{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:56:08Z","timestamp":1775091368407,"version":"3.50.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T00:00:00Z","timestamp":1556841600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670116"],"award-info":[{"award-number":["81670116"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Program of National Natural Science Foundation of China","award":["81730004"],"award-info":[{"award-number":["81730004"]}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"crossref","award":["7171013"],"award-info":[{"award-number":["7171013"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"crossref","award":["Z171100001017084"],"award-info":[{"award-number":["Z171100001017084"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the National Key Research and Development Program of China","award":["2017YFA0105500"],"award-info":[{"award-number":["2017YFA0105500"]}]},{"name":"the National Key Research and Development Program of China","award":["2017YFA0105503"],"award-info":[{"award-number":["2017YFA0105503"]}]},{"name":"the Foundation for Innovative Research Groups of the National Natural Science Foundation of China","award":["81621001"],"award-info":[{"award-number":["81621001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1007\/s00277-019-03698-8","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T17:05:38Z","timestamp":1556903138000},"page":"1733-1742","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Incidence, risk factors and outcomes of sinusoidal obstruction syndrome after haploidentical allogeneic stem cell transplantation"],"prefix":"10.1007","volume":"98","author":[{"given":"Xuan","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruo-Yun","family":"Gui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiu-Sha","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Zhen","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Zhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao-Zhu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0245-6792","authenticated-orcid":false,"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Yu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Jun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Rong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan-Ping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai-Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Jun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,5,3]]},"reference":[{"issue":"1","key":"3698_CR1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.bbmt.2015.11.001","volume":"22","author":"J Apperley","year":"2016","unstructured":"Apperley J, Niederwieser D, Huang XJ, Nagler A, Fuchs E, Szer J, Kodera Y (2016) Haploidentical hematopoietic stem cell transplantation: a global overview comparing Asia, the European Union, and the United States. Biol Blood Marrow Transplant 22(1):23\u201326","journal-title":"Biol Blood Marrow Transplant"},{"issue":"7583","key":"3698_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/3905907","volume":"2016","author":"K Parmesar","year":"2016","unstructured":"Parmesar K, Raj K (2016) Haploidentical stem cell transplantation in adult haematological malignancies. Advances in Hematology, 2016,(2016-5-30) 2016(7583):1\u201316","journal-title":"Advances in Hematology"},{"issue":"2","key":"3698_CR3","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.bbmt.2009.08.024","volume":"16","author":"JA Coppell","year":"2010","unstructured":"Coppell JA, Richardson PG, Soiffer R, Martin PL, Kernan NA, Chen A, Guinan E, Vogelsang G, Krishnan A, Giralt S (2010) Hepatic veno-occlusive disease following stem cell transplantation: incidence, clinical course, and outcome. Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant 16(2):157\u2013168","journal-title":"Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant"},{"issue":"8","key":"3698_CR4","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1038\/bmt.2009.349","volume":"45","author":"SH Lee","year":"2010","unstructured":"Lee SH, Yoo KH, Sung KW, Koo HH, Kwon YJ, Kwon MM, Park HJ, B-K P, Kim YY, Park JA (2010) Hepatic veno-occlusive disease in children after hematopoietic stem cell transplantation: incidence, risk factors, and outcome. Bone Marrow Transplant 45(8):1287\u20131293","journal-title":"Bone Marrow Transplant"},{"issue":"11","key":"3698_CR5","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1016\/j.bbmt.2011.06.006","volume":"17","author":"C Enric","year":"2011","unstructured":"Enric C, Marina DB, Laura RO, Carmen M, Francesc FA, Montserrat R (2011) The incidence of veno-occlusive disease following allogeneic hematopoietic stem cell transplantation has diminished and the outcome improved over the last decade. Biol Blood Marrow Transplant 17(11):1713\u20131720","journal-title":"Biol Blood Marrow Transplant"},{"issue":"11","key":"3698_CR6","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1182\/blood.V85.11.3005.bloodjournal85113005","volume":"85","author":"SI Bearman","year":"1995","unstructured":"Bearman SI (1995) The syndrome of hepatic veno-occlusive disease after marrow transplantation. Blood 85(11):3005\u20133020","journal-title":"Blood"},{"issue":"6","key":"3698_CR7","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1038\/bmt.2015.52","volume":"50","author":"M Mohty","year":"2015","unstructured":"Mohty M, Malard F, Abecassis M, Aerts E, Alaskar A, Aljurf M, Arat M, Bader P, Baron F, Bazarbachi A (2015) Sinusoidal obstruction syndrome\/veno-occlusive disease: current situation and perspectives\u2014a position statement from the European Society for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant 50(6):781","journal-title":"Bone Marrow Transplant"},{"issue":"1","key":"3698_CR8","first-page":"978","volume":"119","author":"W Yu","year":"2013","unstructured":"Yu W, Dai-Hong L, Kai-Yan L, Lan-Ping X, Xiao-Hui Z, Wei H, Huan C, Yu-Hong C, Feng-Rong W, Jing-Zhi W (2013) Long-term follow-up of haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for the treatment of leukemia: nine years of experience at a single center. Cancer 119(1):978\u2013985","journal-title":"Cancer"},{"issue":"1","key":"3698_CR9","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/j.1399-0012.2010.01298.x","volume":"25","author":"YJ Chang","year":"2011","unstructured":"Chang YJ, Huang XJ (2011) Use of G-CSF-stimulated marrow in allogeneic hematopoietic stem cell transplantation settings: a comprehensive review. Clin Transpl 25(1):13\u201323","journal-title":"Clin Transpl"},{"key":"3698_CR10","unstructured":"Huang X-J, Liu D-H, Liu K-Y, Xu L-P, Chen H, Han W, Chen Y-H, Wang J-Z, Gao Z-Y, Zhang Y-C (2006) Haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion for the treatment of hematological malignancies. Bone Marrow Transplant 38(4):291"},{"issue":"3","key":"3698_CR11","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.bbmt.2015.09.024","volume":"22","author":"JH Dalle","year":"2016","unstructured":"Dalle JH, Giralt SA (2016) Hepatic veno-occlusive disease after hematopoietic stem cell transplantation: risk factors and stratification, prophylaxis, and treatment. Biol Blood Marrow Transplant 22(3):400\u2013409","journal-title":"Biol Blood Marrow Transplant"},{"issue":"3","key":"3698_CR12","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/sj.bmt.1705899","volume":"41","author":"V Ho","year":"2008","unstructured":"Ho V, Revta C, Richardson PG (2008) Hepatic veno-occlusive disease after hematopoietic stem cell transplantation: update on defibrotide and other current investigational therapies. Bone Marrow Transplant 41(3):229\u2013237","journal-title":"Bone Marrow Transplant"},{"issue":"7","key":"3698_CR13","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1038\/bmt.2016.130","volume":"51","author":"M Mohty","year":"2016","unstructured":"Mohty M, Malard F, Abecassis M, Aerts E, Alaskar AS, Aljurf M, Arat M, Bader P, Baron F, Bazarbachi A (2016) Revised diagnosis and severity criteria for sinusoidal obstruction syndrome\/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation. Bone Marrow Transplant 51(7):906\u2013912","journal-title":"Bone Marrow