{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:02:16Z","timestamp":1782860536001,"version":"3.54.5"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2016-705"],"award-info":[{"award-number":["2016-705"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s00277-018-3442-2","type":"journal-article","created":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T23:28:55Z","timestamp":1533079735000},"page":"2363-2372","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The cell-of-origin classification of diffuse large B cell lymphoma in a Korean population by the Lymph2Cx assay and its correlation with immunohistochemical algorithms"],"prefix":"10.1007","volume":"97","author":[{"given":"Hee Sang","family":"Hwang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dok Hyun","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Yong","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan-Sik","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Se","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Hyeh","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Seog","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheolwon","family":"Suh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jooryung","family":"Huh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,1]]},"reference":[{"key":"3442_CR1","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/35000501","volume":"403","author":"AA Alizadeh","year":"2000","unstructured":"Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, Boldrick JC, Sabet H, Tran T, Yu X, Powell JI, Yang L, Marti GE, Moore T, Hudson J Jr, Lu L, Lewis DB, Tibshirani R, Sherlock G, Chan WC, Greiner TC, Weisenburger DD, Armitage JO, Warnke R, Levy R, Wilson W, Grever MR, Byrd JC, Botstein D, Brown PO, Staudt LM (2000) Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403:503\u2013511. \n                    https:\/\/doi.org\/10.1038\/35000501","journal-title":"Nature"},{"key":"3442_CR2","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1056\/NEJMoa012914","volume":"346","author":"A Rosenwald","year":"2002","unstructured":"Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, Fisher RI, Gascoyne RD, Muller-Hermelink HK, Smeland EB, Giltnane JM, Hurt EM, Zhao H, Averett L, Yang L, Wilson WH, Jaffe ES, Simon R, Klausner RD, Powell J, Duffey PL, Longo DL, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO, Montserrat E, Lopez-Guillermo A, Grogan TM, Miller TP, LeBlanc M, Ott G, Kvaloy S, Delabie J, Holte H, Krajci P, Stokke T, Staudt LM, Lymphoma\/Leukemia Molecular Profiling Project (2002) The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med 346:1937\u20131947. \n                    https:\/\/doi.org\/10.1056\/NEJMoa012914","journal-title":"N Engl J Med"},{"key":"3442_CR3","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1053\/j.semdp.2011.04.001","volume":"28","author":"C Schneider","year":"2011","unstructured":"Schneider C, Pasqualucci L, Dalla-Favera R (2011) Molecular pathogenesis of diffuse large B-cell lymphoma. Semin Diagn Pathol 28:167\u2013177","journal-title":"Semin Diagn Pathol"},{"key":"3442_CR4","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1053\/j.seminhematol.2015.01.008","volume":"52","author":"RM Young","year":"2015","unstructured":"Young RM, Shaffer AL 3rd, Phelan JD, Staudt LM (2015) B-cell receptor signaling in diffuse large B-cell lymphoma. Semin Hematol 52:77\u201385. \n                    