both influence outcome of mismatched unrelated donor bone marrow transplants. Tissue Antigens 65(6):519\u2013528. https:\/\/doi.org\/10.1111\/j.1399-0039.2005.00396.x","journal-title":"Tissue Antigens"},{"issue":"8","key":"3274_CR16","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1016\/j.bbmt.2006.05.007","volume":"12","author":"SS Farag","year":"2006","unstructured":"Farag SS, Bacigalupo A, Eapen M, Hurley C, Dupont B, Caligiuri MA, Boudreau C, Nelson G, Oudshoorn M, van Rood J, Velardi A, Maiers M, Setterholm M, Confer D, Posch PE, Anasetti C, Kamani N, Miller JS, Weisdorf D, Davies SM, Kir Study Group CfIB, Marrow Transplantation R (2006) The effect of KIR ligand incompatibility on the outcome of unrelated donor transplantation: a report from the center for international blood and marrow transplant research, the European blood and marrow transplant registry, and the Dutch registry. Biol Blood Marrow Transplant 12(8):876\u2013884. https:\/\/doi.org\/10.1016\/j.bbmt.2006.05.007","journal-title":"Biol Blood Marrow Transplant"},{"issue":"22","key":"3274_CR17","doi-asserted-by":"publisher","first-page":"5628","DOI":"10.1182\/blood-2008-12-197467","volume":"113","author":"CG Brunstein","year":"2009","unstructured":"Brunstein CG, Wagner JE, Weisdorf DJ, Cooley S, Noreen H, Barker JN, DeFor T, Verneris MR, Blazar BR, Miller JS (2009) Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensity. Blood 113(22):5628\u20135634. https:\/\/doi.org\/10.1182\/blood-2008-12-197467","journal-title":"Blood"},{"issue":"3","key":"3274_CR18","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/leu.2008.365","volume":"23","author":"R Willemze","year":"2009","unstructured":"Willemze R, Rodrigues CA, Labopin M, Sanz G, Michel G, Socie G, Rio B, Sirvent A, Renaud M, Madero L, Mohty M, Ferra C, Garnier F, Loiseau P, Garcia J, Lecchi L, Kogler G, Beguin Y, Navarrete C, Devos T, Ionescu I, Boudjedir K, Herr AL, Gluckman E, Rocha V (2009) KIR-ligand incompatibility in the graft-versus-host direction improves outcomes after umbilical cord blood transplantation for acute leukemia. Leukemia 23(3):492\u2013500. https:\/\/doi.org\/10.1038\/leu.2008.365","journal-title":"Leukemia"},{"issue":"13","key":"3274_CR19","doi-asserted-by":"publisher","first-page":"2686","DOI":"10.1182\/blood-2009-07-229740","volume":"115","author":"AT Bjorklund","year":"2010","unstructured":"Bjorklund AT, Schaffer M, Fauriat C, Ringden O, Remberger M, Hammarstedt C, Barrett AJ, Ljungman P, Ljunggren HG, Malmberg KJ (2010) NK cells expressing inhibitory KIR for non-self-ligands remain tolerant in HLA-matched sibling stem cell transplantation. Blood 115(13):2686\u20132694. https:\/\/doi.org\/10.1182\/blood-2009-07-229740","journal-title":"Blood"},{"issue":"4","key":"3274_CR20","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1182\/blood-2003-02-0438","volume":"103","author":"MA Cook","year":"2004","unstructured":"Cook MA, Milligan DW, Fegan CD, Darbyshire PJ, Mahendra P, Craddock CF, Moss PA, Briggs DC (2004) The impact of donor KIR and patient HLA-C genotypes on outcome following HLA-identical sibling hematopoietic stem cell transplantation for myeloid leukemia. Blood 103(4):1521\u20131526. https:\/\/doi.org\/10.1182\/blood-2003-02-0438","journal-title":"Blood"},{"issue":"12","key":"3274_CR21","doi-asserted-by":"publisher","first-page":"4878","DOI":"10.1182\/blood-2004-12-4825","volume":"105","author":"KC Hsu","year":"2005","unstructured":"Hsu KC, Keever-Taylor CA, Wilton A, Pinto C, Heller G, Arkun K, O'Reilly RJ, Horowitz MM, Dupont B (2005) Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes. Blood 