Transplant"},{"issue":"1","key":"3698_CR14","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1002\/hep.1840040121","volume":"4","author":"GB McDonald","year":"1984","unstructured":"McDonald GB, Sharma P, Matthews DE, Shulman HM, Thomas ED (1984) Venocclusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisposing factors. Hepatology 4(1):116\u2013122","journal-title":"Hepatology"},{"issue":"6","key":"3698_CR15","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1097\/00007890-198712000-00011","volume":"44","author":"RJ Jones","year":"1987","unstructured":"Jones RJ, Lee KS, Beschorner WE, Vogel VG, Grochow LB, Braine HG, Vogelsang GB, Sensenbrenner LL, Santos GW, Saral R (1987) Venoocclusive disease of the liver following bone marrow transplantation. Transplantation 44(6):778\u2013783","journal-title":"Transplantation"},{"key":"3698_CR16","unstructured":"Al Jefri AH, Abujazar H, Al-Ahmari A, Al RA, Al ZZ, Alhejazi A, Bekadja MA, Ibrahim A, Lahoucine M, Ousia S (2016) Veno-occlusive disease\/sinusoidal obstruction syndrome after haematopoietic stem cell transplantation: Middle East\/North Africa regional consensus on prevention, diagnosis and management. Bone Marrow Transplant 52(4):588\u2013591"},{"issue":"1","key":"3698_CR17","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.bbmt.2008.10.019","volume":"15","author":"L Daihong","year":"2009","unstructured":"Daihong L, Xiaojun H, Kaiyan L, Lanping X, Huan C, Wei H, Yuhong C, Xiaohui Z, Qian J (2009) Haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for treatment of hematological malignancies in children. Biol Blood Marrow Transplant 15(1):91\u201394","journal-title":"Biol Blood Marrow Transplant"},{"key":"3698_CR18","unstructured":"Xu LP, Xu ZL, Wang FR, Mo XD, Han TT, Han W, Chen YH, Zhang YY, Wang JZ, Wang Y (2018) Unmanipulated haploidentical transplantation conditioning with busulfan, cyclophosphamide and anti-thymoglobulin for adult severe aplastic anaemia. Bone Marrow Transplant 53(2):188\u2013192"},{"issue":"1","key":"3698_CR19","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1159\/000481723","volume":"139","author":"XD Mo","year":"2018","unstructured":"Mo XD, Yan X, Hu W, Zhang XH, Xu LP, Wang Y, Xu XD, Wang LN, He XX, Yan CH (2018) Perianal infections in the phase before engraftment after allogeneic hematopoietic stem cell transplantations: a study of the incidence, risk factors, and clinical outcomes. Acta Haematol 139(1):19\u201327","journal-title":"Acta Haematol"},{"issue":"1","key":"3698_CR20","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13045-017-0398-y","volume":"10","author":"LP Xu","year":"2017","unstructured":"Xu LP, Jin S, Wang SQ, Xia LH, Bai H, Gao SJ, Liu QF, Wang JM, Wang X, Jiang M (2017) Upfront haploidentical transplant for acquired severe aplastic anemia: registry-based comparison with matched related transplant. J Hematol Oncol 10(1):25","journal-title":"J Hematol Oncol"},{"issue":"2","key":"3698_CR21","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1182\/blood.V57.2.267.267","volume":"57","author":"KM Sullivan","year":"1981","unstructured":"Sullivan KM, Shulman HM, Storb R, Weiden PL, Witherspoon RP, Mcdonald GB, Schubert MM, Atkinson K, Thomas ED (1981) Chronic graft-versus-host disease in 52 patients: adverse natural course and successful treatment with combination immunosuppression. Blood 57(2):267","journal-title":"Blood"},{"issue":"6","key":"3698_CR22","first-page":"825","volume":"15","author":"D Przepiorka","year":"1995","unstructured":"Przepiorka D, Weisdorf D, Martin P, Klingemann HG, Beatty P, Hows J, Thomas ED (1995) 1994 consensus conference on acute GVHD grading. Bone Marrow Transplant 15(6):825\u2013828","journal-title":"Bone Marrow Transplant"},{"issue":"4","key":"3698_CR23","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1002\/ajh.23640","volume":"89","author":"MD Minden","year":"2014","unstructured":"Minden MD, Hogge DE, Weir SJ, Kasper J, Webster DA, Patton L, Jitkova Y, Hurren R, Gronda M, Goard CA (2014) Oral ciclopirox olamine displays biological activity in a phase I study in patients