https:\/\/doi.org\/10.1053\/j.seminhematol.2015.01.008","journal-title":"Semin Hematol"},{"key":"3442_CR5","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1056\/NEJMoa0802885","volume":"359","author":"G Lenz","year":"2008","unstructured":"Lenz G, Wright G, Dave SS, Xiao W, Powell J, Zhao H, Xu W, Tan B, Goldschmidt N, Iqbal J, Vose J, Bast M, Fu K, Weisenburger DD, Greiner TC, Armitage JO, Kyle A, May L, Gascoyne RD, Connors JM, Troen G, Holte H, Kvaloy S, Dierickx D, Verhoef G, Delabie J, Smeland EB, Jares P, Martinez A, Lopez-Guillermo A, Montserrat E, Campo E, Braziel RM, Miller TP, Rimsza LM, Cook JR, Pohlman B, Sweetenham J, Tubbs RR, Fisher RI, Hartmann E, Rosenwald A, Ott G, Muller-Hermelink HK, Wrench D, Lister TA, Jaffe ES, Wilson WH, Chan WC, Staudt LM, Lymphoma\/Leukemia Molecular Profiling Project (2008) Stromal gene signatures in large-B-cell lymphomas. N Engl J Med 359:2313\u20132323. \n                    https:\/\/doi.org\/10.1056\/NEJMoa0802885","journal-title":"N Engl J Med"},{"key":"3442_CR6","doi-asserted-by":"publisher","first-page":"2835","DOI":"10.1200\/JCO.2015.61.9288","volume":"33","author":"A Younes","year":"2015","unstructured":"Younes A (2015) Prognostic significance of diffuse large B-cell lymphoma cell of origin: seeing the forest and the trees. J Clin Oncol 33:2835\u20132836. \n                    https:\/\/doi.org\/10.1200\/JCO.2015.61.9288","journal-title":"J Clin Oncol"},{"key":"3442_CR7","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1182\/blood-2003-05-1545","volume":"103","author":"CP Hans","year":"2004","unstructured":"Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G, Muller-Hermelink HK, Campo E, Braziel RM, Jaffe ES, Pan Z, Farinha P, Smith LM, Falini B, Banham AH, Rosenwald A, Staudt LM, Connors JM, Armitage JO, Chan WC (2004) Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood 103:275\u2013282. \n                    https:\/\/doi.org\/10.1182\/blood-2003-05-1545","journal-title":"Blood"},{"key":"3442_CR8","doi-asserted-by":"publisher","first-page":"5494","DOI":"10.1158\/1078-0432.CCR-09-0113","volume":"15","author":"WW Choi","year":"2009","unstructured":"Choi WW, Weisenburger DD, Greiner TC, Piris MA, Banham AH, Delabie J, Braziel RM, Geng H, Iqbal J, Lenz G, Vose JM, Hans CP, Fu K, Smith LM, Li M, Liu Z, Gascoyne RD, Rosenwald A, Ott G, Rimsza LM, Campo E, Jaffe ES, Jaye DL, Staudt LM, Chan WC (2009) A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy. Clin Cancer Res 15:5494\u20135502. \n                    https:\/\/doi.org\/10.1158\/1078-0432.CCR-09-0113","journal-title":"Clin Cancer Res"},{"key":"3442_CR9","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1200\/JCO.2010.30.0368","volume":"29","author":"PN Meyer","year":"2011","unstructured":"Meyer PN, Fu K, Greiner TC, Smith LM, Delabie J, Gascoyne RD, Ott G, Rosenwald A, Braziel RM, Campo E, Vose JM, Lenz G, Staudt LM, Chan WC, Weisenburger DD (2011) Immunohistochemical methods for predicting cell of origin and survival in patients with diffuse large B-cell lymphoma treated with rituximab. J Clin Oncol 29:200\u2013207. \n                    https:\/\/doi.org\/10.1200\/JCO.2010.30.0368","journal-title":"J Clin Oncol"},{"key":"3442_CR10","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1038\/leu.2012.83","volume":"26","author":"C Visco","year":"2012","unstructured":"Visco C, Li Y, Xu-Monette ZY, Miranda RN, Green TM, Li Y, Tzankov A, Wen W, Liu WM, Kahl BS, d\u2019Amore ES, Montes-Moreno S, Dybkaer K, Chiu A, Tam