105(12):4878\u20134884. https:\/\/doi.org\/10.1182\/blood-2004-12-4825","journal-title":"Blood"},{"issue":"5","key":"3274_CR22","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.humimm.2007.01.019","volume":"68","author":"KL McQueen","year":"2007","unstructured":"McQueen KL, Dorighi KM, Guethlein LA, Wong R, Sanjanwala B, Parham P (2007) Donor-recipient combinations of group a and B KIR haplotypes and HLA class I ligand affect the outcome of HLA-matched, sibling donor hematopoietic cell transplantation. Hum Immunol 68(5):309\u2013323. https:\/\/doi.org\/10.1016\/j.humimm.2007.01.019","journal-title":"Hum Immunol"},{"issue":"9","key":"3274_CR23","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/j.bbmt.2010.03.004","volume":"16","author":"K Stringaris","year":"2010","unstructured":"Stringaris K, Adams S, Uribe M, Eniafe R, Wu CO, Savani BN, Barrett AJ (2010) Donor KIR genes 2DL5A, 2DS1 and 3DS1 are associated with a reduced rate of leukemia relapse after HLA-identical sibling stem cell transplantation for acute myeloid leukemia but not other hematologic malignancies. Biol Blood Marrow Transplant 16(9):1257\u20131264. https:\/\/doi.org\/10.1016\/j.bbmt.2010.03.004","journal-title":"Biol Blood Marrow Transplant"},{"key":"3274_CR24","doi-asserted-by":"publisher","first-page":"w13717","DOI":"10.4414\/smw.2013.13717","volume":"143","author":"H Wang","year":"2013","unstructured":"Wang H, He Y, Zhai WJ, Wang M, Zhou Z, Zhao YX, Feng SZ, Han MZ (2013) The impact of recipient HLA-Cw and donor killer immunoglobulin-like receptor genotyping on the outcome of patients receiving HLA-matched sibling donor hematopoietic stem cell transplantation for myeloid malignancies. Swiss Med Wkly 143:w13717. https:\/\/doi.org\/10.4414\/smw.2013.13717","journal-title":"Swiss Med Wkly"},{"issue":"8","key":"3274_CR25","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1038\/sj.leu.2403839","volume":"19","author":"S Verheyden","year":"2005","unstructured":"Verheyden S, Schots R, Duquet W, Demanet C (2005) A defined donor activating natural killer cell receptor genotype protects against leukemic relapse after related HLA-identical hematopoietic stem cell transplantation. Leukemia 19(8):1446\u20131451. https:\/\/doi.org\/10.1038\/sj.leu.2403839","journal-title":"Leukemia"},{"issue":"6","key":"3274_CR26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158242","volume":"11","author":"RM Faridi","year":"2016","unstructured":"Faridi RM, Kemp TJ, Dharmani-Khan P, Lewis V, Tripathi G, Rajalingam R, Daly A, Berka N, Storek J, Masood Khan F (2016) Donor-recipient matching for KIR genotypes reduces chronic GVHD and missing inhibitory KIR ligands protect against relapse after Myeloablative, HLA matched hematopoietic cell transplantation. PLoS One 11(6):e0158242. https:\/\/doi.org\/10.1371\/journal.pone.0158242","journal-title":"PLoS One"},{"issue":"2","key":"3274_CR27","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.bbmt.2015.11.1101","volume":"22","author":"SS Farag","year":"2016","unstructured":"Farag SS (2016) Killer cell immunoglobulin-like receptor ligand mismatching: to match or mismatch? Biol Blood Marrow Transplant 22(2):192\u2013194. https:\/\/doi.org\/10.1016\/j.bbmt.2015.11.1101","journal-title":"Biol Blood Marrow Transplant"},{"issue":"2","key":"3274_CR28","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.bbmt.2015.09.018","volume":"22","author":"SA Yahng","year":"2016","unstructured":"Yahng SA, Jeon YW, Yoon JH, Shin SH, Lee SE, Cho BS, Eom KS, Kim YJ, Lee S, Min CK, Cho SG, Kim DW, Lee JW, Min WS, Kim HJ (2016) Negative impact of unidirectional host-versus-graft