with advanced hematologic malignancies. Am J Hematol 89(4):363\u2013368","journal-title":"Am J Hematol"},{"issue":"8","key":"3698_CR24","doi-asserted-by":"publisher","first-page":"3065","DOI":"10.1182\/blood-2005-05-2146","volume":"107","author":"L Dao-Pei","year":"2006","unstructured":"Dao-Pei L, Lujia D, Tong W, Xiao-Jun H, Mei-Jie Z, Wei H, Huan C, Dai-Hong L, Zhi-Yong G, Yu-Hong C (2006) Conditioning including antithymocyte globulin followed by unmanipulated HLA-mismatched\/haploidentical blood and marrow transplantation can achieve comparable outcomes with HLA-identical sibling transplantation. Blood 107(8):3065\u20133073","journal-title":"Blood"},{"key":"3698_CR25","unstructured":"Huang XJ, Chang YJ (2011) Unmanipulated HLA-mismatched\/haploidentical blood and marrow hematopoietic stem cell transplantation. Biol Blood Marrow Transplant J Am Soc Blood & Marrow Transplant 17(2):197\u2013204"},{"issue":"1","key":"3698_CR26","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1111\/bjh.14854","volume":"179","author":"LJ Han","year":"2017","unstructured":"Han LJ, Wang Y, Fan ZP, Huang F, Zhou J, Fu YW, Qu H, Xuan L, Xu N, Ye JY (2017) Haploidentical transplantation compared with matched sibling and unrelated donor transplantation for adults with standard-risk acute lymphoblastic leukaemia in first complete remission. Br J Haematol 179(1):120","journal-title":"Br J Haematol"},{"key":"3698_CR27","unstructured":"Zhang Y-Y, Liu D-H, Liu K-Y, Xu L-P, Chen H, Han W, Wang Y, Huang X-J (2014) HLA-haploidentical hematopoietic SCT from collateral related donors without in vitro T-cell depletion for hematological malignancies. Bone Marrow Transplant 49(4):496"},{"issue":"01","key":"3698_CR28","doi-asserted-by":"publisher","first-page":"027","DOI":"10.1055\/s-2002-23204","volume":"22","author":"LD Deleve","year":"2002","unstructured":"Deleve LD, Shulman HM, Mcdonald GB (2002) Toxic injury to hepatic sinusoids: sinusoidal obstruction syndrome (veno-occlusive disease). Semin Liver Dis 22(01):027\u2013042","journal-title":"Semin Liver Dis"},{"issue":"5","key":"3698_CR29","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1182\/blood-2003-01-0255","volume":"102","author":"W Martha","year":"2003","unstructured":"Martha W, Richardson PG, David Z, Lee SJ, Corey C, Vincent H, Alyea EP, Antin JH, Stone RM, Soiffer RJ (2003) Prior gemtuzumab ozogamicin exposure significantly increases the risk of veno-occlusive disease in patients who undergo myeloablative allogeneic stem cell transplantation. Blood 102(5):1578\u20131582","journal-title":"Blood"},{"issue":"10","key":"3698_CR30","first-page":"3599","volume":"92","author":"E Carreras","year":"1998","unstructured":"Carreras E, Bertz H, Arcese W, Vernant JP, Tom\u00e1s JF, Hagglund H, Bandini G, Esperou H, Russell J, Rubia J, De La (1998) Incidence and outcome of hepatic veno-occlusive disease after blood or marrow transplantation: a prospective cohort study of the European Group for Blood and Marrow Transplantation. European Group for Blood and Marrow Transplantation Chronic Leukemia Working Party. Blood 92(10):3599\u20133604","journal-title":"Blood"},{"issue":"2","key":"3698_CR31","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1002\/pbc.21260","volume":"50","author":"W Jastaniah","year":"2010","unstructured":"Jastaniah W, Harmatz P, Pakbaz Z, Fischer R, Vichinsky E, Walters MC (2010) Transfusional iron burden and liver toxicity after bone marrow transplantation for acute myelogenous leukemia and hemoglobinopathies. Pediatr Blood Cancer 50(2):319\u2013324","journal-title":"Pediatr Blood Cancer"},{"issue":"10","key":"3698_CR32","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1038\/sj.bmt.1705835","volume":"40","author":"DKL Cheuk","year":"2007","unstructured":"Cheuk DKL, Wang P, Lee TL, Chiang AKS, Ha SY, Lau YL, Chan GCF (2007) Risk factors and mortality predictors of hepatic veno-occlusive disease after pediatric hematopoietic stem cell transplantation. Bone Marrow Transplant 40(10):935\u2013944","journal-title":"Bone Marrow