W, Orazi A, Zu Y, Bhagat G, Winter JN, Wang HY, O\u2019Neill S, Dunphy CH, Hsi ED, Zhao XF, Go RS, Choi WW, Zhou F, Czader M, Tong J, Zhao X, van Krieken JH, Huang Q, Ai W, Etzell J, Ponzoni M, Ferreri AJ, Piris MA, Moller MB, Bueso-Ramos CE, Medeiros LJ, Wu L, Young KH (2012) Comprehensive gene expression profiling and immunohistochemical studies support application of immunophenotypic algorithm for molecular subtype classification in diffuse large B-cell lymphoma: a report from the International DLBCL Rituximab-CHOP Consortium Program Study. Leukemia 26:2103\u20132113. \n                    https:\/\/doi.org\/10.1038\/leu.2012.83","journal-title":"Leukemia"},{"key":"3442_CR11","doi-asserted-by":"publisher","first-page":"4836","DOI":"10.1182\/blood-2010-12-322362","volume":"117","author":"G Gutierrez-Garcia","year":"2011","unstructured":"Gutierrez-Garcia G, Cardesa-Salzmann T, Climent F, Gonzalez-Barca E, Mercadal S, Mate JL, Sancho JM, Arenillas L, Serrano S, Escoda L, Martinez S, Valera A, Martinez A, Jares P, Pinyol M, Garcia-Herrera A, Martinez-Trillos A, Gine E, Villamor N, Campo E, Colomo L, Lopez-Guillermo A, l\u2019Estudi dels Limfomes de Catalunya G p, Balears I (2011) Gene-expression profiling and not immunophenotypic algorithms predicts prognosis in patients with diffuse large B-cell lymphoma treated with immunochemotherapy. Blood 117:4836\u20134843. \n                    https:\/\/doi.org\/10.1182\/blood-2010-12-322362","journal-title":"Blood"},{"key":"3442_CR12","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1097\/PAS.0000000000000211","volume":"38","author":"HS Hwang","year":"2014","unstructured":"Hwang HS, Park CS, Yoon DH, Suh C, Huh J (2014) High concordance of gene expression profiling-correlated immunohistochemistry algorithms in diffuse large B-cell lymphoma, not otherwise specified. Am J Surg Pathol 38:1046\u20131057. \n                    https:\/\/doi.org\/10.1097\/PAS.0000000000000211","journal-title":"Am J Surg Pathol"},{"key":"3442_CR13","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.clml.2014.05.002","volume":"14","author":"JA Read","year":"2014","unstructured":"Read JA, Koff JL, Nastoupil LJ, Williams JN, Cohen JB, Flowers CR (2014) Evaluating cell-of-origin subtype methods for predicting diffuse large B-cell lymphoma survival: a meta-analysis of gene expression profiling and immunohistochemistry algorithms. Clin Lymphoma Myeloma Leuk 14:460\u2013467 e462. \n                    https:\/\/doi.org\/10.1016\/j.clml.2014.05.002","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"3442_CR14","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1182\/blood-2013-11-536433","volume":"123","author":"DW Scott","year":"2014","unstructured":"Scott DW, Wright GW, Williams PM, Lih CJ, Walsh W, Jaffe ES, Rosenwald A, Campo E, Chan WC, Connors JM, Smeland EB, Mottok A, Braziel RM, Ott G, Delabie J, Tubbs RR, Cook JR, Weisenburger DD, Greiner TC, Glinsmann-Gibson BJ, Fu K, Staudt LM, Gascoyne RD, Rimsza LM (2014) Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue. Blood 123:1214\u20131217. \n                    https:\/\/doi.org\/10.1182\/blood-2013-11-536433","journal-title":"Blood"},{"key":"3442_CR15","doi-asserted-by":"publisher","first-page":"2848","DOI":"10.1200\/JCO.2014.60.2383","volume":"33","author":"DW Scott","year":"2015","unstructured":"Scott DW, Mottok A, Ennishi D, Wright GW, Farinha P, Ben-Neriah S, Kridel R, Barry GS, Hother C, Abrisqueta P, Boyle M, Meissner B, Telenius