killer cell immunoglobulin-like receptor ligand mismatch on transplantation outcomes after Unmanipulated Haploidentical peripheral blood stem cell transplantation for acute myeloid leukemia. Biol Blood Marrow Transplant 22(2):316\u2013323. https:\/\/doi.org\/10.1016\/j.bbmt.2015.09.018","journal-title":"Biol Blood Marrow Transplant"},{"issue":"3","key":"3274_CR29","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.bbmt.2008.12.497","volume":"15","author":"S Giralt","year":"2009","unstructured":"Giralt S, Ballen K, Rizzo D, Bacigalupo A, Horowitz M, Pasquini M, Sandmaier B (2009) Reduced-intensity conditioning regimen workshop: defining the dose spectrum. Report of a workshop convened by the center for international blood and marrow transplant research. Biol Blood Marrow Transplant 15(3):367\u2013369. https:\/\/doi.org\/10.1016\/j.bbmt.2008.12.497","journal-title":"Biol Blood Marrow Transplant"},{"issue":"4","key":"3274_CR30","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1182\/blood-2004-11-4557","volume":"106","author":"JY Cahn","year":"2005","unstructured":"Cahn JY, Klein JP, Lee SJ, Milpied N, Blaise D, Antin JH, Leblond V, Ifrah N, Jouet JP, Loberiza F, Ringden O, Barrett AJ, Horowitz MM, Socie G, Societe Francaise de Greffe de Moelle et Therapie C, Dana Farber Cancer I, International Bone Marrow Transplant R (2005) Prospective evaluation of 2 acute graft-versus-host (GVHD) grading systems: a joint Societe Francaise de Greffe de Moelle et Therapie Cellulaire (SFGM-TC), Dana Farber cancer institute (DFCI), and international bone marrow transplant registry (IBMTR) prospective study. Blood 106(4):1495\u20131500. https:\/\/doi.org\/10.1182\/blood-2004-11-4557","journal-title":"Blood"},{"issue":"2","key":"3274_CR31","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/j.1365-2141.2007.06652.x","volume":"138","author":"CJ Fraser","year":"2007","unstructured":"Fraser CJ, Scott Baker K (2007) The management and outcome of chronic graft-versus-host disease. Br J Haematol 138(2):131\u2013145. https:\/\/doi.org\/10.1111\/j.1365-2141.2007.06652.x","journal-title":"Br J Haematol"},{"issue":"12","key":"3274_CR32","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.bbmt.2005.09.004","volume":"11","author":"AH Filipovich","year":"2005","unstructured":"Filipovich AH, Weisdorf D, Pavletic S, Socie G, Wingard JR, Lee SJ, Martin P, Chien J, Przepiorka D, Couriel D, Cowen EW, Dinndorf P, Farrell A, Hartzman R, Henslee-Downey J, Jacobsohn D, McDonald G, Mittleman B, Rizzo JD, Robinson M, Schubert M, Schultz K, Shulman H, Turner M, Vogelsang G, Flowers ME (2005) National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biol Blood Marrow Transplant 11(12):945\u2013956. https:\/\/doi.org\/10.1016\/j.bbmt.2005.09.004","journal-title":"Biol Blood Marrow Transplant"},{"issue":"3","key":"3274_CR33","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nri1570","volume":"5","author":"P Parham","year":"2005","unstructured":"Parham P (2005) MHC class I molecules and KIRs in human history, health and survival. Nat Rev Immunol 5(3):201\u2013214. https:\/\/doi.org\/10.1038\/nri1570","journal-title":"Nat Rev Immunol"},{"key":"3274_CR34","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/978-1-59745-223-6_10","volume":"134","author":"MT Dorak","year":"2007","unstructured":"Dorak MT (2007) Role of natural killer cells and killer immunoglobulin-like receptor polymorphisms: association of HLA and KIRs. Methods Mol Med 134:123\u2013144","journal-title":"Methods Mol Med"},{"key":"3274_CR35","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1034\/j.1600-065X.2002.19004.x","volume":"190","author":"KC