Transplant"},{"issue":"10","key":"3698_CR33","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1016\/j.leukres.2013.06.024","volume":"37","author":"H Kim","year":"2013","unstructured":"Kim H, Lee KH, Sang KS, Jung CW, Joo YD, Kim SH, Kim BS, Choi JH, Kwak JY, Min KK (2013) Hepatic sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation in adult patients with idiopathic aplastic anemia. Leuk Res 37(10):1241\u20131247","journal-title":"Leuk Res"},{"key":"3698_CR34","unstructured":"Faraci M, Bertaina A, Luksch R, Calore E, Lanino E, Saglio F, Prete A, Menconi M, De Simone G, Tintori V (2018) Sinusoidal obstruction syndrome\/Veno-occlusive disease after autologous or allogeneic hematopoietic stem cell transplantation in children: a retrospective study of the Italian Hematology-Oncology Association\u2013Hematopoietic Stem Cell Transplantation Group. Biol Blood Marrow Transplant 25(2):313\u2013320"},{"issue":"3","key":"3698_CR35","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/bmt.2015.283","volume":"51","author":"K Yakushijin","year":"2015","unstructured":"Yakushijin K, Atsuta Y, Doki N, Yokota A, Kanamori H, Miyamoto T, Ohwada C, Miyamura K, Nawa Y, Kurokawa M (2015) Sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation: incidence, risk factors and outcomes. Bone Marrow Transplant 51(3):403","journal-title":"Bone Marrow Transplant"},{"issue":"2","key":"3698_CR36","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/BF01695888","volume":"66","author":"E Carreras","year":"1993","unstructured":"Carreras E, Gra\u00f1ena A, Navasa M, Bruguera M, Marco V, Sierra J, Tassies MD, Garc\u00eda-Pag\u00e1n JC, Mart\u00ed JM, Bosch J. (1993) On the reliability of clinical criteria for the diagnosis of hepatic veno-occlusive disease. Ann Hematol 66(2):77\u201380","journal-title":"Ann Hematol"},{"key":"3698_CR37","doi-asserted-by":"crossref","unstructured":"Richardson PG, Smith AR, Grupp SA, Kernan NA, Arai S, Haut PR, Triplett BM, Gillio AP, Symons HJ, Adams RH (2011) Defibrotide (DF) in the treatment of hepatic veno-occlusive disease (VOD) in stem cell transplant (SCT) and non-SCT patients (pts): early intervention improves outcome - updated results of a treatment IND expanded access protocol. Blood 118(21):487","DOI":"10.1182\/blood.V118.21.487.487"},{"issue":"4","key":"3698_CR38","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.jceh.2014.10.002","volume":"4","author":"CQ Fan","year":"2014","unstructured":"Fan CQ, Crawford JM (2014) Sinusoidal obstruction syndrome (hepatic veno-occlusive disease). J Clin Exp Hepatol 4(4):332\u2013346","journal-title":"J Clin Exp Hepatol"},{"issue":"5","key":"3698_CR39","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1002\/hep.22772","volume":"49","author":"LD Deleve","year":"2010","unstructured":"Deleve LD, Dominique-Charles V, Guadalupe GT (2010) Vascular disorders of the liver. Hepatology 49(5):1729\u20131764","journal-title":"Hepatology"},{"issue":"2","key":"3698_CR40","doi-asserted-by":"publisher","first-page":"S108","DOI":"10.1016\/j.bbmt.2014.11.135","volume":"21","author":"S Corbacioglu","year":"2015","unstructured":"Corbacioglu S, Carreras E, Mohty M, Pagliuca A, Ballabio M, Hume R, Bandiera V, Finetto G, Richardson PG (2015) Defibrotide for the treatment of hepatic veno-occlusive disease: an update from the international compassionate use program in 710 patients. Biol Blood Marrow Transplant 21(2):S108\u2013S108","journal-title":"Biol Blood Marrow Transplant"},{"issue":"7","key":"3698_CR41","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/sj.bmt.1705297","volume":"37","author":"H Imran","year":"2006","unstructured":"Imran H, Tleyjeh IM, Zirakzadeh A, Rodriguez V, Khan SP (2006) Use of prophylactic anticoagulation and the risk of hepatic veno-occlusive disease in patients undergoing hematopoietic stem cell transplantation: a systematic review and meta-analysis. Bone Marrow Transplant 37(7):677\u2013686","journal-title":"Bone Marrow Transplant"},{"issue":"5","key":"3698_CR42","doi-asserted-by":"publisher","first-page":"897","DOI":"10.3346\/jkms.2006.21.5.897","volume":"21","author":"S Joon