A, Savage KJ, Sehn LH, Slack GW, Steidl C, Staudt LM, Connors JM, Rimsza LM, Gascoyne RD (2015) Prognostic significance of diffuse large B-cell lymphoma cell of origin determined by digital gene expression in formalin-fixed paraffin-embedded tissue biopsies. J Clin Oncol 33:2848\u20132856. \n                    https:\/\/doi.org\/10.1200\/JCO.2014.60.2383","journal-title":"J Clin Oncol"},{"key":"3442_CR16","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.2217\/fon-2016-0130","volume":"12","author":"GS Nowakowski","year":"2016","unstructured":"Nowakowski GS, Chiappella A, Witzig TE, Spina M, Gascoyne RD, Zhang L, Flament J, Repici J, Vitolo U (2016) ROBUST: Lenalidomide-R-CHOP versus placebo-R-CHOP in previously untreated ABC-type diffuse large B-cell lymphoma. Future Oncol 12:1553\u20131563. \n                    https:\/\/doi.org\/10.2217\/fon-2016-0130","journal-title":"Future Oncol"},{"key":"3442_CR17","doi-asserted-by":"publisher","first-page":"266","DOI":"10.5045\/br.2013.48.4.266","volume":"48","author":"HS Hwang","year":"2013","unstructured":"Hwang HS, Yoon DH, Suh C, Park CS, Huh J (2013) Prognostic value of immunohistochemical algorithms in gastrointestinal diffuse large B-cell lymphoma. Blood Res 48:266\u2013273. \n                    https:\/\/doi.org\/10.5045\/br.2013.48.4.266","journal-title":"Blood Res"},{"key":"3442_CR18","first-page":"275","volume":"8","author":"TX Lu","year":"2015","unstructured":"Lu TX, Gong QX, Wang L, Fan L, Zhang XY, Chen YY, Wang Z, Xu W, Zhang ZH, Li JY (2015) Immunohistochemical algorithm alone is not enough for predicting the outcome of patients with diffuse large B-cell lymphoma treated with R-CHOP. Int J Clin Exp Pathol 8:275\u2013286","journal-title":"Int J Clin Exp Pathol"},{"key":"3442_CR19","doi-asserted-by":"publisher","unstructured":"Xu Q, Tan C, Ni S, Wang Q, Wu F, Liu F, Ye X, Meng X, Sheng W, Du X (2015) Identification and validation of a two-gene expression index for subtype classification and prognosis in diffuse large B-cell lymphoma. Sci Rep 5(10006). \n                    https:\/\/doi.org\/10.1038\/srep10006","DOI":"10.1038\/srep10006"},{"key":"3442_CR20","doi-asserted-by":"publisher","first-page":"22014","DOI":"10.18632\/oncotarget.15782","volume":"8","author":"N Yoon","year":"2017","unstructured":"Yoon N, Ahn S, Yong Yoo H, Jin Kim S, Seog Kim W, Hyeh Ko Y (2017) Cell-of-origin of diffuse large B-cell lymphomas determined by the Lymph2Cx assay: better prognostic indicator than Hans algorithm. Oncotarget 8:22014\u201322022. \n                    https:\/\/doi.org\/10.18632\/oncotarget.15782","journal-title":"Oncotarget"},{"key":"3442_CR21","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"SH Swerdlow","year":"2008","unstructured":"Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (2008) WHO classification of tumours of haematopoietic and lymphoid tissues, 4th edn. IARC, Lyon","edition":"4"},{"key":"3442_CR22","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1200\/JCO.1989.7.11.1630","volume":"7","author":"TA Lister","year":"1989","unstructured":"Lister TA, Crowther D, Sutcliffe SB, Glatstein E, Canellos GP, Young RC, Rosenberg SA, Coltman CA, Tubiana M (1989) Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin\u2019s disease: Cotswolds meeting. J Clin Oncol 7:1630\u20131636. \n                    https:\/\/doi.org\/10.1200\/JCO.1989.7.11.1630","journal-title":"J Clin