Hsu","year":"2002","unstructured":"Hsu KC, Chida S, Geraghty DE, Dupont B (2002) The killer cell immunoglobulin-like receptor (KIR) genomic region: gene-order, haplotypes and allelic polymorphism. Immunol Rev 190:40\u201352","journal-title":"Immunol Rev"},{"key":"3274_CR36","unstructured":"European Bioinformatics Institute (2016) Donor KIR B-content group calculator. http:\/\/www.ebi.ac.uk\/ipd\/kir\/donor_b_content.html"},{"issue":"14","key":"3274_CR37","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1182\/blood-2010-05-283051","volume":"116","author":"S Cooley","year":"2010","unstructured":"Cooley S, Weisdorf DJ, Guethlein LA, Klein JP, Wang T, Le CT, Marsh SG, Geraghty D, Spellman S, Haagenson MD, Ladner M, Trachtenberg E, Parham P, Miller JS (2010) Donor selection for natural killer cell receptor genes leads to superior survival after unrelated transplantation for acute myelogenous leukemia. Blood 116(14):2411\u20132419. https:\/\/doi.org\/10.1182\/blood-2010-05-283051","journal-title":"Blood"},{"key":"3274_CR38","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1751-0473-3-17","volume":"3","author":"Z Bursac","year":"2008","unstructured":"Bursac Z, Gauss CH, Williams DK, Hosmer DW (2008) Purposeful selection of variables in logistic regression. Source Code Biol Med 3:17. https:\/\/doi.org\/10.1186\/1751-0473-3-17","journal-title":"Source Code Biol Med"},{"issue":"1","key":"3274_CR39","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1182\/blood.V94.1.333.413a31_333_339","volume":"94","author":"L Ruggeri","year":"1999","unstructured":"Ruggeri L, Capanni M, Casucci M, Volpi I, Tosti A, Perruccio K, Urbani E, Negrin RS, Martelli MF, Velardi A (1999) Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation. Blood 94(1):333\u2013339","journal-title":"Blood"},{"issue":"7","key":"3274_CR40","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1016\/j.bbmt.2016.04.007","volume":"22","author":"V Rocha","year":"2016","unstructured":"Rocha V, Ruggeri A, Spellman S, Wang T, Sobecks R, Locatelli F, Askar M, Michel G, Arcese W, Iori AP, Purtill D, Danby R, Sanz GF, Gluckman E, Eapen M, Eurocord, Cord Blood Committee Cellular Therapy Immunobiology Working Party of the European Group for Blood and Marrow Transplantation, Netcord, and the Center for International Blood and Marrow Transplant Research (2016) Killer cell immunoglobulin-like receptor-ligand matching and outcomes after unrelated cord blood transplantation in acute myeloid leukemia. Biol Blood Marrow Transplant 22(7):1284\u20131289. https:\/\/doi.org\/10.1016\/j.bbmt.2016.04.007","journal-title":"Biol Blood Marrow Transplant"},{"key":"3274_CR41","doi-asserted-by":"crossref","unstructured":"Beksac K, Beksac M, Dalva K, Karaagaoglu E, Tirnaksiz MB (2015) Impact of \"Killer Immunoglobulin-Like Receptor \/Ligand\" Genotypes on Outcome following Surgery among Patients with Colorectal Cancer: Activating KIRs Are Associated with Long-Term Disease Free Survival. PLoS One 10(7):e0132526","DOI":"10.1371\/journal.pone.0132526"},{"issue":"37","key":"3274_CR42","doi-asserted-by":"publisher","first-page":"13224","DOI":"10.1073\/pnas.0503594102","volume":"102","author":"CA Stewart","year":"2005","unstructured":"Stewart CA, Laugier-Anfossi F, Vely F, Saulquin X, Riedmuller J, Tisserant A, Gauthier L, Romagne F, Ferracci G, Arosa FA, Moretta A, Sun PD, Ugolini S, Vivier E (2005) Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors. Proc Natl Acad Sci U S A 