Sup","year":"2006","unstructured":"Joon Sup S, Jong Jin S, Hyung Nam M, Thad G, Ho Joon I (2006) Prophylactic low-dose heparin or prostaglandin E1 may prevent severe veno-occlusive disease of the liver after allogeneic hematopoietic stem cell transplantation in Korean children. J Korean Med Sci 21(5):897\u2013903","journal-title":"J Korean Med Sci"},{"issue":"2","key":"3698_CR43","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.bbmt.2006.09.012","volume":"13","author":"J Tay","year":"2007","unstructured":"Tay J, Tinmouth A, Fergusson D, Huebsch L, Allan DS (2007) Systematic review of controlled clinical trials on the use of Ursodeoxycholic acid for the prevention of hepatic veno-occlusive disease in hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 13(2):206\u2013217","journal-title":"Biol Blood Marrow Transplant"},{"issue":"1","key":"3698_CR44","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1002\/(SICI)1096-8652(200005)64:1<32::AID-AJH6>3.0.CO;2-N","volume":"64","author":"K Ohashi","year":"2010","unstructured":"Ohashi K, Tanabe J, Watanabe R, Tanaka T, Sakamaki H, Maruta A, Okamoto S, Aotsuka N, Saito K, Nishimura M (2010) The Japanese multicenter open randomized trial of ursodeoxycholic acid prophylaxis for hepatic veno-occlusive disease after stem cell transplantation. Am J Hematol 64(1):32\u201338","journal-title":"Am J Hematol"},{"issue":"4","key":"3698_CR45","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1111\/j.1365-2141.2009.07871.x","volume":"147","author":"B Cappelli","year":"2010","unstructured":"Cappelli B, Chiesa R, Evangelio C, Biffi A, Roccia T, Frugnoli I, Biral E, No\u00e3\u00a8 A, Fossati M, Finizio V (2010) Absence of VOD in paediatric thalassaemic HSCT recipients using defibrotide prophylaxis and intravenous Busulphan. Br J Haematol 147(4):554\u2013560","journal-title":"Br J Haematol"},{"issue":"9823","key":"3698_CR46","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/S0140-6736(11)61938-7","volume":"379","author":"S Corbacioglu","year":"2012","unstructured":"Corbacioglu S, Cesaro S, Faraci M, Valteau-Couanet D, Gruhn B, Rovelli A, Boelens JJ, Hewitt A, Schrum J, Schulz AS (2012) Defibrotide for prophylaxis of hepatic veno-occlusive disease in paediatric haemopoietic stem-cell transplantation: an open-label, phase 3, randomised controlled trial. Lancet 379(9823):1301\u20131309","journal-title":"Lancet"},{"issue":"5","key":"3698_CR47","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.thromres.2005.10.010","volume":"118","author":"I Batsis","year":"2006","unstructured":"Batsis I, Yannaki E, Kaloyannidis P, Sakellari I, Smias C, Georgoulis I, Fassas A, Anagnostopoulos A (2006) Veno-occlusive disease prophylaxis with fresh frozen plasma and heparin in bone marrow transplantation. Thromb Res 118(5):611\u2013618","journal-title":"Thromb Res"},{"issue":"3","key":"3698_CR48","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/sj.bmt.1705724","volume":"40","author":"M Matsumoto","year":"2007","unstructured":"Matsumoto M, Kawa K, Uemura M, Kato S, Ishizashi H, Isonishi A, Yagi H, Y-D P, Takeshima Y, Kosaka Y (2007) Prophylactic fresh frozen plasma may prevent development of hepatic VOD after stem cell transplantation via ADAMTS13-mediated restoration of von Willebrand factor plasma levels. Bone Marrow Transplant 40(3):251","journal-title":"Bone Marrow Transplant"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-019-03698-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00277-019-03698-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-019-03698-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T23:11:00Z","timestamp":1588374660000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00277-019-03698-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,3]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["3698"],"URL":"https:\/\/doi.org\/10.1007\/s00277-019-03698-8","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,3]]},"assertion":[{"value":"1 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendment or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}