Oncol"},{"key":"3442_CR23","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1056\/NEJM199309303291402","volume":"329","author":"International Non-Hodgkin\u2019s Lymphoma Prognostic Factors P","year":"1993","unstructured":"International Non-Hodgkin\u2019s Lymphoma Prognostic Factors P (1993) A predictive model for aggressive non-Hodgkin\u2019s lymphoma. N Engl J Med 329:987\u2013994. \n                    https:\/\/doi.org\/10.1056\/NEJM199309303291402","journal-title":"N Engl J Med"},{"key":"3442_CR24","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1200\/JCO.2006.09.2403","volume":"25","author":"BD Cheson","year":"2007","unstructured":"Cheson BD, Pfistner B, Juweid ME, Gascoyne RD, Specht L, Horning SJ, Coiffier B, Fisher RI, Hagenbeek A, Zucca E, Rosen ST, Stroobants S, Lister TA, Hoppe RT, Dreyling M, Tobinai K, Vose JM, Connors JM, Federico M, Diehl V, International Harmonization Project on Lymphoma (2007) Revised response criteria for malignant lymphoma. J Clin Oncol 25:579\u2013586. \n                    https:\/\/doi.org\/10.1200\/JCO.2006.09.2403","journal-title":"J Clin Oncol"},{"key":"3442_CR25","doi-asserted-by":"publisher","first-page":"276","DOI":"10.11613\/BM.2012.031","volume":"22","author":"ML McHugh","year":"2012","unstructured":"McHugh ML (2012) Interrater reliability: the kappa statistic. Biochem Med (Zagreb) 22:276\u2013282","journal-title":"Biochem Med (Zagreb)"},{"key":"3442_CR26","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1177\/2040620711419001","volume":"2","author":"M Frick","year":"2011","unstructured":"Frick M, Dorken B, Lenz G (2011) The molecular biology of diffuse large B-cell lymphoma. Ther Adv Hematol 2:369\u2013379. \n                    https:\/\/doi.org\/10.1177\/2040620711419001","journal-title":"Ther Adv Hematol"},{"key":"3442_CR27","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nature08638","volume":"463","author":"RE Davis","year":"2010","unstructured":"Davis RE, Ngo VN, Lenz G, Tolar P, Young RM, Romesser PB, Kohlhammer H, Lamy L, Zhao H, Yang Y, Xu W, Shaffer AL, Wright G, Xiao W, Powell J, Jiang JK, Thomas CJ, Rosenwald A, Ott G, Muller-Hermelink HK, Gascoyne RD, Connors JM, Johnson NA, Rimsza LM, Campo E, Jaffe ES, Wilson WH, Delabie J, Smeland EB, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Pierce SK, Staudt LM (2010) Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature 463:88\u201392. \n                    https:\/\/doi.org\/10.1038\/nature08638","journal-title":"Nature"},{"key":"3442_CR28","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1038\/nm.3884","volume":"21","author":"WH Wilson","year":"2015","unstructured":"Wilson WH, Young RM, Schmitz R, Yang Y, Pittaluga S, Wright G, Lih CJ, Williams PM, Shaffer AL, Gerecitano J, de Vos S, Goy A, Kenkre VP, Barr PM, Blum KA, Shustov A, Advani R, Fowler NH, Vose JM, Elstrom RL, Habermann TM, Barrientos JC, McGreivy J, Fardis M, Chang BY, Clow F, Munneke B, Moussa D, Beaupre DM, Staudt LM (2015) Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma. Nat Med 21:922\u2013926. \n                    https:\/\/doi.org\/10.1038\/nm.3884","journal-title":"Nat Med"},{"key":"3442_CR29","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1200\/JCO.2014.55.5714","volume":"33","author":"GS Nowakowski","year":"2015","unstructured":"Nowakowski GS, LaPlant B, Macon WR, Reeder CB, Foran JM, Nelson GD, Thompson CA, Rivera CE, Inwards DJ, Micallef IN, Johnston PB, Porrata LF, Ansell SM, Gascoyne RD, Habermann TM, Witzig TE (2015) Lenalidomide combined with