102(37):13224\u201313229. https:\/\/doi.org\/10.1073\/pnas.0503594102","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"20","key":"3274_CR43","doi-asserted-by":"publisher","first-page":"3045","DOI":"10.1182\/blood-2015-03-634733","volume":"125","author":"N Shah","year":"2015","unstructured":"Shah N (2015) Activating KIR: iN Kase of KIR-ligand mismatch. Blood 125(20):3045\u20133046. https:\/\/doi.org\/10.1182\/blood-2015-03-634733","journal-title":"Blood"},{"issue":"2","key":"3274_CR44","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.bbmt.2015.10.004","volume":"22","author":"X Wu","year":"2015","unstructured":"Wu X, Yao Y, Bao X, Zhou H, Tang X, Han Y, Ma X, Liu Y, Chen J, Zhou H, Jing S, Gu B, Xu Y, Sun A, He J, Wu D (2015) KIR2DS4 and its variant KIR1D are associated with acute graft-versus-host disease, cytomegalovirus, and overall survival after sibling-related HLA-matched transplantation in patients with donors with KIR gene haplotype a. Biol Blood Marrow Transplant 22(2):220\u2013225. https:\/\/doi.org\/10.1016\/j.bbmt.2015.10.004","journal-title":"Biol Blood Marrow Transplant"},{"key":"3274_CR45","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/978-3-642-02309-5_3","volume-title":"Natural Killer Cells","author":"D Middleton","year":"2010","unstructured":"Middleton D, Gonzalez-Galarza F, Meenagh A, Gourraud PA (2010) Diversity of KIR genes, alleles and haplotypes. In: Zimmer J (ed) Natural Killer Cells. Springer Verlag, Berlin Heidelberg, pp 63\u201391. https:\/\/doi.org\/10.1007\/978-3-642-02309-5_3"},{"issue":"12","key":"3274_CR46","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1097\/01.TP.0000164500.16052.3C","volume":"79","author":"AH Elmaagacli","year":"2005","unstructured":"Elmaagacli AH, Ottinger H, Koldehoff M, Peceny R, Steckel NK, Trenschel R, Biersack H, Grosse-Wilde H, Beelen DW (2005) Reduced risk for molecular disease in patients with chronic myeloid leukemia after transplantation from a KIR-mismatched donor. Transplantation 79(12):1741\u20131747","journal-title":"Transplantation"},{"issue":"9","key":"3274_CR47","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1016\/j.bbmt.2016.05.016","volume":"22","author":"V Bachanova","year":"2016","unstructured":"Bachanova V, Weisdorf DJ, Wang T, Marsh SG, Trachtenberg E, Haagenson MD, Spellman SR, Ladner M, Guethlein LA, Parham P, Miller JS, Cooley SA (2016) Donor KIR B genotype improves progression-free survival of non-Hodgkin lymphoma patients receiving unrelated donor transplantation. Biol Blood Marrow Transplant 22(9):1602\u20131607. https:\/\/doi.org\/10.1016\/j.bbmt.2016.05.016","journal-title":"Biol Blood Marrow Transplant"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00277-018-3274-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-018-3274-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-018-3274-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,13]],"date-time":"2019-10-13T00:55:01Z","timestamp":1570928101000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00277-018-3274-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,16]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["3274"],"URL":"https:\/\/doi.org\/10.1007\/s00277-018-3274-0","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,16]]},"assertion":[{"value":"27 March 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was performed in accordance with the Declaration of Helsinki and good clinical practice guidelines and was approved by the local institutional review board of Ankara University Medical School. Written informed consents were obtained from all participants prior to enrollment.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standard"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}