R-CHOP overcomes negative prognostic impact of non-germinal center B-cell phenotype in newly diagnosed diffuse large B-cell lymphoma: a phase II study. J Clin Oncol 33:251\u2013257. \n                    https:\/\/doi.org\/10.1200\/JCO.2014.55.5714","journal-title":"J Clin Oncol"},{"key":"3442_CR30","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1158\/1055-9965.EPI-11-0038","volume":"20","author":"CA Clarke","year":"2011","unstructured":"Clarke CA, Glaser SL, Gomez SL, Wang SS, Keegan TH, Yang J, Chang ET (2011) Lymphoid malignancies in U.S. Asians: incidence rate differences by birthplace and acculturation. Cancer Epidemiol Biomark Prev 20:1064\u20131077. \n                    https:\/\/doi.org\/10.1158\/1055-9965.EPI-11-0038","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"3442_CR31","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1309\/AJCP7YLTQPUSDQ5C","volume":"138","author":"J Sun","year":"2012","unstructured":"Sun J, Yang Q, Lu Z, He M, Gao L, Zhu M, Sun L, Wei L, Li M, Liu C, Zheng J, Liu W, Li G, Chen J (2012) Distribution of lymphoid neoplasms in China: analysis of 4,638 cases according to the World Health Organization classification. Am J Clin Pathol 138:429\u2013434. \n                    https:\/\/doi.org\/10.1309\/AJCP7YLTQPUSDQ5C","journal-title":"Am J Clin Pathol"},{"key":"3442_CR32","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.jfma.2016.09.006","volume":"115","author":"ST Chang","year":"2016","unstructured":"Chang ST, Chen SW, Ho CH, Kuo CC, Sakata S, Takeuchi K, Chuang SS (2016) Immunophenotypic and genetic characteristics of diffuse large B-cell lymphoma in Taiwan. J Formos Med Assoc 115:961\u2013967. \n                    https:\/\/doi.org\/10.1016\/j.jfma.2016.09.006","journal-title":"J Formos Med Assoc"},{"key":"3442_CR33","doi-asserted-by":"publisher","first-page":"2515","DOI":"10.1200\/JCO.2016.70.3660","volume":"35","author":"AM Staiger","year":"2017","unstructured":"Staiger AM, Ziepert M, Horn H, Scott DW, Barth TFE, Bernd HW, Feller AC, Klapper W, Szczepanowski M, Hummel M, Stein H, Lenze D, Hansmann ML, Hartmann S, Moller P, Cogliatti S, Lenz G, Trumper L, Loffler M, Schmitz N, Pfreundschuh M, Rosenwald A, Ott G, German High-Grade Lymphoma Study G (2017) Clinical impact of the cell-of-origin classification and the MYC\/ BCL2 dual expresser status in diffuse large B-cell lymphoma treated within prospective clinical trials of the German high-grade non-Hodgkin\u2019s lymphoma study group. J Clin Oncol 35:2515\u20132526. \n                    https:\/\/doi.org\/10.1200\/JCO.2016.70.3660","journal-title":"J Clin Oncol"},{"key":"3442_CR34","doi-asserted-by":"publisher","first-page":"4127","DOI":"10.1158\/1078-0432.CCR-16-2818","volume":"23","author":"MS Czuczman","year":"2017","unstructured":"Czuczman MS, Trneny M, Davies A, Rule SA, Linton K, Wagner-Johnston N, Gascoyne RD, Slack G, Brousset P, Eberhard DA, Hernandez-Ilizaliturri FJ, Salles G, Witzig TE, Zinzani PL, Wright GW, Staudt LM, Yang Y, Williams PM, Lih CJ, Russo J, Thakurta A, Hagner P, Fustier P, Song D, Lewis ID (2017) A phase 2\/3 multicenter, randomized, open-label study of lenalidomide vs investigator\u2019s choice in patients with relapsed or refractory diffuse large B-cell lymphoma. Clin Cancer Res 23:4127\u20134137. \n                    https:\/\/doi.org\/10.1158\/1078-0432.CCR-16-2818","journal-title":"Clin Cancer Res"},{"issue":"10","key":"3442_CR35","doi-asserted-by":"publisher","first-page":"2228","DOI":"10.3109\/10428194.2013.869326","volume":"55","author":"Christopher D. Fletcher","year":"2014","unstructured":"Fletcher CD, Kahl BS (2014) Central nervous system involvement in diffuse large B-cell lymphoma: an analysis of risks and prevention strategies in the post-rituximab era. Leuk Lymphoma 55:2228\u20132240. \n                    https:\/\/doi.org\/10.3109\/10428194.2013.869326","journal-title":"Leukemia & Lymphoma"},{"key":"3442_CR36","doi-asserted-by":"publisher","first-page":"3150","DOI":"10.1200\/JCO.2015.65.6520","volume":"34","author":"N Schmitz","year":"2016","unstructured":"Schmitz N, Zeynalova S, Nickelsen M, Kansara R, Villa D, Sehn LH, Glass B, Scott DW, Gascoyne RD, Connors JM, Ziepert M, Pfreundschuh M, Loeffler M, Savage KJ (2016) CNS international prognostic index: a risk model for CNS relapse in patients with diffuse large B-cell lymphoma treated with R-CHOP. J Clin Oncol 34:3150\u20133156. \n                    https:\/\/doi.org\/10.1200\/JCO.2015.65.6520","journal-title":"J Clin Oncol"},{"key":"3442_CR37","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1182\/blood-2013-10-530659","volume":"123","author":"CY Cheah","year":"2014","unstructured":"Cheah CY, Wirth A, Seymour JF (2014) Primary testicular lymphoma. Blood 123:486\u2013493. \n                    https:\/\/doi.org\/10.1182\/blood-2013-10-530659","journal-title":"Blood"},{"key":"3442_CR38","doi-asserted-by":"publisher","first-page":"4228","DOI":"10.1182\/blood-2016-06-723536","volume":"128","author":"S Hu","year":"2016","unstructured":"Hu S, Song Y, Li Y, Sun X, Su L, Zhang W, Jia J, Bai O, Liang R, Li X, Zhang H, Gao Y, Zhang W, Xiao X, Bao H, Wang N, Ren H, Cen X, Yang S, Zhao Y, Wang Y, Wang Y, Liu A, Wang J, Shi Y, Yuan M, He X (2016) Primary breast diffuse large B cell lymphoma in the rituximab era: outcomes of a multicenter retrospective study by the Lymphoma and Leukemia Committee of Chinese Geriatric Oncology Society (LLC-CGOS). Blood 128:4228","journal-title":"Blood"},{"key":"3442_CR39","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1007\/s00277-012-1512-4","volume":"91","author":"BS Sohn","year":"2012","unstructured":"Sohn BS, Kim SM, Yoon DH, Kim S, Lee DH, Kim JH, Lee SW, Huh J, Suh C (2012) The comparison between CHOP and R-CHOP in primary gastric diffuse large B cell lymphoma. Ann Hematol 91:1731\u20131739. \n                    https:\/\/doi.org\/10.1007\/s00277-012-1512-4","journal-title":"Ann Hematol"},{"key":"3442_CR40","doi-asserted-by":"publisher","unstructured":"Huang J, Jiang W, Xu R, Huang H, Lv Y, Xia Z, Sun X, Guan Z, Lin T, Li Z (2010) Primary gastric non-Hodgkin\u2019s lymphoma in Chinese patients: clinical characteristics and prognostic factors. BMC Cancer 10(358). \n                    https:\/\/doi.org\/10.1186\/1471-2407-10-358","DOI":"10.1186\/1471-2407-10-358"},{"issue":"6","key":"3442_CR41","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1007\/s00277-013-1701-9","volume":"92","author":"Xiaowu Li","year":"2013","unstructured":"Li X, Xia B, Guo S, Zhan Z, Zhang L, Zhao D, Wu X, Zhang Y (2013) A retrospective analysis of primary gastric diffuse large B-cell lymphoma with or without concomitant mucosa-associated lymphoid tissue (MALT) lymphoma components. Ann Hematol 92:807\u2013815. \n                    https:\/\/doi.org\/10.1007\/s00277-013-1701-9","journal-title":"Annals of Hematology"},{"issue":"20","key":"3442_CR42","doi-asserted-by":"publisher","first-page":"4021","DOI":"10.1182\/blood-2012-10-460063","volume":"121","author":"S. Hu","year":"2013","unstructured":"Hu S, Xu-Monette ZY, Tzankov A, Green T, Wu L, Balasubramanyam A, Liu WM, Visco C, Li Y, Miranda RN, Montes-Moreno S, Dybkaer K, Chiu A, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WW, Zhao X, van Krieken JH, Huang Q, Huh J, Ai W, Ponzoni M, Ferreri AJ, Zhou F, Slack GW, Gascoyne RD, Tu M, Variakojis D, Chen W, Go RS, Piris MA, Moller MB, Medeiros LJ, Young KH (2013) MYC\/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from The International DLBCL Rituximab-CHOP Consortium Program. Blood 121:4021\u20134031; quiz 4250. \n                    https:\/\/doi.org\/10.1182\/blood-2012-10-460063","journal-title":"Blood"},{"key":"3442_CR43","doi-asserted-by":"publisher","first-page":"2760","DOI":"10.1182\/blood-2016-11-747022","volume":"129","author":"D Ennishi","year":"2017","unstructured":"Ennishi D, Mottok A, Ben-Neriah S, Shulha HP, Farinha P, Chan FC, Meissner B, Boyle M, Hother C, Kridel R, Lai D, Saberi S, Bashashati A, Shah SP, Morin RD, Marra MA, Savage KJ, Sehn LH, Steidl C, Connors JM, Gascoyne RD, Scott DW (2017) Genetic profiling of MYC and BCL2 in diffuse large B-cell lymphoma determines cell-of-origin-specific clinical impact. Blood 129:2760\u20132770. \n                    https:\/\/doi.org\/10.1182\/blood-2016-11-747022","journal-title":"Blood"},{"issue":"7","key":"3442_CR44","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1200\/JCO.2006.09.4490","volume":"25","author":"Daphne de Jong","year":"2007","unstructured":"de Jong D, Rosenwald A, Chhanabhai M, Gaulard P, Klapper W, Lee A, Sander B, Thorns C, Campo E, Molina T, Norton A, Hagenbeek A, Horning S, Lister A, Raemaekers J, Gascoyne RD, Salles G, Weller E, Lunenburg Lymphoma Biomarker Consortium (2007) Immunohistochemical prognostic markers in diffuse large B-cell lymphoma: validation of tissue microarray as a prerequisite for broad clinical applications--a study from the Lunenburg Lymphoma Biomarker Consortium. J Clin Oncol 25:805\u2013812. \n                    https:\/\/doi.org\/10.1200\/JCO.2006.09.4490","journal-title":"Journal of Clinical Oncology"},{"key":"3442_CR45","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1111\/j.1600-0609.2007.00892.x","volume":"79","author":"J Linderoth","year":"2007","unstructured":"Linderoth J, Ehinger M, Akerman M, Cavallin-Stahl E, Enblad G, Erlanson M, Jerkeman M (2007) Tissue microarray is inappropriate for analysis of BCL6 expression in diffuse large B-cell lymphoma. Eur J Haematol 79:146\u2013149. \n                    https:\/\/doi.org\/10.1111\/j.1600-0609.2007.00892.x","journal-title":"Eur J Haematol"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00277-018-3442-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-018-3442-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-018-3442-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T13:45:00Z","timestamp":1568987100000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00277-018-3442-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,1]]},"references-count":45,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["3442"],"URL":"https:\/\/doi.org\/10.1007\/s00277-018-3442-2","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,1]]},"assertion":[{"value":"4 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"For the retrospective type of the study, formal consent is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants"}}]}}